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Albert Powers, MD, PhD

Assistant Professor of Psychiatry; Medical & Associate Director, Yale PRIME Psychosis Risk Clinic, Psychiatry

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Selected Publications

Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-riskCollins M, Ji J, Chung Y, Lympus C, Afriyie-Agyemang Y, Addington J, Goodyear B, Bearden C, Cadenhead K, Mirzakhanian H, Tsuang M, Cornblatt B, Carrión R, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Woods S, Powers A, Anticevic A, Cannon T. Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk Molecular Psychiatry 2022, 1-8. PMID: 36434057, DOI: 10.1038/s41380-022-01870-7.
Measuring Voluntary Control Over Hallucinations: The Yale Control Over Perceptual Experiences (COPE) Scales.Mourgues C, Hammer A, Fisher V, Kafadar E, Quagan B, Bien C, Jaeger H, Thomas R, Sibarium E, Negreira AM, Sarisik E, Polisetty V, Nur Eken H, Imtiaz A, Niles H, Sheldon AD, Powers AR. Measuring Voluntary Control Over Hallucinations: The Yale Control Over Perceptual Experiences (COPE) Scales. Schizophrenia Bulletin 2022, 48: 673-683. PMID: 35089361, PMCID: PMC9077437, DOI: 10.1093/schbul/sbab144.
Feasibility Analysis of Phenotype Quantification from Unstructured Clinical InteractionsBarron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Birnbaum M, Constable T, Cecchi G, Krystal J. Feasibility Analysis of Phenotype Quantification from Unstructured Clinical Interactions Computational Psychiatry 2022, 6: 1. DOI: 10.5334/cpsy.78.
Navigating the Benefits and Pitfalls of Online Psychiatric Data CollectionQuagan B, Woods SW, Powers AR. Navigating the Benefits and Pitfalls of Online Psychiatric Data Collection JAMA Psychiatry 2021, 78: 1185-1186. PMID: 34431976, PMCID: PMC9205608, DOI: 10.1001/jamapsychiatry.2021.2315.
Racial and ethnic differences in perception of provider cultural competence among patients with depression and anxiety symptoms: a retrospective, population-based, cross-sectional analysisEken HN, Dee EC, Powers AR, Jordan A. Racial and ethnic differences in perception of provider cultural competence among patients with depression and anxiety symptoms: a retrospective, population-based, cross-sectional analysis The Lancet Psychiatry 2021, 8: 957-968. PMID: 34563316, DOI: 10.1016/s2215-0366(21)00285-6.
Decision Models and Technology Can Help Psychiatry Develop BiomarkersBarron DS, Baker JT, Budde KS, Bzdok D, Eickhoff SB, Friston KJ, Fox PT, Geha P, Heisig S, Holmes A, Onnela JP, Powers A, Silbersweig D, Krystal JH. Decision Models and Technology Can Help Psychiatry Develop Biomarkers Frontiers In Psychiatry 2021, 12: 706655. PMID: 34566711, PMCID: PMC8458705, DOI: 10.3389/fpsyt.2021.706655.
Computational Mechanism for the Effect of Psychosis Community Treatment: A Conceptual Review From Neurobiology to Social InteractionBenrimoh D, Sheldon A, Sibarium E, Powers AR. Computational Mechanism for the Effect of Psychosis Community Treatment: A Conceptual Review From Neurobiology to Social Interaction Frontiers In Psychiatry 2021, 12: 685390. PMID: 34385938, PMCID: PMC8353084, DOI: 10.3389/fpsyt.2021.685390.
Increased face detection responses on the mooney faces test in people at clinical high risk for psychosisSilverstein SM, Thompson JL, Gold JM, Schiffman J, Waltz JA, Williams TF, Zinbarg RE, Mittal VA, Ellman LM, Strauss GP, Walker EF, Woods SW, Levin JA, Kafadar E, Kenney J, Smith D, Powers AR, Corlett PR. Increased face detection responses on the mooney faces test in people at clinical high risk for psychosis Schizophrenia 2021, 7: 26. PMID: 34001909, PMCID: PMC8129098, DOI: 10.1038/s41537-021-00156-1.
