Participate in Research
Yale Child Study Center (YCSC) research teams collaborate to investigate the causes, consequences, and prevention of developmental and behavioral health needs in children, adolescents, and their families. YCSC is actively growing in many areas from basic research in the genetic and neurobiological basis of childhood psychiatric disorders to training clinicians around the world in evidence-based mental health service delivery.
Keep reading for a list of the ongoing research efforts at the Yale Child Study Center to find out how you can participate.
Featured Studies by Category
Categories M to Z
All Studies
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts | CATEGORY 1 | CATEGORY 2 | CATEGORY 3 | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Anxiety & Mood Disorder Program | The Anxiety and Mood Disorders Program uses a range of assessment approaches, several developed by members of our team, including self-reports, behavioral assessments, EEG technology, and fMRI imaging. Currently, we are conducting two large clinical trials: One is testing the effects of a brief computer-based training that targets attentional processes to reduce social anxiety in children, and uses EEG to study the effects of the treatment on the child’s brain. The second is examining the effects of parent-based treatment for reducing childhood anxiety, and uses fMRI to study the effects of the treatment on the child’s brain. | Under 18 | Self-reports, behavioral assessments, EEG technology, and/or fMRI imaging | varies | Anxiety | |||||||||
Autism Biomarkers Consortium for Clinical Trials | The Autism Biomarkers Consortium for Clinical Trials (ABC-CT) is a research study to understand how to better measure social skills in school-age autistic children. We are currently recruiting both non-autistic children and children with a diagnosis of autism between the ages of 6 and 11 years old. A diagnostic and cognitive evaluation is provided to all participants at no cost and participants will be compensated up to $300. To learn more about the study or to participate, please call us at 203-737-3439 or email our team at autism@yale.edu. | 6 to 11 | questionnaires, EEG, eye-tracking, clinical evaluation | up to $300 | call (203) 737-3439
autism@yale.edu | Autism | Typical Development | |||||||
Brain Imaging Study of Emotion Regulation in Children | If you have a child who is 5 to 15 years old and has disruptive behaviors or has NO disruptive behaviors (such as anger, irritability, or aggression), they may be eligible to participate in a free and confidential study that examines your child’s social and emotional skills. This research will lead to new ways of understanding how children processes and regulate their emotions. The study will require two visits. At each visit you and your child will complete questionnaires, and your child will participate in an fMRI scan. Functional magnetic resonance imaging (fMRI) is a technique for measuring and mapping brain activity that is noninvasive and safe. You will also receive a free psychoeducational assessment describing your child’s social and emotional development. The study is conducted at the Yale Child Study Center by caring and supportive research staff. | 5 to 15 | questionnaires and fMRI | up to $100 | Autism | Typical Development | ||||||||
Brain mechanisms of childhood irritability | We are recruiting children and adolescents ages 8 to 15 to participate in an fMRI study to help us understand why some youths are more easily frustrated and irritable than others and how this is related to their brain function. We also aim to study whether and how brain function can be used to predict later outcomes. Therefore, participants will be invited back to our lab for two follow-up visits 6 months and 12 months after the brain scan for clinical evaluation and assessment. Compensation up to $640. If interested, contact Hailing Ding at hailing.ding@yale.edu or affectiveyouth@yale.edu. | 8 to 15 | fMRI | up to $640 | ADHD | Typical Development | ||||||||
Complex Neurodevelopmental Conditions | We are currently recruiting children for a study on repetitive behavior. This study will help us better understand the causes and developmental course of repetitive behavior in children, especially repetitive motor movements involving the fingers, hands, head, or body. We are recruiting children 4 years of age and younger with repetitive behavior, either typically developing, or with autism or other neurodevelopmental conditions such as ADHD. Participation will include a visit to the lab with your child, including a comprehensive diagnostic evaluation, assessment of repetitive behavior, studies of attention, and collection of saliva samples to learn more about genetic factors involved in repetitive behavior. All study visits will occur at the SANA Program at 300 George St., Suite 900, New Haven, CT. We provide free and convenient parking. If you are interested in participating, please fill out our inquiry form or give us a call at (203) 764-5933. | 4 years and younger | comprehensive diagnostic evaluation, assessment of repetitive behavior, studies of attention, and collection of saliva samples | - | call (203) 764-5933 | Autism | Typical Development | |||||||
Comprehensive Therapy for Irritability and Aggression (CTIA) in Autistic Adolescents | The Sukhodolsky Lab is seeking adolescents ages 12 to 19 who have been diagnosed with autism spectrum disorder (ASD) and have elevated levels of irritability to take part in a free and confidential study. Irritability and/or disruptive behaviors may include anger outbursts, temper tantrums, noncompliance, being easily frustrated, physical behaviors, difficulty following directions, and other similarly challenging behaviors. The purpose of this study is to test a novel psychosocial intervention for irritability and aggression in autism (CTIA) in comparison to a supportive psychotherapy control condition. We want to see if CTIA helps reduce irritability and aggressive behavior in adolescents with ASD. Participation involves completing 15 weeks of therapy, which may be conducted in-person at the Yale Child Study Center in New Haven, CT, or remotely by telehealth. Parents and adolescents also complete questionnaires and interviews about symptoms and behaviors before, during, and after treatment. The study provides a comprehensive assessment of autism, including IQ and adaptive function, and treatment for irritability at no cost to families. Families receive up to $250 for participation. Click here to learn more https://medicine.yale.edu/lab/sukhodolsky/ or contact Sydney Anderson at sydeny.anderson@yale.edu or (203) 737-7662. | 12 to 19 | 15 weeks of therapy (remote or in person), interviews, questionnaires | up to $250 | call (203) 737-7662
sydney.anderson@yale.edu | Autism | ||||||||
