Tyrone Cannon
Clark L. Hull Professor of Psychology and Professor of PsychiatryCards
About
Research
Publications
2026
Biophysical modeling of excitation/inhibition balance and conversion to psychosis in the clinical high risk syndrome
Rodriguez-Sanchez J, Hauke D, Pinotsis D, Berndt L, Oloye H, Nicholas S, Hamilton H, Roach B, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Friston K, Addington J, Bearden C, Cadenhead K, Perkins D, Walker E, Woods S, Cannon T, Adams R, Mathalon D. Biophysical modeling of excitation/inhibition balance and conversion to psychosis in the clinical high risk syndrome. Biological Psychiatry 2026 PMID: 42025866, DOI: 10.1016/j.biopsych.2026.04.007.Peer-Reviewed Original ResearchPyramidal cell excitabilityP300 event-related potentialCell excitabilityPyramidal cellsMismatch negativityCHR-PAssociated with disinhibitionCompensatory downregulationDisinhibition of pyramidal cellsEvent-related potentialsPositive symptomsDownregulation of inhibitionP300 amplitude reductionCHR-P participantsInhibitory synaptic functionClinical high-risk syndromeTarget event-related potentialsHigh-risk syndromeSevere positive symptomsAuditory oddball paradigmAmplitude reductionConversion to psychosisClinical high riskSynaptic excitationExcitation/inhibition balanceCannabis and Tobacco Co-Use is Associated with Impaired Neurocognitive Performance in Individuals at Clinical High Risk for Psychosis
Bello D, Connolly J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Brady R, Carrión R, Ward H. Cannabis and Tobacco Co-Use is Associated with Impaired Neurocognitive Performance in Individuals at Clinical High Risk for Psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2026 PMID: 41999882, DOI: 10.1016/j.bpsc.2026.03.021.Peer-Reviewed Original ResearchCo-use of cannabisClinical high riskCHR-PCognitive performanceCannabis useTobacco co-useCo-usePsychotic disordersVerbal learningWorking memoryAttentional performanceNeurocognitive performanceMATRICS Consensus Cognitive BatteryNorth American Prodrome Longitudinal Study 2Associated with lower global cognitive performanceAuditory continuous performance taskAssociated with lower neurocognitive performanceHealthy controlsConsensus Cognitive BatteryContinuous performance taskLow working memoryCHR-P individualsImpaired neurocognitive performanceLongitudinal Study 2Prospective study of individualsCorrelation networks of blood proteins in the neuroimmunology of schizophrenia—replication and extension
Jeffries C, Bizon C, Ford J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Seidman L, Stone W, Walker E, Woods S, Perkins D. Correlation networks of blood proteins in the neuroimmunology of schizophrenia—replication and extension. Translational Psychiatry 2026 PMID: 41965717, DOI: 10.1038/s41398-026-03934-6.Peer-Reviewed Original ResearchNorth American Prodrome Longitudinal Study 2Clinical high riskCommunity controlsLongitudinal Study 2Psychotic disordersPsychosis riskStudy 3Study 2PsychosisHigh riskEmpirical p-valuesGroup of individualsExtracellular matrixCorrelation networkCircuit remodelingCorrelation patternsRemodeling of extracellular matrixProtein dataPromotion of coagulationParticipantsPlasma protein dataSERPINE1Permutation testTIMP1IndividualsSocial withdrawal and hippocampal volume among adolescents at clinical high risk for psychosis and healthy comparisons: The moderating role of neighborhood residential stability
Ku B, Arrant E, Yuan Q, Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E. Social withdrawal and hippocampal volume among adolescents at clinical high risk for psychosis and healthy comparisons: The moderating role of neighborhood residential stability. Schizophrenia Research 2026, 293: 81-90. PMID: 41955767, PMCID: PMC13094779, DOI: 10.1016/j.schres.2026.03.024.Peer-Reviewed Original ResearchClinical high riskSocial withdrawalHippocampal volumeNeighborhood residential stabilityHealthy comparisonNorth American Prodrome Longitudinal Study Phase 2Premorbid Adjustment ScaleModerating RoleResidential stabilityPsychiatric vulnerabilityAdjustment ScaleAssociated with HVCHR-PContextual factorsNeurodevelopmental vulnerabilityPsychosisIntervention effortsBehavioral risk factorsBilateral HVCross-sectional associationsHigh riskFollow-up modelWithdrawalStudy phase 2AdolescentsNeighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons
Ku B, Arrant E, Addington J, Bearden C, Cadenhead K, Cannon T, Carrion R, Keshavan M, Mathalon D, Stone W, Woods S, Walker E, Perkins D, Cao H. Neighborhood social fragmentation and cerebello-thalamo-cortical connectivity in youth at clinical high-risk for psychosis and healthy comparisons. Brain And Environment 2026, 5: 100016. PMID: 41907310, PMCID: PMC13030900, DOI: 10.1016/j.braen.2026.100016.Peer-Reviewed Original ResearchNeighbourhood social fragmentationClinical high riskHealthy comparisonCHR-PSocial fragmentationPsychosis riskNorth American Prodrome Longitudinal Study Phase 2Functional connectivity dataPredictive coding frameworkCerebello-thalamo-cortical connectionsHC youthPsychosisIndividual povertyMaladaptive processesBrain's abilitySocial tiesBelief updatingEducational attainmentSocial worldConnectivity dataYouthStudy phase 2Early interventionNeighborhoodSocial environmentThe Utility of Negative Symptoms in Predicting Transition to Psychosis Among Individuals at Clinical High Risk
