Anna Christina Nobre
Wu Tsai Professor of PsychologyCards
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2026
Feature-temporal predictions dynamically modulate performance, feature-based attentional capture, and motor response activity during visual search
Williams G, Nobre A, Boettcher S. Feature-temporal predictions dynamically modulate performance, feature-based attentional capture, and motor response activity during visual search. Visual Cognition 2026, ahead-of-print: 1-18. DOI: 10.1080/13506285.2026.2645176.Peer-Reviewed Original ResearchMEG Evidence of Concurrent Bilateral and Hemisphere‐Specific Developmental Patterns in Auditory Cortex
Parviainen T, Heikkinen P, Hänninen A, Nobre A. MEG Evidence of Concurrent Bilateral and Hemisphere‐Specific Developmental Patterns in Auditory Cortex. Developmental Science 2026, 29: e70146. PMID: 41814452, PMCID: PMC12979710, DOI: 10.1111/desc.70146.Peer-Reviewed Original ResearchConceptsLeft hemisphereAge-related differencesLanguage inputHemispheric differencesPerceptual learningResponses to tonesLate childhoodAutomatic processingSensory cortexPeriod of developmentAuditory stimuliTime courseSensitive periodCortexAuditory cortexMagnetoencephalographyInverted U-curveDevelopmental patternsCortical auditory responsesHemisphereCortical currentsChildrenN100m.AdultsAuditory responsesNeural Signatures of Flexible Temporal Orienting under Spatial and Motor Uncertainty.
Gao Y, Echeverria-Altuna I, Boettcher S, Nobre A. Neural Signatures of Flexible Temporal Orienting under Spatial and Motor Uncertainty. Journal Of Cognitive Neuroscience 2026, 1-14. PMID: 41790124, DOI: 10.1162/jocn.a.2585.Peer-Reviewed Original ResearchStages of stimulus processingNeural signaturesStimulus processingTemporal orientationTemporal expectationsTemporal predictionTemporal orienting of attentionOrienting of attentionContingent negative variationNeural mechanismsMotor preparationVisual streamMotor predictionNegative variationTarget relevanceColor targetTemporal attentionP300MotorParticipantsPrediction of targetsN2pc
2025
Alzheimer's disease and its severity reduce MEG responses to unexpected auditory stimuli
Krugliak A, van Es M, Perquin M, Shen C, Fye H, Alcock C, Lanskey J, Karadag M, Kocagoncu E, Williams R, Quinn A, Pitt J, Thayanandan T, Lowe S, Raymont V, Singh K, Woolrich M, Nobre A, Rowe J. Alzheimer's disease and its severity reduce MEG responses to unexpected auditory stimuli. Alzheimer's & Dementia 2025, 21: e102668. PMCID: PMC12742538, DOI: 10.1002/alz70856_102668.Peer-Reviewed Original ResearchAssociative learningMild cognitive impairmentAudio-visual oddball taskBaseline assessmentAlzheimer's diseaseConsistent with deficitsMedial temporal lobeHealthy older controlsResponse to unexpected stimuliAmyloid-positive mild cognitive impairmentCognitive deficitsOddball taskNeural responsesNovel soundsEarly phase clinical trialsTemporal lobeAuditory noveltyBrain functionSensor-level analysesCognitive impairmentEntorhinal cortexOlder controlsPhase clinical trialsAuditory stimuliStandard trialsDivergence of cortical neurophysiology across different neurodegenerative disorders compared to healthy ageing
Trubshaw M, Kohl O, Gohil C, van Es M, Quinn A, Yoganathan K, Edmond E, Proudfoot M, Zokaei N, Raymont V, Pitt J, Thayanandan T, Thompson A, Talbot K, Hu M, Perquin M, Kocagoncu E, Rowe J, Woolrich M, Nobre A, Turner M. Divergence of cortical neurophysiology across different neurodegenerative disorders compared to healthy ageing. Progress In Neurobiology 2025, 257: 102865. PMID: 41349953, PMCID: PMC7618949, DOI: 10.1016/j.pneurobio.2025.102865.Peer-Reviewed Original ResearchPower spectrum slopeSpectrum slopeBrain network communicationBeta powerMagnetic fieldHealthy agingEmergence of symptomsSlowing of oscillatory activityPatterns of activityCortical neuronal activityGamma connectivityAging trajectoriesNeuronal activityOscillatory activityNeurodegenerative disordersMagnetoencephalographyCortical neurophysiologyHealthy controlsStages of neurodegenerationMEG recordingsPresymptomatic stageParkinson's diseaseAlzheimer's diseaseDisordersSource of biomarkersImplicit learning across varying temporal scales in individuals with and without mood instability