Confirming P1 as a Stable Biomarker of Attention to Social Threat in Youth | The purpose of the study is to examine how children ages 10 to 14 years attend to faces and whether their attention to faces stays the same over time. Participants will be asked to complete computer tasks showing pictures of faces while we measure the electrical activity in their brain and record their eye movements, and answer questions about their behaviors and feelings. This study consists of four visits over six months and participants are compensated up to $350. (IRB#: 2000029999) | 10 to 14 | four visits over six months, computer tasks, questionnaires | up to $350 | Anxiety | Typical Development | ||||||||
Infant Emotional Development Study | We are currently recruiting infants for a study on emotional development in early childhood. This study will help us develop better methods for early diagnosis and intervention for behavioral and emotional challenges. We are recruiting infants 4 months of age or younger with and without a family history of autism. Participation will include follow-up visits with your infant through 30 months of age. Visits may include assessment of social, adaptive, cognitive, and language development; studies of attention requiring watching videos and listening to sounds; and play-based activities to assess your child’s emotional development. All study visits will occur at our clinic at 300 George St., Suite 900, New Haven, CT. We provide free and convenient parking. If you are interested in participating, please call (203) 764-5933 or email (sanalab@yale.edu). | 4 months or younger | follow-up visits with your infant through 30 months of age; assessment of social, adaptive, cognitive, and language development; watching videos and listening to sounds; play-based activities | - | call (203) 764-5933
sanalab@yale.edu | Autism | Typical Development | |||||||
Neurodevelopmental Biomarkers of Late Diagnosis in Female and Gender Diverse Autism | The Sukhodolsky Lab is seeking volunteers to participate in a research study to help to improve access to autism diagnosis. Autistic people aged 16-30 years are invited to answer questions and complete surveys. These activities can be done out loud, by writing, online or using AAC. The purpose of the study is to advance the knowledge of the autistic experience. We are aiming to learn about why some people get an autism diagnosis when they are young, and other people get an autism diagnosis when they are teens or adults. The study is seeking and welcomes people of all genders and ethnoracial identities to participate. Participation involves 1-2 visits, and participants will be compensated up to $225 for participating, and results of study assessments can be shared with participants free of charge. In addition to the 1-2 visits, participants may also be invited to complete optional activities at other visits such as: interviews (up to 1 hour) and brain scans using MRI (up to 2-3 hours). For more information our if you are interested in participating, please contact Ms. Megan Rutten at sukhodolsky.lab@yale.edu or 203-737-7664. | 16 to 30 | 1-2 visits, interviews (up to 1 hour), brain scans using MRI (up to 2-3 hours). | up to $225 | call 203-737-7664
sukhodolsky.lab@yale.edu | Autism | ||||||||
Neurofeedback from the supplementary motor area for Tourette Syndrome | Does your child have chronic tics or Tourette Syndrome? If your child is 10-16 years old with chronic tics, they may be eligible to receive neurofeedback treatment. We use a form of neurofeedback that involves monitoring brain activity via fMRI. The purpose of this study is to determine if our neurofeedback intervention can reduce tic symptoms and improve our understanding of Tourette Syndrome. Participation can result in compensation up to $880. If you have any further questions or concerns, please contact us at Hampson.lab@yale.edu, or (203)-737-6055. Study Sponsors: National Institute of Mental Health, Department of Human Health Services. HIC#2000033043 | 10 to 16 | fMRI | up to $880 | call (203)-737-6055
Hampson.lab@yale.edu | Tourette's | ||||||||
OCD Genetics Study | Your family has been invited to be part of a study of families in which a child has an Obsessive-Compulsive Disorder (OCD) and his/her parents do not. The purpose of this study is to identify the genetic factors that cause OCD using a family-based approach. This will greatly contribute to our understanding of OCD and may help develop new therapies in the future. This study requires participation from a child and both biological parents, can be done in-person or remotely and participation will be compensated with a $100 Amazon gift card for the family. We are not able to offer you a report of your genetic results because our studies are performed as research. Our research lab does not offer any treatment. | - | blood draw, questionnaires | $100 Amazon gift card | OCD | |||||||||
Online Mental Health Intervention for Adolescents on the Waiting List for Mental Health Services | We are currently recruiting adolescents seeking outpatient services at YCSC for a study testing an online mental health intervention conducted while they are on the waiting list. The online mental health intervention is designed to teach coping and emotion regulation skills for adolescents struggling with mental health symptoms. This study will help us better understand how to best implement an online intervention for adolescents on the waiting list. We are recruiting any adolescent aged 13-17 years on the waiting list for services if they are not currently receiving treatment for the same problem elsewhere. Participants must have access to a mobile device. Participation is completely online. Adolescents will answer questions on their mobile phone or tablet and engage with the online intervention for 20-30 minutes. Then, adolescents will participate in either a focus group or individual interview lasting 60-90 minutes to assess their experience with the intervention. Parents will be contacted before adolescent participation for consent and answer any questions they may have. To learn more about our study, please contact accesslab@yale.edu. This study has been approved by the Yale IRB (HIC #2000035977). | 13-17 | Self-report questionnaires, engaging with an online intervention for mental health, focus groups. | $60 | ACCESS Lab: https://medicine.yale.edu/childstudy/research/clinical-innovations/access-lab/ | accesslab@yale.edu | Online Intervention | |||||||
Pivotal Response Treatment | PRT is a well-studied and effective behavioral treatment for children with autism spectrum disorder (ASD). PRT treatment sessions take place three times a week at the Yale Child Study Center over 16 weeks, and each visit lasts about 1.5 hours. These sessions are play-based, and the PRT team selects games, crafts, and other activities to match the child’s interests while working on social engagement and communication skills. The study requires a successful fMRI and Eye-Tracking Scan before beginning PRT. Before attempting those scans, a phone screener is required to determine the child’s eligibility and answer any questions parents might have. To learn more about this study, contact Grace Fjermedal (grace.fjermedal@yale.edu). | 5 to 15 | play, fMRI, eye-tracking | up to $100 | Autism | |||||||||
