Shveta Bathla
Associate Research ScientistAbout
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Associate Research Scientist
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Shveta Bathla's published research.
Publications Timeline
A big-picture view of Shveta Bathla's research output by year.
Angus Nairn, PhD
Dibyadeep Datta
TuKiet Lam, PhD, BS
Alvaro Duque, PhD
Amy Arnsten, PhD
Elizabeth Woo
19Publications
346Citations
Publications
2026
Nanomaterials for Gene Therapy in Animal Health
Bathla S. Nanomaterials for Gene Therapy in Animal Health. Smart Nanomaterials Technology 2026, 141-166. DOI: 10.1007/978-981-95-4542-1_6.Peer-Reviewed Original ResearchConceptsAnimal healthAgricultural production worldwideEuropean Medicines AgencyOverall animal healthGene therapyEffective delivery systemDelivery of gene therapyNucleic acid-based methodsTarget cellsMilk yieldProduction traitsDisease resistanceMilk productionGene-based treatmentsProduction worldwideLivestock productionLivestock diseasesImmune response stimulationVeterinary fieldAcid-based methodsGenetic therapiesInherited disorderMilkLivestockClinical use
2025
Ryanodine receptor 2-mediated calcium leak is associated with increased glyoxalase I in the aging brain
Woo E, Datta D, Bathla S, Beatty H, Caglayan P, Albizu A, Lam T, Kanyo J, Joyce M, Leslie S, Uchendu S, DeLong J, Guan Q, Li J, Abramson E, Herman A, Cooper D, Licznerski P, Horvath T, Jonas E, Nairn A, Arnsten A, Sansing L. Ryanodine receptor 2-mediated calcium leak is associated with increased glyoxalase I in the aging brain. JCI Insight 2025, 10: e184041. PMID: 41100182, PMCID: PMC12643534, DOI: 10.1172/jci.insight.184041.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPrefrontal cortexCalcium leakImpaired working memoryGlo1 expressionCalcium dysregulationAlzheimer's diseaseRyanodine receptor 2Working memoryAge-related increaseStage of diseaseDownstream consequencesAging BrainAD mouse modelMonths of ageAged macaquesMutant miceReceptor 2Mouse modelRyR2RyanodineBrainMiceLeakDysregulationMacaquesDysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation
Bathla S, Datta D, Bolat D, Woo E, Duque A, Arellano J, Arnsten A, Nairn A. Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation. Frontiers In Aging Neuroscience 2025, 17: 1549770. PMID: 40365352, PMCID: PMC12069431, DOI: 10.3389/fnagi.2025.1549770.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTau pathologyTau hyperphosphorylationAlzheimer's diseaseAssociated with tau hyperphosphorylationSoluble phosphorylated tauSporadic Alzheimer's diseaseCalcium signalingDysregulated calcium signalingTau etiologyEarly stages of ADHyperphosphorylationSignaling pathwayHuman ADInflammatory signaling pathwaysCalpain-2Stages of ADMolecular processesHydrolyze cAMPTauEntorhinal cortexCarboxypeptidase IIGlutamate carboxypeptidase IIDephosphorylationSubcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease
Cai Y, Kanyo J, Wilson R, Bathla S, Cardozo P, Tong L, Qin S, Fuentes L, Pinheiro-de-Sousa I, Huynh T, Sun L, Mansuri M, Tian Z, Gan H, Braker A, Trinh H, Huttner A, Lam T, Petsalaki E, Brennand K, Nairn A, Grutzendler J. Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease. Nature Aging 2025, 5: 504-527. PMID: 40065072, PMCID: PMC11922768, DOI: 10.1038/s43587-025-00823-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAlzheimer's diseaseProximity labeling approachIPSC-derived neuronsSubcellular proteomicsCytoskeleton dynamicsPhosphorylated mTOR levelsDystrophic neuritesLipid transportBiological processesProtein turnoverAD modelHuman induced pluripotent stem cellsAmyloid depositsIPSC modelsProteomicsInduced pluripotent stem cellsPluripotent stem cellsMTOR inhibitionTherapeutic targetAxonal pathologyLabeling approachMTOR levelsMouse brainSpheroid formationAlzheimerSLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation
Pena I, Shi J, Chang S, Yang J, Block S, Adelmann C, Keys H, Ge P, Bathla S, Witham I, Sienski G, Nairn A, Sabatini D, Lewis C, Kory N, Vander Heiden M, Heiman M. SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation. Nature Communications 2025, 16: 978. PMID: 39856062, PMCID: PMC11760969, DOI: 10.1038/s41467-025-56130-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPyridoxal 5'-phosphateGenome-wide CRISPR interference screenPyridoxal 5'-phosphate-dependent enzymeCRISPR interference screenSerine hydroxymethyltransferase-2Active form of vitamin B6One-carbon unitsImpaired cellular proliferationAmino acid metabolismOne-carbon metabolismInterference screenEssential proteinsMolecular machineryNucleotide synthesisCongenital sideroblastic anemiaProliferation defectSLC25A38Acid metabolismErythroleukemia cellsOrnithine aminotransferaseActive formK562 cellsEnzymatic reactionsCellular proliferationPolyamine synthesis
