Scott Woods, MD
Elizabeth Mears and House Jameson Professor of PsychiatryCards
Appointments
Psychiatry
Primary
Child Study Center
Secondary
Contact Info
About
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Titles
Elizabeth Mears and House Jameson Professor of Psychiatry
Biography
Dr. Woods assesses young people at risk for psychosis through his PRIME Clinic, which also offers studies aiming to improve treatment for current symptoms and preventing progression.
Last Updated on April 07, 2025.
Appointments
Psychiatry
ProfessorPrimaryChild Study Center
ProfessorSecondary
Other Departments & Organizations
- Adult Psychiatry
- Child Study Center
- Connecticut Mental Health Center
- MR Core
- PRIME Psychosis Prodrome Research Clinic
- Psychiatry
- Yale Medicine
- Yale Ventures
Education & Training
- Resident
- Massachusetts General Hospital (1984)
- MD
- Baylor College of Medicine (1978)
Research
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Overview
Predictors and Mechanisms of Conversion to Psychosis (MH082022)
Aspirin vs placebo for the psychosis prodrome
D-serine for the psychosis prodrome (MH074356)
Dutetrabenzine for tardive dyskinesia
Huperzine for cognitive enhancement in schizophrenia (MH083436)
Medical Research Interests
Adolescent Psychiatry; Prodromal Symptoms; Psychiatry; Psychotic Disorders
ORCID
0000-0002-3103-5228
Research at a Glance
Yale Co-Authors
Frequent collaborators of Scott Woods's published research.
Publications Timeline
A big-picture view of Scott Woods's research output by year.
Research Interests
Research topics Scott Woods is interested in exploring.
Tyrone Cannon
Albert Powers, MD, PhD
Philip Corlett, PhD
Godfrey Pearlson, MA, MBBS
Zailyn Tamayo
Vinod H. Srihari, MD
77Publications
406Citations
Psychotic Disorders
Prodromal Symptoms
Publications
2025
Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data
Cadenhead K, Kennedy L, Mirzakhanian H, Addington J, Bearden C, Cannon T, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S. Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data. Schizophrenia Bulletin 2025, sbaf133. PMID: 40856400, DOI: 10.1093/schbul/sbaf133.Peer-Reviewed Original ResearchAltmetricConceptsClinical high riskClinical high-risk criteriaLong-term outcomesNorth American Prodrome Longitudinal Study sitesClinical high-risk participantsRates of affective disordersHigh riskLife courseNon-converter groupHigh-risk youthAssessment of individualsPsychosis statesAffective disordersPsychosocial functioningPsychosisTrajectory of diagnosisLonger-term outcomesClinical/functional outcomesLong-term assessmentGeneral populationBaseline dataParticipantsPreliminary dataEarly dataPersonsIdentifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms
Williams T, Gold J, Waltz J, Schiffman J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Kenney J, Pappu M, Corlett P, Tran T, Silverstein S, Zinbarg R, Mittal V. Identifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms. Translational Psychiatry 2025, 15: 311. PMID: 40849429, PMCID: PMC12375010, DOI: 10.1038/s41398-025-03539-5.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCHR-P individualsClinical high riskCHR-PClinical InterviewComputerized assessmentAssessment of psychosis riskStructured Clinical InterviewRisk calculator scoresNeurocognitive mechanismsPsychosis symptomsPsychosis riskBehavioral tasksUnique predictorsMental disordersTask batteryPsychosisTask variablesComparison groupHealthy controlsRisk severityUpdate beliefsTaskMultinomial logistic regressionConsortium studyIndividualsPrediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis
Mukhtar H, Zhou D, Farina E, Saxena A, Cahill J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshwan M, Mathalon D, Perkins D, Stone W, Cho Y, Powers A, Walker E, Woods S. Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis. Psychological Medicine 2025, 55: e241. PMID: 40842369, PMCID: PMC12404330, DOI: 10.1017/s0033291725101372.BooksCitationsAltmetricConceptsClinical high riskCHR-PLifetime historyAugmentation of antidepressant treatmentComorbid major depressionAP useAntidepressant treatmentPositive symptomsMajor depressionAP medicationNAPLS-2Independent predictorsCHR-P.High riskBaseline clinical variablesPsychosisBaseline predictorsClinical variablesParticipantsBaseline characteristicsUnivariate analysisLogistic regression modelsObservational cohortMultivariate analysisAP initiationIncidence, Prevalence, and Stability of Remission in Individuals With Clinical High Risk for Psychosis
Seitz-Holland J, Jacobs G, Reinen J, Mathalon D, Corcoran C, Reichenberg A, Vangel M, Glynn R, Penzel N, Cho K, Castro E, Haidar A, Addington J, Kapur T, Bouix S, Bearden C, Kane J, McGorry P, Woods S, Nelson B, Kahn R, Shenton M, Cecchi G, Pasternak O. Incidence, Prevalence, and Stability of Remission in Individuals With Clinical High Risk for Psychosis. JAMA Network Open 2025, 8: e2525644. PMID: 40762913, PMCID: PMC12326281, DOI: 10.1001/jamanetworkopen.2025.25644.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsClinical high riskClinical high-risk statusAssociated with higher likelihoodModified Global AssessmentLikelihood of remissionRemission criteriaPositive symptomsGlobal Assessment of FunctioningScale of Prodromal SymptomsRemission incidenceModified Global Assessment of FunctioningAssessment of functioningFollow-upStability of remissionHigh riskHigher likelihood of remissionAntidepressant medicationFunctional remissionCognitive variablesCognitive performanceMain OutcomesClinical servicesStudy 3Follow-up visitCohort studyVictimization and engagement with the legal system among individuals at clinical high risk (CHR) for psychosis
Du A, Kennedy L, Addington J, Bearden C, Cannon T, Carrion R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cadenhead K. Victimization and engagement with the legal system among individuals at clinical high risk (CHR) for psychosis. Schizophrenia Research 2025, 284: 7-15. PMID: 40737766, DOI: 10.1016/j.schres.2025.07.015.Peer-Reviewed Original ResearchConceptsLegal systemLegal historyPerpetrators of crimesVictims of crimeHistory of victimizationClinical high-risk youthClinical high riskHistorical risk factorsReport victimizationLegal issuesVictimsCrimeComorbid mental illnessMental illnessYouthClinical high-risk participantsPsychotic illnessLife risk factorsPsychosis symptomsPerpetratorsViolencePsychosisHealthy controlsStudy-3EngagementThe moderating role of lifetime social engagement on the relationship between C-reactive protein and negative symptoms among young adults at clinical high risk for psychosis
Goldsmith D, Yuan Q, Addington J, Bearden C, Cadenhead K, Cannon T, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Woods S, Walker E, Ku B. The moderating role of lifetime social engagement on the relationship between C-reactive protein and negative symptoms among young adults at clinical high risk for psychosis. Brain Behavior And Immunity 2025, 129: 890-897. PMID: 40730261, PMCID: PMC12360851, DOI: 10.1016/j.bbi.2025.07.023.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsScale of Psychosis-risk SymptomsNegative symptomsCHR-P groupClinical high riskCHR-PC-reactive proteinAssociated with negative symptomsNorth American Prodrome Longitudinal StudySocial engagementDevelopment of negative symptomsPsychosis-risk symptomsSimple slope analysesCHR-P individualsYoung adultsHealthy controlsCHR-P subjectsLevels of social engagementSocial engagement levelsEarly developmental periodDepressive symptomsSimple slopesHC subjectsPsychosisHigh riskC-reactive protein valuesMultisensory overweighting of perceptual priors relates to positive symptoms in individuals at clinical high risk of psychosis
Pokorny V, Ellman L, Strauss G, Walker E, Woods S, Powers A, Corlett P, Silverstein S, Waltz J, Gold J, Schiffman J, Mittal V. Multisensory overweighting of perceptual priors relates to positive symptoms in individuals at clinical high risk of psychosis. Journal Of Vision 2025, 25: 2130. DOI: 10.1167/jov.25.9.2130.Peer-Reviewed Original ResearchExploring the pathways between early auditory processing, processing speed, social cognition, and negative symptoms on social functioning in individuals at clinical high risk for psychosis: A structural equation modeling approach
