Xiaojia (Sasha) Guo, PhD
Research Scientist (Nephrology)DownloadHi-Res Photo
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Nephrology
Primary
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About
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Research Scientist (Nephrology)
Appointments
Nephrology
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral fellow
- Weill Medical College of Cornell Univ (2000)
- PhD
- Rutgers University, Cell and Developmental Biology (1994)
- MSc
- University of Western Ontario, Biochemistry (1990)
- BA
- Jiangxi University, Microbilogy (1982)
Research
Overview
We have shown that ESDN down-regulation by RNA interference significantly enhanced PDGF-induced VSMC DNA synthesis and migration. This was associated with increased ERK1/2, Src, and PDGF receptor (PDGFR) phosphorylation, without altering total PDGFR expression levels. In binding assays, ESDN down-regulation significantly increased 125I-PDGF maximum binding (Bmax) to PDGF receptors on VSMCs without altering the binding constant (Kd), raising the possibility that ESDN regulates PDGFR processing. ESDN down-regulation significantly reduced ligand-induced PDGFR ubiquitination. This was associated with a significant reduction in the expression level of c-Cbl, an E3 ubiquitin ligase that ubiquitinylates PDGFR. Thus, ESDN modulates PDGF signaling in VSMCs via regulation ofPDGFRsurface levels. The ESDN effect is mediated, at least in part, through effects on PDGFR ubiquitination.
Continued detailed analyses of the involvement of ESDN in the regulation of RTK-driven pathologies is thus predicted to pave the way for therapeutic strategy for vascular diseases and other diseases involving RTK-driven tissue remodeling.
Continued detailed analyses of the involvement of ESDN in the regulation of RTK-driven pathologies is thus predicted to pave the way for therapeutic strategy for vascular diseases and other diseases involving RTK-driven tissue remodeling.
Medical Subject Headings (MeSH)
Nephrology; Vascular Remodeling
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xiaojia (Sasha) Guo's published research.
Publications Timeline
A big-picture view of Xiaojia (Sasha) Guo's research output by year.
Gary DĂ©sir, MD
Robert Safirstein, MD
Tian-Min Chen
Fred Sanford Gorelick, MD
Gilbert Moeckel, MD, PhD, FASN
Mehran M Sadeghi, MD
26Publications
199Citations
Publications
2024
Renalase peptides reduce pancreatitis severity in mice
Kolodecik T, Guo X, Shugrue C, Guo X, Desir G, Wen L, Gorelick F. Renalase peptides reduce pancreatitis severity in mice. AJP Gastrointestinal And Liver Physiology 2024, 327: g466-g480. PMID: 39010833, DOI: 10.1152/ajpgi.00143.2024.Peer-Reviewed Original ResearchConceptsAcute pancreatitisRecombinant renalaseProsurvival propertiesSeverity of acute pancreatitisModel of acute pancreatitisAcute inflammatory injuryClinically relevant modelAnti-inflammatoryHistological tissue injuryPost-ERCPCerulein modelCerulein-inducedInitial dosePancreatitis severityPreclinical modelsImmunohistochemical markersQuantify inflammationInflammatory changesMale micePancreatitisMacrophage populationsTissue injuryCerulein pancreatitisTherapeutic effectRenalaseRenalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19
Safdar B, Sobiesk M, Bertsimas D, Nowroozpoor A, Deng Y, D’Onofrio G, Dziura J, El-Khoury J, Guo X, Simonov M, Taylor R, Wang M, Desir G. Renalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19. Journal Of Biotechnology And Biomedicine 2024, 07 DOI: 10.26502/jbb.2642-91280139.Peer-Reviewed Original ResearchConcepts
2023
Clinical predictive value of renalase in post-ERCP pancreatitis
Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Clinical predictive value of renalase in post-ERCP pancreatitis. Gastrointestinal Endoscopy 2023, 99: 822-825.e1. PMID: 38103747, DOI: 10.1016/j.gie.2023.12.020.Peer-Reviewed Original ResearchAltmetricConceptsPost-ERCP pancreatitisRenalase levelsPlasma renalase levelsProspective cohort studyPotential clinical roleAcute experimental pancreatitisLongitudinal regression modelsPEP patientsPlasma renalaseCohort studyTertiary hospitalClinical roleExperimental pancreatitisRenalaseAbstractTextERCPPancreatitisFurther studiesAIMSRegression modelsAPOBEC-1 deletion enhances cisplatin-induced acute kidney injury