Reducing Adolescent Suicide Risk in Treatment-Resistant Depression | Yale is conducting a study to examine the safety, efficacy, response predictors, and post treatment trajectory of adolescents (13–17 years old) with treatment-resistant depression and high suicide risk following a conservative repeat dosing Ketamine infusion paradigm compared to an active control, Midazolam. Those who are randomized to Midazolam and remain ill have the option to cross-over to Ketamine in the open phase. All participants will be followed closely for 4 months post-treatment and treated with standard of care depression treatment (medication management and cognitive behavioral therapy). Brain-based predictors of anti-suicidal responses will be assessed via connectome predictive modeling and examining functional brain circuits via fMRI before and after treatment. Compensation is up to $320. To learn more about this study, contact Brooke Rivera, Clinical Coordinator, Yale Pediatric Depression Lab at (203)785-7880 or email PediDepression@yale.edu. | 13 to 17 | Ketamine infusion, standard of care depression treatment | up to &320 | call (203)785-7880
PediDepression@yale.edu | Depression | ||||||||
Social attention in autistic and non-autistic children with intellectual disability | This project studies attention to social images in autistic children with intellectual disability (ID) and non-autistic children with ID. We are studying behavior and brain systems to better understand the different ways these children experience the social world. Participation involves one or two visits to our offices where children and families will talk to a clinician, complete questionnaires, and watch videos while their brain waves and movement are recorded. Children will receive a clinical evaluation and report as well as compensation of $120. To learn more about the study or to participate, please call us at 203-737-3439 or email our team at autism@yale.edu. | 3 to 17 | questionnaires, EEG, eye-tracking, clinical evaluation | $120 | call (203) 737-3439
autism@yale.edu | Autism | ||||||||
SPARK at Yale | SPARK is a growing community of individuals, families, and researchers on a mission to speed up the understanding of autism. Our aims are to: Collect DNA from saliva samples and information through surveys from 50,000 people with autism and both of their parents and share that data with researchers. Make breakthroughs that were never before possible and return our findings to you. SPARK is sponsored by the Simons Foundation Autism Research Initiative (SFARI) and Yale is one of more than 30 participating hospitals and clinics across the country. Why join SPARK? Find possible genetic causes of autism in your own family and power future autism research for years to come. Join other autism research studies and get updates on the latest autism research. Connect with a community of 1400 SPARK participants in our region! | All ages | saliva collection and questionnaires | up to $50 Amazon gift card | call (203) 785-7539
sparkforautism@yale.edu | Autism | ||||||||
Stem Cell Study in Autism | You and your child are invited to participate in a study conducted by Flora Vaccarino, M.D. and colleagues at the Yale Child Study Center. The purpose of this study is to identify factors that influence brain cell development and function in individuals with Autism Spectrum Disorders. We are focusing on how young brain cells (known as “neuronal stem cells”) turn into mature cells (such as “neurons and glia”) and how they all function. | 6 years and up | - | up to $150 | flora.vaccarino@yale.edu
livia.tomasini@yale.edu | Autism | Typical Development | |||||||
Stem Cell Study in Tourette's Disorder | You and your child are invited to participate in a study conducted by Flora Vaccarino, M.D. and colleagues at the Yale Child Study Center. The purpose of this study is to identify factors that influence brain cell development and function in individuals with Autism Spectrum Disorders and Tourette Syndrome. We are focusing on how young brain cells (known as “neuronal stem cells”) turn into mature cells (such as “neurons and glia”) and how they all function. | 16 years old and up | Saliva, blood draw, clinical assessments. | $100 for samples and $100 for clinical assessments | flora.vaccarino@yale.edu
livia.tomasini@yale.edu | Tourette's | Typical Development | |||||||
TABS Study | Your family has been invited to be part of a study of families in which an individual has trichotillomania or other body focused repetitive behavior (BFRB). Although it is well known that genetic factors play a role in causing BFRBs, the responsible genes have not yet been discovered. Recent dramatic advances in genetic techniques hold out the promise that we may soon be able to identify such risk-conferring genes. The purpose of this study is to identify the genetic factors that cause trichotillomania and other BFRBs using a family-based approach. This will greatly contribute to our understanding of these conditions and may help develop new therapies in the future. This study requires participation from an individual impacted by trichotillomania or other BFRB and both biological parents. The study can be done in-person or remotely. We are not able to offer you a report of your genetic results because our studies are performed as research. Our research lab does not offer any treatment. | - | Saliva sample (child and both parents), questionnaire | - | Trichotillomania | |||||||||
Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth | The clinical trial for children 10-14 years old, is testing the effects of a brief computer-based training that targets attentional processes to reduce social anxiety in children. Attention training is a promising treatment for anxiety disorders because the hope is to train the child’s brain to divert from threatening stimuli. Participants will complete the computer program twice a week for four weeks. Study participants receive treatment at no cost and are compensated up to $600. (IRB#: 2000025143) | 10 to 14 | computer based training twice a week for four weeks | up to $600 | Anxiety | Typical Development |
ADHD
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
Brain mechanisms of childhood irritability | We are recruiting children and adolescents ages 8 to 15 to participate in an fMRI study to help us understand why some youths are more easily frustrated and irritable than others and how this is related to their brain function. We also aim to study whether and how brain function can be used to predict later outcomes. Therefore, participants will be invited back to our lab for two follow-up visits 6 months and 12 months after the brain scan for clinical evaluation and assessment. Compensation up to $640. If interested, contact Hailing Ding at hailing.ding@yale.edu or affectiveyouth@yale.edu. | 8 to 15 | fMRI | up to $640 |
Anxiety
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
