Scott Woods, MD
Elizabeth Mears and House Jameson Professor of PsychiatryCards
Appointments
Psychiatry
Primary
Child Study Center
Secondary
Contact Info
About
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Titles
Elizabeth Mears and House Jameson Professor of Psychiatry
Biography
Dr. Woods assesses young people at risk for psychosis through his PRIME Clinic, which also offers studies aiming to improve treatment for current symptoms and preventing progression.
Last Updated on April 07, 2025.
Appointments
Psychiatry
ProfessorPrimaryChild Study Center
ProfessorSecondary
Other Departments & Organizations
- Adult Psychiatry
- Child Study Center
- Connecticut Mental Health Center
- MR Core
- PRIME Psychosis Prodrome Research Clinic
- Psychiatry
- Yale Medicine
- Yale New Haven Health System
- Yale Ventures
Education & Training
- Resident
- Massachusetts General Hospital (1984)
- MD
- Baylor College of Medicine (1978)
Research
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Overview
Predictors and Mechanisms of Conversion to Psychosis (MH082022)
Aspirin vs placebo for the psychosis prodrome
D-serine for the psychosis prodrome (MH074356)
Dutetrabenzine for tardive dyskinesia
Huperzine for cognitive enhancement in schizophrenia (MH083436)
Medical Research Interests
Adolescent Psychiatry; Prodromal Symptoms; Psychiatry; Psychotic Disorders
ORCID
0000-0002-3103-5228
Research at a Glance
Yale Co-Authors
Frequent collaborators of Scott Woods's published research.
Publications Timeline
A big-picture view of Scott Woods's research output by year.
Research Interests
Research topics Scott Woods is interested in exploring.
Tyrone Cannon
Albert Powers, MD, PhD
Philip Corlett, PhD
Godfrey Pearlson, MA, MBBS
Zailyn Tamayo
Catalina Mourgues-Codern
85Publications
609Citations
Psychotic Disorders
Prodromal Symptoms
Publications
2026
Biophysical modeling of excitation/inhibition balance and conversion to psychosis in the clinical high risk syndrome
Rodriguez-Sanchez J, Hauke D, Pinotsis D, Berndt L, Oloye H, Nicholas S, Hamilton H, Roach B, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Friston K, Addington J, Bearden C, Cadenhead K, Perkins D, Walker E, Woods S, Cannon T, Adams R, Mathalon D. Biophysical modeling of excitation/inhibition balance and conversion to psychosis in the clinical high risk syndrome. Biological Psychiatry 2026 PMID: 42025866, DOI: 10.1016/j.biopsych.2026.04.007.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPyramidal cell excitabilityP300 event-related potentialCell excitabilityPyramidal cellsMismatch negativityCHR-PAssociated with disinhibitionCompensatory downregulationDisinhibition of pyramidal cellsEvent-related potentialsPositive symptomsDownregulation of inhibitionP300 amplitude reductionCHR-P participantsInhibitory synaptic functionClinical high-risk syndromeTarget event-related potentialsHigh-risk syndromeSevere positive symptomsAuditory oddball paradigmAmplitude reductionConversion to psychosisClinical high riskSynaptic excitationExcitation/inhibition balanceCannabis and Tobacco Co-Use is Associated with Impaired Neurocognitive Performance in Individuals at Clinical High Risk for Psychosis
Bello D, Connolly J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Brady R, Carrión R, Ward H. Cannabis and Tobacco Co-Use is Associated with Impaired Neurocognitive Performance in Individuals at Clinical High Risk for Psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2026 PMID: 41999882, DOI: 10.1016/j.bpsc.2026.03.021.Peer-Reviewed Original ResearchConceptsCo-use of cannabisClinical high riskCHR-PCognitive performanceCannabis useTobacco co-useCo-usePsychotic disordersVerbal learningWorking memoryAttentional performanceNeurocognitive performanceMATRICS Consensus Cognitive BatteryNorth American Prodrome Longitudinal Study 2Associated with lower global cognitive performanceAuditory continuous performance taskAssociated with lower neurocognitive performanceHealthy controlsConsensus Cognitive BatteryContinuous performance taskLow working memoryCHR-P individualsImpaired neurocognitive performanceLongitudinal Study 2Prospective study of individualsCorrelation networks of blood proteins in the neuroimmunology of schizophrenia—replication and extension
