2001
Structure and function of GABAC receptors: a comparison of native versus recombinant receptors
Zhang D, Pan Z, Awobuluyi M, Lipton S. Structure and function of GABAC receptors: a comparison of native versus recombinant receptors. Trends In Pharmacological Sciences 2001, 22: 121-132. PMID: 11239575, DOI: 10.1016/s0165-6147(00)01625-4.Peer-Reviewed Original ResearchConceptsRecombinant receptorsGABA receptorsIonotropic GABA receptorsRetinal signal processingInhibitory receptorsGABAC receptorsPharmacological profileBrain regionsSpecific drugsReceptorsNative receptorMajor molecular componentsUnique functional rolesFunctional roleMolecular determinantsSlow activationCompelling evidenceSubunit compositionMolecular basisRetina
2000
Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation
Choi Y, Tenneti L, Le D, Ortiz J, Bai G, Chen H, Lipton S. Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nature Neuroscience 2000, 3: 15-21. PMID: 10607390, DOI: 10.1038/71090.Peer-Reviewed Original ResearchConceptsS-nitrosylationMolecular basisIon channelsCritical cysteine residuesEndogenous S-nitrosylationSite-directed mutagenesisEndogenous nitric oxideIon channel activityNR2A subunitNitric oxideCysteine residuesSingle cysteineIon channel modulationChannel activityPhysiological conditionsSubunitsChannel modulationCell systemNMDA receptorsMutagenesisCysteineResiduesRegulationAlanineModulation
1992
chapter 26 Molecular Basis for the Potential Use of NMDA Receptor Open-Channel Blockers in the Treatment of Cerebral Ischemia and Other Brain Insults
Lipton S, Heinemann S. chapter 26 Molecular Basis for the Potential Use of NMDA Receptor Open-Channel Blockers in the Treatment of Cerebral Ischemia and Other Brain Insults. 1992, 470-478. DOI: 10.1016/b978-0-7216-9428-3.50031-7.Peer-Reviewed Original Research