Anxiety & Mood Disorder Program | The Anxiety and Mood Disorders Program uses a range of assessment approaches, several developed by members of our team, including self-reports, behavioral assessments, EEG technology, and fMRI imaging. Currently, we are conducting two large clinical trials: One is testing the effects of a brief computer-based training that targets attentional processes to reduce social anxiety in children, and uses EEG to study the effects of the treatment on the child’s brain. The second is examining the effects of parent-based treatment for reducing childhood anxiety, and uses fMRI to study the effects of the treatment on the child’s brain. | Under 18 | Self-reports, behavioral assessments, EEG technology, and/or fMRI imaging | varies | ||
Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth | The clinical trial for children 10-14 years old, is testing the effects of a brief computer-based training that targets attentional processes to reduce social anxiety in children. Attention training is a promising treatment for anxiety disorders because the hope is to train the child’s brain to divert from threatening stimuli. Participants will complete the computer program twice a week for four weeks. Study participants receive treatment at no cost and are compensated up to $600. (IRB#: 2000025143) | 10 to 14 | computer based training twice a week for four weeks | up to $600 | ||
Confirming P1 as a Stable Biomarker of Attention to Social Threat in Youth | The purpose of the study is to examine how children ages 10 to 14 years attend to faces and whether their attention to faces stays the same over time. Participants will be asked to complete computer tasks showing pictures of faces while we measure the electrical activity in their brain and record their eye movements, and answer questions about their behaviors and feelings. This study consists of four visits over six months and participants are compensated up to $350. (IRB#: 2000029999) | 10 to 14 | four visits over six months, computer tasks, questionnaires | up to $350 |
Autism
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
SPARK at Yale | SPARK is a growing community of individuals, families, and researchers on a mission to speed up the understanding of autism. Our aims are to: Collect DNA from saliva samples and information through surveys from 50,000 people with autism and both of their parents and share that data with researchers. Make breakthroughs that were never before possible and return our findings to you. SPARK is sponsored by the Simons Foundation Autism Research Initiative (SFARI) and Yale is one of more than 30 participating hospitals and clinics across the country. Why join SPARK? Find possible genetic causes of autism in your own family and power future autism research for years to come. Join other autism research studies and get updates on the latest autism research. Connect with a community of 1400 SPARK participants in our region! | All ages | saliva collection and questionnaires | up to $50 Amazon gift card | call (203) 785-7539
sparkforautism@yale.edu | |
Infant Emotional Development Study | We are currently recruiting infants for a study on emotional development in early childhood. This study will help us develop better methods for early diagnosis and intervention for behavioral and emotional challenges. We are recruiting infants 4 months of age or younger with and without a family history of autism. Participation will include follow-up visits with your infant through 30 months of age. Visits may include assessment of social, adaptive, cognitive, and language development; studies of attention requiring watching videos and listening to sounds; and play-based activities to assess your child’s emotional development. All study visits will occur at our clinic at 300 George St., Suite 900, New Haven, CT. We provide free and convenient parking. If you are interested in participating, please call (203) 764-5933 or email (sanalab@yale.edu). | 4 months or younger | follow-up visits with your infant through 30 months of age; assessment of social, adaptive, cognitive, and language development; watching videos and listening to sounds; play-based activities | - | call (203) 764-5933
sanalab@yale.edu | |
Complex Neurodevelopmental Conditions | We are currently recruiting children for a study on repetitive behavior. This study will help us better understand the causes and developmental course of repetitive behavior in children, especially repetitive motor movements involving the fingers, hands, head, or body. We are recruiting children 4 years of age and younger with repetitive behavior, either typically developing, or with autism or other neurodevelopmental conditions such as ADHD. Participation will include a visit to the lab with your child, including a comprehensive diagnostic evaluation, assessment of repetitive behavior, studies of attention, and collection of saliva samples to learn more about genetic factors involved in repetitive behavior. All study visits will occur at the SANA Program at 300 George St., Suite 900, New Haven, CT. We provide free and convenient parking. If you are interested in participating, please fill out our inquiry form or give us a call at (203) 764-5933. | 4 years and younger | comprehensive diagnostic evaluation, assessment of repetitive behavior, studies of attention, and collection of saliva samples | - | call (203) 764-5933 | |
Social attention in autistic and non-autistic children with intellectual disability | This project studies attention to social images in autistic children with intellectual disability (ID) and non-autistic children with ID. We are studying behavior and brain systems to better understand the different ways these children experience the social world. Participation involves one or two visits to our offices where children and families will talk to a clinician, complete questionnaires, and watch videos while their brain waves and movement are recorded. Children will receive a clinical evaluation and report as well as compensation of $120. To learn more about the study or to participate, please call us at 203-737-3439 or email our team at autism@yale.edu. | 3 to 17 | questionnaires, EEG, eye-tracking, clinical evaluation | $120 | call (203) 737-3439
autism@yale.edu | |
Brain Imaging Study of Emotion Regulation in Children | If you have a child who is 5 to 15 years old and has disruptive behaviors or has NO disruptive behaviors (such as anger, irritability, or aggression), they may be eligible to participate in a free and confidential study that examines your child’s social and emotional skills. This research will lead to new ways of understanding how children processes and regulate their emotions. The study will require two visits. At each visit you and your child will complete questionnaires, and your child will participate in an fMRI scan. Functional magnetic resonance imaging (fMRI) is a technique for measuring and mapping brain activity that is noninvasive and safe. You will also receive a free psychoeducational assessment describing your child’s social and emotional development. The study is conducted at the Yale Child Study Center by caring and supportive research staff. | 5 to 15 | questionnaires and fMRI | up to $100 | ||
