Michael Chiorazzi, MD, PhD
Assistant Professor of Internal Medicine (Medical Oncology)
Research & Publications
Biography
News
Locations
Coauthors
Selected Publications
- Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironmentChiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins K, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze L, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Goedegebuure S, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Kluger Y, Palucka K, Fields R, Flavell R. Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment. Journal For ImmunoTherapy Of Cancer 2023, 11: e006921. PMID: 37487666, PMCID: PMC10373695, DOI: 10.1136/jitc-2023-006921.
- Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cellsTyagi T, Jain K, Yarovinsky TO, Chiorazzi M, Du J, Castro C, Griffin J, Korde A, Martin KA, Takyar SS, Flavell RA, Patel AA, Hwa J. Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells. Journal Of Experimental Medicine 2022, 220: e20212218. PMID: 36305874, PMCID: PMC9814191, DOI: 10.1084/jem.20212218.
- Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and functionMartinek J, Lin J, Kim KI, Wang VG, Wu TC, Chiorazzi M, Boruchov H, Gulati A, Seeniraj S, Sun L, Marches F, Robson P, Rongvaux A, Flavell RA, George J, Chuang JH, Banchereau J, Palucka K. Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function. Cell Reports Medicine 2022, 3: 100621. PMID: 35584631, PMCID: PMC9133468, DOI: 10.1016/j.xcrm.2022.100621.
- Abstract 3441: Transcriptional profiles of CD14+ cells in situ in melanoma reveal plasticity, localization dependent function and specific T cell interactionsMartinek J, Kim K, Lin J, Wu T, Borouchov H, Gulati A, Sun L, Wang V, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract 3441: Transcriptional profiles of CD14+ cells in situ in melanoma reveal plasticity, localization dependent function and specific T cell interactions. Cancer Research 2020, 80: 3441-3441. DOI: 10.1158/1538-7445.am2020-3441.
- Abstract A103: Transcriptional profiles of CD14+ cells in situ in melanoma reveal plasticity, localization-dependent function, and specific T-cell interactionsMartinek J, in Kim K, Wu T, Boruchov H, Gulati A, Sun L, Wang V, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract A103: Transcriptional profiles of CD14+ cells in situ in melanoma reveal plasticity, localization-dependent function, and specific T-cell interactions. Cancer Immunology Research 2020, 8: a103-a103. DOI: 10.1158/2326-6074.tumimm19-a103.
- Abstract 1507: Transcriptional profiles of CD14+ cells in situ in melanoma tumors reveal plasticity and localization dependent functionMartinek J, Kim K, Wu T, Wang V, Brookes H, Sun L, Gulati A, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract 1507: Transcriptional profiles of CD14+ cells in situ in melanoma tumors reveal plasticity and localization dependent function. 2019, 1507-1507. DOI: 10.1158/1538-7445.sabcs18-1507.
- Abstract 1507: Transcriptional profiles of CD14+ cells in situ in melanoma tumors reveal plasticity and localization dependent functionMartinek J, Kim K, Wu T, Wang V, Brookes H, Sun L, Gulati A, George J, Henrich P, Marches F, Rongvaux A, Chiorazzi M, Chuang J, Robson P, Flavell R, Banchereau J, Palucka K. Abstract 1507: Transcriptional profiles of CD14+ cells in situ in melanoma tumors reveal plasticity and localization dependent function. Cancer Research 2019, 79: 1507-1507. DOI: 10.1158/1538-7445.am2019-1507.
- No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILsBailis W, Shyer JA, Chiorazzi M, Flavell RA. No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs. Cancer Cell 2017, 32: 280-281. PMID: 28898693, PMCID: PMC6939383, DOI: 10.1016/j.ccell.2017.08.013.
- Related F-box proteins control cell death in Caenorhabditis elegans and human lymphomaChiorazzi M, Rui L, Yang Y, Ceribelli M, Tishbi N, Maurer CW, Ranuncolo SM, Zhao H, Xu W, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Shaham S, Staudt LM. Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3943-3948. PMID: 23431138, PMCID: PMC3593917, DOI: 10.1073/pnas.1217271110.
