Albert Powers, MD, PhD
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Appointments
Psychiatry
Primary
Titles
Medical & Associate Director, Yale PRIME Psychosis Risk Clinic, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Titles
Medical & Associate Director, Yale PRIME Psychosis Risk Clinic, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Titles
Medical & Associate Director, Yale PRIME Psychosis Risk Clinic, Psychiatry
Contact Info
About
Titles
Associate Professor of Psychiatry
Medical & Associate Director, Yale PRIME Psychosis Risk Clinic, PsychiatryBiography
Dr. Powers is an Associate Professor at the Yale University Department of Psychiatry and Medical Director and Associate Director of the PRIME Psychosis Risk Clinic at Yale. In addition to treating individuals who suffer from the symptoms of early psychosis, he uses computational approaches to understand how sensory systems might go awry to produce hallucinations and other symptoms of psychosis.
Appointments
Psychiatry
Associate Professor on TermPrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Interdepartmental Neuroscience Program
- Janeway Society
- Neural Disorders
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Powers Lab
- PRIME Psychosis Prodrome Research Clinic
- Psychiatry
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- Resident
- Yale School of Medicine (2016)
- Chief Resident, Neuroscience Research Training Program
- Yale School of Medicine (2016)
- PhD
- Vanderbilt University School of Medicine (2012)
- MD
- Vanderbilt University School of Medicine (2012)
- BA
- Yale University (2004)
Research
Overview
Medical Subject Headings (MeSH)
Behavioral Sciences; Computational Biology; Hallucinations; Patient-Specific Modeling; Psychotic Disorders; Resilience, Psychological; Risk Assessment; Schizophrenia; Stress Disorders, Traumatic
Research at a Glance
Yale Co-Authors
Frequent collaborators of Albert Powers's published research.
Publications Timeline
A big-picture view of Albert Powers's research output by year.
Research Interests
Research topics Albert Powers is interested in exploring.
Philip Corlett, PhD
Ely Sibarium
Scott Woods, MD
Vinod Srihari, MD
Andrew Sheldon, MD/PhD
John Krystal, MD
76Publications
2,588Citations
Psychotic Disorders
Hallucinations
Schizophrenia
Risk Assessment
Publications
2024
Recent social stress and severity of auditory hallucinations
Farina E, Mourgues-Codern C, Sibarium E, Powers A. Recent social stress and severity of auditory hallucinations. Schizophrenia Research 2024, 269: 64-70. PMID: 38733801, PMCID: PMC11180583, DOI: 10.1016/j.schres.2024.04.024.Peer-Reviewed Original ResearchConceptsHearing voicesVoice-hearersAuditory verbal hallucinationsNon-clinical voice-hearersCross-sectional designSocial stressDepressive symptom severitySelf-reported aspectsPsychosocial interventionsAuditory hallucinationsClinical distressAdverse social experiencesHearingSeverity of auditory hallucinationsAdministered self-report measuresRecent stressMedication-resistant auditory verbal hallucinationsDistressRelational demographicsDaily social stressRegression modelsSocial stressorsSymptom severityAuditory experienceHallucination severity11. Role of Prediction Errors in the Relationship Between Ethnoracial Discrimination and Delusions
