Cortical astrocytes in culture stained with GFAP (red). DAPI is blue.
The Vaccarino Lab
Somatic mosaicism
Somatic mosaicism is the accumulation of mutations in DNA sequence or copy number in cellular genomes after fertilization (typically in the form of copy number variations, single nucleotide...
Induced Pluripotent Stem Cells & Developmental Disorders
In our lab we produce iPSC from skin fibroblasts of ASD patients and control subjects and use them to study differences in human embryonic neuronal development between these two populations.
The Role of Fibroblast Growth Factor Receptors in the Morphogenesis and Maturation of the Neocortex
Our studies have shown that Fgf signaling regulates the surface expansion of the cerebral cortex and the hippocampus.
Cortico-basal ganglia interactions in movement disorders: Tourette Syndrome
Using stereology, we showed a decrease in number of GABAergic and cholinergic interneurons in postmortem basal ganglia tissue from subjects with Tourette.