Guo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.Peer-Reviewed Original ResearchCitationsAltmetricmRNA Editing via the Apobec1 Gene Promotes Recovery from AKI
Guo X, Velazquez H, Xu L, Cheng Z, Chen T, Tian Y, Bewersdorf J, Blanc V, Davidson N, Safirstein R, Desir G. mRNA Editing via the Apobec1 Gene Promotes Recovery from AKI. Journal Of The American Society Of Nephrology 2023, 34: 451-451. DOI: 10.1681/asn.20233411s1451b.Peer-Reviewed Original ResearchRenalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms
Guo X, Chen R, Chen T, Safirstein R, Jonas E, Desir G. Renalase Ameliorates AKI by Altering Mitochondrial Function to Induce Cellular Repair Mechanisms. Journal Of The American Society Of Nephrology 2023, 34: 117-117. DOI: 10.1681/asn.20233411s1117b.Peer-Reviewed Original ResearchSa1408 PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITIS
Muniraj T, Desir G, Gorelick F, Guo X, Ciarleglio M, Deng Y, Jamidar P, Farrell J, Aslanian H, Laine L. Sa1408 PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITIS. Gastroenterology 2023, 164: s-384-s-385. DOI: 10.1016/s0016-5085(23)01894-2.Peer-Reviewed Original ResearchPlasma renalase levels are associated with the development of acute pancreatitis
Wang M, Weiss F, Guo X, Kolodecik T, Bewersdorf J, Laine L, Lerch M, Desir G, Gorelick F. Plasma renalase levels are associated with the development of acute pancreatitis. Pancreatology 2023, 23: 158-162. PMID: 36697349, DOI: 10.1016/j.pan.2023.01.001.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAcute pancreatitisSevere diseasePlasma renalase levelsAcute pancreatitis patientsSevere acute pancreatitisAcute pancreatitis modelPlasma renalaseRenalase levelsSignificant morbidityPancreatitis patientsPlasma levelsHealthy controlsPancreatitis modelPancreatitisPatientsPlasma samplesRenalaseDiseaseNonparametric statistical analysisSecretory proteinsMorbidityStatistical analysisMortalityLevels
2022
Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI
Guo X, Xu L, Velazquez H, Chen T, Blanc V, Davidson N, Moeckel G, Safirstein R, Desir G. Apobec-1 Limits Cisplatin and Ischemia-Reperfusion-Induced AKI. Journal Of The American Society Of Nephrology 2022, 33: 359-360. DOI: 10.1681/asn.20223311s1359e.Peer-Reviewed Original ResearchRenalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis
Guo X, Chen R, Chen T, Moeckel G, Safirstein R, Jonas E, Desir G. Renalase Protects Renal Injury by Maintaining Mitochondrial Dynamic Homeostasis. Journal Of The American Society Of Nephrology 2022, 33: 359-359. DOI: 10.1681/asn.20223311s1359d.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity West Haven VA Medical Center
Peer Review Groups and Grant Study SectionsCommittee MemberDetailsBiosafety Subcommittee member2011 - 2022activity Utility of Renalase as a Novel Biomarker to Stratify Pancreatic Adenocarcinoma Candidates for Surgery
Poster PresentationUtility of Renalase as a Novel Biomarker to Stratify Pancreatic Adenocarcinoma Candidates for SurgeryDetails01/01/2021 - Present51st Annual Meeting of the American Pancreatic AssociationSponsored by American Pancreatic Associationactivity Heightened Innate Immune Response to COVID-19 Infection in CKD: Implications to Poorer Outcome During CKD.
Poster PresentationHeightened Innate Immune Response to COVID-19 Infection in CKD: Implications to Poorer Outcome During CKD.Details01/01/2021 - PresentASN annual conference Kidney Week 2021Sponsored by American Society of Nephrologyactivity mRNA editing via Apobec-1 limits regulated necrosis from cisplatin (CP)-induced Acute Kidney Injury (AKI) by regulating the disposal of pro-ferroptotic triglycerides
Poster PresentationmRNA editing via Apobec-1 limits regulated necrosis from cisplatin (CP)-induced Acute Kidney Injury (AKI) by regulating the disposal of pro-ferroptotic triglyceridesDetails01/01/2020 - PresentKidney Week, 2020 Annual Meeting of American Society of NephrologySponsored by American Society of Nephrologyactivity A Renalase Peptide Encapsulated in Renal-selective Mesoscale Nanoparticle Protected Cisplatin-induced Chronic Kidney Disease
Poster PresentationA Renalase Peptide Encapsulated in Renal-selective Mesoscale Nanoparticle Protected Cisplatin-induced Chronic Kidney DiseaseDetails01/01/2020 - PresentKidney Week, 2020 Annual Meeting of American Society of NephrologySponsored by American Society of Nephrology
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