- Characterization of early stages of human B cell development by gene expression profilingHystad M, Myklebust J, Bø T, Sivertsen E, Rian E, Forfang L, Munthe E, Rosenwald A, Chiorazzi M, Jonassen I, Staudt L, Smeland E. Characterization of early stages of human B cell development by gene expression profiling. The Journal Of Immunology 2009, 182: 5882-5882. DOI: 10.4049/jimmunol.0990031.
- Characterization of Early Stages of Human B Cell Development by Gene Expression ProfilingHystad ME, Myklebust JH, Bø TH, Sivertsen EA, Rian E, Forfang L, Munthe E, Rosenwald A, Chiorazzi M, Jonassen I, Staudt LM, Smeland EB. Characterization of Early Stages of Human B Cell Development by Gene Expression Profiling. The Journal Of Immunology 2007, 179: 3662-3671. PMID: 17785802, DOI: 10.4049/jimmunol.179.6.3662.
- Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding geneMaurer CW, Chiorazzi M, Shaham S. Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene. Development 2007, 134: 1357-1368. PMID: 17329362, DOI: 10.1242/dev.02818.
- Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survivalWiestner A, Tehrani M, Chiorazzi M, Wright G, Gibellini F, Nakayama K, Liu H, Rosenwald A, Muller-Hermelink HK, Ott G, Chan WC, Greiner TC, Weisenburger DD, Vose J, Armitage JO, Gascoyne RD, Connors JM, Campo E, Montserrat E, Bosch F, Smeland EB, Kvaloy S, Holte H, Delabie J, Fisher RI, Grogan TM, Miller TP, Wilson WH, Jaffe ES, Staudt LM. Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival. Blood 2007, 109: 4599-4606. PMID: 17299095, PMCID: PMC1885523, DOI: 10.1182/blood-2006-08-039859.
- Characterization of Early Human B Cell Development by Gene Expression Profiling.Hystad M, Bo T, Rian E, Myklebust J, Sivertsen E, Forfang L, Chiorazzi M, Rosenwald A, Jonassen I, Staudt L, Smeland E. Characterization of Early Human B Cell Development by Gene Expression Profiling. Blood 2006, 108: 1352. DOI: 10.1182/blood.v108.11.1352.1352.
- Cyclin D1–negative mantle cell lymphoma: a clinicopathologic study based on gene expression profilingFu K, Weisenburger DD, Greiner TC, Dave S, Wright G, Rosenwald A, Chiorazzi M, Iqbal J, Gesk S, Siebert R, De Jong D, Jaffe ES, Wilson WH, Delabie J, Ott G, Dave BJ, Sanger WG, Smith LM, Rimsza L, Braziel RM, Müller-Hermelink H, Campo E, Gascoyne RD, Staudt LM, Chan C. Cyclin D1–negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling. Blood 2005, 106: 4315-4321. PMID: 16123218, PMCID: PMC1895253, DOI: 10.1182/blood-2005-04-1753.
- Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune CellsDave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan W, Fisher RI, Braziel RM, Rimsza LM, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Connors JM, Lansdorp PM, Ouyang Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe ES, Simon R, Yang L, Powell J, Zhao H, Goldschmidt N, Chiorazzi M, Staudt LM. Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells. New England Journal Of Medicine 2004, 351: 2159-2169. PMID: 15548776, DOI: 10.1056/nejmoa041869.
- Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin LymphomaRosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD, Chan WC, Zhao T, Haioun C, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Campo E, Montserrat E, Lopez-Guillermo A, Ott G, Muller-Hermelink HK, Connors JM, Braziel R, Grogan TM, Fisher RI, Miller TP, LeBlanc M, Chiorazzi M, Zhao H, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Staudt LM. Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma. Journal Of Experimental Medicine 2003, 198: 851-862. PMID: 12975453, PMCID: PMC2194208, DOI: 10.1084/jem.20031074.
- The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphomaRosenwald A, Wright G, Wiestner A, Chan C, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt LM. The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma. Cancer Cell 2003, 3: 185-197. PMID: 12620412, DOI: 10.1016/s1535-6108(03)00028-x.