Huey Cai
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2024
Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease: A Prospective Study Among Racially Diverse Populations
Deng K, Pan X, Voehler M, Cai Q, Cai H, Shu X, Gupta D, Lipworth L, Zheng W, Yu D. Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease: A Prospective Study Among Racially Diverse Populations. Journal Of The American Heart Association 2024, 13: e034364. PMID: 38726919, PMCID: PMC11179824, DOI: 10.1161/jaha.124.034364.Peer-Reviewed Original ResearchConceptsIncident coronary heart diseaseAssociated with incident coronary heart diseaseCoronary heart diseaseMetabolic health statusOdds ratioCase-control study of coronary heart diseaseHealth statusDiverse populationsStudy of coronary heart diseaseCoronary heart disease riskRisk of coronary heart diseaseUnconditional logistic regressionBlood lipidsRacially diverse populationLipoprotein cholesterolHeart diseaseCase-control studyHigh-density lipoprotein cholesterolBlood lipoprotein profilesChinese adultsLow-density lipoprotein triglyceridesPotential confoundersLow-density lipoprotein cholesterolGeographically diverse populationsLogistic regressionIntegrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions
Dareng E, Coetzee S, Tyrer J, Peng P, Rosenow W, Chen S, Davis B, Dezem F, Seo J, Nameki R, Reyes A, Aben K, Anton-Culver H, Antonenkova N, Aravantinos G, Bandera E, Freeman L, Beckmann M, Beeghly-Fadiel A, Benitez J, Bernardini M, Bjorge L, Black A, Bogdanova N, Bolton K, Brenton J, Budzilowska A, Butzow R, Cai H, Campbell I, Cannioto R, Chang-Claude J, Chanock S, Chen K, Chenevix-Trench G, Group A, Chiew Y, Cook L, DeFazio A, Dennis J, Doherty J, Dörk T, du Bois A, Dürst M, Eccles D, Ene G, Fasching P, Flanagan J, Fortner R, Fostira F, Gentry-Maharaj A, Giles G, Goodman M, Gronwald J, Haiman C, Håkansson N, Heitz F, Hildebrandt M, Høgdall E, Høgdall C, Huang R, Jensen A, Jones M, Kang D, Karlan B, Karnezis A, Kelemen L, Kennedy C, Khusnutdinova E, Kiemeney L, Kjaer S, Kupryjanczyk J, Labrie M, Lambrechts D, Larson M, Le N, Lester J, Li L, Lubiński J, Lush M, Marks J, Matsuo K, May T, McLaughlin J, McNeish I, Menon U, Missmer S, Modugno F, Moffitt M, Monteiro A, Moysich K, Narod S, Nguyen-Dumont T, Odunsi K, Olsson H, Onland-Moret N, Park S, Pejovic T, Permuth J, Piskorz A, Prokofyeva D, Riggan M, Risch H, Rodríguez-Antona C, Rossing M, Sandler D, Setiawan V, Shan K, Song H, Southey M, Steed H, Sutphen R, Swerdlow A, Teo S, Terry K, Thompson P, Thomsen L, Titus L, Trabert B, Travis R, Tworoger S, Valen E, Van Nieuwenhuysen E, Edwards D, Vierkant R, Webb P, Group O, Weinberg C, Weise R, Wentzensen N, White E, Winham S, Wolk A, Woo Y, Wu A, Yan L, Yannoukakos D, Zeinomar N, Zheng W, Ziogas A, Berchuck A, Goode E, Huntsman D, Pearce C, Ramus S, Sellers T, Consortium T, Freedman M, Lawrenson K, Schildkraut J, Hazelett D, Plummer J, Kar S, Jones M, Pharoah P, Gayther S. Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions. American Journal Of Human Genetics 2024, 111: 1061-1083. PMID: 38723632, PMCID: PMC11179261, DOI: 10.1016/j.ajhg.2024.04.011.Peer-Reviewed Original ResearchTranscriptome-wide association studyRisk lociAssociation studiesTranscription factor ChIP-seqSusceptibility genesGenome-wide association analysisGenome-wide association studiesCausal risk variantsControls of European originTranscriptome-wide associationEpithelial ovarian cancerVariant Effect PredictorIntegrative multi-omics analysisMulti-omics analysisChIP-seqChromatin marksGenomic regionsFine-mappingSusceptibility lociInteractome analysisAssociation analysisEpithelial ovarian cancer histotypesRisk variantsTissue-specificLociDiabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium
Ho N, Abe S, Rahman S, Islam R, Saito E, Gupta P, Pednekar M, Sawada N, Tsugane S, Tamakoshi A, Kimura T, Shu X, Gao Y, Koh W, Cai H, Wen W, Sakata R, Tsuji I, Malekzadeh R, Pourshams A, Kanemura S, Kim J, Chen Y, Ito H, Oze I, Nagata C, Wada K, Sugawara Y, Park S, Shin A, Yuan J, Wang R, Kweon S, Shin M, Poustchi H, Vardanjani H, Ahsan H, Chia K, Matsuo K, Qiao Y, Rothman N, Zheng W, Inoue M, Kang D, Boffetta P. Diabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium. International Journal Of Cancer 2024, 155: 854-870. PMID: 38661292, DOI: 10.1002/ijc.34965.Peer-Reviewed Original ResearchLiver cancer incidenceAsia Cohort ConsortiumBaseline diabetesCancer incidenceCohort ConsortiumAssociated with increased liver cancer riskMortality of liver cancerHazard ratioLiver cancer mortalityTwo-stage meta-analysisLiver cancer riskMeta-analysisCox proportional hazards modelsBody mass indexFollow-up timeProportional hazards modelCancer mortalityCancer riskTobacco smokeBaseline ageCumulative incidence of deathCancer diagnosisCohort studyMeta-analytic approachMass indexFamily history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants
Huang D, Song M, Abe S, Rahman M, Islam M, Saito E, De la Torre K, Sawada N, Tamakoshi A, Shu X, Cai H, Hozawa A, Kanemura S, Kim J, Chen Y, Ito H, Sugawara Y, Park S, Shin M, Hirabayashi M, Kimura T, Gao Y, Wen W, Oze I, Shin A, Ahn Y, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Rothman N, Zheng W, Inoue M, Kang D. Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants. Gastric Cancer 2024, 27: 701-713. PMID: 38649672, PMCID: PMC11193690, DOI: 10.1007/s10120-024-01499-1.Peer-Reviewed Original ResearchFamily history of gastric cancerHistory of gastric cancerGastric cancer incidenceIncident gastric cancerCancer incidenceFamily historyRisk of incident gastric cancerBurden of gastric cancerHazard ratioGastric cancer deathsAsia Cohort ConsortiumGastric cancer mortalityRisk of gastric cancerConfidence intervalsGastric cancer riskRandom-effects meta-analysesCox proportional hazards regressionProportional hazards regressionCase-control studyCohort ConsortiumCancer mortalityCancer surveillanceCancer riskTargeted educationStratified analysisCirculating microRNAs in association with pancreatic cancer risk within 5 years
Wang C, Cai H, Cai Q, Wu J, Stolzenberg‐Solomon R, Guo X, Zhu C, Gao Y, Berlin J, Ye F, Zheng W, Setiawan V, Shu X. Circulating microRNAs in association with pancreatic cancer risk within 5 years. International Journal Of Cancer 2024, 155: 519-531. PMID: 38602070, PMCID: PMC11214275, DOI: 10.1002/ijc.34956.Peer-Reviewed Original ResearchPancreatic cancer riskCancer riskOdds ratioCohort studyAssociated with pancreatic cancer riskSouthern Community Cohort StudyYears prior to cancer diagnosisOvarian Cancer Screening TrialConfidence intervalsYears prior to diagnosisMultiethnic Cohort StudyCommunity Cohort StudyCancer Screening TrialConditional logistic regression analysisMen's Health StudyCase-control pairsProspective cohort studyCase-control studyCancer screeningLogistic regression analysisHealth StudyScreening TrialStratified analysisCancer diagnosisDiscovery stageSodium Intake and Cause-Specific Mortality Among Predominantly Low-Income Black and White US Residents
Yoon H, Cai Q, Yang J, Lipworth L, Cai H, Yu D, Steinwandel M, Gupta D, Blot W, Zheng W, Shu X. Sodium Intake and Cause-Specific Mortality Among Predominantly Low-Income Black and White US Residents. JAMA Network Open 2024, 7: e243802. PMID: 38530308, PMCID: PMC10966417, DOI: 10.1001/jamanetworkopen.2024.3802.Peer-Reviewed Original ResearchPopulation-attributable riskCause-specific mortalityLow-income BlackHazard ratioWhite individualsCohort studyBlack individualsPopulation-attributable risk estimatesSouthern Community Cohort StudyCommunity health centersMultivariable-adjusted Cox regressionCommunity Cohort StudyDietary sodium intakeEstimate hazard ratiosPublic health programsAssociated with sodium intakeFood frequency questionnaireSodium intakeLow-income AmericansCurrent dietary recommendationsLow-income individualsReduce sodium intakeCVD mortalityExcess dietary sodiumNo significant associationGut Microbiome of Patients With Breast Cancer in Vietnam
