Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsDana Small, PhD
Professor Adjunct of PsychiatryAbout
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Titles
Professor Adjunct of Psychiatry
Director, Modern Diet and Physiology Research Center
Biography
I am a psychologist and neuroscientist with graduate degrees in Neuroscience and Clinical Psychology from McGill University. My research focuses on understanding how sensory, metabolic and neural signals are integrated to determine food choices and on how the dysregulation of these systems contribute to the development of obesity, diabetes and cognitive impairment. My group primarily uses neuroimaging, neuropsychological and metabolic methodologies in humans; however, we also have collaborations with a number of basic research labs at Yale and abroad where we use a revere translational approach to pursue mechanistic questions in rodent models that arise from findings in humans. My laboratory generally consists of 1-2 phd students; 3-4 post-docs; a research associate professor and a handful of international interns and Yale undergraduates. I have trained 5 PhD students, 12 post-doctoral fellows and over 40 undergraduates and medical students. The lab has been continuously funded by the National Institutes of Health since 2003.
In addition to my activities at Yale, I am also involved in a number of initiatives related to advancing knowledge and treatment of diabetes and obesity. I am co-leading a National Institutes of Health workgroup developing a neuropsychological battery for use in obesity and diabetes trials and chairing the annual meeting for the Society for the Study of Ingestive Behavior. I am executive editor at Appetite and Biological Psychiatry and a member of the National Academy of Sciences Board on Behavior, Cognitive and Sensory Sciences.
Appointments
Psychiatry
Professor AdjunctPrimary
Other Departments & Organizations
- Center for Nicotine and Tobacco Use Research at Yale (CENTURY)
- Connecticut Mental Health Center
- Diabetes Research Center
- MR Core
- Obesity Research Working Group
- Psychiatry
- Small Lab
- Stress & Addiction Clinical Research Program
- Yale Stress Center
- Yale Tobacco Center of Regulatory Science
- Yale Ventures
Education & Training
- PhD
- McGill University (2001)
- MSc
- McGill University (1998)
Research
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Overview
- The role of central insulin sensitivity on cognition in prediabetes
- Central coding of taste and flavor.
- Physiological mechanisms underlying food choice and ingestive behavior
- The impact of diet, adiposity and metabolic dysfunction on brain structure and function, including mood, cognition and addiction.
- Targeting the gut-brain axis for weight-loss maintenance
- Determining the role of the gut-brain axis in alcohol dependence
- Understanding the mechanisms underlying dopamine adaptations in response to diet, adiposity and metabolic dysfunction.
Medical Research Interests
ORCID
0000-0001-7363-1100
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Anna Christina Nobre
Fangyong Li, MS, MPH
Kathryn M Wall, MS, MA
Todd Constable, PhD
Akiko Iwasaki, PhD
Albert Ko, MD
Obesity
Dopamine
Motivation
Neuroimaging
Energy Metabolism
Psychophysics
Publications
2025
The interoceptive origin of reinforcement learning
Weber L, Yee D, Small D, Petzschner F. The interoceptive origin of reinforcement learning. Trends In Cognitive Sciences 2025, 29: 840-854. PMID: 40500611, PMCID: PMC12400946, DOI: 10.1016/j.tics.2025.05.008.Peer-Reviewed Original ResearchCitationsAltmetricBeyond hedonic eating
Small D. Beyond hedonic eating. Science 2025, 387: 1353-1354. PMID: 40146849, DOI: 10.1126/science.adw3646.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Sniffing out meaning: Chemosensory and semantic neural network changes in sommeliers
Carreiras M, Quiñones I, Chen H, Vázquez‐Araujo L, Small D, Frost R. Sniffing out meaning: Chemosensory and semantic neural network changes in sommeliers. Human Brain Mapping 2024, 45: e26564. PMID: 38339911, PMCID: PMC10823763, DOI: 10.1002/hbm.26564.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNeural circuitsFractional anisotropyRight superior longitudinal fasciculusSuperior longitudinal fasciculusRelevant sensory inputNeural network changesBrain responsesSemantic narrativesSemantic knowledgeMediation analysisPerceptual informationOlfactory circuitsLongitudinal fasciculusSensory processingChemosensory processingSensory neural circuitsVerbal descriptionsSemantic networkWine complexitySensory inputSemantic operationsWine tastingWine consumersTasting wineWine
2022
Olfactory decoding is positively associated with ad libitum food intake in sated humans
Perszyk EE, Davis XS, Small DM. Olfactory decoding is positively associated with ad libitum food intake in sated humans. Appetite 2022, 180: 106351. PMID: 36270421, DOI: 10.1016/j.appet.2022.106351.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAd libitum food intakeBody weight regulationFood intakeWeight regulationLong-term body weight regulationHealthy human adultsFunctional magnetic resonancePiriform cortexSatiety stateUnivariate analysisBody weightMeal consumptionPrevious functional magnetic resonanceNonfood odorsWeight changeBrain activationIntakeHuman adultsMulti-voxel pattern analysisHungry stateRole of olfactionOlfactory codingNeural patternsMagnetic resonanceAmygdalaFunctional Connectivity of the Nucleus Accumbens and Changes in Appetite in Patients With Depression
