About
The Department of Anesthesiology relieves the suffering of those in need through the delivery of safe, effective, and timely anesthesia care, advances the field of anesthesiology through excellence in research, and strives to train the next generation of caregivers.
Research
Publications
2025
Response to: “Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)” by Kopp et al
Kopp S, Vandermeulen E, McBane R, Perlas A, Leffert L, Horlocker T. Response to: “Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)” by Kopp et al. Regional Anesthesia & Pain Medicine 2025, rapm-2025-106881. PMID: 40484652, DOI: 10.1136/rapm-2025-106881.Peer-Reviewed Original ResearchEvidence-Based Clinical Practice Guidelines on Postdural Puncture Headache: A Consensus Report From a Multisociety International Working Group
Uppal V, Russell R, Sondekoppam R, Ansari J, Baber Z, Chen Y, DelPizzo K, Dirzu D, Kalagara H, Kissoon N, Kranz P, Leffert L, Lim G, Lobo C, Lucas D, Moka E, Rodriguez, Sehmbi H, Vallejo M, Volk T, Narouze S. Evidence-Based Clinical Practice Guidelines on Postdural Puncture Headache: A Consensus Report From a Multisociety International Working Group. Obstetric Anesthesia Digest 2025, 45: 61-63. DOI: 10.1097/01.aoa.0001113000.54578.7c.Peer-Reviewed Original ResearchPostdural puncture headacheEvidence-based clinical practice guidelinesPuncture headacheClinical questionsManagement of postdural puncture headacheClinical practice guidelinesSpinal anesthesia administrationPrevention of postdural puncture headacheInternational Working GroupMedical careMedical specialtiesPractice guidelinesComplication of dural punctureDaily activitiesDural punctureLiterature searchWorking GroupConsensus reportPreventionAnesthesia administrationGuidelinesHeadacheCareMultisocietySpecialtyRegional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)
Kopp S, Vandermeulen E, McBane R, Perlas A, Leffert L, Horlocker T. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition). Regional Anesthesia & Pain Medicine 2025, rapm-2024-105766. PMID: 39880411, DOI: 10.1136/rapm-2024-105766.Peer-Reviewed Original ResearchAmerican Society of Regional AnesthesiaDeep venous thrombosisEvidence-based guidelinesRegional anesthesiaThrombolytic therapyComplications associated with regional anesthesiaRecurrent deep venous thrombosisAmerican SocietyRandomized Controlled TrialsAnticoagulant doseNeural blockadeVenous thrombosisCase seriesCatastrophic complicationPatient characteristicsClinical trialsHigh dosesPatientsPublished guidelinesControlled TrialsPainAnesthesiaPatient safetyTherapyDoseChapter 27 Anesthetic considerations for patients with neurologic disorders in pregnancy
Rubin P, Leffert L. Chapter 27 Anesthetic considerations for patients with neurologic disorders in pregnancy. 2025, 289-295. DOI: 10.1016/b978-0-443-21707-4.00027-6.Peer-Reviewed Original ResearchNeuraxial anesthesiaNeurological disordersReports of adverse outcomesPregnant patientsLaboring patientsLabor floorNeuraxial proceduresCase reportAnesthetic alternativeAnesthetic considerationsAdverse outcomesEvidence-based literaturePatientsIncrease patient satisfactionPatient satisfactionPregnancyNeurological conditionsAnesthesiaDisordersFetusesPathophysiology
2024
Postdural puncture headache: Beyond the evidence
Berg A, Lucas D, Leffert L. Postdural puncture headache: Beyond the evidence. Best Practice & Research Clinical Anaesthesiology 2024, 38: 267-277. PMID: 39764816, DOI: 10.1016/j.bpa.2024.11.004.Peer-Reviewed Original ResearchPostdural puncture headacheCalcitonin gene-related peptideAccidental dural punctureCerebrospinal fluidRelease of calcitonin gene-related peptideManagement of postdural puncture headacheTreat postdural puncture headacheLabor epidural analgesiaGene-related peptideAutonomic nervous systemCerebrospinal fluid dynamicsEvidence-based recommendationsEpidural analgesiaPuncture headacheDural punctureIntrathecal catheterNeuraxial proceduresCSF lossSphenopalatine ganglionAssociated with activationCerebral arteryCerebral vasodilationChronic manifestationsTherapeutic strategiesRoutine useFentanyl in the Labor Epidural Impacts the Results of Intrapartum and Postpartum Maternal and Neonatal Toxicology Tests
Siegel M, Mahowald G, Uljon S, James K, Leffert L, Sullivan M, Hernandez S, Gray J, Schiff D, Bernstein S. Fentanyl in the Labor Epidural Impacts the Results of Intrapartum and Postpartum Maternal and Neonatal Toxicology Tests. Obstetric Anesthesia Digest 2024, 44: 47-48. DOI: 10.1097/01.aoa.0001005456.46508.bf.Peer-Reviewed Original ResearchEvidence-based clinical practice guidelines on postdural puncture headache: infographics
Uppal V, Russell R, Kalagara H, Leffert L, Narouze S. Evidence-based clinical practice guidelines on postdural puncture headache: infographics. Regional Anesthesia & Pain Medicine 2024, 49: 502-504. PMID: 38373816, DOI: 10.1136/rapm-2024-105280.Peer-Reviewed Original Research
2022
In Response
Pearson ACS, Leffert LR, Kain ZN. In Response. Anesthesia & Analgesia 2022, 135: e3-e4. PMID: 35709456, DOI: 10.1213/ane.0000000000006014.Commentaries, Editorials and LettersBupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC–MS/MS
Mahowald G, Khaliq T, Basu S, Griggs D, Siegel M, Leffert L, Bernstein S, Flood JG, Uljon S. Bupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC–MS/MS. The Journal Of Applied Laboratory Medicine 2022, 7: 854-862. PMID: 35259249, DOI: 10.1093/jalm/jfac009.Peer-Reviewed Original ResearchThe Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States
Katz D, Bateman B, Kjaer K, Turner D, Spence N, Habib A, George R, Toledano R, Grant G, Madden H, Butwick A, Lynde G, Minehart R, Beilin Y, Houle T, Sharpe E, Kodali B, Bharadwaj S, Farber M, Palanisamy A, Prabhu M, Gonzales N, Landau R, Leffert L. The Society for Obstetric Anesthesia and Perinatology Coronavirus Disease 2019 Registry: An Analysis of Outcomes Among Pregnant Women Delivering During the Initial Severe Acute Respiratory Syndrome Coronavirus-2 Outbreak in the United States. Obstetric Anesthesia Digest 2022, 42: 27-28. DOI: 10.1097/01.aoa.0000816828.87126.61.Peer-Reviewed Original Research