David Rosenthal, MD
Associate Professor of Medicine (General Medicine)Cards
About
Research
Publications
2025
Long-Term Feeding Tube Use in Head and Neck Cancer Survivors—An Analysis of Patient- and Treatment-Related Factors
Galloway T, Pugh S, Ridge J, Nguyen-Tan P, Rosenthal D, Gillison M, Garden A, Dunlap N, Caudell J, Jones C, Bauman J, Bahig H, Shenouda G, Currey A, Koyfman S, Stokes W, Read N, Lyness J, Yom S, Le Q. Long-Term Feeding Tube Use in Head and Neck Cancer Survivors—An Analysis of Patient- and Treatment-Related Factors. International Journal Of Radiation Oncology • Biology • Physics 2025, 123: 703-712. PMID: 40473230, PMCID: PMC12396613, DOI: 10.1016/j.ijrobp.2025.05.064.Peer-Reviewed Original ResearchIntensity modulated radiation therapyOropharynx cancer patientsOropharynx cancerFeeding tube useTube useAccelerated fractionationTreatment initiationPredictive factorsFeeding tubeIntensity modulated radiation therapy techniquesTreated with 3DCRTSecondary analysis of patientsT4 tumor stageAnalysis of patientsTreatment related factorsPost hoc secondary analysisTreatment completionYears of smokingSecondary analysisChemoradiation trialsConcurrent chemotherapyMedian followupConcomitant boostConformal radiationRadiation therapyIdentifying multi-level social determinants for disparities in survival and patient-reported outcomes in national head and neck cancer trials.
Bai J, Borges M, Nguyen-Tan F, Rosenthal D, Caudell J, Gillison M, Mell L, Bruner D, Yeager K, Eldridge R, Thorstad W, Xu M, Medek S, Echevarria M, Awan M, Shin D, Pugh S, Yom S. Identifying multi-level social determinants for disparities in survival and patient-reported outcomes in national head and neck cancer trials. Journal Of Clinical Oncology 2025, 43: 11066-11066. DOI: 10.1200/jco.2025.43.16_suppl.11066.Peer-Reviewed Original ResearchSocial determinants of healthArea-level social determinants of healthQoL declineTravel burdenDesigning community-based interventionsHead and neck cancerOdds ratioHazard ratioNeighborhood socioeconomic deprivationDeterminants of healthCommunity-based interventionsConfidence intervalsLogistic regression assessed associationsImprove cancer outcomesPatient's zip codeCox proportional hazards regressionPatient-reported outcomesMultivariable Cox proportional hazards regressionProportional hazards regressionSocioeconomic deprivationSocial determinantsHead and neck cancer trialsNon-HispanicCancer outcomesZip codesMachine learning predicting acute pain and opioid dose in radiation treated oropharyngeal cancer patients
Salama V, Humbert-Vidan L, Godinich B, Wahid K, ElHabashy D, Naser M, He R, Mohamed A, Sahli A, Hutcheson K, Gunn G, Rosenthal D, Fuller C, Moreno A. Machine learning predicting acute pain and opioid dose in radiation treated oropharyngeal cancer patients. Frontiers In Pain Research 2025, 6: 1567632. PMID: 40256643, PMCID: PMC12006146, DOI: 10.3389/fpain.2025.1567632.Peer-Reviewed Original ResearchMorphine equivalent daily doseBaseline pain scoresPain intensityOpioid doseRadiation therapyAnalgesic efficacyPain scoresAcute painPatients treated with RTOral cavity/oropharyngeal cancerPersonalized pain managementPredicting pain intensityOropharyngeal cancer patientsAcute pain severityEquivalent daily doseEarly risk stratificationVital signsLogistic regressionRisk stratification modelOpioid requirementsPain severityDaily doseRetrospective studyRisk stratificationPain managementPREVALENCE OF MANIFESTATIONS LINKED TO AFFERENT BAROREFLEX FAILURE AMONG OROPHARYNGEAL CANCER SURVIVORS TREATED WITH RADIATION THERAPY
Van Bergen Diaz P, Bandrey D, Patin S, Prathapa N, Mbagwu G, Hughes A, Song J, Naser M, Hutcheson K, Rosenthal D, Moreno A, Mouhayar E, Deswal A, Fuller C, Koutroumpakis E. PREVALENCE OF MANIFESTATIONS LINKED TO AFFERENT BAROREFLEX FAILURE AMONG OROPHARYNGEAL CANCER SURVIVORS TREATED WITH RADIATION THERAPY. Journal Of The American College Of Cardiology 2025, 85: 2505. DOI: 10.1016/s0735-1097(25)02989-4.Peer-Reviewed Original ResearchEvaluating observer reliability and diagnostic accuracy of CT-LEFAT criteria for post-treatment head and neck lymphedema: A prospective blinded comparative analysis