Kroemer NB, Opel N, Teckentrup V, Li M, Grotegerd D, Meinert S, Lemke H, Kircher T, Nenadić I, Krug A, Jansen A, Sommer J, Steinsträter O, Small DM, Dannlowski U, Walter M. Functional Connectivity of the Nucleus Accumbens and Changes in Appetite in Patients With Depression. JAMA Psychiatry 2022, 79: 993-1003. PMID: 36001327, PMCID: PMC9403857, DOI: 10.1001/jamapsychiatry.2022.2464.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMajor depressive disorderNAcc functional connectivityFunctional connectivityBody weightNucleus accumbensTreatment of MDDResting-state functional connectivityCase-control studySymptom-specific associationsHealthy control participantsIdentification of biomarkersClassification of diagnosesCohort studyMost patientsMean ageDepressive episodeDepressive disorderReduced appetiteMagnetic resonance imaging dataMAIN OUTCOMESubstantial burdenDepressive symptomsPatientsVentromedial prefrontal cortexReward circuitDietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial
Fang X, Davis X, Flack KD, Duncan C, Li F, White M, Grilo C, Small DM. Dietary adaptation for weight loss maintenance at Yale (DAWLY): Protocol and predictions for a randomized controlled trial. Frontiers In Nutrition 2022, 9: 940064. PMID: 35967820, PMCID: PMC9369668, DOI: 10.3389/fnut.2022.940064.Peer-Reviewed Original ResearchConceptsWeight loss maintenanceHigh-fat dietWeight loss treatmentLoss maintenanceWeight lossLoss treatmentStandard behavioral weight loss treatmentShort-term weight lossBehavioral weight loss interventionBehavioral weight loss treatmentGut-brain pathwaysPlacebo-controlled trialGut-brain axisVagal afferent pathwaysGut-brain signalingDietary fat intakeOverweight/obesityWeight loss interventionPrecision medicine approachEnergy-dense foodsLoss interventionFat intakeAfferent pathwaysHabitual intakeMetabolic healthChronic pain precedes disrupted eating behavior in low-back pain patients
Lin Y, De Araujo I, Stanley G, Small D, Geha P. Chronic pain precedes disrupted eating behavior in low-back pain patients. PLOS ONE 2022, 17: e0263527. PMID: 35143525, PMCID: PMC8830732, DOI: 10.1371/journal.pone.0263527.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLow back pain patientsChronic low back pain patientsFat-rich foodsPain patientsChronic painCLBP patientsSBP patientsNucleus accumbensBack pain patientsChronic pain patientsHealthy control subjectsNucleus accumbens volumePain chronificationFat ingestionHedonic feedingPatient populationAccumbens volumeControl subjectsLimbic brainPainEarly coursePatientsBehavioral alterationsHedonic perceptionNeurological standpointCorrection to: Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting
Laughlin M, Cooke B, Boutelle K, Savage CR, Kravitz A, Small D, Arvanitakis Z, Martin A, Stoeckel LE. Correction to: Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting. International Journal Of Obesity 2022, 46: 889-889. PMID: 35046495, PMCID: PMC8960406, DOI: 10.1038/s41366-022-01074-7.Peer-Reviewed Original Research
2021
Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting
Laughlin M, Cooke B, Boutelle K, Savage CR, Kravitz A, Small D, Arvanitakis Z, Martin A, Stoeckel LE. Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting. International Journal Of Obesity 2021, 46: 718-725. PMID: 34934178, PMCID: PMC8960390, DOI: 10.1038/s41366-021-01025-8.Peer-Reviewed Original ResearchCitationsAltmetricDietary lipids as regulators of reward processes: multimodal integration matters
Berland C, Small DM, Luquet S, Gangarossa G. Dietary lipids as regulators of reward processes: multimodal integration matters. Trends In Endocrinology And Metabolism 2021, 32: 693-705. PMID: 34148784, DOI: 10.1016/j.tem.2021.05.008.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDietary lipidsFunctional modulatorsModern food environmentLipid sensingPalatable dietObesity pandemicDopamine transmissionDA circuitsFeeding behaviorBody homeostasisDA signalingReward circuitRecent findingsDA systemEnergy-related signalsGenetic conditionsFood environmentFood overconsumptionNeural substratesLipidsRecent reportsSignalingRegulatorHomeostasisReward processes
Academic Achievements & Community Involvement
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Activities
activity Frontiers in Neuroscience
2009 - PresentPeer Review Groups and Grant Study SectionsReviewerDetailsEditorialactivity The Association for Chemoreception Sciences
06/01/2008 - PresentCommitteesSecretaryDetailsExecutive Committeeactivity European Journal of Neuroscience
06/01/2008 - PresentPeer Review Groups and Grant Study SectionsEditorDetailsEditorialactivity Chemosensory Perception
02/01/2007 - PresentPeer Review Groups and Grant Study SectionsEditorDetailsEditorialactivity The Obesity Society
06/01/2009 - PresentPeer Review Groups and Grant Study SectionsReviewerDetailsStudy Section
Honors
honor Alan Epstein Award for a seminal research contribution to the field of ingestive behavior. Awarded by the Society for the Study of Ingestive Behavior
07/28/2015International AwardSociety for the Study of Ingestive BehaviorDetailsUnited Stateshonor Appointed to the National Academy of Sciences Board on Behavioral, Cognitive and Sensory Sciences (BBCSS)
01/01/2015National AwardNational Academy of SciencesDetailsUnited Stateshonor Ruth Pike Award for contributions to nutrition research
03/11/2010National AwardPenn State UniversityDetailsUnited Stateshonor Firmenich Young Investigator Award for Research in Fragrance and Flavors,
10/01/2007International AwardFirmenichDetailsUnited Stateshonor Invitee 18th Annual Kavli Frontiers of Science Symposium for Young Investigators
01/01/2006International AwardNational Academy of SciencesDetailsUnited States
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