Mary Daly
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Harvey Risch, MD, PhD
12Publications
382Citations
Publications
2024
Physical activity during adolescence and early adulthood and breast cancer risk before age 40 years
Kehm R, Genkinger J, Knight J, Maclnnis R, Liao Y, Li S, Weideman P, Chung W, Kurian A, Colonna S, Andrulis I, Buys S, Daly M, John E, Hopper J, Terry M. Physical activity during adolescence and early adulthood and breast cancer risk before age 40 years. Cancer Epidemiology Biomarkers & Prevention 2024, of1-of9. PMID: 39404779, DOI: 10.1158/1055-9965.epi-24-0743.Peer-Reviewed Original ResearchConceptsRecreational physical activityPhysical activityStrenuous recreational physical activityAssociated with BC riskBreast cancerBreast cancer riskBC risk factorsEarly adulthoodCox proportional hazards regression modelsProportional hazards regression modelsHazards regression modelsBC riskCancer riskLowest quartileFamily cohortStudy enrollmentRisk factorsRegression modelsYoung womenStudy centersWomenAdolescentsAgeCohortAdulthoodPregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk
McDonald J, Liao Y, Knight J, John E, Kurian A, Daly M, Buys S, Huang Y, Frost C, Andrulis I, Colonna S, Friedlander M, Hopper J, Chung W, Genkinger J, MacInnis R, Terry M, Amor D, Andrews L, Antill Y, Balleine R, Beesley J, Bennett I, Bogwitz M, Bodek S, Botes L, Brennan M, Brown M, Buckley M, Burke J, Butow P, Caldon L, Campbell I, Cao M, Chakrabarti A, Chauhan D, Chauhan M, Chenevix-Trench G, Christian A, Cohen P, Colley A, Crook A, Cui J, Courtney E, Cummings M, Dawson S, deFazio A, Delatycki M, Dickson R, Dixon J, Edwards S, Farshid G, Fellows A, Fenton G, Field M, Flanagan J, Fong P, Forrest L, Fox S, French J, Friedlander M, Gaff C, Gattas M, George P, Greening S, Harris M, Hart S, Harraka P, Hayward N, Hopper J, Hoskins C, Hunt C, James P, Jenkins M, Kidd A, Kirk J, Koehler J, Kollias J, Lakhani S, Lawrence M, Lee J, Li S, Lindeman G, Lippey J, Lipton L, Lobb L, Loi S, Mann G, Marsh D, McLachlan S, Meiser B, Milne R, Nightingale S, O'Connell S, O'Sullivan S, Gallego Ortega D, Pachter N, Pang J, Pathak G, Patterson B, Pearn A, Phillips K, Pieper E, Ramus S, Rickard E, Ragunathan A, Robinson B, Saleh M, Skandarajah A, Salisbury E, Saunders C, Saunus J, Savas P, Scott R, Scott C, Sexton A, Shaw J, Shelling A, Srinivasa S, Simpson P, Southey M, Spurdle A, Taylor J, Taylor R, Thorne H, Trainer A, Tucker K, Visvader J, Walker L, Williams R, Winship I, Young M, Zaheed M. Pregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk. JAMA Network Open 2024, 7: e2427441. PMID: 39186276, DOI: 10.1001/jamanetworkopen.2024.27441.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPregnancy-related factorsFull-term pregnancyBC riskNulliparous womenProspective Family Study CohortBreast Cancer Family RegistryBreast cancerBC diagnosisER-negative BCCohort studyHazard ratioCancer Family RegistryBreast cancer riskPersonal history of BCBC family historyCohort study of womenHistory of BCCohort of womenCox proportional hazards regression modelsProportional hazards regression modelsStudy of womenER-negative diseaseFamily RegistryHazards regression modelsScreening guidelinesWhat Proportion of BRCA–Associated Breast Cancer Is Human Epidermal Growth Factor 2–Low and Eligible for Additional Targeted Therapy?
