Tyrone Cannon
Clark L. Hull Professor of Psychology and Professor of PsychiatryCards
About
Research
Publications
2025
Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data
Cadenhead K, Kennedy L, Mirzakhanian H, Addington J, Bearden C, Cannon T, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S. Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data. Schizophrenia Bulletin 2025, sbaf133. PMID: 40856400, DOI: 10.1093/schbul/sbaf133.Peer-Reviewed Original ResearchClinical high riskClinical high-risk criteriaLong-term outcomesNorth American Prodrome Longitudinal Study sitesClinical high-risk participantsRates of affective disordersHigh riskLife courseNon-converter groupHigh-risk youthAssessment of individualsPsychosis statesAffective disordersPsychosocial functioningPsychosisTrajectory of diagnosisLonger-term outcomesClinical/functional outcomesLong-term assessmentGeneral populationBaseline dataParticipantsPreliminary dataEarly dataPersonsDecoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort
Neuner L, Weyer C, Kambeitz-Ilankovic L, Korda A, Dwyer D, Antonucci L, Kambeitz J, Upthegrove R, Salokangas R, Hietala J, Pantelis C, Lencer R, Wood S, Brambilla P, Borgwardt S, Bertolino A, Romer G, Meisenzahl E, Dannlowski U, Falkai P, Cannon T, Koutsouleris N, Hahn L, Haas S, Hasan A, Hoff C, Khanyaree I, Krämer C, Melo A, Muckenhuber-Sternbauer S, Köhler Y, Oeztuerk O, Penzel N, Popovic D, Rangnick A, von Saldern S, Sanfelici R, Spangemacher M, Tupac A, Fernanda Urquijo M, Weiske J, Wosgien A, Blume K, Hedderich D, Julkowski D, Kaiser N, Lichtenstein T, Milz R, Nikolaides A, Pilgram T, Seves M, Wassen M, Andreou C, Egloff L, Harrisberger F, Heitz U, Lenz C, Leanza L, Mackintosh A, Smieskova R, Studerus E, Walter A, Widmayer S, Day C, Lowri Griffiths S, Iqbal M, Pelton M, Mallikarjun P, Stainton A, Lin A, Denissoff A, Ellilä A, From T, Heinimaa M, Ilonen T, Jalo P, Laurikainen H, Luutonen A, Mäkela A, Paju J, Pesonen H, Säilä R, Toivonen A, Turtonen O, Botterweck S, Kluthausen N, Antoch G, Caspers J, Wittsack H, Blasi G, Pergola G, Caforio G, Fazio L, Quarto T, Gelao B, Romano R, Andriola I, Falsetti A, Barone M, Passiatore R, Sangiuliano M, Surmann M, Bienek O, Beatriz Solana A, Abraham M, Schirmer T, Altamura C, Belleri M, Bottinelli F, Ferro A, Re M, Monzani E, Sberna M, D’Agostino A, Del Fabro L, Perna G, Nobile M, Alciati A, Balestrieri M, Bonivento C, Cabras G, Fabbro F, Garzitto M, Piccin S. Decoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort. Schizophrenia Bulletin 2025, sbaf135. PMID: 40856416, DOI: 10.1093/schbul/sbaf135.Peer-Reviewed Original ResearchGray matter volumeWhite matter volumeNeuroanatomical correlatesPsychosis riskMatter volumeCHR-PNAPLS-2Moderation analysisNorth American Prodrome Longitudinal StudyClinical high-risk stateHippocampal gray matter volumeEarly Psychosis ManagementAnterior cingulate cortexCerebellar white matter volumeVoxel-based morphometryRecent-onset depressionLongitudinal studyRisk scoreHigh-risk statePsychosis managementDiagnostic boundariesPost-hocVerbal memoryCingulate cortexPsychosocial deficitsPrediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis
Mukhtar H, Zhou D, Farina E, Saxena A, Cahill J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshwan M, Mathalon D, Perkins D, Stone W, Cho Y, Powers A, Walker E, Woods S. Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis. Psychological Medicine 2025, 55: e241. PMID: 40842369, PMCID: PMC12404330, DOI: 10.1017/s0033291725101372.BooksClinical high riskCHR-PLifetime historyAugmentation of antidepressant treatmentComorbid major depressionAP useAntidepressant treatmentPositive symptomsMajor depressionAP medicationNAPLS-2Independent predictorsCHR-P.High riskBaseline clinical variablesPsychosisBaseline predictorsClinical variablesParticipantsBaseline characteristicsUnivariate analysisLogistic regression modelsObservational cohortMultivariate analysisAP initiationVictimization and engagement with the legal system among individuals at clinical high risk (CHR) for psychosis
