Youngsun Cho, MD, PhD
Assistant ProfessorCards
Appointments
About
Titles
Assistant Professor
Biography
Dr. Youngsun T. Cho is an Assistant Professor in the Child Study Center and Department of Psychiatry at Yale University. She is a child, adolescent and adult psychiatrist. She holds an MD/PhD degree from the University of Rochester, and completed dissertation work on amygdala neuroanatomy and reward processing using fMRI. She completed psychiatry residency in the Neuroscience Research Training Program (NRTP) at Yale, and a child and adolescent psychiatry fellowship at the Yale Child Study Center.
Her current research focuses on the development of cognitive and motivational brain circuits in adolescents with depression and adolescents with schizophrenia using fMRI, and pharmacologic neuroimaging to identify mechanisms of potential treatments. Her work is funded by the NIMH, and the Brain and Behavior Research Foundation.
Appointments
Child Study Center
Assistant ProfessorFully JointPsychiatry
Assistant ProfessorFully Joint
Other Departments & Organizations
- Anticevic Lab
- Center for Brain & Mind Health
- Child Study Center
- Cho Lab
- Clinical Neuroscience Research Unit
- Division of Neurocognition, Neurocomputation & Neurogenetics
- Interdepartmental Neuroscience Program
- Janeway Society
- MR Core
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Psychiatry
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
Education & Training
- PhD
- Univ of Rochester School of Medicine & Dentistry (2013)
- MD
- Univ of Rochester School of Medicine & Dentistry (2013)
- MS
- University of Rochester School of Medicine & Dentistry (2009)
- BS
- Massachusetts Institute of Technology (2005)
Research
Overview
Medical Research Interests
ORCID
0000-0001-8639-3869- View Lab Website
Cho Lab
Research at a Glance
Yale Co-Authors
Clara Fonteneau, PhD
Zailyn Tamayo
Kangjoo Lee, PhD
Nicole Popp Santamauro, MA
Albert Powers, MD, PhD
John Cahill, MD, PhD
Publications
2025
Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis
Mukhtar H, Zhou D, Farina E, Saxena A, Cahill J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshwan M, Mathalon D, Perkins D, Stone W, Cho Y, Powers A, Walker E, Woods S. Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis. Psychological Medicine 2025, 55: e241. DOI: 10.1017/s0033291725101372.Peer-Reviewed Original ResearchAltmetricConceptsClinical high riskCHR-PLifetime historyAugmentation of antidepressant treatmentComorbid major depressionAP useAntidepressant treatmentPositive symptomsMajor depressionAP medicationNAPLS-2Independent predictorsCHR-P.High riskBaseline clinical variablesPsychosisBaseline predictorsClinical variablesParticipantsBaseline characteristicsUnivariate analysisLogistic regression modelsObservational cohortMultivariate analysisAP initiation481. Resting-State Perfusion and Executive Control Task Performance in Psychosis Spectrum Disorder
Cail C, Rahmati M, Fonteneau C, Zharyy C, Forselius-Bielen K, Beri E, Miller E, Santamauro N, Anticevic A, Cortes-Briones J, Proulx E, Preller K, Cho Y. 481. Resting-State Perfusion and Executive Control Task Performance in Psychosis Spectrum Disorder. Biological Psychiatry 2025, 97: s295-s296. DOI: 10.1016/j.biopsych.2025.02.719.Peer-Reviewed Original Research533. Bold Signal Can Capture Individual Variability in Spatial Working Memory Deficits Induced by Ketamine
Rahmati M, Moujaes F, Purg N, Fonteneau C, Santamauro N, Tamayo Z, Repovs G, Preller K, Anticevic A, Fineberg S, Murray J, Krystal J, Cho Y. 533. Bold Signal Can Capture Individual Variability in Spatial Working Memory Deficits Induced by Ketamine. Biological Psychiatry 2025, 97: s317. DOI: 10.1016/j.biopsych.2025.02.772.Peer-Reviewed Original Research541. Identifying Neurobiological Mechanisms of Psychosis-Risk
Brege S, Lee K, Tamayo Z, Grent-'t-Jong T, Anticevic A, Uhlhaas P, Cho Y, Fonteneau C. 541. Identifying Neurobiological Mechanisms of Psychosis-Risk. Biological Psychiatry 2025, 97: s321. DOI: 10.1016/j.biopsych.2025.02.780.Peer-Reviewed Original Research478. Cross-Site Quality Assessment of Data From a Pharmacologic Neuroimaging Trial Targeting Working Memory Neural Circuits in Schizophrenia
