Michael DiGiovanna, MD, PhD
Professor of Internal Medicine (Medical Oncology)Cards
About
Research
Overview
We study signal transduction by growth factor receptor tyrosine
kinases, focusing on the EGFR/HER2/ErbB family, including the impact of
signaling by these receptors on clinical outcomes and response to
targeted therapies for cancer, and their potential as therapeutic
targets in novel combination therapies. A major focus in our laboratory
has been the interaction of HER2 signaling with estrogen receptor (ER)
signaling in breast cancer, and with IGF-I receptor
signaling, and the effects of inhibitors of these receptors in
combination targeted therapies. We have also found that in breast
cancer patients, tumors harboring activated HER2 have adverse
prognosis, and these tumors have co-overexpression of EGFR. We continue
to study how signaling by these receptors impacts responses to
different types of therapies and explore targeting these receptors in
combination with other novel targeted therapeutics.
Medical Research Interests
Academic Achievements & Community Involvement
Clinical Care
Overview
Michael DiGiovanna, MD, PhD, is a professor of internal medicine at Yale School of Medicine and, as a Yale Medicine oncologist, treats cancer patients at the Yale Cancer Center. His primary focus is the treatment and management of breast cancer.
Dr. DiGiovanna has conducted both clinical and laboratory-based research having led a translational laboratory focused on signal transduction in breast cancer. His research delves into breast cancer treatment strategies, including studies of targeted drug combinations for treating breast cancer. Dr. DiGiovanna’s work has been recognized with several awards and grants, including an American Cancer Society Research Scholar Grant and a Women's Health Investigator Award.
Clinical Specialties
Fact Sheets
Hormonal Therapy for Cancer
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Board Certifications
Medical Oncology
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2017
- Original Certification Date
- 1997
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