Forester E, Belsare A, Kim D, Whitaker K, Obeid E, Goldstein L, Bleicher R, Daly M, Williams A. What Proportion of BRCA–Associated Breast Cancer Is Human Epidermal Growth Factor 2–Low and Eligible for Additional Targeted Therapy? Journal Of Surgical Research 2024, 299: 217-223. PMID: 38776577, DOI: 10.1016/j.jss.2024.04.032.Peer-Reviewed Original ResearchConceptsTriple negative breast cancerHuman epidermal growth factor 2HER2-lowBreast cancerTargeted therapyMetachronous contralateral breast cancerPathogenic variantsHuman epidermal growth factor 2 statusBRCA-associated breast cancerRetrospective chart review of patientsChart review of patientsContralateral breast cancerBRCA gene statusInvasive breast cancerTargeted therapy optionsReview of patientsHR+/HER2- breast cancerRetrospective chart reviewNegative breast cancerFluorescence in situ hybridizationHER2 dataMetastatic settingTrastuzumab deruxtecanHER2-positiveGrowth factor 2Prevalence and predictors of aspirin/NSAID use among patients with Lynch syndrome (LS).
Singhal S, Chertok Y, Osorio N, Chavez J, Riggs E, Daly M, Hall M. Prevalence and predictors of aspirin/NSAID use among patients with Lynch syndrome (LS). Journal Of Clinical Oncology 2024, 42: 19-19. DOI: 10.1200/jco.2024.42.3_suppl.19.Peer-Reviewed Original ResearchAltmetricConceptsLynch syndromeAssociated with CPCP useLS patientsPatient advocacy websitesPatient-level factorsPersonal historyColonoscopy surveillanceCP benefitColorectal CAHereditary cancerPatients' perceptionsLifetime riskAdvocacy websitesMarital statusCP usersImpact uptakePrevention benefitsLS participantsPerceptions of CPE-surveyCancer CenterPrevention modalitiesNon-usersPerceived inconveniencePerceptions of cancer prevention options for Lynch syndrome (LS) in a multi-national convenience sample.
Hall M, Singhal S, Osorio N, Chavez J, Riggs E, Chertock Y, Daly M. Perceptions of cancer prevention options for Lynch syndrome (LS) in a multi-national convenience sample. Journal Of Clinical Oncology 2024, 42: 77-77. DOI: 10.1200/jco.2024.42.3_suppl.77.Peer-Reviewed Original ResearchConceptsLynch syndromeCancer prevention optionsCA riskNon-usersOne-time surveySupport groupsConvenience sampleCA preventionStratified analysisFox Chase Cancer CenterNegative public attitudesPrevention optionsColonoscopyMSI-H tumorsCA-PTPerceptions of efficacyCancer CenterSide-effect riskPersonal historyBelief statementsSide effect concernsInternational patientsSide effectsMSI-HRiskChildhood physical activity and pubertal timing: findings from the LEGACY girls study
Kehm R, Knight J, Houghton L, McDonald J, Schwartz L, Goldberg M, Chung W, Frost C, Wei Y, Bradbury A, Keegan T, Daly M, Buys S, Andrulis I, John E, Terry M. Childhood physical activity and pubertal timing: findings from the LEGACY girls study. International Journal Of Epidemiology 2024, 53: dyad193. PMID: 38205889, PMCID: PMC10859159, DOI: 10.1093/ije/dyad193.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBreast cancer family historyBody mass index-for-age z-scorePhysical activityChildhood physical activityCancer family historyLEGACY Girls StudyAssociated with later menarcheParametric survival regression modelsOrganized PAMetabolic equivalentsInverse oddsEarly childhoodSociodemographic factorsEffect modificationAssociated with ageLater menarcheNorth American cohortFamily historySurvival regression modelsStudy enrollmentMiddle childhoodAmerican cohortQuestionnaire dataPotential mediatorsZ-score
