1995
An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth.
Dreyer E, Leifer D, Heng J, McConnell J, Gorla M, Levin L, Barnstable C, Lipton S. An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 11195-11199. PMID: 7479964, PMCID: PMC40598, DOI: 10.1073/pnas.92.24.11195.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, Anti-IdiotypicAstrocytesCells, CulturedCerebral CortexNeuritesNeuronsProtein BindingRatsReceptors, Cell SurfaceRetinal Ganglion CellsThy-1 AntigensConceptsNeurite outgrowthThy-1 functionsNeuronal Thy-1Thy-1Abundant glycoproteinMammalian neuronsNervous systemAnti-idiotype monoclonal antibodyCentral nervous system neuronsMonoclonal antibodiesBinding sitesCentral nervous systemAnti-idiotype antibodiesCertain monoclonal antibodiesBinding assaysCompetitive binding assaysProteinOutgrowthSystem neuronsDendritic developmentAntibodiesNeuronsSitesGlycoproteinCells
1988
The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro
Karschin A, Aizenman E, Lipton. The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro. Journal Of Neuroscience 1988, 8: 2895-2906. PMID: 2842467, PMCID: PMC6569411, DOI: 10.1523/jneurosci.08-08-02895.1988.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsGanglion cellsMK-801Excitatory amino acid receptorsRat retinal ganglion cellsWhole-cell patch-clamp techniqueCultured ganglion cellsKainate-activated currentsKainate-induced currentsAmino acid receptorsConcentrations of NMDAApplication of kainateKainate-induced responsesPresence of NMDAReceptor-ion channel complexRetinal ganglion cellsNoncompetitive NMDA antagonistPatch-clamp techniqueDegree of blockAnticonvulsant MK-801Ganglion cell membraneDissociative anesthetic phencyclidineMicroM kainateKainate currentsLarge inward currentsResponses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat.
Aizenman E, Frosch M, Lipton S. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. The Journal Of Physiology 1988, 396: 75-91. PMID: 2842491, PMCID: PMC1192034, DOI: 10.1113/jphysiol.1988.sp016951.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAmino AcidsAnimalsCells, CulturedRatsReceptors, Amino AcidReceptors, Cell SurfaceRetinaRetinal Ganglion CellsConceptsNon-desensitizing currentsDesensitizing componentGanglion cellsInward currentsExcitatory amino acid receptorsExcitatory amino acid responsesAgonist concentrationsWhole-cell voltage-clamp techniqueAmino acid receptorsL-glutamate responsesRetinal ganglion cellsHigh agonist concentrationsAmino acid responsesVoltage-clamp techniqueMicroM kynurenateQuisqualate responseMicroM kainateNMDA responsesNMDA currentsRat retinaAgonist doseQuisqualateAcid receptorsPharmacological propertiesAcid response