Huque Z, O'Brien K, Rossi-Goldthorpe R, Kenney J, Mittal V, Strauss G, Walker E, Schiffman J, Woods S, Powers A, Silverstein S, Waltz J, Gold J, Corlett P, Ellman L. 11. Role of Prediction Errors in the Relationship Between Ethnoracial Discrimination and Delusions. Biological Psychiatry 2024, 95: s78-s79. DOI: 10.1016/j.biopsych.2024.02.189.Peer-Reviewed Original ResearchAltmetricDifferent learning aberrations relate to delusion-like beliefs with different contents
Rossi-Goldthorpe R, Silverstein S, Gold J, Schiffman J, Waltz J, Williams T, Powers A, Woods S, Zinbarg R, Mittal V, Ellman L, Strauss G, Walker E, Levin J, Castiello S, Kenney J, Corlett P. Different learning aberrations relate to delusion-like beliefs with different contents. Brain 2024, awae122. PMID: 38637303, DOI: 10.1093/brain/awae122.Peer-Reviewed Original ResearchCitationsAltmetricConceptsProbabilistic reversal learningDelusion-like beliefsProbabilistic reversal learning taskBlocked cueControl cuesBelief convictionBlock taskClinical high-risk statusKamin blocking taskSymptom-specific effectsPrediction error accountLevels of paranoiaIntact learningAberrant learningKamin blockingParanoid individualsPersecutory delusionsCue presentationReversal learningPredicting psychosisCognitive tasksBehavioral resultsDecreased learningDelusionsParanoiaAccelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
Wannan C, Nelson B, Addington J, Allott K, Anticevic A, Arango C, Baker J, Bearden C, Billah T, Bouix S, Broome M, Buccilli K, Cadenhead K, Calkins M, Cannon T, Cecci G, Chen E, Cho K, Choi J, Clark S, Coleman M, Conus P, Corcoran C, Cornblatt B, Diaz-Caneja C, Dwyer D, Ebdrup B, Ellman L, Fusar-Poli P, Galindo L, Gaspar P, Gerber C, Glenthøj L, Glynn R, Harms M, Horton L, Kahn R, Kambeitz J, Kambeitz-Ilankovic L, Kane J, Kapur T, Keshavan M, Kim S, Koutsouleris N, Kubicki M, Kwon J, Langbein K, Lewandowski K, Light G, Mamah D, Marcy P, Mathalon D, McGorry P, Mittal V, Nordentoft M, Nunez A, Pasternak O, Pearlson G, Perez J, Perkins D, Powers A, Roalf D, Sabb F, Schiffman J, Shah J, Smesny S, Spark J, Stone W, Strauss G, Tamayo Z, Torous J, Upthegrove R, Vangel M, Verma S, Wang J, Rossum I, Wolf D, Wolff P, Wood S, Yung A, Agurto C, Alvarez-Jimenez M, Amminger P, Armando M, Asgari-Targhi A, Cahill J, Carrión R, Castro E, Cetin-Karayumak S, Chakravarty M, Cho Y, Cotter D, D’Alfonso S, Ennis M, Fadnavis S, Fonteneau C, Gao C, Gupta T, Gur R, Gur R, Hamilton H, Hoftman G, Jacobs G, Jarcho J, Ji J, Kohler C, Lalousis P, Lavoie S, Lepage M, Liebenthal E, Mervis J, Murty V, Nicholas S, Ning L, Penzel N, Poldrack R, Polosecki P, Pratt D, Rabin R, Eichi H, Rathi Y, Reichenberg A, Reinen J, Rogers J, Ruiz-Yu B, Scott I, Seitz-Holland J, Srihari V, Srivastava A, Thompson A, Turetsky B, Walsh B, Whitford T, Wigman J, Yao B, Yuen H, Ahmed U, Byun A, Chung Y, Do K, Hendricks L, Huynh K, Jeffries C, Lane E, Langholm C, Lin E, Mantua V, Santorelli G, Ruparel K, Zoupou E, Adasme T, Addamo L, Adery L, Ali M, Auther A, Aversa S, Baek S, Bates K, Bathery A, Bayer J, Beedham R, Bilgrami Z, Birch S, Bonoldi I, Borders O, Borgatti R, Brown L, Bruna A, Carrington H, Castillo-Passi R, Chen J, Cheng N, Ching A, Clifford C, Colton B, Contreras P, Corral S, Damiani S, Done M, Estradé A, Etuka B, Formica M, Furlan R, Geljic M, Germano C, Getachew R, Goncalves M, Haidar A, Hartmann J, Jo A, John O, Kerins S, Kerr M, Kesselring I, Kim H, Kim N, Kinney K, Krcmar M, Kotler E, Lafanechere M, Lee C, Llerena J, Markiewicz C, Matnejl P, Maturana A, Mavambu A, Mayol-Troncoso R, McDonnell A, McGowan A, McLaughlin D, McIlhenny R, McQueen B, Mebrahtu Y, Mensi M, Hui C, Suen Y, Wong S, Morrell N, Omar M, Partridge A, Phassouliotis C, Pichiecchio A, Politi P, Porter C, Provenzani U, Prunier N, Raj J, Ray S, Rayner V, Reyes M, Reynolds K, Rush S, Salinas C, Shetty J, Snowball C, Tod S, Turra-Fariña G, Valle D, Veale S, Whitson S, Wickham A, Youn S, Zamorano F, Zavaglia E, Zinberg J, Woods S, Shenton M. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis. Schizophrenia Bulletin 2024, 50: 496-512. PMID: 38451304, PMCID: PMC11059785, DOI: 10.1093/schbul/sbae011.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical high-risk individualsClinical high riskNational Institute of Mental HealthInstitute of Mental HealthAttenuated positive symptomsPersistent negative symptomsTransition to psychosisCHR statusHigh riskNegative symptomsPositive symptomsAnxiety symptomsPsychosocial functioningCognitive dataOutcomes of individualsDigital health technologiesDaily surveysPsychosisSCZPublic health needsMental healthNovel pharmacological interventionsSchizophreniaClinical outcomesHealth needsThe mechanisms underlying conditioning of phantom percepts differ between those with hallucinations and synesthesia
del Rio M, Kafadar E, Fisher V, D’Costa R, Powers A, Ward J. The mechanisms underlying conditioning of phantom percepts differ between those with hallucinations and synesthesia. Scientific Reports 2024, 14: 5607. PMID: 38453946, PMCID: PMC10920618, DOI: 10.1038/s41598-024-53663-3.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsCorrection: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. Correction: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1567-1567. PMID: 38351175, DOI: 10.1038/s41380-024-02481-0.Peer-Reviewed Original ResearchOn the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1361-1381. PMID: 38302562, DOI: 10.1038/s41380-024-02415-w.Peer-Reviewed Original ResearchAltmetricConceptsSources of heterogeneitySystematic reviewProportion of patientsMeta-analysisSubgroup analysisCochrane Database of Systematic ReviewsDatabase of Systematic ReviewsMeta-analysis of studies of patientsPsychosis onsetProspective cohort studyCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsAPA PsycInfoNarrative synthesisMeta-analysis estimatesCochrane Central RegisterPrevention of psychosisAscertainment methodsWeb of Science Core CollectionRecall biasQualitative studyAssess heterogeneityCohort studyOvid MEDLINE
2023
Evidence for Reduced Sensory Precision and Increased Reliance on Priors in Hallucination-Prone Individuals in a General Population Sample
Benrimoh D, Fisher V, Seabury R, Sibarium E, Mourgues C, Chen D, Powers A. Evidence for Reduced Sensory Precision and Increased Reliance on Priors in Hallucination-Prone Individuals in a General Population Sample. Schizophrenia Bulletin 2023, 50: 349-362. PMID: 37830405, PMCID: PMC10919780, DOI: 10.1093/schbul/sbad136.Peer-Reviewed Original ResearchCitationsConceptsSensory evidenceSensory precisionHallucinatory experiencesHallucination severityCH rateHallucination-prone individualsIncoming sensory evidencePrior weightingLinguistic versionsGaussian filter modelNonlinguistic stimuliPerceptual inferencePerceptual statesPerceptual beliefsResponse confidenceAuditory informationTask behaviorGeneral population sampleOnline sampleAuditory hallucinationsGeneral population participantsStimuliPast resultsParticipantsTaskDevelopment of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS
Woods S, Parker S, Kerr M, Walsh B, Wijtenburg S, Prunier N, Nunez A, Buccilli K, Mourgues‐Codern C, Brummitt K, Kinney K, Trankler C, Szacilo J, Colton B, Ali M, Haidar A, Billah T, Huynh K, Ahmed U, Adery L, Marcy P, Allott K, Amminger P, Arango C, Broome M, Cadenhead K, Chen E, Choi J, Conus P, Cornblatt B, Glenthøj L, Horton L, Kambeitz J, Kapur T, Keshavan M, Koutsouleris N, Langbein K, Lavoie S, Diaz‐Caneja C, Mathalon D, Mittal V, Nordentoft M, Pasternak O, Pearlson G, Gaspar P, Shah J, Smesny S, Stone W, Strauss G, Wang J, Corcoran C, Perkins D, Schiffman J, Perez J, Mamah D, Ellman L, Powers A, Coleman M, Anticevic A, Fusar‐Poli P, Kane J, Kahn R, McGorry P, Bearden C, Shenton M, Nelson B, Calkins M, Hendricks L, Bouix S, Addington J, McGlashan T, Yung A, Schizophrenia T. Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS. Early Intervention In Psychiatry 2023, 18: 255-272. PMID: 37641537, PMCID: PMC10899527, DOI: 10.1111/eip.13457.Peer-Reviewed Original ResearchCitationsAltmetricBarriers and solutions to the adoption of translational tools for computational psychiatry
Benrimoh D, Fisher V, Mourgues C, Sheldon A, Smith R, Powers A. Barriers and solutions to the adoption of translational tools for computational psychiatry. Molecular Psychiatry 2023, 28: 2189-2196. PMID: 37280282, PMCID: PMC10611570, DOI: 10.1038/s41380-023-02114-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMainstream research directionIntegration of tasksComputational psychiatryComputational tasksComputational expertiseGame platformFormal modelDevelopment of tasksTaskLimited ecological validityResearch directionsEcological validityComputational methodsTest-retest reliabilityMore positive impactsInformation processingLarge-scale research projectProcessingHuman brainResearch project
Clinical Trials
Current Trials
Song-making In a Group (SING)
HIC ID2000026376RoleSub InvestigatorPrimary Completion Date08/31/2024Recruiting ParticipantsTesting a Computationally-Informed, Personalized Intervention for Hallucinations
HIC ID2000024774RolePrincipal InvestigatorPrimary Completion Date03/31/2024Recruiting ParticipantsGenderBothAge18 years - 65 yearsAMPA Receptor Components of the Anti-Depressant Ketamine Response
HIC ID2000021345RoleSub InvestigatorPrimary Completion Date06/30/2032Recruiting ParticipantsGenderBothAge18 years - 65 yearsPredictive Coding and Unusual Experiences
HIC ID2000021858RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge18 years - 55 years
Academic Achievements and Community Involvement
activity Associate
Professional OrganizationsAmerican College of Neuropsychopharmacology (ACNP)Details2022 - PresentDescriptionAssociate Memberhonor Young Physician-Scientist Award
National AwardAmerican Society for Clinical InvestigationDetails01/26/2022United Statesactivity Guest Editor
Journal ServiceSchizophrenia ResearchDetails11/01/2020 - 01/01/2022DescriptionGuest Editor, Special Issue on Computational Approaches to Understanding Psychosishonor Carol and Eugene Ludwig Award for Early Career Research
National AwardLudwig Family FoundationDetails12/08/2021United Stateshonor Second Prize, Yale Digital Pitchfest
Yale University AwardYale Office for Cooperative ResearchDetails12/01/2021United States
Links & Media
News
- June 01, 2023
Center for Brain and Mind Health First Annual Symposium
- September 07, 2022
PRIME Clinic Receives Four Additional Years of SAMHSA Funding
- June 09, 2022
Janeway Society Celebrates Achievements of Junior Faculty
- January 25, 2022
Yale Researchers Develop First Tool to Measure the Amount and Types of Control Voice-hearers Exhibit
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