Host: Dr Markus Müschen
"Aberrantly spliced surface proteoforms with new roles in immunotherapy”
Our most recent work informed the central hypothesis that non-canonical exon usage plays a dual role in leukemia and other pediatric cancers. On the one hand, it provides cancers with intrinsic mechanisms of epitope loss, which can render targeted immunotherapy ineffective. On the other hand, alternative splicing could be a source of cancer-specific epitopes and as such could aid immunotherapy. By simultaneously exploring the effects of alternative splicing on antigen loss and neo-epitope gain, we aspire to lay ground for the development of new immunotherapeutics that would target pediatric cancers with the specificity current modalities do not possess.
Join Online: https://yale.zoom.us/j/9860675...;
Meeting ID: 986 0675 0547
Meeting Passcode: 585644
Perelman School of Medicine at the University of PennsylvaniaAndrei Thomas-Tikhonenko, PhDProfessor of Pathology & Laboratory Medicine and Pediatrics