Pivotal Response Treatment | PRT is a well-studied and effective behavioral treatment for children with autism spectrum disorder (ASD). PRT treatment sessions take place three times a week at the Yale Child Study Center over 16 weeks, and each visit lasts about 1.5 hours. These sessions are play-based, and the PRT team selects games, crafts, and other activities to match the child’s interests while working on social engagement and communication skills. The study requires a successful fMRI and Eye-Tracking Scan before beginning PRT. Before attempting those scans, a phone screener is required to determine the child’s eligibility and answer any questions parents might have. To learn more about this study, contact Grace Fjermedal (grace.fjermedal@yale.edu). | 5 to 15 | play, fMRI, eye-tracking | up to $100 | ||
Autism Biomarkers Consortium for Clinical Trials | The Autism Biomarkers Consortium for Clinical Trials (ABC-CT) is a research study to understand how to better measure social skills in school-age autistic children. We are currently recruiting both non-autistic children and children with a diagnosis of autism between the ages of 6 and 11 years old. A diagnostic and cognitive evaluation is provided to all participants at no cost and participants will be compensated up to $300. To learn more about the study or to participate, please call us at 203-737-3439 or email our team at autism@yale.edu. | 6 to 11 | questionnaires, EEG, eye-tracking, clinical evaluation | up to $300 | call (203) 737-3439
autism@yale.edu | |
Stem Cell Study in Autism | You and your child are invited to participate in a study conducted by Flora Vaccarino, M.D. and colleagues at the Yale Child Study Center. The purpose of this study is to identify factors that influence brain cell development and function in individuals with Autism Spectrum Disorders. We are focusing on how young brain cells (known as “neuronal stem cells”) turn into mature cells (such as “neurons and glia”) and how they all function. | 6 years and up | - | up to $150 | flora.vaccarino@yale.edu
livia.tomasini@yale.edu | |
Comprehensive Therapy for Irritability and Aggression (CTIA) in Autistic Adolescents | The Sukhodolsky Lab is seeking adolescents ages 12 to 19 who have been diagnosed with autism spectrum disorder (ASD) and have elevated levels of irritability to take part in a free and confidential study. Irritability and/or disruptive behaviors may include anger outbursts, temper tantrums, noncompliance, being easily frustrated, physical behaviors, difficulty following directions, and other similarly challenging behaviors. The purpose of this study is to test a novel psychosocial intervention for irritability and aggression in autism (CTIA) in comparison to a supportive psychotherapy control condition. We want to see if CTIA helps reduce irritability and aggressive behavior in adolescents with ASD. Participation involves completing 15 weeks of therapy, which may be conducted in-person at the Yale Child Study Center in New Haven, CT, or remotely by telehealth. Parents and adolescents also complete questionnaires and interviews about symptoms and behaviors before, during, and after treatment. The study provides a comprehensive assessment of autism, including IQ and adaptive function, and treatment for irritability at no cost to families. Families receive up to $250 for participation. Click here to learn more https://medicine.yale.edu/lab/sukhodolsky/ or contact Sydney Anderson at sydeny.anderson@yale.edu or (203) 737-7662. | 12 to 19 | 15 weeks of therapy (remote or in person), interviews, questionnaires | up to $250 | call (203) 737-7662
sydney.anderson@yale.edu | |
Neurodevelopmental Biomarkers of Late Diagnosis in Female and Gender Diverse Autism | The Sukhodolsky Lab is seeking volunteers to participate in a research study to help to improve access to autism diagnosis. Autistic people aged 16-30 years are invited to answer questions and complete surveys. These activities can be done out loud, by writing, online or using AAC. The purpose of the study is to advance the knowledge of the autistic experience. We are aiming to learn about why some people get an autism diagnosis when they are young, and other people get an autism diagnosis when they are teens or adults. The study is seeking and welcomes people of all genders and ethnoracial identities to participate. Participation involves 1-2 visits, and participants will be compensated up to $225 for participating, and results of study assessments can be shared with participants free of charge. In addition to the 1-2 visits, participants may also be invited to complete optional activities at other visits such as: interviews (up to 1 hour) and brain scans using MRI (up to 2-3 hours). For more information our if you are interested in participating, please contact Ms. Megan Rutten at sukhodolsky.lab@yale.edu or 203-737-7664. | 16 to 30 | 1-2 visits, interviews (up to 1 hour), brain scans using MRI (up to 2-3 hours). | up to $225 | call 203-737-7664
sukhodolsky.lab@yale.edu | |
Transcranial Magnetic Stimulation (TMS) Study | This study will evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS), a type of noninvasive brain stimulation. TMS is a therapy that has been approved for depression and obsessive-compulsive disorder and we are looking to see if it can also help autistic people. This method uses magnetic waves to influence brain activity. Participation includes two visits that involve answering questions and solving puzzles, as well as a recording of brain waves (using EEG) and watching videos on a computer screen. Compensation is $100 per visit. To learn more about the study or to participate, please call us at 203-737-3439 or email our team at autism@yale.edu. | 18 to 40 | clinical assessments, TMS, EEG and eye tracking experiments | $100 per visit | call (203) 737-3439
autism@yale.edu | |
Transcranial Magnetic Stimulation (TMS) for Depression in Autism | This study will evaluate the effects of Transcranial Magnetic Stimulation (TMS), a type of noninvasive brain stimulation for potentially treating depression in autistic individuals. TMS is a therapy that has been approved for conditions like depression, anxious depression, and obsessive-compulsive disorder. Depression is common in autism so there is a need to better understand why autistic individuals have higher rates of depression than neurotypical individuals. In addition, many autistic individuals with depression may not respond to standard antidepressant medications. In our study, we conduct clinical assessments, then EEG and eye tracking experiments before and after TMS. Study participants will be compensated up to $250. To learn more about the study or to participate, please call us at 203-737-3439 or email our team at autism@yale.edu. | 18 to 40 | clinical assessments, TMS, EEG and eye tracking experiments | up to &250 | call 203-737-3439
autism@yale.edu | |