Jeffries C, Bizon C, Ford J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Seidman L, Stone W, Walker E, Woods S, Perkins D. Correlation networks of blood proteins in the neuroimmunology of schizophrenia—replication and extension. Translational Psychiatry 2026 PMID: 41965717, DOI: 10.1038/s41398-026-03934-6.Peer-Reviewed Original ResearchConceptsNorth American Prodrome Longitudinal Study 2Clinical high riskCommunity controlsLongitudinal Study 2Psychotic disordersPsychosis riskStudy 3Study 2PsychosisHigh riskEmpirical p-valuesGroup of individualsExtracellular matrixCorrelation networkCircuit remodelingCorrelation patternsRemodeling of extracellular matrixProtein dataPromotion of coagulationParticipantsPlasma protein dataSERPINE1Permutation testTIMP1IndividualsSocial withdrawal and hippocampal volume among adolescents at clinical high risk for psychosis and healthy comparisons: The moderating role of neighborhood residential stability
Ku B, Arrant E, Yuan Q, Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E. Social withdrawal and hippocampal volume among adolescents at clinical high risk for psychosis and healthy comparisons: The moderating role of neighborhood residential stability. Schizophrenia Research 2026, 293: 81-90. PMID: 41955767, PMCID: PMC13094779, DOI: 10.1016/j.schres.2026.03.024.Peer-Reviewed Original ResearchConceptsClinical high riskSocial withdrawalHippocampal volumeNeighborhood residential stabilityHealthy comparisonNorth American Prodrome Longitudinal Study Phase 2Premorbid Adjustment ScaleModerating RoleResidential stabilityPsychiatric vulnerabilityAdjustment ScaleAssociated with HVCHR-PContextual factorsNeurodevelopmental vulnerabilityPsychosisIntervention effortsBehavioral risk factorsBilateral HVCross-sectional associationsHigh riskFollow-up modelWithdrawalStudy phase 2AdolescentsNeighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons
Ku B, Arrant E, Addington J, Bearden C, Cadenhead K, Cannon T, Carrion R, Keshavan M, Mathalon D, Stone W, Woods S, Walker E, Perkins D, Cao H. Neighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons. Brain And Environment 2026, 5: 100016. PMID: 41907310, PMCID: PMC13030900, DOI: 10.1016/j.braen.2026.100016.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNeighbourhood social fragmentationClinical high riskHealthy comparisonCHR-PSocial fragmentationPsychosis riskNorth American Prodrome Longitudinal Study Phase 2Functional connectivity dataPredictive coding frameworkCerebello-thalamo-cortical connectionsHC youthPsychosisIndividual povertyMaladaptive processesBrain's abilitySocial tiesBelief updatingEducational attainmentSocial worldConnectivity dataYouthStudy phase 2Early interventionNeighborhoodSocial environmentThe Utility of Negative Symptoms in Predicting Transition to Psychosis Among Individuals at Clinical High Risk
Arnovitz M, Cornblatt B, Auther A, McLaughlin D, Addington J, Bearden C, Cadenhead K, Cannon T, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Kane J, Carrión R. The Utility of Negative Symptoms in Predicting Transition to Psychosis Among Individuals at Clinical High Risk. Schizophrenia Bulletin 2026, 52: sbaf244. PMID: 41863384, PMCID: PMC13005126, DOI: 10.1093/schbul/sbaf244.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNegative symptomsClinical high riskDepressive symptomsCHR-NTCHR-PSymptom modelNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsHealthy controlsCalgary Depression ScaleExpressive negative symptomsNegative symptom severitySocial anhedoniaCHR-TSymptom severityPsychosisIdeational richnessProdromal symptomsDepression ScaleLongitudinal studyHigh riskData support considerationSymptomsHigh-risk individualsFollow-upVisual P300 and risk for psychosis onset in youth at clinical high-risk