Magnetic Resonance Spectroscopy Investigation of Conditioned Auditory PerceptsMichaels T, Chen C, Hancock R, Corlett P, Powers A. Magnetic Resonance Spectroscopy Investigation of Conditioned Auditory Percepts Biological Psychiatry 2021, 89: s154. DOI: 10.1016/j.biopsych.2021.02.395.
Parsing the Mechanistic Heterogeneity of Hallucinations Using Theory- and Data-Driven Computational ApproachesKafadar E, Quagan B, Hammer A, Jaeger H, Mourgues C, Sibarium E, Negreira A, Sarisik E, Lim C, Powers A. Parsing the Mechanistic Heterogeneity of Hallucinations Using Theory- and Data-Driven Computational Approaches Biological Psychiatry 2021, 89: s337-s338. DOI: 10.1016/j.biopsych.2021.02.843.
Preliminary Evaluation of Phenotypic Features from Clinical InteractionsBarron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Baker J, Constable T, Cecchi G, Krystal J. Preliminary Evaluation of Phenotypic Features from Clinical Interactions Journal Of Pain 2021, 22: 594. DOI: 10.1016/j.jpain.2021.03.068.
Regression dynamic causal modeling for resting‐state fMRIFrässle S, Harrison SJ, Heinzle J, Clementz BA, Tamminga CA, Sweeney JA, Gershon ES, Keshavan MS, Pearlson GD, Powers A, Stephan KE. Regression dynamic causal modeling for resting‐state fMRI Human Brain Mapping 2021, 42: 2159-2180. PMID: 33539625, PMCID: PMC8046067, DOI: 10.1002/hbm.25357.
Computerized Assessment of Psychosis Risk †Mittal VA, Ellman LM, Strauss GP, Walker EF, Corlett PR, Schiffman J, Woods SW, Powers AR, Silverstein SM, Waltz JA, Zinbarg R, Chen S, Williams T, Kenney J, Gold JM. Computerized Assessment of Psychosis Risk † Journal Of Psychiatry And Brain Science 2021, 6: e210011. PMID: 34307899, PMCID: PMC8302046, DOI: 10.20900/jpbs.20210011.
Voluntary control of auditory hallucinations: phenomenology to therapeutic implicationsSwyer A, Powers AR. Voluntary control of auditory hallucinations: phenomenology to therapeutic implications Schizophrenia 2020, 6: 19. PMID: 32753641, PMCID: PMC7403299, DOI: 10.1038/s41537-020-0106-8.
Enhancing Psychosis Risk Prediction Through Computational Cognitive NeuroscienceGold JM, Corlett PR, Strauss GP, Schiffman J, Ellman LM, Walker EF, Powers AR, Woods SW, Waltz JA, Silverstein SM, Mittal VA. Enhancing Psychosis Risk Prediction Through Computational Cognitive Neuroscience Schizophrenia Bulletin 2020, 46: sbaa091-. PMID: 32648913, PMCID: PMC7707066, DOI: 10.1093/schbul/sbaa091.
Modeling perception and behavior in individuals at clinical high risk for psychosis: Support for the predictive processing frameworkKafadar E, Mittal VA, Strauss GP, Chapman HC, Ellman LM, Bansal S, Gold JM, Alderson-Day B, Evans S, Moffatt J, Silverstein SM, Walker EF, Woods SW, Corlett PR, Powers AR. Modeling perception and behavior in individuals at clinical high risk for psychosis: Support for the predictive processing framework Schizophrenia Research 2020, 226: 167-175. PMID: 32593735, PMCID: PMC7774587, DOI: 10.1016/j.schres.2020.04.017.
