2025
Biomarker Panels for Discriminating Risk of CKD Progression in Children.
Greenberg J, Abraham A, Xu Y, Schelling J, Coca S, Schrauben S, Wilson F, Waikar S, Vasan R, Gutierrez O, Shlipak M, Ix J, Warady B, Kimmel P, Bonventre J, Parikh C, Denburg M, Furth S. Biomarker Panels for Discriminating Risk of CKD Progression in Children. Journal Of The American Society Of Nephrology 2025 PMID: 39820177, DOI: 10.1681/asn.0000000602.Peer-Reviewed Original ResearchPlasma KIM-1CKD progressionKIM-1Alpha 1-microglobulinUrine albumin/creatinineBaseline urine protein-to-creatinine ratiosBiomarker panelRisk factorsRisk of CKD progressionAssociated with CKD progressionUrine alpha-1-microglobulinRisk group classificationProtein-to-creatinine ratioUrine protein-to-creatinine ratioClinical risk factorsChildren 6 monthsHigh-risk groupUrine KIM-1Clinically relevant biomarkersConventional risk factorsCombination of biomarkersTubular healthBaseline eGFRMedian ageEGFR decline
2024
Is mild dehydration a risk for progression of childhood chronic kidney disease?
Le Page A, Johnson E, Greenberg J. Is mild dehydration a risk for progression of childhood chronic kidney disease? Pediatric Nephrology 2024, 39: 3177-3191. PMID: 38632124, PMCID: PMC11413076, DOI: 10.1007/s00467-024-06332-6.Peer-Reviewed Original ResearchChronic kidney diseaseChronic kidney disease aetiologyKidney diseaseGraphical abstractA higher resolution versionMild dehydrationRisk of CKD progressionConcentrating capacityChronic kidney disease populationFrequency of dehydrationChildhood chronic kidney diseaseImpact renal functionRisk of complicationsLow fluid intakeAssessment of dehydrationChronic kidney disease outcomesHyperfiltration injuryRandomised controlled trialsArginine vasopressinRenal functionCKD progressionFluid intakeTreatment planningAdequate hydrationRisk factorsControlled trials