Scott Woods, MD
Professor of PsychiatryCards
Appointments
Psychiatry
Primary
Child Study Center
Secondary
Contact Info
About
Titles
Professor of Psychiatry
Biography
Dr. Woods assesses young people at risk for psychosis through his PRIME Clinic, which also offers studies aiming to improve treatment for current symptoms and preventing progression.
Appointments
Psychiatry
ProfessorPrimaryChild Study Center
ProfessorSecondary
Other Departments & Organizations
- Adult Psychiatry
- Child Study Center
- Connecticut Mental Health Center
- MR Center
- PRIME Psychosis Prodrome Research Clinic
- Psychiatry
- Yale Medicine
- Yale Ventures
Education & Training
- Resident
- Massachusetts General Hospital (1984)
- MD
- Baylor College of Medicine (1978)
Research
Overview
Predictors and Mechanisms of Conversion to Psychosis (MH082022)
Aspirin vs placebo for the psychosis prodrome
D-serine for the psychosis prodrome (MH074356)
Dutetrabenzine for tardive dyskinesia
Huperzine for cognitive enhancement in schizophrenia (MH083436)
Medical Research Interests
Adolescent Psychiatry; Prodromal Symptoms; Psychiatry; Psychotic Disorders
ORCID
0000-0002-3103-5228
Research at a Glance
Yale Co-Authors
Frequent collaborators of Scott Woods's published research.
Publications Timeline
A big-picture view of Scott Woods's research output by year.
Research Interests
Research topics Scott Woods is interested in exploring.
Tyrone Cannon
Albert Powers, MD, PhD
Vinod H. Srihari, MD
Maria Ferrara, MD
Carolyn Fredericks, MD
Melissa C Funaro, MLS, MS
34Publications
168Citations
Psychotic Disorders
Prodromal Symptoms
Publications
2024
Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis.
Hamilton H, Roach B, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Tsuang M, Walker E, Woods S, Cannon T, Mathalon D. Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis. Clinical EEG And Neuroscience 2024, 15500594241294035. PMID: 39552576, DOI: 10.1177/15500594241294035.Peer-Reviewed Original ResearchConceptsNMDAR-dependent plasticityClinical high riskGray matter volumeMismatch negativityMagnetic resonance imagingGray matter lossShort-term plasticityMMN amplitudeMatter volumeN-methyl-D-aspartateHigh riskCHR-PPro-inflammatory cytokine levelsPathogenesis of schizophreniaModel of schizophreniaBiomarkers of schizophreniaMismatch negativity amplitudeCHR-P individualsNorth American Prodrome Longitudinal StudyEvent-related potentialsAberrant neurodevelopmental processesInfluence of psychosisSubcortical gray matter volumesTotal gray matter volumeNMDAR hypofunctionAttention Deficit Hyperactivity Disorder among Youth at Clinical High Risk of Psychosis
Braun A, Liu L, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Cannon T, Addington J. Attention Deficit Hyperactivity Disorder among Youth at Clinical High Risk of Psychosis. Schizophrenia Bulletin Open 2024, sgae028. DOI: 10.1093/schizbullopen/sgae028.Peer-Reviewed Original ResearchConceptsClinical high riskCo-morbid ADHDClinical high risk of psychosisPredictors of transition to psychosisNorth American Prodrome Longitudinal StudySubstance useClinical high-risk individualsClinical high-risk participantsClinical high-risk youthHigh risk of psychosisAttention deficit hyperactivity disorderNegative psychotic symptomsTransition to psychosisCo-morbid disordersNon-ADHD groupRisk of psychosisDeficit hyperactivity disorderCo-morbidityIncreased substance useAssociated with numerous adverse outcomesPsychotic symptomsNumerous adverse outcomesPremorbid functioningSocial cognitionADHD groupProtective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores
Cadenhead K, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S. Protective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores. Schizophrenia Bulletin 2024, sbae182. PMID: 39488001, DOI: 10.1093/schbul/sbae182.Peer-Reviewed Original ResearchConceptsClinical high riskClinical high-risk participantsClinical high-risk researchPremorbid functioningResilient outcomesProtective factorsClinical high-risk youthClinical high-risk populationsReduced startle reactivityPrediction of psychosisAssociated with greater resilienceHigh-risk youthStudy of protective factorsStartle reactivityPsychotic conversionBrain areasPsychosisChildhood environmentBrain developmentGreater resilienceExploratory analysisLife experiencesPreventive interventionsSocial engagementHispanic heritageNeighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons
Ku B, Yuan Q, Haardörfer R, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Druss B, Walker E, Anglin D. Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons. Psychiatry Research 2024, 342: 116222. PMID: 39378539, DOI: 10.1016/j.psychres.2024.116222.Peer-Reviewed Original ResearchAltmetricConceptsHealthy comparisonPositive symptomsCHR-PPeer victimizationNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsAttenuated positive symptomsPositive psychotic symptomsClinical high riskFewer life eventsAssociated with schizophreniaEthnoracial diversityPsychotic symptomsHigh riskPrevent psychosisDepressive symptomsStructural equation modelingLife eventsProdromal symptomsPsychosisDiscriminatory experiencesEthnoracial minoritiesSocial determinantsNeighborhood povertyEthnoracial groupsImpact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis
Giampetruzzi E, Walker E, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, LoPilato A. Impact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis. Psychiatry Research 2024, 342: 116214. PMID: 39368239, DOI: 10.1016/j.psychres.2024.116214.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAdverse childhood experiencesClinical high riskEffects of protective factorsInternalizing disordersDepressive disorderCHR-PEmotional neglectSelf-harm/suicideProtective factorsChildhood experiencesHigher levels of adverse childhood experiencesHistory of depressive disorderSexual abuseLevels of adverse childhood experiencesInternalizing psychiatric disordersChildhood sexual abusePresence of protective factorsImpact of adverse childhood experiencesAnxiety disordersAdministered measuresPsychiatric diagnosisPsychiatric disordersPsychiatric outcomesChild adversitySubstance useA Computational Account of the Development and Evolution of Psychotic Symptoms.