Paracingulate Sulcus Length Is Shorter in Voice-Hearers Regardless of Need for Care.Powers AR, van Dyck LI, Garrison JR, Corlett PR. Paracingulate Sulcus Length Is Shorter in Voice-Hearers Regardless of Need for Care. Schizophrenia Bulletin 2020, 46: 1520-1523. PMID: 32432706, PMCID: PMC7707078, DOI: 10.1093/schbul/sbaa067.
S197. PAVLOVIAN CONDITIONED HALLUCINATIONS TASKS AND PSYCHOMETRIC THRESHOLDING IN ENRICHED ONLINE SAMPLEKafadar E, Lim C, Powers A. S197. PAVLOVIAN CONDITIONED HALLUCINATIONS TASKS AND PSYCHOMETRIC THRESHOLDING IN ENRICHED ONLINE SAMPLE Schizophrenia Bulletin 2020, 46: s113-s114. PMCID: PMC7234405, DOI: 10.1093/schbul/sbaa031.263.
Commentary. Toward a core outcomes assessment set for clinical high riskWoods SW, Mourgues-Codern CV, Powers AR. Commentary. Toward a core outcomes assessment set for clinical high risk Schizophrenia Research 2020, 227: 78-80. PMID: 32414650, PMCID: PMC8215729, DOI: 10.1016/j.schres.2020.05.008.
Counterpoint. Early intervention for psychosis risk syndromes: Minimizing risk and maximizing benefitWoods SW, Bearden CE, Sabb FW, Stone WS, Torous J, Cornblatt BA, Perkins DO, Cadenhead KS, Addington J, Powers AR, Mathalon DH, Calkins ME, Wolf DH, Corcoran CM, Horton LE, Mittal VA, Schiffman J, Ellman LM, Strauss GP, Mamah D, Choi J, Pearlson GD, Shah JL, Fusar-Poli P, Arango C, Perez J, Koutsouleris N, Wang J, Kwon JS, Walsh BC, McGlashan TH, Hyman SE, Gur RE, Cannon TD, Kane JM, Anticevic A. Counterpoint. Early intervention for psychosis risk syndromes: Minimizing risk and maximizing benefit Schizophrenia Research 2020, 227: 10-17. PMID: 32402605, PMCID: PMC8218020, DOI: 10.1016/j.schres.2020.04.020.
Preliminary Phenotypic Feature Capture During Clinical InteractionBarron D, Heisig S, Norel R, Agurto C, Quagan B, Powers A, Baker J, Constable R, Cecchi G, Krystal J. Preliminary Phenotypic Feature Capture During Clinical Interaction Biological Psychiatry 2020, 87: s212-s213. DOI: 10.1016/j.biopsych.2020.02.552.
Direct and Indirect Coping Strategies Used by Voice-Hearers to Control Their ExperiencesQuagan B, Mourgues C, Powers A. Direct and Indirect Coping Strategies Used by Voice-Hearers to Control Their Experiences Biological Psychiatry 2020, 87: s162. DOI: 10.1016/j.biopsych.2020.02.429.
Development of the Voice Hearing Control Scales: And Instrument to Assess Control and Efficacy Over Voice-Hearing ExperiencesMourgues C, Quagan B, Powers A. Development of the Voice Hearing Control Scales: And Instrument to Assess Control and Efficacy Over Voice-Hearing Experiences Biological Psychiatry 2020, 87: s159-s160. DOI: 10.1016/j.biopsych.2020.02.423.
Pavlovian Conditioned Hallucinations Tasks and Psychometric Thresholding in an Enriched Online SampleKafadar E, Lim C, Powers A. Pavlovian Conditioned Hallucinations Tasks and Psychometric Thresholding in an Enriched Online Sample Biological Psychiatry 2020, 87: s208-s209. DOI: 10.1016/j.biopsych.2020.02.542.
