2023
IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii
Clark J, Weizman O, Aldridge D, Shallberg L, Eberhard J, Lanzar Z, Wasche D, Huck J, Zhou T, Ring A, Hunter C. IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii. Cell Reports 2023, 42: 112147. PMID: 36827187, PMCID: PMC10131179, DOI: 10.1016/j.celrep.2023.112147.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansImmunity, InnateInterleukin-12Interleukin-18Killer Cells, NaturalToxoplasmaToxoplasmosis, AnimalConceptsInnate lymphoid cellsIL-18IL-18BPNatural killerToxoplasma gondiiIL-18 binding proteinEndogenous IL-18Exogenous IL-18Cell-mediated pathologyPathological immune responsesProduction of IFNAnti-pathogen responsesCell productionInterleukin-18Immune pathologyImmune responseLymphoid cellsCell responsesInnate resistanceCD4IFNGondiiInfectionPathologyLimited role
2016
Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance
O’Sullivan T, Rapp M, Fan X, Weizman O, Bhardwaj P, Adams N, Walzer T, Dannenberg A, Sun J. Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance. Immunity 2016, 45: 428-441. PMID: 27496734, PMCID: PMC5004886, DOI: 10.1016/j.immuni.2016.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBasic-Leucine Zipper Transcription FactorsCell DifferentiationCells, CulturedCytokinesHumansImmunity, InnateInflammation MediatorsInsulin ResistanceInterferon-gammaInterleukin-12LymphocytesMacrophagesMiceMice, Inbred C57BLMice, TransgenicObesitySTAT4 Transcription FactorT-Box Domain ProteinsConceptsNatural killerInsulin resistanceInnate lymphoid cell functionLocal proinflammatory cytokine productionObesity-Associated Insulin ResistanceNon-barrier tissuesObesity-related pathologiesProinflammatory cytokine productionImmature NK cellsProinflammatory macrophage polarizationGroup 1 ILCsIL-12 receptorLymphoid cell functionAdipose tissue depotsTranscription factor NFIL3Parabiotic miceNK cellsCytokine productionTissue residencyT-betMacrophage polarizationReporter miceTissue depotsMetabolic diseasesEpithelial barrier