2023
A Likelihood Ratio Approach for Utilizing Case‐Control Data in the Clinical Classification of Rare Sequence Variants: Application to BRCA1 and BRCA2
Zanti M, O′Mahony D, Parsons M, Li H, Dennis J, Aittomäkkiki K, Andrulis I, Anton-Culver H, Aronson K, Augustinsson A, Becher H, Bojesen S, Bolla M, Brenner H, Brown M, Buys S, Canzian F, Caputo S, Castelao J, Chang-Claude J, Collaborators G, Czene K, Daly M, De Nicolo A, Devilee P, Dörk T, Dunning A, Dwek M, Eccles D, Engel C, Evans D, Fasching P, Gago-Dominguez M, García-Closas M, García-Sáenz J, Gentry-Maharaj A, Giele W, Giles G, Glendon G, Goldberg M, Garcia E, Güendert M, Guénel P, Hahnen E, Haiman C, Hall P, Hamann U, Harkness E, Hogervorst F, Hollestelle A, Hoppe R, Hopper J, Houdayer C, Houlston R, Howell A, Investigators A, Jakimovska M, Jakubowska A, Jernström H, John E, Kaaks R, Kitahara C, Koutros S, Kraft P, Kristensen V, Lacey J, Lambrechts D, Léoné M, Lindblom A, Lubiński J, Lush M, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Martinez M, Menon U, Milne R, Monteiro A, Murphy R, Neuhausen S, Nevanlinna H, Newman W, Offit K, Park S, James P, Peterlongo P, Peto J, Plaseska-Karanfilska D, Punie K, Radice P, Rashid M, Rennert G, Romero A, Rosenberg E, Saloustros E, Sandler D, Schmidt M, Schmutzler R, Shu X, Simard J, Southey M, Stone J, Stoppa-Lyonnet D, Tamimi R, Tapper W, Taylor J, Teo S, Teras L, Terry M, Thomassen M, Troester M, Vachon C, Vega A, Vreeswijk M, Wang Q, Wappenschmidt B, Weinberg C, Wolk A, Zheng W, Feng B, Couch F, Spurdle A, Easton D, Goldgar D, Michailidou K. A Likelihood Ratio Approach for Utilizing Case‐Control Data in the Clinical Classification of Rare Sequence Variants: Application to BRCA1 and BRCA2. Human Mutation 2023, 2023: 1-17. PMID: 38725546, PMCID: PMC11080979, DOI: 10.1155/2023/9961341.Peer-Reviewed Original ResearchCitationsAltmetricAdolescent Physical Activity and Breast Cancer Risk in Young Women: Findings From the ProF-SC Study
Kehm R, Genkinger J, MacInnis R, John E, Knight J, Kurian A, Colonna S, Chung W, Phillips K, Andrulis I, Buys S, Daly M, Hopper J, Terry M. Adolescent Physical Activity and Breast Cancer Risk in Young Women: Findings From the ProF-SC Study. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 858-858. DOI: 10.1158/1055-9965.epi-23-0358.Peer-Reviewed Original ResearchConceptsRecreational physical activityAdolescent physical activityBreast cancer riskPhysical activityBC diagnosisBC riskCancer riskAssociation of recreational physical activityStrenuous recreational physical activityReduce breast cancer riskIncidence of breast cancerNo history of BCStatistically significant multiplicative interactionReduced risk of BCBreast cancerReduce BC riskHistory of BCRisk of BCYoung womenReduced riskSignificant multiplicative interactionCox proportional hazards regression modelsFollow-upProportional hazards regression modelsMultivariate Cox proportional hazards regression models
