Samuel Brady Sondalle, MD, PhD
About
Titles
Clinical Fellow
Solnit Integrated Program, Yale Child Study CenterBiography
Dr. Sondalle is a Solnit Integrated Fellow in Child, Adolescent, and Adult Psychiatry at the Yale University School of Medicine. He is also co-chief fellow of the Solnit Integrated training program for the 2024-2025 academic year. He grew up in rural Wisconsin. As a first-generation college graduate, he majored in both Biology and Chemistry at Ripon College in Wisconsin. He participated in summer research as an undergraduate in the Chemistry department at UW-Madison and at the Harvard Stem Cell Institute. Dr. Sondalle completed his M.D. and Ph.D. training in the Medical Scientist Training Program at the Yale University School of Medicine. His Ph.D. research in Genetics investigated the biological process of making ribosomes, the cellular machines responsible for protein production, and how defects in this process cause human disease. Dr. Sondalle is devoted to caring for adolescents and young adults as they transition into adulthood, particularly individuals who identify as LGBTQIA+ and individuals from rural communities. His clinical interests include psychodynamic psychopharmacology, psychodynamic psychotherapy, humanistic psychotherapy, internal family systems therapy, the treatment of personality disorders, and the treatment of complex trauma. Dr. Sondalle's clinical work has been greatly influenced by the work of Carl Rogers who once said: “This process of the good life ... involves the stretching and growing of becoming more and more of one's potentialities. It involves the courage to be. It means launching oneself fully into the stream of life.”
Appointments
Child Study Center
Clinical FellowPrimary
Other Departments & Organizations
Education & Training
- MD
- Yale University School of Medicine (2020)
- PhD
- Yale University, Genetics (2018)
- MPhil
- Yale University, Genetics (2015)
- AB
- Ripon College, Chemistry and Biology (double major) (2011)
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Susan Baserga, MD, PhD
Laura Abriola
Publications
2023
Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing
McCool M, Bryant C, Huang H, Ogawa L, Farley-Barnes K, Sondalle S, Abriola L, Surovtseva Y, Baserga S. Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing. RNA Biology 2023, 20: 257-271. PMID: 37246770, PMCID: PMC10228412, DOI: 10.1080/15476286.2023.2217392.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPre-rRNA accumulationRibosome biogenesisNonessential roleEukaryotic ribosome biogenesisEssential cellular processesNucleolar stress responsePre-rRNA levelsRRNA processingLikely orthologCellular processesAssociated proteinsTumor suppressorStress responseHuman cellsProtein synthesisProtein 7Human counterpartBiogenesisYeastOrthologsHomologSubcomplexAccumulationRRNATranscription
2019
Fanconi anemia protein FANCI functions in ribosome biogenesis
Sondalle SB, Longerich S, Ogawa LM, Sung P, Baserga SJ. Fanconi anemia protein FANCI functions in ribosome biogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 2561-2570. PMID: 30692263, PMCID: PMC6377447, DOI: 10.1073/pnas.1811557116.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2018
RPSA, a candidate gene for isolated congenital asplenia, is required for pre-rRNA processing and spleen formation in Xenopus
Griffin JN, Sondalle SB, Robson A, Mis EK, Griffin G, Kulkarni SS, Deniz E, Baserga SJ, Khokha MK. RPSA, a candidate gene for isolated congenital asplenia, is required for pre-rRNA processing and spleen formation in Xenopus. Development 2018, 145: dev166181. PMID: 30337486, PMCID: PMC6215398, DOI: 10.1242/dev.166181.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPre-rRNA processingSmall ribosomal subunitCommon disease-associated mutationDisease-associated mutationsRpsA mRNARibosome biogenesisRibosome productionRibosome functionRibosomal subunitCandidate genesHuman mRNAsProtein componentsImpairs expressionSpleen developmentMolecular patterningRPSASpleen anlageMutationsXenopusGenesFirst animal modelUniversal requirementMRNA
2017
Ribosomes Need Straight A’s to Sleep
Sondalle SB, Baserga SJ. Ribosomes Need Straight A’s to Sleep. Cell 2017, 169: 565-567. PMID: 28475888, PMCID: PMC5640166, DOI: 10.1016/j.cell.2017.04.019.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsThe pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma
Tao T, Sondalle SB, Shi H, Zhu S, Perez-Atayde AR, Peng J, Baserga SJ, Look AT. The pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma. Oncogene 2017, 36: 3852-3867. PMID: 28263972, PMCID: PMC5501763, DOI: 10.1038/onc.2016.527.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDigestive organ expansion factorSmall ribosomal subunitPeripheral sympathetic nervous systemPre-ribosomal RNA processingTransgenic zebrafish modelOverexpression of MYCNNeuroblastoma cellsRibosome biogenesisSSU processomeNucleolar factorsRNA processingSympathetic nervous systemRibosomal subunitZebrafish modelHuman neuroblastoma cell lineTumor growth rateHuman neuroblastoma cellsNeuroblastoma cell linesNovel siteZebrafishCell linesNervous systemHuman neuroblastomaDisease penetranceNeuroblastomaA Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism
