Hitten Zaveri, PhD
Associate Professor of NeurologyCards
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Contact Info
About
Titles
Associate Professor of Neurology
Biography
Dr. Zaveri has received academic training in electrical engineering, computer engineering, biomedical engineering, neurology and epilepsy. He is the director of the Computational Neurophysiology Laboratory, co-director of the BioSense Laboratory and co-director of the Yale Clinical Neuroscience Group for Neuroanalytics (YNN). His research interests lie at the intersection of neuroscience, engineering and mathematics.
Appointments
Neurology
Associate Professor on TermPrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Epilepsy & Seizures
- Neuro Intensive Care & Neurological Emergencies
- Neurology
- Yale Clinical Neuroscience Group for Neuroanalytics
Education & Training
- Postdoctoral Associate
- Yale University (1997)
- PhD
- University of Michigan, Bioengineering (1993)
- MSEE
- University of Michigan, Bioengineering (1987)
- MSEE
- University of Michigan, Electrical Engineering (1987)
- BSEE
- University of Michigan, Computer Engineering (1983)
- BSEE
- University of Michigan, Electrical Engineering (1982)
Research
Overview
There are two aspects to our work on epilepsy. First, we seek to understand, through experiments and analysis, how seizures the seemingly random disruption of brain function, are generated and how they spread through the brain. Second, we are developing brain implantable devices to sense, analyze and control aberrant brain activity. These devices include a wireless, battery-free, multimodal intracranial sensor to continuously monitor brain neurochemistry and electrophysiology and devices to detect and predict the onset of a seizure and intervene to terminate a seizure once it has been detected or predicted. Further information on our research can be found in our publications.
- Understand how seizures are generated
- Develop implantable multimodal sensors for direct brain sensing
- Accurately locate the seizure onset area
- Detect and predict the onset of seizures in real-time
- Develop interventional methods to terminate or abort seizures
Medical Subject Headings (MeSH)
ORCID
0000-0001-7830-0052- View Lab Website
Yale Clinical Neuroscience Group for Neuroanalytics
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Robert Bradford Duckrow, MD
Lawrence Hirsch, MD
Tore Eid, MD, PhD
Roni Dhaher, PhD
Ronald Coifman, PhD
Dennis Spencer, MD
Publications
2024
Modeling seizure networks in neuron-glia cultures using microelectrode arrays
Boddeti U, Langbein J, McAfee D, Altshuler M, Bachani M, Zaveri H, Spencer D, Zaghloul K, Ksendzovsky A. Modeling seizure networks in neuron-glia cultures using microelectrode arrays. Frontiers In Network Physiology 2024, 4: 1441345. PMID: 39290793, PMCID: PMC11405204, DOI: 10.3389/fnetp.2024.1441345.Peer-Reviewed Original ResearchConceptsNetwork changesSeizure networkSeizure modelsDays of chronic treatmentDimensionality reductionNetwork developmentDrug-resistant epilepsyNeuron-glia culturesMean firing rateNetworkTreatment failureChronic treatmentMicroelectrode arraysResection surgeryRetrospective studyFiring rateSeizuresExperience seizuresNeurological disordersStability of infraslow correlation structure in time-shifted intracranial EEG signals
Joshi R, Duckrow R, Goncharova I, Hirsch L, Spencer D, Godwin D, Zaveri H. Stability of infraslow correlation structure in time-shifted intracranial EEG signals. Frontiers In Network Physiology 2024, 4: 1441294. DOI: 10.3389/fnetp.2024.1441294.Peer-Reviewed Original ResearchConceptsInfraslow activityContact pairsFrequency bandMagnitude-squared coherenceAntiseizure medicationsMedically refractory epilepsy patientsElectrode contact pairsHigher-frequency activityRefractory epilepsy patientsDC-coupled recordingsIcEEG epochsEEG frequency bandsEnvelope correlationOptimal parametersClinical relevanceSeizure riskIntracranial EEGEpilepsy patientsPatientsIntracranial EEG signalsTaperTraditional EEG frequency bandsMapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositoriesA CMOS Nanosensing System For Continuous Brain Multianalyte Monitoring
Gu Y, Vazquez J, Murray D, Zaveri H, Spencer D. A CMOS Nanosensing System For Continuous Brain Multianalyte Monitoring. 2024, 00: 693-697. DOI: 10.1109/ectc51529.2024.00113.Peer-Reviewed Original ResearchAntiseizure Medications in Post-stroke Seizures: A Systematic Review and Network Meta-analysis (P8-1.012)