The IRIS Study | The IRIS clinical trial is evaluating an oral investigational medication, ML-004, to see if it may help alleviate some of the symptoms that interfere with communication in those with autism spectrum disorder (ASD). Participants may be able to take part in the clinical trial if they are between the ages of 18 and 45 years old, have a diagnosis of autism spectrum disorder (ASD), have a clinical trial/care partner willing to assist during the trial. The clinical trial/care partner is someone who lives with or has frequent contact with the clinical trial participant (parent, spouse, friend, etc.) and is willing and able to provide information about the participant and attend some trial visits. The clinical trial team will discuss additional eligibility criteria with you. | 18 to 45 | medication, office visits | - | marcia.questel@yale.edu or morgan.patterson@yale.edu |
Childhood Disintegrative Disorder
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
Yale CDD Study | Does your child have childhood disintegrative disorder (CDD) or autism spectrum disorder (ASD) with a history of normal development followed by a regression (loss of skills) around 3 years of age or later? We invite you to participate in the Yale CDD study. | - | Forms, questionnaires, saliva samples | - | yale.cdd@yale.edu
(203) 868-0653 |
Depression
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
Reducing Adolescent Suicide Risk in Treatment-Resistant Depression | Yale is conducting a study to examine the safety, efficacy, response predictors, and post treatment trajectory of adolescents (13–17 years old) with treatment-resistant depression and high suicide risk following a conservative repeat dosing Ketamine infusion paradigm compared to an active control, Midazolam. Those who are randomized to Midazolam and remain ill have the option to cross-over to Ketamine in the open phase. All participants will be followed closely for 4 months post-treatment and treated with standard of care depression treatment (medication management and cognitive behavioral therapy). Brain-based predictors of anti-suicidal responses will be assessed via connectome predictive modeling and examining functional brain circuits via fMRI before and after treatment. Compensation is up to $320. To learn more about this study, contact Brooke Rivera, Clinical Coordinator, Yale Pediatric Depression Lab at (203)785-7880 or email PediDepression@yale.edu. | 13 to 17 | Ketamine infusion, standard of care depression treatment | up to &320 | call (203)785-7880
PediDepression@yale.edu | |
Teen Brain Imaging Study | The Cho Lab at Yale is running a research study to examine how the brain supports cognition and motivation in teenagers, ages 13-17 years old. We would like to understand how these brain changes contribute to depression and schizophrenia or psychosis in teenagers. Typically developing teenagers, teenagers who have depression or teenagers who have schizophrenia/psychosis may be eligible to participate. The study is confidential, and teenagers are compensated for their participation. For further details please email ChoLab@yale.edu or call 203-815-9874. | 13 to 17 | Clinical assessments, MRI, IQ testing | Up to &650 | call 203-815-9874
ChoLab@yale.edu | |
Transcranial Magnetic Stimulation (TMS) for Depression in Autism | This study will evaluate the effects of Transcranial Magnetic Stimulation (TMS), a type of noninvasive brain stimulation for potentially treating depression in autistic individuals. TMS is a therapy that has been approved for conditions like depression, anxious depression, and obsessive-compulsive disorder. Depression is common in autism so there is a need to better understand why autistic individuals have higher rates of depression than neurotypical individuals. In addition, many autistic individuals with depression may not respond to standard antidepressant medications. In our study, we conduct clinical assessments, then EEG and eye tracking experiments before and after TMS. Study participants will be compensated up to $250. To learn more about the study or to participate, please call us at 203-737-3439 or email our team at autism@yale.edu. | 18 to 40 | clinical assessments, TMS, EEG and eye tracking experiments | up to &250 | call 203-737-3439
autism@yale.edu |
OCD
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
OCD Genetics Study | Your family has been invited to be part of a study of families in which a child has an Obsessive-Compulsive Disorder (OCD) and his/her parents do not. The purpose of this study is to identify the genetic factors that cause OCD using a family-based approach. This will greatly contribute to our understanding of OCD and may help develop new therapies in the future. This study requires participation from a child and both biological parents, can be done in-person or remotely and participation will be compensated with a $100 Amazon gift card for the family. We are not able to offer you a report of your genetic results because our studies are performed as research. Our research lab does not offer any treatment. | - | blood draw, questionnaires | $100 Amazon gift card |
Online Intervention
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
Online Mental Health Intervention for Adolescents on the Waiting List for Mental Health Services | We are currently recruiting adolescents seeking outpatient services at YCSC for a study testing an online mental health intervention conducted while they are on the waiting list. The online mental health intervention is designed to teach coping and emotion regulation skills for adolescents struggling with mental health symptoms. This study will help us better understand how to best implement an online intervention for adolescents on the waiting list. We are recruiting any adolescent aged 13-17 years on the waiting list for services if they are not currently receiving treatment for the same problem elsewhere. Participants must have access to a mobile device. Participation is completely online. Adolescents will answer questions on their mobile phone or tablet and engage with the online intervention for 20-30 minutes. Then, adolescents will participate in either a focus group or individual interview lasting 60-90 minutes to assess their experience with the intervention. Parents will be contacted before adolescent participation for consent and answer any questions they may have. To learn more about our study, please contact accesslab@yale.edu. This study has been approved by the Yale IRB (HIC #2000035977). | 13-17 | Self-report questionnaires, engaging with an online intervention for mental health, focus groups. | $60 | ACCESS Lab: https://medicine.yale.edu/childstudy/research/clinical-innovations/access-lab/ | accesslab@yale.edu |
Pregnancy
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
UPWARDS Study | The purpose of the UPWARDS Study is to develop a better approach to identify pregnant individuals who are having difficulty with their emotional wellbeing and may need extra help or support during and after pregnancy. We’d love to have you join and play an important role in our study. | - | passive data collection, questionnaires | up to $190 |