Paolini NA, Attwood M, Sondalle SB, dos Santos Vieira C, van Adrichem AM, di Summa FM, O’Donohue M, Gleizes PE, Rachuri S, Briggs JW, Fischer R, Ratcliffe PJ, Wlodarski MW, Houtkooper RH, von Lindern M, Kuijpers TW, Dinman JD, Baserga SJ, Cockman ME, MacInnes AW. A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism. American Journal Of Human Genetics 2017, 100: 506-522. PMID: 28257692, PMCID: PMC5339345, DOI: 10.1016/j.ajhg.2017.01.034.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAutism Spectrum DisorderCarrier ProteinsCells, CulturedChildChild, PreschoolCodonDevelopmental DisabilitiesExomeFemaleFibroblastsGenetic VariationHearing LossHumansIntellectual DisabilityMaleMicrocephalyMutationMutation, MissenseNuclear ProteinsOxidative StressProtein BiosynthesisRibosomal ProteinsRibosomesSequence AlignmentSequence Analysis, DNAConceptsMRNA translationRibosomal protein gene mutationsRP gene mutationsAmino acid substitutionsDefective ribosomesSubunit biogenesisCodon translationRibosomal subunitPolysome formationGene mutationsProline residuesDe novo missense mutationsAcid substitutionsLoop regionProtein synthesisBone marrow failurePhenylalanine residuesNovo missense mutationMechanistic distinctionsPrimary cellsMissense mutationsRibosomopathiesProtein gene mutationsUnrelated individualsMutations
2016
The Contributions of the Ribosome Biogenesis Protein Utp5/WDR43 to Craniofacial Development
Sondalle SB, Baserga SJ, Yelick PC. The Contributions of the Ribosome Biogenesis Protein Utp5/WDR43 to Craniofacial Development. Journal Of Dental Research 2016, 95: 1214-1220. PMID: 27221611, PMCID: PMC5076753, DOI: 10.1177/0022034516651077.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRibosomal proteinsCraniofacial developmentRibosome biogenesis proteinsRibosomal protein functionHuman craniofacial developmentTissue-specific defectsDiverse cell typesHuman ribosomopathiesBiogenesis proteinsTranslational machineryProtein functionDistinct functionsTranslational mechanismsTissue differentiationCell typesWDR43Global defectsProteinExciting researchSurprising similaritiesUnderstanding of rolesRibosomopathiesBiogenesisMachineryMutationsA nucleolar role for the Fanconi anemia pathway protein, FANCI, in rDNA transcription
Sondalle S, Longerich S, Sung P, Baserga S. A nucleolar role for the Fanconi anemia pathway protein, FANCI, in rDNA transcription. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.1048.1.Peer-Reviewed Original ResearchConceptsRNA polymerase IRibosome biogenesisDNA repairFanconi anemiaNucleolar proteinsNucleolar roleHeLa cell nuclear extractsPre-ribosomal RNANovel regulatory mechanismCell nuclear extractsDNA repair defectsInterstrand DNA crosslinksMature ribosomesRDNA transcriptionRRNA transcriptionLarge subunitNucleolar functionFA proteinsFANCIUbiquitination stateSubcellular fractionationReduced transcriptionPolymerase IBiogenesisRegulatory mechanisms
2015
The Ribosome Biogenesis Factor Nol11 Is Required for Optimal rDNA Transcription and Craniofacial Development in Xenopus
Griffin JN, Sondalle SB, del Viso F, Baserga SJ, Khokha MK. The Ribosome Biogenesis Factor Nol11 Is Required for Optimal rDNA Transcription and Craniofacial Development in Xenopus. PLOS Genetics 2015, 11: e1005018. PMID: 25756904, PMCID: PMC4354908, DOI: 10.1371/journal.pgen.1005018.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCranial neural crestCraniofacial developmentRibosome biogenesisRibosome biogenesis proteinsRibosome biogenesis defectsProduction of ribosomesPre-rRNA transcriptionHuman tissue culture cellsMulticellular organismsTissue culture cellsBiogenesis proteinsRDNA transcriptionBiogenesis defectsCraniofacial cartilageRRNA transcriptionNucleolar proteinsP53 rescueNeural crestCell survivalTranscriptionSkeletal phenotypeCulture cellsCritical functionsRibosomopathiesBiogenesis
2013
Human diseases of the SSU processome
Sondalle SB, Baserga SJ. Human diseases of the SSU processome. Biochimica Et Biophysica Acta 2013, 1842: 758-764. PMID: 24240090, PMCID: PMC4058823, DOI: 10.1016/j.bbadis.2013.11.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNorth American Indian childhood cirrhosisSSU processome componentsSSU processomeBowen-Conradi syndromeHuman diseasesSmall subunit processomeProduction of ribosomesRibosomal protein assemblyLarge ribonucleoproteinRibosome biogenesisFunctional ribosomesEukaryotic cellsProcessomeProtein assembliesCellular machinesRibosomesRNA cleavageProtein synthesisRibonucleoproteinEukaryotesCirhinAssemblyRRNAsRibosomopathiesBiogenesis
Academic Achievements and Community Involvement
activity Member
Professional OrganizationsAmerican Academy of Child and Adolescent PsychiatryDetails2018 - Presentactivity Member
Professional OrganizationsAmerican Psychiatric AssociationDetails2018 - Presenthonor Outstanding Young Alumni Award
Other AwardRipon CollegeDetails08/06/2021United Stateshonor The M.D./Ph.D. Award
Yale School of Medicine AwardYale School of MedicineDetails05/18/2020United Stateshonor Ruth L. Kirschstein National Research Service Award (F30DK109582, 2016-2018)
National AwardNational Institutes of HealthDetails04/01/2016United States