Nenad Sestan, MD, PhD
Harvey and Kate Cushing Professor of Neuroscience, and Professor of Comparative Medicine, of Genetics and of PsychiatryCards
About
Research
Publications
2026
NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development
Sonthalia S, Herb B, Adkins R, Orvis J, Li G, Liao X, Yu Q, Blanco X, Casella A, Liu J, Stein-O’Brien G, Caffo B, Hertzano R, Mahurkar A, Xu J, Gillis J, Werner J, Ma S, Kim S, Micali N, Sestan N, Rakic P, Santpere G, Ament S, Colantuoni C. NeMO Analytics: a compendium of transcriptomic data for the exploration of neocortical development. Nature Neuroscience 2026, 29: 978-991. PMID: 41882195, PMCID: PMC13061640, DOI: 10.1038/s41593-026-02204-4.Peer-Reviewed Original ResearchAdaptive evolution of gene regulatory networks in mammalian neocortex
Li Z, Kaur N, Santpere G, Muchnik S, Sindhu S, Qi C, Shibata M, Clément O, Klarić T, de Martin X, Luria V, Cho H, Li M, Shibata A, Choi S, Kim H, Tebbenkamp A, Ma S, Han W, Kim S, Pochareddy S, Duy P, Xing X, Bao Y, Xu X, Gladwyn-Ng I, Cullen H, Paolino A, Fenlon L, Kozulin P, Suárez R, Risgaard R, Gulden F, Karger A, Suzuki I, Hirata T, Gobeske K, Richards L, Sousa A, Heng J, Sestan N. Adaptive evolution of gene regulatory networks in mammalian neocortex. Nature 2026, 653: 156-166. PMID: 41851468, PMCID: PMC13149332, DOI: 10.1038/s41586-026-10226-y.Peer-Reviewed Original ResearchHuman-specific features of the cerebellum and ZP2-regulated synapse development
Kim S, Cherskov A, Sindhwani A, Choi S, Kim H, Li M, Zhang M, Mato-Blanco X, Liu Y, Micali N, Young D, Estacion M, Zhang Y, Ruiz-Jiménez J, Nadkarni A, Luria V, Sindhu S, Chatterjee I, Shibata A, Liang D, Cho H, Park S, Spajic A, Kovner R, Glavan M, Chen R, Risgaard R, Li X, Pochareddy S, Karger A, Huttner A, Morozov Y, Daadi E, Colantuoni C, Gobeske K, Ely J, Hof P, Daadi M, Sherwood C, Duque A, Ma S, Sousa A, Waxman S, Rakic P, Santpere G, Sanders S, Sestan N. Human-specific features of the cerebellum and ZP2-regulated synapse development. Cell 2026, 189: 1802-1819.e28. PMID: 41819103, DOI: 10.1016/j.cell.2026.02.014.Peer-Reviewed Original ResearchEndovascular thrombectomy for acute stroke: evolving eligibility criteria and adjunct therapies
Glavan M, Liu J, Sampaio Silva G, Nguyen T, Zhou J, Sestan N, Kimberly W, Sheth K. Endovascular thrombectomy for acute stroke: evolving eligibility criteria and adjunct therapies. The Lancet Neurology 2026, 25: 61-76. PMID: 41389830, DOI: 10.1016/s1474-4422(25)00356-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2025
PsychENCODE at 10: From genomic maps to mechanistic insights in mental illness
Roussos P, Vaccarino F, Weng Z, Sestan N, Gerstein M, Geschwind D. PsychENCODE at 10: From genomic maps to mechanistic insights in mental illness. Neuron 2025, 113: 4099-4102. PMID: 41412064, DOI: 10.1016/j.neuron.2025.11.027.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSpatial dynamics of brain development and neuroinflammation
Zhang D, Rubio Rodríguez-Kirby L, Lin Y, Wang W, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Bao S, Wang S, Chen X, Gao F, Wang D, Xu H, Ma C, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R. Spatial dynamics of brain development and neuroinflammation. Nature 2025, 647: 213-227. PMID: 41193846, PMCID: PMC12589135, DOI: 10.1038/s41586-025-09663-y.Peer-Reviewed Original ResearchThe new frontier in understanding human and mammalian brain development
Nowakowski T, Nano P, Matho K, Chen X, Corrigan E, Ding W, Gao Y, Heffel M, Jayakumar J, Kaplan H, Kronman F, Kovner R, Mannens C, Song M, Steyert M, Venkatesan S, Wallace J, Wang L, Werner J, Zhang D, Yuan G, Zuo G, Ament S, Colantuoni C, Dulac C, Fan R, Gillis J, Kriegstein A, Krienen F, Kim Y, Linnarsson S, Mitra P, Pollen A, Sestan N, Tward D, van Velthoven C, Yao Z, Bhaduri A, Zeng H. The new frontier in understanding human and mammalian brain development. Nature 2025, 647: 51-59. PMID: 41193845, PMCID: PMC13108688, DOI: 10.1038/s41586-025-09652-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsUnique and divergent features of human brain development
Salamon I, Doyle D, Bandler R, Pattabiraman K, Sestan N. Unique and divergent features of human brain development. Current Opinion In Neurobiology 2025, 95: 103133. PMID: 41187489, PMCID: PMC12626412, DOI: 10.1016/j.conb.2025.103133.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEarly developmental origins of cortical disorders modeled in human neural stem cells
Mato-Blanco X, Kim S, Jourdon A, Ma S, Choi S, Giani A, Paredes M, Tebbenkamp A, Liu F, Duque A, Vaccarino F, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. Early developmental origins of cortical disorders modeled in human neural stem cells. Nature Communications 2025, 16: 6347. PMID: 40634286, PMCID: PMC12241556, DOI: 10.1038/s41467-025-61316-w.Peer-Reviewed Original ResearchHigher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques
Joyce M, Ivanov T, Krienen F, Mitchell J, Ma S, Inoue W, Nandy A, Datta D, Duque A, Arellano J, Gupta R, Gonzalez-Burgos G, Lewis D, Sestan N, McCarroll S, Martinez-Trujillo J, Froudist-Walsh S, Arnsten A. Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques. Communications Biology 2025, 8: 974. PMID: 40594842, PMCID: PMC12214923, DOI: 10.1038/s42003-025-08297-0.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News & Links
News
- October 23, 2025
2025 Yale-KU Forum: Clinical and Basic Neuroscience
- July 10, 2024
Highlighting Yale’s Neuroscience Research
- July 03, 2024
Bandler Honored with 2024 National Institute of Mental Health Outstanding Resident Award
- October 26, 2023Source: Yale News
Researchers Identify Key Genes in the Development of the Primate Brain
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Neuroscience
PO Box 208001, 333 Cedar Street
New Haven, CT 06520-8001
United States