Schizophrenia/Psychosis
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
Teen Brain Imaging Study | The Cho Lab at Yale is running a research study to examine how the brain supports cognition and motivation in teenagers, ages 13-17 years old. We would like to understand how these brain changes contribute to depression and schizophrenia or psychosis in teenagers. Typically developing teenagers, teenagers who have depression or teenagers who have schizophrenia/psychosis may be eligible to participate. The study is confidential, and teenagers are compensated for their participation. For further details please email ChoLab@yale.edu or call 203-815-9874. | 13 to 17 | Clinical assessments, MRI, IQ testing | Up to &650 | call 203-815-9874
ChoLab@yale.edu |
Tourette's Disorder
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
Neurofeedback from the supplementary motor area for Tourette Syndrome | Does your child have chronic tics or Tourette Syndrome? If your child is 10-16 years old with chronic tics, they may be eligible to receive neurofeedback treatment. We use a form of neurofeedback that involves monitoring brain activity via fMRI. The purpose of this study is to determine if our neurofeedback intervention can reduce tic symptoms and improve our understanding of Tourette Syndrome. Participation can result in compensation up to $880. If you have any further questions or concerns, please contact us at Hampson.lab@yale.edu, or (203)-737-6055. Study Sponsors: National Institute of Mental Health, Department of Human Health Services. HIC#2000033043 | 10 to 16 | fMRI | up to $880 | call (203)-737-6055
Hampson.lab@yale.edu | |
Stem Cell Study in Tourette's Disorder | You and your child are invited to participate in a study conducted by Flora Vaccarino, M.D. and colleagues at the Yale Child Study Center. The purpose of this study is to identify factors that influence brain cell development and function in individuals with Autism Spectrum Disorders and Tourette Syndrome. We are focusing on how young brain cells (known as “neuronal stem cells”) turn into mature cells (such as “neurons and glia”) and how they all function. | 16 years old and up | Saliva, blood draw, clinical assessments. | $100 for samples and $100 for clinical assessments | flora.vaccarino@yale.edu
livia.tomasini@yale.edu | |
TIC Genetics Study | The purpose of the TIC Genetics Study is to identify the genetic factors that cause Tourette Syndrome and tics using a family-based approach. This will greatly contribute to our understanding of Tourette Syndrome and may help develop new therapies in the future. This study requires participation from a child and both biological parents, can be done in-person or remotely, and participation will be compensated with a $100 Amazon gift card for the family. | - | blood draw (child and both parents), questionnaires | $100 Amazon gift card |
Trichotillomania
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
TABS Study | Your family has been invited to be part of a study of families in which an individual has trichotillomania or other body focused repetitive behavior (BFRB). Although it is well known that genetic factors play a role in causing BFRBs, the responsible genes have not yet been discovered. Recent dramatic advances in genetic techniques hold out the promise that we may soon be able to identify such risk-conferring genes. The purpose of this study is to identify the genetic factors that cause trichotillomania and other BFRBs using a family-based approach. This will greatly contribute to our understanding of these conditions and may help develop new therapies in the future. This study requires participation from an individual impacted by trichotillomania or other BFRB and both biological parents. The study can be done in-person or remotely. We are not able to offer you a report of your genetic results because our studies are performed as research. Our research lab does not offer any treatment. | - | Saliva sample (child and both parents), questionnaire | - | ||
Valbenazine for the Treatment of Trichotillomania in Adults | If you are an adult with trichotillomania, you may be eligible to participate in an in-person research study run by the Yale School of Medicine. This study will examine the efficacy of Valbenazine for the treatment of trichotillomania. Valbenazine is a dopamine-depleting agent that is currently FDA-approved for tardive dyskinesia and has a relatively safe side-effect profile in initial trials. While enrolled in the trial, you will receive regular psychiatric and medical assessments of symptoms at no cost. Additionally, you will receive a stipend of up to $590 over the course of 26 weeks for your participation. In-person visits occur about every two weeks and are held at 350 George St. New Haven, CT 06511. If you are interested in the trial or wish to learn more, please do not hesitate to contact us by phone at (203)785-7880 or email at blochresearch@yale.edu if you have any questions about the trial. | - | medication, psychiatric and medical assessments | stipend of up to $590 over the course of 26 weeks | call (203)785-7880
blochresearch@yale.edu |
Typically Developing Individuals
| Study Name | Study Information | Age | Procedure | Compensation | Website | Contacts |
|---|---|---|---|---|---|---|
Infant Emotional Development Study | We are currently recruiting infants for a study on emotional development in early childhood. This study will help us develop better methods for early diagnosis and intervention for behavioral and emotional challenges. We are recruiting infants 4 months of age or younger with and without a family history of autism. Participation will include follow-up visits with your infant through 30 months of age. Visits may include assessment of social, adaptive, cognitive, and language development; studies of attention requiring watching videos and listening to sounds; and play-based activities to assess your child’s emotional development. All study visits will occur at our clinic at 300 George St., Suite 900, New Haven, CT. We provide free and convenient parking. If you are interested in participating, please call (203) 764-5933 or email (sanalab@yale.edu). | 4 months or younger | follow-up visits with your infant through 30 months of age; assessment of social, adaptive, cognitive, and language development; watching videos and listening to sounds; play-based activities | - | call (203) 764-5933
sanalab@yale.edu | |
