Tore Eid, MD, PhD
Professor of Laboratory Medicine, of Neurosurgery, and of Cellular and Molecular PhysiologyCards
About
Research
Overview
Medical Research Interests
Clinical Chemistry Tests; Epilepsy; Immunohistochemistry; Mass Spectrometry; Medical Laboratory Science; Neurosurgery; Toxicology
Public Health Interests
Chronic Diseases; Substance Use, Addiction
Publications
2025
T49 Effects of Nicotine Flux and Form on Speed and Total Amount of Arterial Blood Nicotine Delivery during Acute E-Cigarette Vaping
Baldassarri S, McKinney E, Mysirlidis S, Sharma M, Blohowiak R, Joseph P, Eid T, Nadim H, Hanna E, Karaoghlanian N, Adeniji A, Shihadeh A, Eissenberg T, Krishnan-Sarin S, O'Malley S, El-Hellani A, Talih S. T49 Effects of Nicotine Flux and Form on Speed and Total Amount of Arterial Blood Nicotine Delivery during Acute E-Cigarette Vaping. Drug And Alcohol Dependence 2025, 267: 111817. DOI: 10.1016/j.drugalcdep.2024.111817.Peer-Reviewed Original Research
2023
Nicotine flux as a powerful tool for regulating nicotine delivery from e-cigarettes: Protocol of two complimentary randomized crossover clinical trials
El-Hellani A, Hanna E, Sharma M, Blohowiak R, Joseph P, Eid T, Nadim H, El-Hage R, Salman R, Karaoghlanian N, Adeniji A, Salam S, Talih F, Elbejjani M, Breland A, Eissenberg T, Shihadeh A, Baldassarri S, Talih S. Nicotine flux as a powerful tool for regulating nicotine delivery from e-cigarettes: Protocol of two complimentary randomized crossover clinical trials. PLOS ONE 2023, 18: e0291786. PMID: 37733666, PMCID: PMC10513228, DOI: 10.1371/journal.pone.0291786.Peer-Reviewed Original ResearchExploring CITEs of Inflammation in the Human Epilepsy Brain
Eid T. Exploring CITEs of Inflammation in the Human Epilepsy Brain. Epilepsy Currents 2023, 23: 191-192. PMID: 37334410, PMCID: PMC10273812, DOI: 10.1177/15357597231161460.Peer-Reviewed Original ResearchThreshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration
MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration. Experimental And Clinical Psychopharmacology 2023, 31: 37-45. PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioDose of nicotineNicotine reinforcementSubjective effectsDiscriminative stimulus effectsHeart rate increaseDoses of nicotineSelf-administration procedureSubjective positive effectsDaily smokersBaseline cravingIntravenous nicotineOvernight abstinenceCigarette cravingDrug effectsMetabolite ratiosStimulus effectsSecondary analysisPlaceboSelf-AdministrationNicotine choiceTobacco productsNicotinePleasurable effectsYoung adults
2022
A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force
Bindila L, Eid T, Mills JD, Hildebrand MS, Brennan GP, Masino SA, Whittemore V, Perucca P, Reid CA, Patel M, Wang KK, van Vliet E. A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force. Epilepsia Open 2022 PMID: 36259125, DOI: 10.1002/epi4.12662.Peer-Reviewed Original ResearchCase report formsCommon data elementsILAE/AES Joint Translational Task ForceRodent epilepsy modelsPreclinical common data elementsPreclinical epilepsy researchTask ForceEpilepsy modelStudy protocolRodent modelsInternational LeagueEpilepsy researchReport formsData elementsLipidomicsMetabolomics methodologyA companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force
van Vliet E, Hildebrand MS, Mills JD, Brennan GP, Eid T, Masino SA, Whittemore V, Bindila L, Wang KK, Patel M, Perucca P, Reid CA. A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force. Epilepsia Open 2022 PMID: 35950645, DOI: 10.1002/epi4.12640.Peer-Reviewed Original ResearchCatch the Rhythm!
