Kartik Pattabiraman, MD, PhD
Assistant Professor in the Child Study CenterDownloadHi-Res Photo
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Child Study Center
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Neuroscience
Secondary
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Solnit Integrated Program, Yale Child Study Center
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Appointments
Child Study Center
Primary
Neuroscience
Secondary
Additional Titles
Solnit Integrated Program, Yale Child Study Center
Contact Info
Appointments
Child Study Center
Primary
Neuroscience
Secondary
Additional Titles
Solnit Integrated Program, Yale Child Study Center
Contact Info
About
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Titles
Assistant Professor in the Child Study Center
Solnit Integrated Program, Yale Child Study Center
Biography
Kartik Pattabiraman is an assistant professor and child psychiatrist at the Yale Child Study Center. He received his M.D. and Ph.D. from University of California, San Francisco. He completed his Ph.D. thesis work in the laboratory of John Rubenstein M.D., Ph.D. Afterward, he completed his clinical training in adult and child psychiatry and his postdoctoral training in the laboratory of Nenad Sestan M.D., Ph.D.
Last Updated on February 13, 2024.
Appointments
Child Study Center
Assistant ProfessorPrimaryNeuroscience
Assistant ProfessorSecondary
Other Departments & Organizations
- Albert J. Solnit Integrated Training Program
- All Institutions
- Center for Brain & Mind Health
- Child Study Center
- Interdepartmental Neuroscience Program
- Janeway Society
- Neural Disorders
- Neuroscience
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Outpatient Therapy Services for Youth
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Alfred J Solnit Integrated Fellowship
- Yale University (2022)
- Residency
- Yale Child Study Center (2022)
- PhD
- University of California, San Franciso, Neuroscience (2016)
- MD
- University of California, San Franciso, Neuroscience (2016)
- ScB
- Brown University, Neuroscience (2007)
Research
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Overview
Medical Research Interests
Cerebral Cortex; Developmental Disabilities; Embryonic and Fetal Development; Gene Regulatory Networks; Schizophrenia
Public Health Interests
Child/Adolescent Health
ORCID
0000-0002-3924-426X- View Lab Website
Pattabiraman Lab Website
Research at a Glance
Yale Co-Authors
Frequent collaborators of Kartik Pattabiraman's published research.
Publications Timeline
A big-picture view of Kartik Pattabiraman's research output by year.
Research Interests
Research topics Kartik Pattabiraman is interested in exploring.
Nenad Sestan, MD, PhD
Marina Picciotto, PhD
Navjot Kaur, PhD, MS
Rothem Kovner
Dan Doyle
Hyesun Cho, PhD
15Publications
950Citations
Cerebral Cortex
Gene Regulatory Networks
Publications
Featured Publications
Regulation of prefrontal patterning and connectivity by retinoic acid
Shibata M, Pattabiraman K, Lorente-Galdos B, Andrijevic D, Kim SK, Kaur N, Muchnik SK, Xing X, Santpere G, Sousa AMM, Sestan N. Regulation of prefrontal patterning and connectivity by retinoic acid. Nature 2021, 598: 483-488. PMID: 34599305, PMCID: PMC9018119, DOI: 10.1038/s41586-021-03953-x.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPrefrontal cortexRetinoic acidGranular layer 4Neocortex of humansRetinoic acid signalingCerebral cortexRetinoic acid receptorsMotor cortexMotor areaMediodorsal thalamusFetal developmentCortical expansionAcid receptorsGenetic deletionDendritic spinogenesisLayer 4Synthesizing enzymesCortexAcid signalingNeural developmentMiceCritical roleSignalingThalamusSpinogenesis
2025
Unique and divergent features of human brain development
Salamon I, Doyle D, Bandler R, Pattabiraman K, Sestan N. Unique and divergent features of human brain development. Current Opinion In Neurobiology 2025, 95: 103133. PMID: 41187489, PMCID: PMC12626412, DOI: 10.1016/j.conb.2025.103133.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBrain developmentHuman brain developmentAnthropoid primatesHuman brain evolutionClaims of human uniquenessNoninvasive brain imagingHuman phenotypic traitsBrain evolutionHuman uniquenessHuman brainBrain imagingDivergent featuresEvolutionary hypothesesFeatures of human brain developmentMorphological adaptationsHuman-specificEvolutionary historyBrainHuman experienceGenotype-to-phenotype relationships10.3 Connecting ASD Risk Genes to Circuits: Multilevel Characterization of the Cortical Subplate
Pattabiraman K. 10.3 Connecting ASD Risk Genes to Circuits: Multilevel Characterization of the Cortical Subplate. Journal Of The American Academy Of Child And Adolescent Psychiatry 2025, 64: s350. DOI: 10.1016/j.jaac.2025.07.774.Peer-Reviewed Original Research54. Molecular Specification of Claustro-Amygdalar and Paleocortical Excitatory Neurons and Connectivity
Kaur N, Kovner R, Andrijevic D, Zhu T, Shibata M, Shibata A, Pattabiraman K, Minuer Y, Picciotto M, Huang H, Sestan N. 54. Molecular Specification of Claustro-Amygdalar and Paleocortical Excitatory Neurons and Connectivity. Biological Psychiatry 2025, 97: s117. DOI: 10.1016/j.biopsych.2025.02.291.Peer-Reviewed Original ResearchConceptsSpecification of claustro-amygdalar and palaeocortical neurons and circuits
