Robert Safirstein, MD
Professor Emeritus of Medicine (Nephrology)Cards
About
Research
Publications
2026
Tu1823 TWO MOUSE MODELS OF CHRONIC KIDNEY DISEASE INCREASE THE SEVERITY AND DELAY THE RESOLUTION OF CERULEIN-INDUCED ACUTE PANCREATITIS.
Kolodecik T, Shugrue C, Guo X, Desir G, Safirstein R, Gorelick F. Tu1823 TWO MOUSE MODELS OF CHRONIC KIDNEY DISEASE INCREASE THE SEVERITY AND DELAY THE RESOLUTION OF CERULEIN-INDUCED ACUTE PANCREATITIS. Gastrointestinal Endoscopy 2026, 103: s-2279-s-2280. DOI: 10.1016/s0016-5107(26)05328-9.Peer-Reviewed Original ResearchTu1823 TWO MOUSE MODELS OF CHRONIC KIDNEY DISEASE INCREASE THE SEVERITY AND DELAY THE RESOLUTION OF CERULEIN-INDUCED ACUTE PANCREATITIS.
Kolodecik T, Shugrue C, Guo X, Desir G, Safirstein R, Gorelick F. Tu1823 TWO MOUSE MODELS OF CHRONIC KIDNEY DISEASE INCREASE THE SEVERITY AND DELAY THE RESOLUTION OF CERULEIN-INDUCED ACUTE PANCREATITIS. Gastroenterology 2026, 170: s-2279-s-2280. DOI: 10.1016/s0016-5085(26)05397-7.Peer-Reviewed Original Research
2025
Acute kidney injury markers in pediatric pancreatitis: Differentiating disease states and assessing severity
Garlapally V, Guo X, Hornung L, Delgado K, Cruz‐Monserrate Z, Safirstein R, Gorelick F, Desir G, Goldstein S, Abu‐El‐Haija M. Acute kidney injury markers in pediatric pancreatitis: Differentiating disease states and assessing severity. Journal Of Pediatric Gastroenterology And Nutrition 2025, 82: 770-780. PMID: 41384696, PMCID: PMC13185510, DOI: 10.1002/jpn3.70285.Peer-Reviewed Original ResearchAcute kidney injuryChronic pancreatitisAcute pancreatitisMild APUrinary NGALCystatin CEnzyme-linked immunosorbent assayAP patientsKIM-1Kidney functionAcute kidney injury markersPlasma KIM-1AP subjectsKidney injury markersPlasma cystatin CGlomerular filtration rateDifferentiate disease statesModerate/severe APPediatric pancreatitisPediatric APAP severityPediatric patientsPlasma creatinineKidney injuryInjury markersRenalase, HIV viremia, and all-cause mortality in people with and without HIV
Chang J, So-Armah K, Guo X, Kundu S, Safirstein R, Marconi V, Freiberg M, Brown S, Justice A, Desir G. Renalase, HIV viremia, and all-cause mortality in people with and without HIV. AIDS 2025, 39: 1490-1494. PMCID: PMC13089388, DOI: 10.1097/qad.0000000000004195.Peer-Reviewed Original Research
2023
APOBEC-1 deletion enhances cisplatin-induced acute kidney injury
Guo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina DG, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.Peer-Reviewed Original ResearchmRNA Editing via the Apobec1 Gene Promotes Recovery from AKI
Guo X, Velazquez H, Xu L, Cheng Z, Chen T, Tian Y, Bewersdorf J, Blanc V, Davidson N, Safirstein R, Desir G. mRNA Editing via the Apobec1 Gene Promotes Recovery from AKI. Journal Of The American Society Of Nephrology 2023, 34: 451-451. DOI: 10.1681/asn.20233411s1451b.Peer-Reviewed Original ResearchRenalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms
Guo X, Chen R, Chen T, Safirstein R, Jonas E, Desir G. Renalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms. Journal Of The American Society Of Nephrology 2023, 34: 117-117. DOI: 10.1681/asn.20233411s1117b.Peer-Reviewed Original Research
2022
Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI
Guo X, Xu L, Velazquez H, Chen T, Blanc V, Davidson N, Moeckel G, Safirstein R, Desir G. Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI. Journal Of The American Society Of Nephrology 2022, 33: 359-360. DOI: 10.1681/asn.20223311s1359e.Peer-Reviewed Original ResearchRenalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis
Guo X, Chen R, Chen T, Moeckel G, Safirstein R, Jonas E, Desir G. Renalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis. Journal Of The American Society Of Nephrology 2022, 33: 359-359. DOI: 10.1681/asn.20223311s1359d.Peer-Reviewed Original ResearchEarly life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study
Wang Y, Li F, Chu C, Zhang X, Zhang X, Liao Y, Du M, Zou T, Ma Q, Chen C, Wang D, Wang K, Yan Y, Sun Y, Hu G, Jia H, Li H, Niu Z, Yan R, Man Z, Wang L, Luo W, Zhang J, Li C, Lu W, Chang J, Safirstein R, Lu Y, Mu J. Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study. EClinicalMedicine 2022, 48: 101420. PMID: 35516445, PMCID: PMC9065297, DOI: 10.1016/j.eclinm.2022.101420.Peer-Reviewed Original ResearchBody mass indexDistinct BMI trajectoriesFirst Affiliated HospitalBMI trajectoriesOdds ratioXi'an Jiaotong UniversityAffiliated HospitalCardiovascular diseaseBody mass index (BMI) trajectoriesClinical Research AwardHigher BMI trajectoriesProspective cohort studySystolic blood pressureRisk of albuminuriaUnadjusted odds ratioNon-communicable disease preventionHigher UACRCohort studyBlood pressureCreatinine ratioRenal diseaseUrinary albuminVascular dysfunctionBMI groupsStudy cohort