Complex Neurodevelopmental Conditions | We are currently recruiting children for a study on repetitive behavior. This study will help us better understand the causes and developmental course of repetitive behavior in children, especially repetitive motor movements involving the fingers, hands, head, or body. We are recruiting children 4 years of age and younger with repetitive behavior, either typically developing, or with autism or other neurodevelopmental conditions such as ADHD. Participation will include a visit to the lab with your child, including a comprehensive diagnostic evaluation, assessment of repetitive behavior, studies of attention, and collection of saliva samples to learn more about genetic factors involved in repetitive behavior. All study visits will occur at the SANA Program at 300 George St., Suite 900, New Haven, CT. We provide free and convenient parking. If you are interested in participating, please fill out our inquiry form or give us a call at (203) 764-5933. | 4 years and younger | comprehensive diagnostic evaluation, assessment of repetitive behavior, studies of attention, and collection of saliva samples | - | call (203) 764-5933 | |
Brain Imaging Study of Emotion Regulation in Children | If you have a child who is 5 to 15 years old and has disruptive behaviors or has NO disruptive behaviors (such as anger, irritability, or aggression), they may be eligible to participate in a free and confidential study that examines your child’s social and emotional skills. This research will lead to new ways of understanding how children processes and regulate their emotions. The study will require two visits. At each visit you and your child will complete questionnaires, and your child will participate in an fMRI scan. Functional magnetic resonance imaging (fMRI) is a technique for measuring and mapping brain activity that is noninvasive and safe. You will also receive a free psychoeducational assessment describing your child’s social and emotional development. The study is conducted at the Yale Child Study Center by caring and supportive research staff. | 5 to 15 | questionnaires and fMRI | up to $100 | ||
Autism Biomarkers Consortium for Clinical Trials | The Autism Biomarkers Consortium for Clinical Trials (ABC-CT) is a research study to understand how to better measure social skills in school-age autistic children. We are currently recruiting both non-autistic children and children with a diagnosis of autism between the ages of 6 and 11 years old. A diagnostic and cognitive evaluation is provided to all participants at no cost and participants will be compensated up to $300. To learn more about the study or to participate, please call us at 203-737-3439 or email our team at autism@yale.edu. | 6 to 11 | questionnaires, EEG, eye-tracking, clinical evaluation | up to $300 | call (203) 737-3439
autism@yale.edu | |
Stem Cell Study in Autism | You and your child are invited to participate in a study conducted by Flora Vaccarino, M.D. and colleagues at the Yale Child Study Center. The purpose of this study is to identify factors that influence brain cell development and function in individuals with Autism Spectrum Disorders. We are focusing on how young brain cells (known as “neuronal stem cells”) turn into mature cells (such as “neurons and glia”) and how they all function. | 6 years and up | - | up to $150 | flora.vaccarino@yale.edu
livia.tomasini@yale.edu | |
Brain mechanisms of childhood irritability | We are recruiting children and adolescents ages 8 to 15 to participate in an fMRI study to help us understand why some youths are more easily frustrated and irritable than others and how this is related to their brain function. We also aim to study whether and how brain function can be used to predict later outcomes. Therefore, participants will be invited back to our lab for two follow-up visits 6 months and 12 months after the brain scan for clinical evaluation and assessment. Compensation up to $640. If interested, contact Hailing Ding at hailing.ding@yale.edu or affectiveyouth@yale.edu. | 8 to 15 | fMRI | up to $640 | ||
Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth | The clinical trial for children 10-14 years old, is testing the effects of a brief computer-based training that targets attentional processes to reduce social anxiety in children. Attention training is a promising treatment for anxiety disorders because the hope is to train the child’s brain to divert from threatening stimuli. Participants will complete the computer program twice a week for four weeks. Study participants receive treatment at no cost and are compensated up to $600. (IRB#: 2000025143) | 10 to 14 | computer based training twice a week for four weeks | up to $600 | ||
Confirming P1 as a Stable Biomarker of Attention to Social Threat in Youth | The purpose of the study is to examine how children ages 10 to 14 years attend to faces and whether their attention to faces stays the same over time. Participants will be asked to complete computer tasks showing pictures of faces while we measure the electrical activity in their brain and record their eye movements, and answer questions about their behaviors and feelings. This study consists of four visits over six months and participants are compensated up to $350. (IRB#: 2000029999) | 10 to 14 | four visits over six months, computer tasks, questionnaires | up to $350 | ||
Teen Brain Imaging Study | The Cho Lab at Yale is running a research study to examine how the brain supports cognition and motivation in teenagers, ages 13-17 years old. We would like to understand how these brain changes contribute to depression and schizophrenia or psychosis in teenagers. Typically developing teenagers, teenagers who have depression or teenagers who have schizophrenia/psychosis may be eligible to participate. The study is confidential, and teenagers are compensated for their participation. For further details please email ChoLab@yale.edu or call 203-815-9874. | 13 to 17 | Clinical assessments, MRI, IQ testing | Up to &650 | call 203-815-9874
ChoLab@yale.edu | |
Stem Cell Study in Tourette's Disorder | You and your child are invited to participate in a study conducted by Flora Vaccarino, M.D. and colleagues at the Yale Child Study Center. The purpose of this study is to identify factors that influence brain cell development and function in individuals with Autism Spectrum Disorders and Tourette Syndrome. We are focusing on how young brain cells (known as “neuronal stem cells”) turn into mature cells (such as “neurons and glia”) and how they all function. | 16 years old and up | Saliva, blood draw, clinical assessments. | $100 for samples and $100 for clinical assessments | flora.vaccarino@yale.edu
livia.tomasini@yale.edu | |
Transcranial Magnetic Stimulation (TMS) Study | This study will evaluate the effects of repetitive Transcranial Magnetic Stimulation (rTMS), a type of noninvasive brain stimulation. TMS is a therapy that has been approved for depression and obsessive-compulsive disorder and we are looking to see if it can also help autistic people. This method uses magnetic waves to influence brain activity. Participation includes two visits that involve answering questions and solving puzzles, as well as a recording of brain waves (using EEG) and watching videos on a computer screen. Compensation is $100 per visit. To learn more about the study or to participate, please call us at 203-737-3439 or email our team at autism@yale.edu. | 18 to 40 | clinical assessments, TMS, EEG and eye tracking experiments | $100 per visit | call (203) 737-3439
autism@yale.edu |