2022
Common variants in breast cancer risk loci predispose to distinct tumor subtypes
Ahearn T, Zhang H, Michailidou K, Milne R, Bolla M, Dennis J, Dunning A, Lush M, Wang Q, Andrulis I, Anton-Culver H, Arndt V, Aronson K, Auer P, Augustinsson A, Baten A, Becher H, Behrens S, Benitez J, Bermisheva M, Blomqvist C, Bojesen S, Bonanni B, Børresen-Dale A, Brauch H, Brenner H, Brooks-Wilson A, Brüning T, Burwinkel B, Buys S, Canzian F, Castelao J, Chang-Claude J, Chanock S, Chenevix-Trench G, Clarke C, Collée J, Cox A, Cross S, Czene K, Daly M, Devilee P, Dörk T, Dwek M, Eccles D, Evans D, Fasching P, Figueroa J, Floris G, Gago-Dominguez M, Gapstur S, García-Sáenz J, Gaudet M, Giles G, Goldberg M, González-Neira A, Alnæs G, Grip M, Guénel P, Haiman C, Hall P, Hamann U, Harkness E, Heemskerk-Gerritsen B, Holleczek B, Hollestelle A, Hooning M, Hoover R, Hopper J, Howell A, Jakimovska M, Jakubowska A, John E, Jones M, Jung A, Kaaks R, Kauppila S, Keeman R, Khusnutdinova E, Kitahara C, Ko Y, Koutros S, Kristensen V, Krüger U, Kubelka-Sabit K, Kurian A, Kyriacou K, Lambrechts D, Lee D, Lindblom A, Linet M, Lissowska J, Llaneza A, Lo W, MacInnis R, Mannermaa A, Manoochehri M, Margolin S, Martinez M, McLean C, Meindl A, Menon U, Nevanlinna H, Newman W, Nodora J, Offit K, Olsson H, Orr N, Park-Simon T, Patel A, Peto J, Pita G, Plaseska-Karanfilska D, Prentice R, Punie K, Pylkäs K, Radice P, Rennert G, Romero A, Rüdiger T, Saloustros E, Sampson S, Sandler D, Sawyer E, Schmutzler R, Schoemaker M, Schöttker B, Sherman M, Shu X, Smichkoska S, Southey M, Spinelli J, Swerdlow A, Tamimi R, Tapper W, Taylor J, Teras L, Terry M, Torres D, Troester M, Vachon C, van Deurzen C, van Veen E, Wagner P, Weinberg C, Wendt C, Wesseling J, Winqvist R, Wolk A, Yang X, Zheng W, Couch F, Simard J, Kraft P, Easton D, Pharoah P, Schmidt M, García-Closas M, Chatterjee N. Common variants in breast cancer risk loci predispose to distinct tumor subtypes. Breast Cancer Research 2022, 24: 2. PMID: 34983606, PMCID: PMC8725568, DOI: 10.1186/s13058-021-01484-x.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
Zhang H, Ahearn TU, Lecarpentier J, Barnes D, Beesley J, Qi G, Jiang X, O’Mara T, Zhao N, Bolla MK, Dunning AM, Dennis J, Wang Q, Ful ZA, Aittomäki K, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Arun BK, Auer PL, Azzollini J, Barrowdale D, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bialkowska K, Blanco A, Blomqvist C, Bogdanova NV, Bojesen SE, Bonanni B, Bondavalli D, Borg A, Brauch H, Brenner H, Briceno I, Broeks A, Brucker SY, Brüning T, Burwinkel B, Buys SS, Byers H, Caldés T, Caligo MA, Calvello M, Campa D, Castelao JE, Chang-Claude J, Chanock SJ, Christiaens M, Christiansen H, Chung WK, Claes KBM, Clarke CL, Cornelissen S, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Diez O, Domchek SM, Dörk T, Dwek M, Eccles DM, Ekici AB, Evans DG, Fasching PA, Figueroa J, Foretova L, Fostira F, Friedman E, Frost