UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner
Kim DJ, Iwasaki A, Chien AL, Kang S. UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner. JCI Insight 2022, 7: e156344. PMID: 35316219, PMCID: PMC9090247, DOI: 10.1172/jci.insight.156344.Peer-Reviewed Original ResearchConceptsSpecificity protein 1DNA damageSp1-dependent mannerProtein 1Activator protein-1HaCaT human immortalized keratinocytesExtracellular matrix componentsTranscription factorsAryl hydrocarbon receptorHuman immortalized keratinocytesMatrix componentsHydrocarbon receptorPotential targetImmortalized keratinocytesROSSun-exposed skinType IV collagenMMP2 expressionAhRMatrix metalloproteinasesMechanistic studiesMMP2IV collagenTopical treatmentMMP-1