Leyuan Xu, PhD
Associate Professor TermCards
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2026
CXCR6+ T cells promote apoptosis and necroptosis in proximal tubules during AKI-to-CKD transition
Li X, Melchinger I, Chen Y, Guo J, Cantley L, Xu L. CXCR6+ T cells promote apoptosis and necroptosis in proximal tubules during AKI-to-CKD transition. Cell Death & Disease 2026, 17: 359. PMID: 41876471, PMCID: PMC13039913, DOI: 10.1038/s41419-026-08644-x.Peer-Reviewed Original ResearchApplying dendrimer nanoprobes to the diagnosis and evaluation of kidney fibrosis
Li X, Xu L. Applying dendrimer nanoprobes to the diagnosis and evaluation of kidney fibrosis. Nanomedicine 2026, 21: 885-898. PMID: 41674334, PMCID: PMC13060051, DOI: 10.1080/17435889.2026.2628240.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsArginase-1 Expressing Macrophages Interact with Myofibroblasts to Regulate Insulin-Like Growth Factor-1-Dependent Tubule Repair
Bharathan B, Frimpong B, Xu L, Cantley L. Arginase-1 Expressing Macrophages Interact with Myofibroblasts to Regulate Insulin-Like Growth Factor-1-Dependent Tubule Repair. Kidney360 2026, 7: 1241-1250. PMID: 41628890, PMCID: PMC13337152, DOI: 10.34067/kid.0000001150.Peer-Reviewed Original Research
2025
Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction
Reghuvaran A, Kumar A, Lin Q, Rajeevan N, Banu K, Sun Z, Shi H, Barsotti G, Tanvir E, Pell J, Perincheri S, Wei C, Bharathan B, Planoutene M, Eichmann A, Mas V, Zhang W, Cantley L, Xu L, Das B, He J, Menon M. Design of precision therapeutics for a CKD risk allele by targeting Shroom3-Rock interaction. Nature Communications 2025, 17: 1086. PMID: 41469391, PMCID: PMC12852734, DOI: 10.1038/s41467-025-67854-7.Peer-Reviewed Original ResearchEngineering polyamidoamine dendrimer nanoparticles for targeted drug delivery to proximal tubular cells after renal ischemia/reperfusion injury
Li X, Cantley L, Xu L. Engineering polyamidoamine dendrimer nanoparticles for targeted drug delivery to proximal tubular cells after renal ischemia/reperfusion injury. Journal Of Controlled Release 2025, 388: 114323. PMID: 41101700, PMCID: PMC12548566, DOI: 10.1016/j.jconrel.2025.114323.Peer-Reviewed Original Research
2024
Adamts1 and Cyst Expansion in Polycystic Kidney Disease
Kakade V, Akman Z, Motrapu M, Cassini M, Xu L, Moeckel G, Somlo S, Cantley L. Adamts1 and Cyst Expansion in Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2024, 36: 559-570. PMID: 39514301, PMCID: PMC11975248, DOI: 10.1681/asn.0000000557.Peer-Reviewed Original ResearchVCAM-1 mediates proximal tubule-immune cell cross talk in failed tubule recovery during AKI-to-CKD transition
Melchinger I, Guo K, Li X, Guo J, Cantley L, Xu L. VCAM-1 mediates proximal tubule-immune cell cross talk in failed tubule recovery during AKI-to-CKD transition. American Journal Of Physiology. Renal Physiology 2024, 327: f610-f622. PMID: 39116349, PMCID: PMC11483080, DOI: 10.1152/ajprenal.00076.2024.Peer-Reviewed Original Research
2023
Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury
Wen Y, Su E, Xu L, Menez S, Moledina DG, Obeid W, Palevsky P, Mansour S, Devarajan P, Cantley L, Cahan P, Parikh C, Project K, Injury T. Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury. Science Translational Medicine 2023, 15: eade7287-eade7287. PMID: 38091407, PMCID: PMC11405121, DOI: 10.1126/scitranslmed.ade7287.Peer-Reviewed Original ResearchmRNA Editing via the Apobec1 Gene Promotes Recovery from AKI
Guo X, Velazquez H, Xu L, Cheng Z, Chen T, Tian Y, Bewersdorf J, Blanc V, Davidson N, Safirstein R, Desir G. mRNA Editing via the Apobec1 Gene Promotes Recovery from AKI. Journal Of The American Society Of Nephrology 2023, 34: 451-451. DOI: 10.1681/asn.20233411s1451b.Peer-Reviewed Original ResearchThe ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events
Menez S, Wen Y, Xu L, Moledina DG, Thiessen-Philbrook H, Hu D, Obeid W, Bhatraju P, Ikizler T, Siew E, Chinchilli V, Garg A, Go A, Liu K, Kaufman J, Kimmel P, Himmelfarb J, Coca S, Cantley L, Parikh C. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events. Kidney International 2023, 104: 1194-1205. PMID: 37652206, PMCID: PMC10840723, DOI: 10.1016/j.kint.2023.08.007.Peer-Reviewed Original Research
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