West N, Attia S, Kaffey Z, Dede C, Mulder S, El-Habashy D, Neuberger R, Naser M, Frank S, Mao S, McMillan H, Smith B, Rosenthal D, Lai S, Hutcheson K, Moreno A, Fuller C, Group A. Evaluating observer reliability and diagnostic accuracy of CT-LEFAT criteria for post-treatment head and neck lymphedema: A prospective blinded comparative analysis. Oral Oncology 2025, 164: 107265. PMID: 40174310, PMCID: PMC12087970, DOI: 10.1016/j.oraloncology.2025.107265.Peer-Reviewed Original ResearchConceptsHead and neck cancerArea under the curveDiagnostic accuracyRadiation therapyFat strandingHead-and-neck cancer patients treated with RTPatients treated with RTContrast-enhanced CT scanHead and neck lymphedemaIntra-observer agreementEvaluate diagnostic accuracyROC-AUC analysisNeck lymphedemaNeck cancerInter-observer reliabilityIntra-rater reliabilityCT scanFleiss’ kappa analysisDiagnostic performanceInter-rater reliabilityIntra-observerAUC analysisKappa analysisLymphedemaPhysician ratersAdvanced External Beam Stereotactic Radiotherapy for Skull Base Reirradiation
Wang H, Alsanea F, Rhee D, Zhang X, Liu W, Yang J, Wen Z, Zhao Y, Williamson T, Hunter R, Balter P, Briere T, Zhu R, Lee A, Moreno A, Reddy J, Garden A, Rosenthal D, Gunn G, Phan J. Advanced External Beam Stereotactic Radiotherapy for Skull Base Reirradiation. Cancers 2025, 17: 540. PMID: 39941906, PMCID: PMC11817895, DOI: 10.3390/cancers17030540.Peer-Reviewed Original ResearchIntensity-modulated proton therapyVolumetric-modulated arc therapyStereotactic body radiation therapyGK plansIntensity‐modulated proton therapy plansStereotactic body radiation therapy plansModern treatment planning systemsTreatment plan qualityTreatment planning systemDose fall-offVarian TrueBeam STxSteep dose gradientsProton therapy machineExternal beam radiotherapy modalityLow-dose regionRadiation delivery systemsCK plansIMPT plansTrueBeam STxAdjacent critical structuresDose gradientArc therapyConformal doseDose spreadTarget coverageDetection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar squamous cell carcinoma survivors: a cross-sectional internally-matched carotid isodose analysis
Koutroumpakis E, Naser M, Mohamed A, Eraj S, Jarre A, Shiao J, Kamal M, Perni S, Phan J, Morrison W, Frank S, Gunn G, Garden A, Deswal A, Abe J, Rosenthal D, Mouhayar E, Fuller C. Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar squamous cell carcinoma survivors: a cross-sectional internally-matched carotid isodose analysis. Clinical And Translational Radiation Oncology 2025, 51: 100912. PMID: 39867727, PMCID: PMC11762641, DOI: 10.1016/j.ctro.2025.100912.Peer-Reviewed Original ResearchPost-RT CT scansCT scanTonsillar cancerPatients treated with definitive surgeryDose rangeContrast-enhanced CT scanCarotid arteryCT scans of patientsIrradiated carotid arteriesUnilateral radiation therapySignificant dose-response trendSurveillance CT scansTreated with intensityNo significant dose-response trendScans of patientsDose-response effectDose-response trendDose-response relationshipStatistically significant differenceUnilateral radiotherapyConcurrent chemoradiationInduction chemotherapyIsodose lineRadiation therapyDefinitive surgery
2024
Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer
Bronk J, Augustyn A, Mohamed A, Fuller C, Garden A, Moreno A, Lee A, Morrison W, Phan J, Reddy J, Rosenthal D, Spiotto M, Frank S, Dadu R, Busaidy N, Zafereo M, Wang J, Maniakas A, Ferrarotto R, Iyer P, Cabanillas M, Gunn G. Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer. Radiotherapy And Oncology 2024, 202: 110602. PMID: 39489425, PMCID: PMC11720968, DOI: 10.1016/j.radonc.2024.110602.Peer-Reviewed Original ResearchIntensity modulated radiation therapyLoco-regional progressionAnaplastic thyroid cancerTarget volumeConcurrent chemotherapyRadiation therapyThyroid cancerHigh dosesAreas of gross diseaseMedian progression free survivalMedian IMRT doseGross tumor volumeMedian overall survivalProgression free survivalNeo-adjuvant strategiesDeformable image registrationIntensive treatment scheduleLevels II-VDiagnostic CTsIMRT dosePlanning CTsGross diseaseLocoregional diseaseUnresectable diseaseFree survivalMetrics Derived from Architecture of Tumor-Infiltrating Lymphocytes are Associated with Overall Survival in HPV-Positive Oropharyngeal Squamous Cell Carcinoma Patients: Results from NRG/RTOG 0129 and 0522