Realizing the Clinical Potential of Computational Psychiatry: Report From the Banbury Center Meeting, February 2019Browning M, Carter CS, Chatham C, Ouden H, Gillan CM, Baker JT, Chekroud AM, Cools R, Dayan P, Gold J, Goldstein RZ, Hartley CA, Kepecs A, Lawson RP, Mourao-Miranda J, Phillips ML, Pizzagalli DA, Powers A, Rindskopf D, Roiser JP, Schmack K, Schiller D, Sebold M, Stephan KE, Frank MJ, Huys Q, Paulus M. Realizing the Clinical Potential of Computational Psychiatry: Report From the Banbury Center Meeting, February 2019 Biological Psychiatry 2020, 88: e5-e10. PMID: 32113656, DOI: 10.1016/j.biopsych.2019.12.026.
Development of Voluntary Control Over Voice-Hearing Experiences:Evidence from Treatment-Seeking and Non-Treatment-Seeking Voice-HearersMourgues C, Negreira AM, Quagan B, Mercan NE, Niles H, Kafadar E, Bien C, Kamal F, Powers AR. Development of Voluntary Control Over Voice-Hearing Experiences:Evidence from Treatment-Seeking and Non-Treatment-Seeking Voice-Hearers Schizophrenia Bulletin Open 2020, 1: sgaa052-. PMID: 33196043, PMCID: PMC7643545, DOI: 10.1093/schizbullopen/sgaa052.
Predictive validity of conversion from the clinical high risk syndrome to frank psychosisYoviene Sykes LA, Ferrara M, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Perkins DO, Mathalon DH, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH, Woodberry KA, Powers AR, Ponce AN, Cahill JD, Pollard JM, Srihari VH, Woods SW. Predictive validity of conversion from the clinical high risk syndrome to frank psychosis Schizophrenia Research 2019, 216: 184-191. PMID: 31864837, PMCID: PMC7239715, DOI: 10.1016/j.schres.2019.12.002.
Duration of the psychosis prodromePowers AR, Addington J, Perkins DO, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH, Woods SW. Duration of the psychosis prodrome Schizophrenia Research 2019, 216: 443-449. PMID: 31806523, PMCID: PMC7539292, DOI: 10.1016/j.schres.2019.10.051.
Psychotic Experiences in the General PopulationPowers AR. Psychotic Experiences in the General Population JAMA Psychiatry 2019, 76: 1228-1229. PMID: 31553416, PMCID: PMC8215730, DOI: 10.1001/jamapsychiatry.2019.2391.
Reliability, Validity, Epidemiology, and Cultural Variation of the Structured Interview for Psychosis-Risk Syndromes (SIPS) and the Scale of Psychosis-Risk Symptoms (SOPS)Woods S, Walsh B, Powers A, McGlashan T. Reliability, Validity, Epidemiology, and Cultural Variation of the Structured Interview for Psychosis-Risk Syndromes (SIPS) and the Scale of Psychosis-Risk Symptoms (SOPS) 2019, 85-113. DOI: 10.1007/978-3-030-17336-4_5.
Integration of Literature Across Countries: Challenges, Opportunities, and Implications for Future ResearchWalsh B, Woods S, Powers A. Integration of Literature Across Countries: Challenges, Opportunities, and Implications for Future Research 2019, 369-378. DOI: 10.1007/978-3-030-17336-4_21.
Does hallucination perceptual modality impact psychosis risk?Niles H, Walsh B, Woods S, Powers A. Does hallucination perceptual modality impact psychosis risk? Acta Psychiatrica Scandinavica 2019, 140: 360-370. PMID: 31355420, PMCID: PMC6752971, DOI: 10.1111/acps.13078.
