Meet Dr. Stephanie HaleneMarch 17, 2022
Stephanie Halene, MD, PhD, cares for patients with hematologic malignancies, and works to bridge the gap between the clinic and the basic science laboratories.
To CiteDCA Citation Guide
- 00:00I'm Stephanie Helena.
- 00:01I am associate professor of
- 00:03hematology and internal medicine.
- 00:05And I'm the chief of hematology,
- 00:08and I focus on Mallard display.
- 00:10JE and acute myeloid leukemia.
- 00:12To me, the most important thing is
- 00:15to build a team that seamlessly
- 00:17transitioned from the clinic all
- 00:20the way to basic science that
- 00:22brings questions from the clinic
- 00:24to the basic science laboratories,
- 00:27and that brings innovation from the basic
- 00:30science laboratories back to the patient.
- 00:32Advancements in in medicine.
- 00:34A general in hematology have been.
- 00:36Absolutely amazing and we are in a
- 00:39phenomenal time for for innovation.
- 00:41I think a lot of it comes from our
- 00:45deeper understanding of diseases.
- 00:47We have so many technologies at our
- 00:50fingertips to understand what causes disease,
- 00:53what drives disease,
- 00:54what results in resistance is to therapies,
- 00:57and as a result we can develop novel
- 01:01therapies that we never had the
- 01:03opportunity to do that are no longer these.
- 01:07Sledge hammer chemotherapies but very
- 01:09targeted at what drives the cancer.
- 01:12One area that my laboratory is
- 01:15particularly interested in is how
- 01:17RNA modifications and we look
- 01:20at how this RNA is altered,
- 01:22for example through mutations and so
- 01:25called splicing factors or through
- 01:28abnormalities and RNA editing.
- 01:30And we have identified a couple
- 01:33of mechanisms in that area that
- 01:35we may be able to exploit in the
- 01:38therapy of hematologic diseases.