Cortical astrocytes in culture stained with GFAP (red). DAPI is blue.
The Vaccarino Lab
The Role of Fibroblast Growth Factor Receptors in the Morphogenesis and Maturation of the Neocortex
Our studies have shown that Fgf signaling acts upstream of Notch to regulate the surface expansion of the cerebral cortex and the hippocampus. We are currently studying dose-specific Fgf...
Perinatal Hypoxic Injury
Our laboratory employs a mouse model of hypoxia that simulates the immature lung development typical in very low birth weight premature (VLBW) children (<1kg). Much of our current research...
Induced Pluripotent Stem Cells & Developmental Disorders
In our lab we produce iPSC from skin fibroblasts of ASD patients and control subjects and use them to study differences in human embryonic neuronal development between these two populations.
Cortico-basal ganglia interactions in movement disorders: Tourette Syndrome
Using stereology, we showed (Kalanithi et al, 2005; Kataoka et al, 2010) a decrease in number of PV and cholinergic interneurons in postmortem basal ganglia tissue from five subjects with...
Somatic mosaicism
Somatic mosaicism is the accumulation of mutations in DNA sequence or copy number in cellular genomes after fertilization (typically in the form of copy number variations, single nucleotide...