Du A, Kennedy L, Addington J, Bearden C, Cannon T, Carrion R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cadenhead K. Victimization and engagement with the legal system among individuals at clinical high risk (CHR) for psychosis. Schizophrenia Research 2025, 284: 7-15. PMID: 40737766, DOI: 10.1016/j.schres.2025.07.015.Peer-Reviewed Original ResearchLegal systemLegal historyPerpetrators of crimesVictims of crimeHistory of victimizationClinical high-risk youthClinical high riskHistorical risk factorsReport victimizationLegal issuesVictimsCrimeComorbid mental illnessMental illnessYouthClinical high-risk participantsPsychotic illnessLife risk factorsPsychosis symptomsPerpetratorsViolencePsychosisHealthy controlsStudy-3EngagementThe moderating role of lifetime social engagement on the relationship between C-reactive protein and negative symptoms among young adults at clinical high risk for psychosis
Goldsmith D, Yuan Q, Addington J, Bearden C, Cadenhead K, Cannon T, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Woods S, Walker E, Ku B. The moderating role of lifetime social engagement on the relationship between C-reactive protein and negative symptoms among young adults at clinical high risk for psychosis. Brain Behavior And Immunity 2025, 129: 890-897. PMID: 40730261, PMCID: PMC12360851, DOI: 10.1016/j.bbi.2025.07.023.Peer-Reviewed Original ResearchConceptsScale of Psychosis-risk SymptomsNegative symptomsCHR-P groupClinical high riskCHR-PC-reactive proteinAssociated with negative symptomsNorth American Prodrome Longitudinal StudySocial engagementDevelopment of negative symptomsPsychosis-risk symptomsSimple slope analysesCHR-P individualsYoung adultsHealthy controlsCHR-P subjectsLevels of social engagementSocial engagement levelsEarly developmental periodDepressive symptomsSimple slopesHC subjectsPsychosisHigh riskC-reactive protein valuesExploring the pathways between early auditory processing, processing speed, social cognition, and negative symptoms on social functioning in individuals at clinical high risk for psychosis: A structural equation modeling approach
Carrión R, John M, Dorvil S, Auther A, McLaughlin D, Arnovitz M, Bachman P, Belger A, Duncan E, Hamilton H, Johannesen J, Ku B, Light G, Niznikiewicz M, Roach B, Addington J, Bearden C, Cadenhead K, Cannon T, Keshavan M, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Mathalon D, Cornblatt B. Exploring the pathways between early auditory processing, processing speed, social cognition, and negative symptoms on social functioning in individuals at clinical high risk for psychosis: A structural equation modeling approach. Biological Psychiatry 2025 PMID: 40633882, DOI: 10.1016/j.biopsych.2025.06.033.Peer-Reviewed Original ResearchClinical high riskNegative symptomsEvent-related potentialsCHR-P individualsCHR-PPsychosis onsetSocial cognitionMismatch negativityStructural equation modelingSocial functioningProcessing deficitsProcessing speedNorth American Prodrome Longitudinal StudyEarly information processing deficitsAssociated with social functioningAuditory processingInformation processing deficitsSocial functioning difficultiesPoor social functioningSocial functioning impairmentAuditory event-related potentialsAuditory processing deficitsEarly auditory processingEarly intervention strategiesNeurophysiological deficitsCognitive subtypes in youth at clinical high risk for psychosis