Corredor G, Harris J, Koyuncu C, Pathak T, Pandav K, Toro P, Yang K, Faraji F, Castro P, Sandulache V, Koyfman S, Nguyen F, Garden A, Caudell J, Jones C, Rosenthal D, Le Q, Lewis J, Madabhushi A. Metrics Derived from Architecture of Tumor-Infiltrating Lymphocytes are Associated with Overall Survival in HPV-Positive Oropharyngeal Squamous Cell Carcinoma Patients: Results from NRG/RTOG 0129 and 0522. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s130. DOI: 10.1016/j.ijrobp.2024.07.236.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesDisease-free survivalOverall survivalHazard ratioHPV+ OPSCCPoor survivalRisk of disease-free survivalOropharyngeal squamous cell carcinoma patientsDisease-free survival modelsSquamous cell carcinoma patientsTreated with standard therapyRisk of overall survivalAssociated with overall survivalHigh-risk ptsRisk scoreCell carcinoma patientsRisk of poor survivalSubsets of patientsCox regression modelsLow-risk counterpartsHPV-PositivePrimary tumorCarcinoma patientsStandard therapyInstitutional cohortAssociation of Biologically Effective Dose and Survival in Patients Receiving Head and Neck Stereotactic Body Radiation Therapy
Márquez C, Phan J, Lee A, Reddy J, Garden A, Gunn G, Frank S, Fuller C, Moreno A, Morrison W, Rosenthal D, Spiotto M. Association of Biologically Effective Dose and Survival in Patients Receiving Head and Neck Stereotactic Body Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e770-e771. DOI: 10.1016/j.ijrobp.2024.07.1694.Peer-Reviewed Original ResearchStereotactic body radiation therapyHead and neck cancerBiologically Effective DoseRadiation therapyPerformance statusN stagePatients treated with stereotactic body radiation therapyTreat recurrent head and neck cancerPatients treated with initial surgeryRecurrent head and neck cancerHigher biologically effective dosesIncreasing BEDMedian follow-up durationAssociated with improved survivalHead and neck cancer patientsEffective doseNo survival improvementSurgically resected patientsNational Cancer DatabaseFractionation schemeAssociated with enhanced survivalCox regression modelsDose escalationHPV statusResected patients
Academic Achievements & Community Involvement
Clinical Care
Overview
David Rosenthal, MD, is a primary care physician who specializes in general internal medicine. He focuses on providing comprehensive health care services, especially to populations such as veterans experiencing homelessness.
As an associate professor at Yale School of Medicine, Dr. Rosenthal’s research interests include health care services for vulnerable populations and health informatics, aiming to improve accessibility and efficacy of care for all. He has developed and implemented innovative technology solutions to enhance patient care, including mobile apps for substance use disorder management.
Dr. Rosenthal received his medical training from Northwestern University Feinberg School of Medicine, followed by an internship and primary care residency at Brigham and Women's Hospital. He has been recognized by the Aspen Institute as a Health Innovator Fellow for his contributions to public health and innovation.
Clinical Specialties
Board Certifications
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2012
News & Links
News
- June 11, 2025
Yale Internal Medicine Faculty and Trainees Receive Outstanding Teaching Awards
- March 11, 2025
Yale Department of Internal Medicine Faculty Promotions and Appointments (March 2025)
- January 15, 2025
Student Auction Supports New Haven Nonprofits
- July 08, 2024
Dean Ranney Joins Other Public Health Thought Leaders at Aspen Ideas: Health Festival
Get In Touch
Contacts
General Internal Medicine
150 Sargent Dr
New Haven, CT 06511
United States