F61. TRIVIAL TRANSITIONS? SIPS-DEFINED CONVERSIONS TO PSYCHOSIS: ONE YEAR OUTCOMESykes L, Ferrara M, Cahill J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Perkins D, Mathalon D, Seidman L, Tsuang M, Walker E, Powers A, McGlashan T, Woodberry K, Ponce A, Srihari V, Woods S. F61. TRIVIAL TRANSITIONS? SIPS-DEFINED CONVERSIONS TO PSYCHOSIS: ONE YEAR OUTCOME Schizophrenia Bulletin 2019, 45: s277-s278. PMCID: PMC6455394, DOI: 10.1093/schbul/sbz018.473.
29.1 COMPUTATIONAL MODELING OF PERCEPTION AND BEHAVIOR REVEALS HIDDEN INSIGHTS INTO MECHANISMS OF PSYCHOTIC SYMPTOMSPowers A, Mathys C, Corlett P. 29.1 COMPUTATIONAL MODELING OF PERCEPTION AND BEHAVIOR REVEALS HIDDEN INSIGHTS INTO MECHANISMS OF PSYCHOTIC SYMPTOMS Schizophrenia Bulletin 2019, 45: s136-s136. PMCID: PMC6455883, DOI: 10.1093/schbul/sbz022.117.
From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum PsychosesHumpston CS, Adams RA, Benrimoh D, Broome MR, Corlett PR, Gerrans P, Horga G, Parr T, Pienkos E, Powers AR, Raballo A, Rosen C, Linden DEJ. From Computation to the First-Person: Auditory-Verbal Hallucinations and Delusions of Thought Interference in Schizophrenia-Spectrum Psychoses Schizophrenia Bulletin 2019, 45: s56-s66. PMID: 30715542, PMCID: PMC6357975, DOI: 10.1093/schbul/sby073.
Beyond Trauma: A Multiple Pathways Approach to Auditory Hallucinations in Clinical and Nonclinical PopulationsLuhrmann TM, Alderson-Day B, Bell V, Bless JJ, Corlett P, Hugdahl K, Jones N, Larøi F, Moseley P, Padmavati R, Peters E, Powers AR, Waters F. Beyond Trauma: A Multiple Pathways Approach to Auditory Hallucinations in Clinical and Nonclinical Populations Schizophrenia Bulletin 2019, 45: s24-s31. PMID: 30715545, PMCID: PMC6357973, DOI: 10.1093/schbul/sby110.
Hallucinations and Strong PriorsCorlett PR, Horga G, Fletcher PC, Alderson-Day B, Schmack K, Powers AR. Hallucinations and Strong Priors Trends In Cognitive Sciences 2018, 23: 114-127. PMID: 30583945, PMCID: PMC6368358, DOI: 10.1016/j.tics.2018.12.001.
Conditioned hallucinations: historic insights and future directionsCorlett PR, Powers AR. Conditioned hallucinations: historic insights and future directions World Psychiatry 2018, 17: 361-362. PMID: 30192086, PMCID: PMC6127761, DOI: 10.1002/wps.20557.
Guided by Voices: Hallucinations and the Psychosis SpectrumPowers AR, Corlett PR, Ross DA. Guided by Voices: Hallucinations and the Psychosis Spectrum Biological Psychiatry 2018, 84: e43-e45. PMID: 30165952, PMCID: PMC6696907, DOI: 10.1016/j.biopsych.2018.07.015.
Aligning Computational Psychiatry With the Hearing Voices Movement: Hearing Their VoicesPowers AR, Bien C, Corlett PR. Aligning Computational Psychiatry With the Hearing Voices Movement: Hearing Their Voices JAMA Psychiatry 2018, 75: 640-641. PMID: 29801029, PMCID: PMC6129977, DOI: 10.1001/jamapsychiatry.2018.0509.
Shamanism and psychosis: Shared mechanisms?Powers AR, Corlett PR. Shamanism and psychosis: Shared mechanisms? Behavioral And Brain Sciences 2018, 41: e83. PMID: 31064450, DOI: 10.1017/s0140525x1700214x.
Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups.Woods SW, Powers AR, Taylor JH, Davidson CA, Johannesen JK, Addington J, Perkins DO, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH. Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups. Schizophrenia Bulletin 2017, 44: 254-263. PMID: 29036402, PMCID: PMC5814797, DOI: 10.1093/schbul/sbx138.
Pavlovian conditioning–induced hallucinations result from overweighting of perceptual priorsPowers AR, Mathys C, Corlett PR. Pavlovian conditioning–induced hallucinations result from overweighting of perceptual priors Science 2017, 357: 596-600. PMID: 28798131, PMCID: PMC5802347, DOI: 10.1126/science.aan3458.
Varieties of Voice-Hearing: Psychics and the Psychosis Continuum.Powers AR, Kelley MS, Corlett PR. Varieties of Voice-Hearing: Psychics and the Psychosis Continuum. Schizophrenia Bulletin 2016, 43: 84-98. PMID: 28053132, PMCID: PMC5216860, DOI: 10.1093/schbul/sbw133.
Hallucinations as Top-Down Effects on PerceptionPowers AR, Kelley M, Corlett PR. Hallucinations as Top-Down Effects on Perception Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2016, 1: 393-400. PMID: 28626813, PMCID: PMC5469545, DOI: 10.1016/j.bpsc.2016.04.003.
Generalization of multisensory perceptual learning.Powers Iii AR, Hillock-Dunn A, Wallace MT. Generalization of multisensory perceptual learning. Scientific Reports 2016, 6: 23374. PMID: 27000988, PMCID: PMC4802214, DOI: 10.1038/srep23374.
Ketamine-Induced HallucinationsPowers A, Gancsos MG, Finn ES, Morgan PT, Corlett PR. Ketamine-Induced Hallucinations Psychopathology 2015, 48: 376-385. PMID: 26361209, PMCID: PMC4684980, DOI: 10.1159/000438675.
The effects of visual training on multisensory temporal processingStevenson RA, Wilson MM, Powers AR, Wallace MT. The effects of visual training on multisensory temporal processing Experimental Brain Research 2013, 225: 479-489. PMID: 23307155, PMCID: PMC3606590, DOI: 10.1007/s00221-012-3387-y.
Fulfilling Our Leadership ResponsibilityGorrindo P, Tedeschi SK, Powers AR, Niswender K. Fulfilling Our Leadership Responsibility JAMA 2013, 309: 147-148. PMID: 23299605, DOI: 10.1001/jama.2012.165720.
Neural Correlates of Multisensory Perceptual LearningPowers AR, Hevey MA, Wallace MT. Neural Correlates of Multisensory Perceptual Learning Journal Of Neuroscience 2012, 32: 6263-6274. PMID: 22553032, PMCID: PMC3366559, DOI: 10.1523/jneurosci.6138-11.2012.
Binding of sights and sounds: Age-related changes in multisensory temporal processingHillock AR, Powers AR, Wallace MT. Binding of sights and sounds: Age-related changes in multisensory temporal processing Neuropsychologia 2010, 49: 461-467. PMID: 21134385, PMCID: PMC3140703, DOI: 10.1016/j.neuropsychologia.2010.11.041.
Perceptual Training Narrows the Temporal Window of Multisensory BindingPowers AR, Hillock AR, Wallace MT. Perceptual Training Narrows the Temporal Window of Multisensory Binding Journal Of Neuroscience 2009, 29: 12265-12274. PMID: 19793985, PMCID: PMC2771316, DOI: 10.1523/jneurosci.3501-09.2009.

Clinical Trials

Conditions	Study Title
	Song-making In a Group (SING)
Addictive Behaviors	Testing a Computationally-Informed, Personalized Intervention for Hallucinations
Mental Health & Behavioral Research	Study of Brain Function Across the Lifespan
Mental Health & Behavioral Research	Predictive Coding and Unusual Experiences
Mental Health & Behavioral Research	Sleep Dependent Learning in Schizophrenia and Psychosis Risk Syndrome
Mental Health & Behavioral Research	Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

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