Carrión R, John M, Dorvil S, Auther A, McLaughlin D, Arnovitz M, Bachman P, Belger A, Duncan E, Hamilton H, Johannesen J, Ku B, Light G, Niznikiewicz M, Roach B, Addington J, Bearden C, Cadenhead K, Cannon T, Keshavan M, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Mathalon D, Cornblatt B. Exploring the pathways between early auditory processing, processing speed, social cognition, and negative symptoms on social functioning in individuals at clinical high risk for psychosis: A structural equation modeling approach. Biological Psychiatry 2025 PMID: 40633882, DOI: 10.1016/j.biopsych.2025.06.033.Peer-Reviewed Original ResearchAltmetricConceptsClinical high riskNegative symptomsEvent-related potentialsCHR-P individualsCHR-PPsychosis onsetSocial cognitionMismatch negativityStructural equation modelingSocial functioningProcessing deficitsProcessing speedNorth American Prodrome Longitudinal StudyEarly information processing deficitsAssociated with social functioningAuditory processingInformation processing deficitsSocial functioning difficultiesPoor social functioningSocial functioning impairmentAuditory event-related potentialsAuditory processing deficitsEarly auditory processingEarly intervention strategiesNeurophysiological deficitsCognitive subtypes in youth at clinical high risk for psychosis
Yassin W, Green J, Keshavan M, del Re E, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Mathalon D, Perkins D, Walker E, Woods S, Stone W. Cognitive subtypes in youth at clinical high risk for psychosis. Psychiatry And Clinical Neurosciences 2025 PMID: 40600477, DOI: 10.1111/pcn.13861.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClinical high riskCognitive subtypesWorking memoryClinical high-risk groupWorking memory domainsConversion statusPsychotic disordersCognitive clustersVerbal abilityCHR patientsCognitive measuresMemory domainCognitive domainsNAPLS-2Cognitive trajectoriesPsychosisImpairment groupIntact groupHealthy controlsFunction trajectoriesIntervention strategiesBaseline differencesMemoryHigh riskMonths of follow-upFunctional Correlates of Atypical Visuoperceptual Organization in a Multisite Clinical High-Risk Sample
Pokorny V, Tran T, Williams T, Kenney J, Silverstein S, Gold J, Waltz J, Schiffman J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Corlett P, Mittal V. Functional Correlates of Atypical Visuoperceptual Organization in a Multisite Clinical High-Risk Sample. Journal Of Psychopathology And Clinical Science 2025, 134: 527-539. PMID: 40193439, PMCID: PMC12162206, DOI: 10.1037/abn0000992.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsClinical high riskPsychotic-like Experiences groupClinical high-risk statusClinical high-risk samplesMeasures of cognitive abilityClinical high-risk groupHigh-risk sampleMeasuring perceptual organizationFaces taskPsychotic disordersPerceptual priorsCognitive abilitiesCognitive functionClinical groupsPerceptual organizationHealthy control groupContext-sensitiveSocial functioningTwo-tone imagesTarget circleSymbolic codeEbbinghausFunctional correlatesTaskParticipants
Clinical Trials
Current Trials
ProNET
HIC ID2000029159RolePrincipal InvestigatorPrimary Completion Date12/31/2024Recruiting ParticipantsSchizophrenia Spectrum Biomarkers Consortium (SSBC)
HIC ID2000029485RoleSub InvestigatorPrimary Completion Date12/31/2030Recruiting ParticipantsStudy of Brain Function Across the Lifespan
HIC ID2000020891RoleSub InvestigatorPrimary Completion Date07/31/2022Recruiting ParticipantsGenderBothAge18 years - 65 yearsSleep Dependent Learning in Schizophrenia and Psychosis Risk Syndrome
HIC ID1201009524RoleSub InvestigatorPrimary Completion Date01/31/2022Recruiting ParticipantsGenderBothAge18 years - 55 years
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