2024
Diagnosis of Alzheimer’s disease‐ Analysis of cross‐species biomarkers
Bathla S. Diagnosis of Alzheimer’s disease‐ Analysis of cross‐species biomarkers. Alzheimer's & Dementia 2024, 20: e095406. PMCID: PMC11712473, DOI: 10.1002/alz.095406.Peer-Reviewed Original ResearchConceptsEntorhinal cortexAD patientsP-tauTau pathologyAged rhesus monkeysDKI miceQuantitative phospho-proteomicsPrefrontal cortexStages of ADAntibody-free methodAged monkeysMultifactorial neurodegenerative disorderChronic treatmentNon-human primatesAged rhesus macaquesMouse tauEnvironmental linksPhospho-proteomicsPhosphorylation sitesTau hyperphosphorylationRhesus monkeysP-tau181 concentrationsWestern blot analysisLumipulse platformCortexOptimal conditions for carrying out trypsin digestions on complex proteomes: From bulk samples to single cells
Mansuri M, Bathla S, Lam T, Nairn A, Williams K. Optimal conditions for carrying out trypsin digestions on complex proteomes: From bulk samples to single cells. Journal Of Proteomics 2024, 297: 105109. PMID: 38325732, PMCID: PMC10939724, DOI: 10.1016/j.jprot.2024.105109.Peer-Reviewed Original ResearchCitationsAltmetricConceptsComplex proteomesProtein cleavage activityOptimal conditionsTrypsin digestion protocolReversed phase HPLC separationMass spectrometry workflowMS-based proteomicsMass spectrometric analysisC-terminal amino acid residuesTrypsin digestionChromatographic separationDigestion protocolAmino acid residuesHPLC separationMS/MS analysisGlobal proteomic analysisSingle cellsSample matrixSpectrometric analysisCleavage specificityGeneration of peptidesAcid residuesDown proteinsProteomic analysisCleavage activity
2023
Human-specific features and developmental dynamics of the brain N-glycome
Klarić T, Gudelj I, Santpere G, Novokmet M, Vučković F, Ma S, Doll H, Risgaard R, Bathla S, Karger A, Nairn A, Luria V, Bečeheli I, Sherwood C, Ely J, Hof P, Sousa A, Josić D, Lauc G, Sestan N. Human-specific features and developmental dynamics of the brain N-glycome. Science Advances 2023, 9: eadg2615. PMID: 38055821, PMCID: PMC10699788, DOI: 10.1126/sciadv.adg2615.Peer-Reviewed Original ResearchCitationsAltmetricChronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques
Bathla S, Datta D, Liang F, Barthelemy N, Wiseman R, Slusher B, Asher J, Zeiss C, Ekanayake‐Alper D, Holden D, Terwilliger G, Duque A, Arellano J, van Dyck C, Bateman R, Xie Z, Nairn A, Arnsten A. Chronic GCPII (glutamate‐carboxypeptidase‐II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2023, 9: e12431. PMID: 37915375, PMCID: PMC10617575, DOI: 10.1002/trc2.12431.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSporadic Alzheimer's diseaseEntorhinal cortexGCPII inhibitionDorsolateral prefrontal cortexChronic inhibitionTau pathologyTau hyperphosphorylationAged macaquesType 3 metabotropic glutamate receptorAlzheimer's diseasePrefrontal cortexRhesus macaquesVehicle-treated monkeysAged rhesus macaquesMetabotropic glutamate receptorsApparent side effectsAmyloid beta 1Regulation of calciumGCPII inhibitorsKey etiological factorGCPII activityPrimate dlPFCNeuronal damageCSF analysisCalcium dysregulation
2022
Deciphering Spatial Protein–Protein Interactions in Brain Using Proximity Labeling
Mathew B, Bathla S, Williams KR, Nairn AC. Deciphering Spatial Protein–Protein Interactions in Brain Using Proximity Labeling. Molecular & Cellular Proteomics 2022, 21: 100422. PMID: 36198386, PMCID: PMC9650050, DOI: 10.1016/j.mcpro.2022.100422.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein-protein interactionsProximity labelingBiological functionsComplex protein-protein interactionsProximity labeling methodProtein-DNA interactionsCell-cell communicationMost biological functionsDistinct cell typesProtein-RNANerve cell functionCell typesBiomolecular complexesCellular levelPhysical interactionProteomeCell functionSpecific subsetProteinSynaptic plasticityComplete catalogLabeling methodRecent advancesPowerful toolAxonal projections
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