Powers A, Angelos P, Bond A, Farina E, Fredericks C, Gandhi J, Greenwald M, Hernandez-Busot G, Hosein G, Kelley M, Mourgues C, Palmer W, Rodriguez-Sanchez J, Seabury R, Toribio S, Vin R, Weleff J, Woods S, Benrimoh D. A Computational Account of the Development and Evolution of Psychotic Symptoms. Biological Psychiatry 2024 PMID: 39260466, DOI: 10.1016/j.biopsych.2024.08.026.Peer-Reviewed Original ResearchConceptsPsychotic symptomsSymptom formationEmergence of psychotic symptomsConversion to psychosisPrediction error signalsIncoming sensory informationHallucination severityDiminished signal-to-noise ratioComputational accountPsychiatric interventionNeural systemsHallucinationsIncreasing convictionOver-reliancePsychosisSensory informationLongitudinal developmentSymptomsBelief formationBeyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis
Deng W, Chong B, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cannon T. Beyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39260565, DOI: 10.1016/j.bpsc.2024.08.020.Peer-Reviewed Original ResearchConceptsClinical high riskCHR-PTrajectory groupsMaintenance of symptomsOnset of psychosisNon-convertersHealthy controlsDiagnostic constructSymptom trajectoriesPsychosisAffective comorbiditiesAssess symptomsHeightened riskFunctional impairmentSymptomsEtiological risk factorsFunctional outcomesImminent onsetLevels of intensityRemissionRisk factorsIndividualsPhase 3DistressImpairmentSleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis
Cohen S, Goldsmith D, Ning C, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Woods S, Walker E, Miller B. Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis. Psychiatry Research 2024, 341: 116147. PMID: 39197223, DOI: 10.1016/j.psychres.2024.116147.Peer-Reviewed Original ResearchAltmetricConceptsPsychosis-risk symptomsClinical high riskSuicidal ideationCHR-P individualsCHR-PSleep disturbanceTerminal insomniaNorth American Prodrome Longitudinal StudyAssociated with conversion to psychosisSleep problemsConversion to psychosisTreatment of sleep disturbancesAssociated with SIIndices of sleep disturbanceMultiple indicesPsychosisIdeationLongitudinal intervention studyInsomniaLongitudinal studySchizophreniaSymptomsSleepSymptom scoresInvestigate relationshipsOccasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts
Kennedy L, Ku B, Addington J, Amir C, Bearden C, Cannon T, Carrión R, Cornblatt B, Keshavan M, Perkins D, Mathalon D, Stone W, Walker E, Woods S, Cadenhead K. Occasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts. Schizophrenia Research 2024, 271: 319-331. PMID: 39084107, DOI: 10.1016/j.schres.2024.07.032.Peer-Reviewed Original ResearchAltmetricConceptsClinical high riskCannabis use frequencyPremorbid functioningCannabis usePsychosis cohortSocial functioningCannabis usersAssociated with greater symptom severityAssociated with better neurocognitionNorth American Prodrome Longitudinal StudyClinical high-risk participantsClinical high-risk youthClinical high-risk populationsUse groupRates of cannabis useCannabis use groupsMeasures of IQCannabis use patternsGreater symptom severityHigher premorbid functioningFollow-up analysisPsychosis sampleHigher IQNeurocognitive domainsFirst-episodeSex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis
Chintoh A, Liu L, Braun A, Akseer S, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, McGlashan T, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Cannon T, Addington J. Sex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis. Schizophrenia Research 2024, 271: 153-160. PMID: 39029145, DOI: 10.1016/j.schres.2024.07.030.Peer-Reviewed Original ResearchAltmetricConceptsClinical high riskClinical high-risk individualsSex differencesNegative symptomsTransition to psychosisInvestigate sex differencesNo sex differencesSchizophreniform disorderCHR individualsPsychosisSubstance useSchizophreniaSymptomsHigh riskIndividualsSchizophreniformAnxietyClinical presentationSexDepressionDisordersBaselineDifferencesMaleYouth
Clinical Trials
Current Trials
ProNET
HIC ID2000029159RolePrincipal InvestigatorPrimary Completion Date12/31/2024Recruiting ParticipantsStudy of Brain Function Across the Lifespan
HIC ID2000020891RoleSub InvestigatorPrimary Completion Date07/31/2022Recruiting ParticipantsGenderBothAge18 years - 65 yearsSleep Dependent Learning in Schizophrenia and Psychosis Risk Syndrome
HIC ID1201009524RoleSub InvestigatorPrimary Completion Date01/31/2022Recruiting ParticipantsGenderBothAge18 years - 55 years
News
News
- November 13, 2024
Woods, Cho Awarded $76M NIH Grant to Conduct Clinical Trials for Youth at Risk for Schizophrenia
- September 07, 2022
PRIME Clinic Receives Four Additional Years of SAMHSA Funding
- February 14, 2022
Yale Department of Psychiatry #2 in Psychiatric Research Funding
- June 08, 2021
Caring for young people's mental health at PRIME
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Psychiatry
300 George St
New Haven, CT 06511-
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