Eid T, Zaveri HP. Catch the Rhythm! Epilepsy Currents 2022, 22: 249-251. PMID: 36187149, PMCID: PMC9483758, DOI: 10.1177/15357597221099066.Peer-Reviewed Original ResearchPlasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans
Gueorguieva R, Schwartz EKC, MacLean RR, DeVito EE, Eid T, Wu R, O’Malley S, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans. Frontiers In Pharmacology 2022, 13: 844824. PMID: 35431934, PMCID: PMC9009207, DOI: 10.3389/fphar.2022.844824.Peer-Reviewed Original ResearchSubjective drug effectsPlasma Mg concentrationHeart rateDrug effectsIntravenous deliveryNon-menthol cigarette smokersPlacebo-controlled studyTest sessionsCigarette smokersMenthol smokersAcute effectsIntravenous nicotineGlucuronide concentrationsMAIN OUTCOMENicotine infusionMenthol glucuronideSecondary analysisPlasma MgE-cigarettesBehavioral effectsMenthol exposureNicotineSmokersPhysiological effectsE-liquidsEffects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real?
Vera MA, Eid T, El-Khoury JM. Effects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real? Clinical Chemistry 2022, 68: 607-608. PMID: 36103316, DOI: 10.1093/clinchem/hvab222.Peer-Reviewed Original ResearchImpact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science
De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.Peer-Reviewed Original ResearchConceptsAbuse potentialPositive subjective drug effectsSubjective drug effectsHuman laboratory studiesPositive subjective effectsAttention functionSmoking urgesOvernight abstinencePotential therapeutic effectsEffects of nicotineHeart rate increaseDelivery rateDependent smokersExperimental sessionsSubjective effectsNicotine dependenceIntravenous nicotineBlood pressureSaline infusionAcute effectsTherapeutic effectHeart rateDrug effectsAcute responseCrossover design
Clinical Trials
Current Trials
Studying the Adult Brain
HIC ID2000025671RoleSub InvestigatorPrimary Completion Date07/31/2025Recruiting ParticipantsImaging mGluR5 and synaptic density in psychiatric disorders
HIC ID2000020186RoleSub InvestigatorPrimary Completion Date01/31/2018Recruiting ParticipantsGenderBothAge18 years - 80 yearsImaging SV2A in mood disorders
HIC ID1511016789RoleSub InvestigatorPrimary Completion Date03/15/2022Recruiting ParticipantsGenderBothAge18 years - 70 yearsExamination of Glutamate and mGluR5 in Psychiatric Disorders
HIC ID1101007933RoleSub InvestigatorPrimary Completion Date08/31/2022Recruiting ParticipantsGenderBothAge18 years - 65 years
Academic Achievements & Community Involvement
Clinical Care
Overview
Tore Eid, MD, PhD, is a clinical pathologist and National Institutes of Health-funded researcher.
He diagnoses and monitors conditions including multiple myeloma, substance use, neurological disorders, and metabolic and endocrine disorders through analysis of blood, urine, cerebrospinal fluid, and expert pathology consultations.
Dr. Eid is a professor of laboratory medicine, of neurosurgery, and of cellular & molecular physiology at Yale School of Medicine. His research explores the chemical and metabolic processes that drive brain disorders, with a focus on epilepsy, to advance the development of more precise and effective treatments. One of Dr. Eid’s key discoveries is that deficiency of the enzyme glutamine synthetase in the brain is likely a critical contributor to certain forms of human epilepsy—a finding that has advanced our understanding of the disease’s underlying causes.
His research also encompasses minimally invasive health monitoring, including discovering chemical biomarkers in easily accessible biofluids—such as saliva, sweat, subcutaneous fluid, and breath—to monitor health in real time across a range of conditions, including epilepsy, traumatic brain injury, mood disorders, substance use, diabetes, and cancer.
Clinical Specialties
Pathology; Laboratory Medicine; Addiction Medicine
News
News
- September 27, 2023
$20M Federal Grant Renewed for Yale Tobacco Center of Regulatory Science
- June 04, 2019
Celebrating Student Research and Scholarship at Yale School of Medicine
- March 29, 2019
Past Scholars Reflect on Being a Scholar
- September 17, 2018
$20 Million Grant Will Fund Continued Research by Yale Tobacco Center of Regulatory Science
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Laboratory Medicine
PO Box 208035
New Haven, CT 06520-8035
United States
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