D, Gago-Dominguez M, Gapstur SM, Garber J, García-Sáenz JA, Gaudet MM, Gayther SA, Giles GG, Godwin AK, Goldberg MS, Goldgar DE, González-Neira A, Greene MH, Gronwald J, Guénel P, Häberle L, Hahnen E, Haiman CA, Hake CR, Hall P, Hamann U, Harkness EF, Heemskerk-Gerritsen BAM, Hillemanns P, Hogervorst FBL, Holleczek B, Hollestelle A, Hooning MJ, Hoover RN, Hopper JL, Howell A, Huebner H, Hulick PJ, Imyanitov EN, Isaacs C, Izatt L, Jager A, Jakimovska M, Jakubowska A, James P, Janavicius R, Janni W, John E, Jones M, Jung A, Kaaks R, Kapoor P, Karlan B, Keeman R, Khan S, Khusnutdinova E, Kitahara C, Ko Y, Konstantopoulou I, Koppert L, Koutros S, Kristensen V, Laenkholm A, Lambrechts D, Larsson S, Laurent-Puig P, Lazaro C, Lazarova E, Lejbkowicz F, Leslie G, Lesueur F, Lindblom A, Lissowska J, Lo W, Loud J, Lubinski J, Lukomska A, MacInnis R, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Martinez M, Matricardi L, McGuffog L, McLean C, Mebirouk N, Meindl A, Menon U, Miller A, Mingazheva E, Montagna M, Mulligan A, Mulot C, Muranen T, Nathanson K, Neuhausen S, Nevanlinna H, Neven P, Newman W, Nielsen F, Nikitina-Zake L, Nodora J, Offit K, Olah E, Olopade O, Olsson H, Orr N, Papi L, Papp J, Park-Simon T, Parsons M, Peissel B, Peixoto A, Peshkin B, Peterlongo P, Peto J, Phillips K, Piedmonte M, Plaseska-Karanfilska D, Prajzendanc K, Prentice R, Prokofyeva D, Rack B, Radice P, Ramus S, Rantala J, Rashid M, Rennert G, Rennert H, Risch H, Romero A, Rookus M, Rübner M, Rüdiger T, Saloustros E, Sampson S, Sandler D, Sawyer E, Scheuner M, Schmutzler R, Schneeweiss A, Schoemaker M, Schöttker B, Schürmann P, Senter L, Sharma P, Sherman M, Shu X, Singer C, Smichkoska S, Soucy P, Southey M, Spinelli J, Stone J, Stoppa-Lyonnet D, Swerdlow A, Szabo C, Tamimi R, Tapper W, Taylor J, Teixeira M, Terry M, Thomassen M, Thull D, Tischkowitz M, Toland A, Tollenaar R, Tomlinson I, Torres D, Troester M, Truong T, Tung N, Untch M, Vachon C, van den Ouweland A, van der Kolk L, van Veen E, vanRensburg E, Vega A, Wappenschmidt B, Weinberg C, Weitzel J, Wildiers H, Winqvist R, Wolk A, Yang X, Yannoukakos D, Zheng W, Zorn K, Milne R, Kraft P, Simard J, Pharoah P, Michailidou K, Antoniou A, Schmidt M, Chenevix-Trench G, Easton D, Chatterjee N, García-Closas M. Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses. Nature Genetics 2020, 52: 572-581. PMID: 32424353, PMCID: PMC7808397, DOI: 10.1038/s41588-020-0609-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSusceptibility lociAssociation studiesGenome-wide association studiesCell-specific enhancerWide association studyNovel breast cancer susceptibility lociNovel susceptibility lociBasal mammary cellsBreast cancer susceptibility lociCancer susceptibility lociTriple-negative diseaseCancer susceptibility variantsChip heritabilityNovel lociPolygenic risk scoresSilico analysisLociSusceptibility variantsGenetic correlationsRisk scoreMammary cellsHuman epidermal growth factor receptor 2 (HER2) statusEpidermal growth factor receptor 2 statusBreast cancer susceptibility variantsEuropean ancestry
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