Hamilton H, Roach B, Nicholas S, Dembo R, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Perkins D, Walker E, Woods S, Cannon T, Mathalon D. Visual P300 and risk for psychosis onset in youth at clinical high-risk. Biological Psychiatry 2026 PMID: 41771336, DOI: 10.1016/j.biopsych.2026.02.013.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical high riskHealthy comparisonEvent-related potentialsCHR individualsPsychosis onsetP3b deficitsPsychosis conversionNorth American Prodrome Longitudinal StudyVisual P300 event-related potentialsThree-stimulus visual oddball taskPathogenesis of psychosisPrediction of psychosis onsetP300 event-related potentialVisual oddball taskInfrequent target stimuliAssociated with future outcomesCHR participantsNovelty P3aNovel stimuliNAPLS-2Target stimuliSymptom severityOddball taskP300 amplitudePsychosisComputational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample
Luther L, Cooper J, Treadway M, Knippenberg A, Walker E, Gold J, Waltz J, Schiffman J, Ellman L, Mittal V, Zinbarg R, Silverstein S, Corlett P, Powers A, Woods S, Allen D, Lahti A, Strauss G. Computational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample. Molecular Psychiatry 2026, 1-11. PMID: 41691110, DOI: 10.1038/s41380-026-03474-x.Peer-Reviewed Original ResearchAltmetricConceptsEffort-based decision-makingNegative symptomsReward magnitudeDepressive disorderNegative symptom measuresClinical high riskFirst-episode psychosisMentally ill sampleMultiple psychiatric diagnosesReward taskSymptom measuresBipolar disorderNeuropsychological testsEffort expenditurePsychiatric diagnosisIll sampleDiagnostic groupsSubjective valueHealthy control groupCognitive impairmentHC groupBias modelRewardDisordersPsychosisContributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk
Guest R, Addington J, Bearden C, Cadenhead K, Cornblatt B, Mathalon D, Perkins D, Tsuang M, Woods S, Cannon T, Keshavan M, Stone W, Walker E. Contributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk. Schizophrenia Research 2026, 290: 98-105. PMID: 41671768, DOI: 10.1016/j.schres.2026.02.004.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsWechsler Abbreviated ScaleHealthy control participantsCHR-PCognitive functionBetter cognitive functionCortical thicknessControl participantsWechsler Abbreviated Scale of IntelligenceNorth American Prodrome Longitudinal StudyEarly stages of psychosisCHR-P samplesStages of psychosisClinical high riskFull-scale IQAssociated with better cognitive functionStructural MRI scansAberrant neurodevelopmental processesScale of IntelligenceRegional cortical thicknessPsychosis-riskOnset of illnessCognitive deficitsCHR-P.Cortical substratesFrontoparietal regionsStepped care for young people at clinical high risk for psychosis: a real-world study
Broekhuijse A, Saxena A, Walsh B, Mourgues-Codern C, Mukhtar H, Howard S, Woods SW, Powers AR, Farina EA. Stepped care for young people at clinical high risk for psychosis: a real-world study. 2026 DOI: 10.64898/2026.02.05.26345683.Peer-Reviewed Original Research In Press
Clinical Trials
Current Trials
ProNET
IRB ID2000029159RolePrincipal InvestigatorPrimary Completion Date12/31/2024Recruiting ParticipantsSchizophrenia Spectrum Biomarkers Consortium (SSBC)
IRB ID2000029485RoleSub InvestigatorPrimary Completion Date12/31/2030Recruiting ParticipantsStudy of Brain Function Across the Lifespan
IRB ID2000020891RoleSub InvestigatorPrimary Completion Date07/31/2022Recruiting ParticipantsGenderBothAge18 years - 65 yearsSleep Dependent Learning in Schizophrenia and Psychosis Risk Syndrome
IRB ID1201009524RoleSub InvestigatorPrimary Completion Date01/31/2022Recruiting ParticipantsGenderBothAge18 years - 55 years
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News
- May 20, 2026
Hyman Honored with 2026 Yale Department of Psychiatry Mental Health Advocacy Award
- April 08, 2026
Yale-NAMI Conference on Neuroscience, Mental Health and Society Scheduled for May 9
- March 23, 2026
Powers Honored with SIRS Research Excellence Award
- February 17, 2026
Yale Psychiatry Ranks Second in Nation in NIH Research Funding
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