Kaur N, Kovner R, Gulden F, Pletikos M, Andrijevic D, Zhu T, Silbereis J, Shibata M, Shibata A, Liu Y, Ma S, Salla N, de Martin X, Klarić T, Burke M, Franjic D, Cho H, Yuen M, Chatterjee I, Soric P, Esakkimuthu D, Moser M, Santpere G, Mineur Y, Pattabiraman K, Picciotto M, Huang H, Sestan N. Specification of claustro-amygdalar and palaeocortical neurons and circuits. Nature 2025, 638: 469-478. PMID: 39814878, PMCID: PMC11821539, DOI: 10.1038/s41586-024-08361-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBasolateral amygdala complexPrefrontal cortex connectivityPrefrontal cortexNeuropsychiatric disordersExcitatory neuronsSymptoms of neuropsychiatric disordersEarly-life disruptionAmygdala complexPiriform cortexTemporal cortexDevelopmental shiftReciprocal connectionsCortexClaustrumBehavior modificationSensory informationTranscription factor SOX4DisordersTfap2dNeuronsSimilar alterationsCross-species analysisPiriformSOX11Transcription factors
2024
15.3 Connecting ASD Risk Genes to Circuits: Multi-Level Characterization of the Cortical Subplate
Pattabiraman K. 15.3 Connecting ASD Risk Genes to Circuits: Multi-Level Characterization of the Cortical Subplate. Journal Of The American Academy Of Child And Adolescent Psychiatry 2024, 63: s334. DOI: 10.1016/j.jaac.2024.07.719.Peer-Reviewed Original ResearchTranscriptome-Connectome association from fetal stage to adulthood
Ouyang M, Poddar T, Santpere G, Andrijevic D, Ma S, Pattabiraman K, Gobeske K, Sestan N, Huang H. Transcriptome-Connectome association from fetal stage to adulthood. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/2389.Peer-Reviewed Original Research
2023
Molecular and cellular mechanisms of human cortical connectivity
Luria V, Ma S, Shibata M, Pattabiraman K, Sestan N. Molecular and cellular mechanisms of human cortical connectivity. Current Opinion In Neurobiology 2023, 80: 102699. PMID: 36921362, DOI: 10.1016/j.conb.2023.102699.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2021
Transcriptional network orchestrating regional patterning of cortical progenitors
Ypsilanti AR, Pattabiraman K, Catta-Preta R, Golonzhka O, Lindtner S, Tang K, Jones IR, Abnousi A, Juric I, Hu M, Shen Y, Dickel DE, Visel A, Pennachio LA, Hawrylycz M, Thompson CL, Zeng H, Barozzi I, Nord AS, Rubenstein JL. Transcriptional network orchestrating regional patterning of cortical progenitors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2024795118. PMID: 34921112, PMCID: PMC8713794, DOI: 10.1073/pnas.2024795118.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRegional patterningEnhancer-gene interactionsTranscription factor networkTF ChIP-seqExpression of hundredsCortical progenitorsVentricular zoneRadial glial stem cellsMutant miceEpigenomic marksTF networksDNA accessibilityGenomic programmingTranscriptional networksGlial stem cellsFactor networkChIP-seqStem cellsVZ cellsPatterningProgenitorsEnhancerMouse cortexExpressionCellsHominini-specific regulation of CBLN2 increases prefrontal spinogenesis
Shibata M, Pattabiraman K, Muchnik SK, Kaur N, Morozov YM, Cheng X, Waxman SG, Sestan N. Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis. Nature 2021, 598: 489-494. PMID: 34599306, PMCID: PMC9018127, DOI: 10.1038/s41586-021-03952-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsCalcium-Binding ProteinsDendritesEnhancer Elements, GeneticFemaleHumansIntercellular Signaling Peptides and ProteinsMacacaMental DisordersMiceNerve Tissue ProteinsNervous System DiseasesNeural Cell Adhesion MoleculesPhylogenyPrefrontal CortexPromoter Regions, GeneticSOXD Transcription FactorsTranscriptomeUp-RegulationConceptsCerebellin 2Prefrontal cortexCerebral cortex regionsDendritic spine formationInitiation of synaptogenesisLaminar distributionDendritic spinesNervous systemNeuropsychiatric disordersSpine formationLevel of expressionCortex regionsGenetic humanizationCortical gradientsDisproportionate increaseSpecies differencesNeurexinsSpinogenesisDysfunctionMolecular basisPathogenesisExpressionCortexSynaptogenesisSpine
Academic Achievements & Community Involvement
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Honors
honor Klingenstein Simons Fellowship Awards in Neuroscience
07/01/2024National AwardEsther A. & Joseph Klingenstein Fundhonor Deeda Blair Research Initiative for Disorders of the Brain Award
07/01/2024National AwardFoundation for the National Institutes of Healthhonor Bridge to Independence
07/01/2022National AwardSimons Foundation Autism Research Initiative (SFARI)DetailsUnited Stateshonor Career Award for Medical Scientists
06/27/2022National AwardBurroughs Wellcome FundDetailsUnited States
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- June 25, 2024Source: FNIH
Pattabiraman receives award from the Deeda Blair Research Initiative for Disorders of the Brain
- October 11, 2023
Yale Child Study Center Community Celebrates Professional Progression
- June 08, 2023
Yale Child Study Center welcomes 2023 summer interns
- April 03, 2023
2023 Trainee Pilot Research Award Recipients Announced
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