Yassin W, Green J, Keshavan M, del Re E, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Mathalon D, Perkins D, Walker E, Woods S, Stone W. Cognitive subtypes in youth at clinical high risk for psychosis. Psychiatry And Clinical Neurosciences 2025 PMID: 40600477, DOI: 10.1111/pcn.13861.Peer-Reviewed Original ResearchClinical high riskCognitive subtypesWorking memoryClinical high-risk groupWorking memory domainsConversion statusPsychotic disordersCognitive clustersVerbal abilityCHR patientsCognitive measuresMemory domainCognitive domainsNAPLS-2Cognitive trajectoriesPsychosisImpairment groupIntact groupHealthy controlsFunction trajectoriesIntervention strategiesBaseline differencesMemoryHigh riskMonths of follow-upAltered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity
Mason A, Palmer W, Cao H, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Mathalon D, Walker E, Woods S, Cannon T. Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity. Schizophrenia Research 2025, 281: 115-121. PMID: 40328092, DOI: 10.1016/j.schres.2025.04.034.Peer-Reviewed Original ResearchConceptsInferior parietal lobe activityPsychotic symptom severityParietal lobe activityDevelopmental traumaDelusion severityHallucination severityMemory taskNeurocognitive measuresMemory processesMemory performanceSymptom severityScale of Psychosis-risk SymptomsNorth American Prodrome Longitudinal StudyPoorer episodic memory performanceRisk of psychotic symptomsPaired-associate memory taskAssociated with memory processingMemory-associated regionsTrauma-exposed individualsEpisodic memory processesEpisodic memory tasksPsychosis-risk symptomsClinical high riskEpisodic memory performanceSubclinical delusionsTrajectories of positive symptoms and suicidality in individuals at clinical high risk for psychosis
Deng W, MacNutt C, Addington J, Bearden C, Cadenhead K, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cannon T. Trajectories of positive symptoms and suicidality in individuals at clinical high risk for psychosis. Journal Of Affective Disorders 2025, 384: 208-213. PMID: 40334865, DOI: 10.1016/j.jad.2025.05.023.Peer-Reviewed Original ResearchConceptsPositive symptomsClinical high riskSuicidal ideationCHR-PMeasures of suicidal ideationEarly stages of psychosisPersistence of suicidal ideationSeverity of depressive symptomsPositive symptom severityAssessment timepointsCHR-P participantsEmergence of suicidalityStages of psychosisCHR-P populationTargeted suicide prevention strategiesPsychotic disordersEarly psychosisSuicide prevention strategiesDepressive symptomsSymptom severityPsychosisIdeationDelusionsSuicideHallucinationsResponse to Psychotherapy by Clients With Varying Levels of Distress Treated in a Graduate Student Outpatient Clinic
O’Brien M, O’Leary C, Cannon T, Lympus C, Salinger J, Prelli F, Gale M. Response to Psychotherapy by Clients With Varying Levels of Distress Treated in a Graduate Student Outpatient Clinic. Training And Education In Professional Psychology 2025, 19: 124-133. DOI: 10.1037/tep0000508.Peer-Reviewed Original ResearchOutcome Questionnaire-45Levels of distressResponse to psychotherapyPositive therapeutic allianceIndividual psychotherapyCognitive reappraisalPerseverative thinkingTherapeutic allianceSelf-CompassionTraining clinicTherapeutic relationshipPsychological processesPsychological skillsPsychotherapyCourse of treatmentEnd treatmentRepeated-measures analysisRepeated-measures analysis of varianceDistressContext variablesRepeated-measuresClientsAnalysis of varianceDoctoral studentsOutpatient clinic