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YCSC Grand Rounds: "You Contain Multitudes – Somatic Mosaic Mutations in Neuropsychiatric Disorders"

Yale Child Study Center

Session Description

Although it was long assumed that all cells in the brain had identical genomes, it has more recently been shown that each neuronal genome has hundreds of somatic mutations at birth, and more than a thousand by late in life, with point mutations accumulating remarkably linearly with age. Damaging somatic mutations that are shared by multiple cells in the brain contribute to risk of pediatric and adult epilepsy, autism spectrum disorder, and schizophrenia. The learning objectives for this session are to understand:

  1. The concept of somatic mutation
  2. Somatic mutation contribution to risk of autism spectrum disorder
  3. That genomes are constantly changing

This will be a hybrid session, held live and in person from the Cohen Auditorium and simulcast via Zoom.

Continuing Education

The 2023-2024 YCSC Grand Rounds series has been approved for eligibility for Continuing Medical Education (CME) credits. Yale School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Individual event designation details are provided at applicable live events.

This program has been approved for one Continuing Education Credit Hour by the National Association of Social Workers, CT and meets the continuing education criteria for Social Work, Marriage & Family Therapist, Professional Counselor, and Licensed Psychologist Licensure renewal. This session also meets the requirement for cultural competence. Additional information will be provided at the live event.


  • Chief of Genetics and Genomics and HHMI Investigator, Boston Children's Hospital

    Christopher A. Walsh, MD, PhD
    Bullard Professor of Neurology and Pediatrics, Harvard Medical School



Host Organization




Grand Rounds
Apr 202430Tuesday