Zharyy C, Fonteneau C, Rahmati M, Price A, Gil R, Govil P, Grinband J, Gur R, Haubold N, Heffernan Z, Lu J, Mayer M, Ranganathan M, Santamauro N, Tamayo Z, Van Snellenberg J, Wolf D, Group T, Anticevic A, Lieberman J, Kantrowitz J, Abi-Dargham A, Gur R, Krystal J, Cho Y. 478. Cross-Site Quality Assessment of Data From a Pharmacologic Neuroimaging Trial Targeting Working Memory Neural Circuits in Schizophrenia. Biological Psychiatry 2025, 97: s294. DOI: 10.1016/j.biopsych.2025.02.716.Peer-Reviewed Original ResearchConcepts384. Cognitive-Motivational Phenotypes in Late Childhood
Chen Y, Lin C, Okolo J, Brege S, Pham P, Lee K, Ji J, Cho Y. 384. Cognitive-Motivational Phenotypes in Late Childhood. Biological Psychiatry 2025, 97: s254-s255. DOI: 10.1016/j.biopsych.2025.02.622.Peer-Reviewed Original Research124. Dynamic Structure-Function Coupling Across Intrinsic Brain States Reveals Links to Individual Cognitive and Behavioral Outcomes
Howell A, Cho Y, Murray J, Anticevic A, Lee K. 124. Dynamic Structure-Function Coupling Across Intrinsic Brain States Reveals Links to Individual Cognitive and Behavioral Outcomes. Biological Psychiatry 2025, 97: s146. DOI: 10.1016/j.biopsych.2025.02.361.Peer-Reviewed Original Research275. Motivational Effects on Cognition in Adolescents With Depression and Neurotypical Peers
Pham P, Agrawal S, Frazier A, Chen Y, Cho Y. 275. Motivational Effects on Cognition in Adolescents With Depression and Neurotypical Peers. Biological Psychiatry 2025, 97: s209. DOI: 10.1016/j.biopsych.2025.02.513.Peer-Reviewed Original Research
2024
Individual differences in spatial working memory strategies differentially reflected in the engagement of control and default brain networks
Suljič N, Kraljič A, Rahmati M, Cho Y, Ozimič A, Murray J, Anticevic A, Repovš G. Individual differences in spatial working memory strategies differentially reflected in the engagement of control and default brain networks. Cerebral Cortex 2024, 34: bhae350. PMID: 39214852, PMCID: PMC11364466, DOI: 10.1093/cercor/bhae350.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCategorical representationsWorking memoryBrain activityFunctional magnetic resonance imaging studySpatial working memory strategySpatial Working Memory taskFrontoparietal network activitySpatial working memoryWorking Memory TaskEngagement of controlAssociated with distinct patternsWorking memory strategiesMagnetic resonance imaging studiesNetwork activityMemory taskBrain systemsAttentional resourcesTask trialsBrain networksMemory strategiesStimulus informationStronger deactivationTiming of stimuliHealthy participantsSpatial representation249. Interactive Effects of Motivation and Cognition in Adolescents With Depression and Neurotypical Peers
Pham P, Frazier A, Agrawal S, Anticevic A, Cho Y. 249. Interactive Effects of Motivation and Cognition in Adolescents With Depression and Neurotypical Peers. Biological Psychiatry 2024, 95: s201. DOI: 10.1016/j.biopsych.2024.02.484.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD
HIC ID2000023688RoleSub InvestigatorPrimary Completion Date07/31/2024Recruiting ParticipantsGenderBothAge18 years - 65 yearsTeen Brain and Behavior Study
HIC ID1111009332RoleSub InvestigatorPrimary Completion Date12/21/2022Recruiting ParticipantsGenderBothAge13 years - 17 yearsBiomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder
HIC ID0803003626RoleSub InvestigatorPrimary Completion Date04/19/2025Recruiting ParticipantsGenderBothAge18 years - 70 years
News
News
- February 07, 2025
2024-2025 YCSC postdoctoral scholar travel awardees announced
- November 13, 2024
Woods, Cho Awarded $76M NIH Grant to Conduct Clinical Trials for Youth at Risk for Schizophrenia
- April 12, 2024
Spring 2024 postgraduate associate travel award recipients announced
- January 30, 2024
ASCI Recognizes Early-career Yale Faculty and Trainees