Misra S, Dawson J, Kwan P, Kasner S, Grotta J, Larsson D, Tanaka T, Zaveri H, Wang S, Khan E, Funaro M, Perla S, Dev P, Hussain T, Liebeskind D, Yasuda C, Elshahat A, Hitawala G, Wang E, Kitagawa R, Pathak A, Zhao Y, Scalzo F, Ihara M, Zelano J, Sunnerhagen K, Walters M, Jette N, Quinn T, Mishra N. Antiseizure Medications in Post-stroke Seizures: A Systematic Review and Network Meta-analysis (P8-1.012). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205632.Peer-Reviewed Original ResearchAltmetricSystematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchCitationsConceptsSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regions
2023
Outcomes in Patients With Poststroke Seizures
Misra S, Kasner S, Dawson J, Tanaka T, Zhao Y, Zaveri H, Eldem E, Vazquez J, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Nicolo J, Mazumder R, Yasuda C, Sunnerhagen K, Ihara M, Ross J, Liebeskind D, Kwan P, Quinn T, Engel J, Mishra N. Outcomes in Patients With Poststroke Seizures. JAMA Neurology 2023, 80: 1155-1165. PMID: 37721736, PMCID: PMC10507596, DOI: 10.1001/jamaneurol.2023.3240.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPoststroke seizuresPoor functional outcomeLate seizuresEarly seizuresStroke subtypesFunctional outcomeOdds ratioSystematic reviewJoanna Briggs Institute toolsHemorrhagic stroke subtypesOutcomes of patientsHistory of strokeTrials of interventionsRisk of biasMeta-Analyses (PRISMA) checklistPreferred Reporting ItemsMeta-regression analysisWeb of ScienceRecurrent strokeGreater disabilityPoor outcomeDementia riskSubgroup analysisBias assessmentEgger's testQuantitative assessment of burst suppression as a predictor of seizure recurrence in refractory status epilepticus
Fong M, Pu K, Jadav R, Khan T, Hirsch L, Zaveri H. Quantitative assessment of burst suppression as a predictor of seizure recurrence in refractory status epilepticus. Clinical Neurophysiology 2023, 150: 98-105. PMID: 37060844, PMCID: PMC11265649, DOI: 10.1016/j.clinph.2023.03.011.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsSeizure forecasting: Where do we stand?
Andrzejak R, Zaveri H, Schulze‐Bonhage A, Leguia M, Stacey W, Richardson M, Kuhlmann L, Lehnertz K. Seizure forecasting: Where do we stand? Epilepsia 2023, 64: s62-s71. PMID: 36780237, PMCID: PMC10423299, DOI: 10.1111/epi.17546.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2022
High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter
McGrath H, Zaveri H, Collins E, Jafar T, Chishti O, Obaid S, Ksendzovsky A, Wu K, Papademetris X, Spencer D. High-resolution cortical parcellation based on conserved brain landmarks for localization of multimodal data to the nearest centimeter. Scientific Reports 2022, 12: 18778. PMID: 36335146, PMCID: PMC9637135, DOI: 10.1038/s41598-022-21543-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEpilepsy surgery cohortStandardized brain regionsBrain structure-function relationshipsSurgery cohortClinical usefulnessBrain metricsAnatomical locationBrain regionsBrain localizationCortical parcellationOwn unique benefitsIntracranial electroencephalographyAnatomical designationBrain anatomyHuman brain anatomyHuman brainBrain atlasBrain landmarksBrain atlasesParcellationMagnetic resonanceNearest centimeterAnatomical featuresAnatomyCortical localization
Academic Achievements & Community Involvement
activity Epilepsy networks
LectureIWSP7Details08/03/2015 - PresentMelbourne, VIC, AustraliaSponsored by University of MelbourneAbstract/SynopsisInternational workshop on seizure prediction
activity International Epilepsy Electrophysiology Portal
CommitteesBoard MemberDetails2010 - 2014activity Sixth International Workshop on Seizure Prediction
CommitteesBoard MemberDetails2013 - 2013activity Fifth International Workshop on Seizure Prediction
CommitteesBoard MemberDetails09/19/2011 - 09/23/2011activity American Epilepsy Society
CommitteesCommittee MemberDetailsInvestigators' Workshop Committee2008 - 2010
News & Links
News
- December 18, 2022
Yale Insights in Cardiovascular Medicine: 2022
- March 30, 2022Source: YaleNews
Wu Tsai Institute Postdocs Bridge Disciplines in the Study of Cognition
- January 18, 2022Source: Yale News/Yale Engineering Magazine)
Less Wattage, More Brain Power
- December 17, 2020Source: Scientific American
Forecasts of Epilepsy Seizures Could Become a Reality
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Locations
Lippard Laboratory of Clinical Investigation (LLCI)
Academic Office
15 York Street, Rm 714 A
New Haven, CT 06510
Appointments
203.737.5407