WEBVTT

NOTE duration:"00:01:46.5600000"

NOTE recognizability:0.804

NOTE language:en-us

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I'm Stephanie Helena.

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I am associate professor of

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hematology and internal medicine.

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And I'm the chief of hematology,

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and I focus on Mallard display.

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JE and acute myeloid leukemia.

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To me, the most important thing is

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to build a team that seamlessly

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transitioned from the clinic all

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the way to basic science that

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brings questions from the clinic

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to the basic science laboratories,

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and that brings innovation from the basic

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science laboratories back to the patient.

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Advancements in in medicine.

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A general in hematology have been.

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Absolutely amazing and we are in a

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phenomenal time for for innovation.

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I think a lot of it comes from our

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deeper understanding of diseases.

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We have so many technologies at our

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fingertips to understand what causes disease,

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what drives disease,

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what results in resistance is to therapies,

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and as a result we can develop novel

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therapies that we never had the

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opportunity to do that are no longer these.

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Sledge hammer chemotherapies but very

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targeted at what drives the cancer.

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One area that my laboratory is

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particularly interested in is how

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RNA modifications and we look

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at how this RNA is altered,

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for example through mutations and so

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called splicing factors or through

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abnormalities and RNA editing.

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And we have identified a couple

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of mechanisms in that area that

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we may be able to exploit in the

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therapy of hematologic diseases.