Victor Luria, PhD
Research Scientist in NeuroscienceCards
About
Research
Publications
2025
De Novo Genes: Current Status and Future Goals
Casola C, Luria V, Vakirlis N, Zhao L. De Novo Genes: Current Status and Future Goals. Genome Biology And Evolution 2025, 17: evaf230. PMID: 41313722, PMCID: PMC12708343, DOI: 10.1093/gbe/evaf230.Peer-Reviewed Original ResearchDe Novo Gene Emergence: Summary, Classification, and Challenges of Current Methods
Grandchamp A, Aubel M, Eicholt L, Roginski P, Luria V, Karger A, Dohmen E. De Novo Gene Emergence: Summary, Classification, and Challenges of Current Methods. Genome Biology And Evolution 2025, 17: evaf197. PMID: 41126639, PMCID: PMC12605812, DOI: 10.1093/gbe/evaf197.Peer-Reviewed Original ResearchDeNoFo: a file format and toolkit for standardized, comparable de novo gene annotation
Dohmen E, Aubel M, Eicholt L, Roginski P, Luria V, Karger A, Grandchamp A. DeNoFo: a file format and toolkit for standardized, comparable de novo gene annotation. Bioinformatics 2025, 41: btaf539. PMID: 41051215, PMCID: PMC12516307, DOI: 10.1093/bioinformatics/btaf539.Peer-Reviewed Original Research
2024
Expression of Random Sequences and de novo Evolved Genes From the Mouse in Human Cells Reveals Functional Diversity and Specificity
Aldrovandi S, Castro J, Ullrich K, Karger A, Luria V, Tautz D. Expression of Random Sequences and de novo Evolved Genes From the Mouse in Human Cells Reveals Functional Diversity and Specificity. Genome Biology And Evolution 2024, 16: evae175. PMID: 39663928, PMCID: PMC11635099, DOI: 10.1093/gbe/evae175.Peer-Reviewed Original ResearchConceptsOpen reading frameGene open reading frameCellular regulatory pathwaysNoncoding DNAReading frameHuman cell linesHuman genomeAlpha-helicesGrowth experimentsCellular physiologyFunctional diversityPositive selectionBeta-sheetTranscriptomic responseRegulatory pathwaysAdaptive advantageHuman cellsGenesCell clonesCell linesSequenceClonesRandom sequencePathwayCellsIndividual variation in the emergence of anterior-to-posterior neural fates from human pluripotent stem cells
Kim S, Seo S, Stein-O’Brien G, Jaishankar A, Ogawa K, Micali N, Luria V, Karger A, Wang Y, Kim H, Hyde T, Kleinman J, Voss T, Fertig E, Shin J, Bürli R, Cross A, Brandon N, Weinberger D, Chenoweth J, Hoeppner D, Sestan N, Colantuoni C, McKay R. Individual variation in the emergence of anterior-to-posterior neural fates from human pluripotent stem cells. Stem Cell Reports 2024, 19: 1336-1350. PMID: 39151428, PMCID: PMC11411333, DOI: 10.1016/j.stemcr.2024.07.004.Peer-Reviewed Original ResearchHuman pluripotent stem cellsEarly mammalian developmentConsequences of variationPluripotent stem cellsTranscriptomic variationMammalian developmentTranscriptomic patternsTranscriptomic traitsReplicate linesMesendodermal lineagesNeural fateAdult tissuesLineagesHindbrain fateTranscriptional signatureTranscriptomic signaturesEarly eventLineage biasHuman pluripotent stem cell linesStem cellsFateIndividual variationAnterior to posterior structuresEpigenetic originCells
2023
Human-specific features and developmental dynamics of the brain N-glycome
Klarić T, Gudelj I, Santpere G, Novokmet M, Vučković F, Ma S, Doll H, Risgaard R, Bathla S, Karger A, Nairn A, Luria V, Bečeheli I, Sherwood C, Ely J, Hof P, Sousa A, Josić D, Lauc G, Sestan N. Human-specific features and developmental dynamics of the brain N-glycome. Science Advances 2023, 9: eadg2615. PMID: 38055821, PMCID: PMC10699788, DOI: 10.1126/sciadv.adg2615.Peer-Reviewed Original ResearchMolecular and cellular mechanisms of human cortical connectivity