Arnovitz M, Cornblatt B, Auther A, McLaughlin D, Addington J, Bearden C, Cadenhead K, Cannon T, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Kane J, Carrión R. The Utility of Negative Symptoms in Predicting Transition to Psychosis Among Individuals at Clinical High Risk. Schizophrenia Bulletin 2026, 52: sbaf244. PMID: 41863384, PMCID: PMC13005126, DOI: 10.1093/schbul/sbaf244.Peer-Reviewed Original ResearchConceptsNegative symptomsClinical high riskDepressive symptomsCHR-NTCHR-PSymptom modelNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsHealthy controlsCalgary Depression ScaleExpressive negative symptomsNegative symptom severitySocial anhedoniaCHR-TSymptom severityPsychosisIdeational richnessProdromal symptomsDepression ScaleLongitudinal studyHigh riskData support considerationSymptomsHigh-risk individualsFollow-upVisual P300 and risk for psychosis onset in youth at clinical high-risk
Hamilton H, Roach B, Nicholas S, Dembo R, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Perkins D, Walker E, Woods S, Cannon T, Mathalon D. Visual P300 and risk for psychosis onset in youth at clinical high-risk. Biological Psychiatry 2026 PMID: 41771336, DOI: 10.1016/j.biopsych.2026.02.013.Peer-Reviewed Original ResearchClinical high riskHealthy comparisonEvent-related potentialsCHR individualsPsychosis onsetP3b deficitsPsychosis conversionNorth American Prodrome Longitudinal StudyVisual P300 event-related potentialsThree-stimulus visual oddball taskPathogenesis of psychosisPrediction of psychosis onsetP300 event-related potentialVisual oddball taskInfrequent target stimuliAssociated with future outcomesCHR participantsNovelty P3aNovel stimuliNAPLS-2Target stimuliSymptom severityOddball taskP300 amplitudePsychosisContributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk
Guest R, Addington J, Bearden C, Cadenhead K, Cornblatt B, Mathalon D, Perkins D, Tsuang M, Woods S, Cannon T, Keshavan M, Stone W, Walker E. Contributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk. Schizophrenia Research 2026, 290: 98-105. PMID: 41671768, DOI: 10.1016/j.schres.2026.02.004.Peer-Reviewed Original ResearchConceptsWechsler Abbreviated ScaleHealthy control participantsCHR-PCognitive functionBetter cognitive functionCortical thicknessControl participantsWechsler Abbreviated Scale of IntelligenceNorth American Prodrome Longitudinal StudyEarly stages of psychosisCHR-P samplesStages of psychosisClinical high riskFull-scale IQAssociated with better cognitive functionStructural MRI scansAberrant neurodevelopmental processesScale of IntelligenceRegional cortical thicknessPsychosis-riskOnset of illnessCognitive deficitsCHR-P.Cortical substratesFrontoparietal regions
2025
Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity
Hua J, Roach B, Hamilton H, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Perkins D, Stone W, Walker E, Woods S, Cannon T, Mathalon D. Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity. Biological Psychiatry Global Open Science 2025, 6: 100664. PMID: 41646831, PMCID: PMC12870832, DOI: 10.1016/j.bpsgos.2025.100664.Peer-Reviewed Original ResearchCHR-CInter-trial phase coherenceAuditory oddball paradigmHealthy controlsClinical high riskCHR-PMismatch negativityCHR-NCNorth American Prodrome Longitudinal Study 2High riskTheta oscillationsClinical outcomesGeneration of theta oscillationsAssociated with clinical outcomesMismatch negativity deficitsOddball paradigmPsychosis conversionMismatch negativity amplitudeCHR-P samplesEvent-related oscillationsCHR-P individualsPassive auditory oddball paradigmFollow-upSchizophrenia biomarkersStandard tonesPsychosis-proneness is associated with reduced cognitive error-monitoring during instrumental learning
Zhao W, McDougle S, Cannon T. Psychosis-proneness is associated with reduced cognitive error-monitoring during instrumental learning. Schizophrenia Research Cognition 2025, 43: 100408. PMID: 41438020, PMCID: PMC12719759, DOI: 10.1016/j.scog.2025.100408.Peer-Reviewed Original ResearchPost-error slowingPsychosis-pronenessError monitoringPositive schizotypyWorking memoryInstrumental learningMultidimensional Schizotypy Scale-BriefLearning tasksExecutive function deficitsInstrumental learning taskImpaired error monitoringReinforcement learning taskCognitive inflexibilityBelief inflexibilityWM loadWM capacityWM limitationsCognitive profilePost-errorSchizotypyFunctional deficitsVisuomotorBriefInflexibilityPerformance monitoring