Nguyen S, Tran H, Long J, Shrubsole M, Cai H, Yang Y, Nguyen L, Nguyen G, Nguyen C, Ta T, Wu J, Cai Q, Zheng W, Tran T, Shu X. Gut Microbiome of Patients With Breast Cancer in Vietnam. JCO Global Oncology 2024, 10: e2300234. PMID: 38359370, PMCID: PMC10881109, DOI: 10.1200/go.23.00234.Peer-Reviewed Original ResearchConceptsGut microbiome health indexGut microbiomeTaxa abundanceA-diversityUnhealthy gut microbiomeGut microbiome of patientsStool samplesShotgun metagenomic sequencingGut microbial diversityAbundance of speciesBreast cancerMicrobiome of patientsMetagenomic sequencingInvestigated taxaGut microbiotaB-diversityMicrobial diversityDiagnosis delayDecreased abundanceIncreased abundanceMicrobiomeHigher intake of fiberGutIntake of fiberTaxaGut microbiome in association with chemotherapy‐induced toxicities among patients with breast cancer
Nguyen S, Tran H, Long J, Shrubsole M, Cai H, Yang Y, Cai Q, Tran T, Zheng W, Shu X. Gut microbiome in association with chemotherapy‐induced toxicities among patients with breast cancer. Cancer 2024, 130: 2014-2030. PMID: 38319284, DOI: 10.1002/cncr.35229.Peer-Reviewed Original ResearchGut microbiomeChemotherapy-induced toxicityRisk of severe neutropeniaReductive tricarboxylic acid cycleMetabolic pathwaysGut microbial diversityTricarboxylic acid cycleSevere nausea/vomitingSevere neutropeniaBreast cancerFamily LachnospiraceaeIncreased risk of severe neutropeniaShotgun metagenomicsClass NegativicutesGut microbiotaB-diversityMicrobial diversityAcid cycleChao1 indexSevere hematologic toxicityA-diversityFirst-line treatmentMicrobiomeMultivariate logistic regressionGutAssociations between Plasma Tocopherols and Lung Cancer Risk: Results from the Southern Community Cohort Study.
Yoon H, Wu J, Shidal C, Sun Y, Franke A, Yang J, Braithwaite D, Courtney R, Cai H, Blot W, Shu X, Zheng W, Cai Q. Associations between Plasma Tocopherols and Lung Cancer Risk: Results from the Southern Community Cohort Study. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 480-488. PMID: 38284815, PMCID: PMC10990776, DOI: 10.1158/1055-9965.epi-23-1107.Peer-Reviewed Original ResearchLung cancer riskAssociated with lung cancer riskSouthern Community Cohort StudyCommunity Cohort StudyCancer riskAfrican AmericansIncident lung cancer casesOdds ratioCohort studyLow-income African AmericansEuropean AmericansYear of blood drawEstimate odds ratiosNested case-control studyConditional logistic regressionLung cancer preventionLung cancer casesSignificant risk reductionCase-control studyCurrent smokersCohort enrollmentInverse associationPotential confoundersCancer casesStratified analysis
2023
Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans
Deng K, Gupta D, Shu X, Lipworth L, Zheng W, Thomas V, Cai H, Cai Q, Wang T, Yu D. Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans. Circulation Genomic And Precision Medicine 2023, 16: e004230. PMID: 38014580, PMCID: PMC10843634, DOI: 10.1161/circgen.123.004230.Peer-Reviewed Original ResearchConceptsCase-control study of coronary heart diseaseLife's Essential 8 scoreLife's Essential 8Associated with lower CHD riskLower CHD riskLow-income BlackCoronary heart diseaseCHD riskSouthern Community Cohort StudyStudy of coronary heart diseaseRobust to adjustmentRisk of coronary heart diseaseCommunity Cohort StudyNested case-control studyConditional logistic regressionLow-income AmericansHeart diseaseWhite AmericansCase-control studyLow-income individualsMetabolite signaturesChinese adultsHealth statusCardiovascular healthCHD prevention