Atkinson L, Zokaei N, Panchal P, Nelissen N, Saunders K, Rushworth M, Darby D, Geddes J, Harmer C, Harrison P, Nobre A. Implicit learning across varying temporal scales in individuals with and without mood instability. Journal Of Affective Disorders 2025, 395: 120728. PMID: 41260366, PMCID: PMC7618815, DOI: 10.1016/j.jad.2025.120728.Peer-Reviewed Original ResearchConceptsMood Disorder QuestionnaireMood instabilityImplicit learningBipolar disorderContextual cuesExperimental sessionsMood disorder questionnaire scoresContextual cueing taskAssociated with greater instabilityLearning of regularitiesGroups of participantsCueing taskMood ratingsLearning slopePsychiatric disordersBetween-subjects experimental studyStimulus regularitiesMDQ scoreMoodCognitive impairmentCognitionCuesParticipantsDisordersAlternate daysAlzheimer's disease and its progression reduce pyramidal cell gain and connectivity
Lanskey J, Jafarian A, Karadag M, Kocagoncu E, Williams R, Yadav P, Quinn A, Pitt J, Thayanandan T, Lowe S, Perkinton M, Timmers M, Raymont V, Singh K, Woolrich M, Nobre A, Henson R, Rowe J. Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity. Alzheimer's & Dementia 2025, 21: e70805. PMID: 41137705, PMCID: PMC12553034, DOI: 10.1002/alz.70805.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseIn vivo assaysTest-retest reliabilitySensitive to Alzheimer's diseaseHuman diseasesAD mechanismsNeurophysiological deficitsCell gainDisease mechanismsLoss of neuronsMismatch negativity amplitudeCell functionExperimental medicine studiesDynamic causal modelingMismatch negativity paradigmPyramidal cellsEmpirical Bayes analysisMismatch negativity responseEvoked responsesIntervention studiesAlzheimerSymptomatic ADPotential biomarkersCognitive declineHealthy adultsDisambiguating dimensions of external and internal brain processes
van Ede F, Gresch D, Nobre A. Disambiguating dimensions of external and internal brain processes. Trends In Neurosciences 2025, 49: 5-7. PMID: 41111012, DOI: 10.1016/j.tins.2025.10.001.Peer-Reviewed Original ResearchDivergent Brain Network Activity in Asymptomatic C9orf72 and SOD1 Variant Carriers Compared With Established Amyotrophic Lateral Sclerosis
Trubshaw M, Gohil C, Edmond E, Proudfoot M, Yoganathan K, Wuu J, Northall A, Kohl O, Stagg C, Nobre A, Talbot K, Thompson A, Benatar M, Woolrich M, Turner M. Divergent Brain Network Activity in Asymptomatic C9orf72 and SOD1 Variant Carriers Compared With Established Amyotrophic Lateral Sclerosis. Human Brain Mapping 2025, 46: e70345. PMID: 41042072, PMCID: PMC12492477, DOI: 10.1002/hbm.70345.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisAt-risk populationsGenetically at-risk groupSymptomatic amyotrophic lateral sclerosisAsymptomatic gene carriersSOD1-amyotrophic lateral sclerosisResting-state MEG recordingsPreventive therapeutic interventionsLateral sclerosisC9orf72 amyotrophic lateral sclerosisPathogenic variantsTherapy efficacyVariant carriersHealthy controlsChronic adaptive changesFrontal oscillatory activityHigh riskAt-risk groupsGene carriersOscillatory activityTherapeutic interventionsCortical pathologyBeta frequency powerNeurodevelopmental factorsC9orf72 carriersConfidence and Insight into Working Memory Are Shaped by Attention and Recent Performance
Chekroud S, Nobre A, Kolling N. Confidence and Insight into Working Memory Are Shaped by Attention and Recent Performance. Journal Of Cognitive Neuroscience 2025, 37: 1685-1702. PMID: 40136267, PMCID: PMC7617916, DOI: 10.1162/jocn_a_02326.Peer-Reviewed Original ResearchInternally directed attentionWorking memoryConfidence judgmentsIntrospective judgmentsMemory performanceAccuracy of confidence judgmentsMemory contentWorking-memory maintenanceWorking memory contentsObjective memory performanceWorking-memory contentsRetrospective cuesProbe itemMemory qualityMemory errorsAlpha desynchronizationIntrospective insightsMemoryJudgmentItemsParticipantsRetrocueCuesAttentionSequential process
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