Luria V, Ma S, Shibata M, Pattabiraman K, Sestan N. Molecular and cellular mechanisms of human cortical connectivity. Current Opinion In Neurobiology 2023, 80: 102699. PMID: 36921362, DOI: 10.1016/j.conb.2023.102699.Peer-Reviewed Original Research
2021
Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation
Li F, Rane R, Luria V, Xiong Z, Chen J, Li Z, Catullo R, Griffin P, Schiffer M, Pearce S, Lee S, McElroy K, Stocker A, Shirriffs J, Cockerell F, Coppin C, Sgrò C, Karger A, Cain J, Weber J, Santpere G, Kirschner M, Hoffmann A, Oakeshott J, Zhang G. Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation. Molecular Ecology Resources 2021, 22: 1559-1581. PMID: 34839580, PMCID: PMC9299920, DOI: 10.1111/1755-0998.13561.Peer-Reviewed Original ResearchConceptsClimate generalistsDrosophila speciesGenus DrosophilaPhylogenomic analysisSignificant phylogenetic incongruenceEvolutionary genomic studiesMelanogaster species groupGenome-wide signalsDifferent climatic nichesHigh-quality assemblySmall population sizeIncomplete lineageSubgenus DrosophilaAsymmetric introgressionSubgenus SophophoraPhylogenetic incongruenceNew transcriptomesGene gainClimatic nicheGenome diversityNatural populationsWidespread speciesGenomic signalsSpecies groupsClimate nicheNoncanonical open reading frames encode functional proteins essential for cancer cell survival
Prensner J, Enache O, Luria V, Krug K, Clauser K, Dempster J, Karger A, Wang L, Stumbraite K, Wang V, Botta G, Lyons N, Goodale A, Kalani Z, Fritchman B, Brown A, Alan D, Green T, Yang X, Jaffe J, Roth J, Piccioni F, Kirschner M, Ji Z, Root D, Golub T. Noncanonical open reading frames encode functional proteins essential for cancer cell survival. Nature Biotechnology 2021, 39: 697-704. PMID: 33510483, PMCID: PMC8195866, DOI: 10.1038/s41587-020-00806-2.Peer-Reviewed Original ResearchConceptsCancer cell linesOpen reading framePotential therapeutic targetCell linesGrowth inhibitory effectsCancer cell survivalInduced gene expression changesBreast cancerTherapeutic targetHuman cancer cell linesReading frameProtein expressionActive proteinProtein 1Gene expression changesCell survivalBiological effectsExpression changesViability defectsHuman genomeGenomic analysisCodon mutagenesisEctopic expressionFunctional proteinsKnockout
2020
TBIO-26. NON-CANONICAL OPEN READING FRAMES ENCODE FUNCTIONAL PROTEINS ESSENTIAL FOR CANCER CELL SURVIVAL
Prensner J, Enache O, Luria V, Krug K, Clauser K, Dempster J, Karger A, Wang L, Stumbraite K, Wang V, Botta G, Lyons N, Goodale A, Kalani Z, Fritchman B, Brown A, Alan D, Green T, Yang X, Jaffe J, Roth J, Piccioni F, Kirschner M, Ji Z, Root D, Golub T. TBIO-26. NON-CANONICAL OPEN READING FRAMES ENCODE FUNCTIONAL PROTEINS ESSENTIAL FOR CANCER CELL SURVIVAL. Neuro-Oncology 2020, 22: iii471-iii471. PMCID: PMC7715501, DOI: 10.1093/neuonc/noaa222.849.Peer-Reviewed Original ResearchOpen reading frameNon-canonical open reading framesProtein translationReading frameMultiple cancer typesPutative non-coding RNAProtein-coding genesSingle-cell RNA sequencingNon-canonical proteinsFunctional genomic screensCancer-implicated genesCancer cell linesCell-autonomous mannerNon-coding RNANon-coding RNAsGene expression changesPotential cancer therapeutic targetCell linesHEK293T cellsCancer cell survivalCancer therapeutic targetNon-gonadal tissuesCell cycle arrestRibosome profilingCancer cell types