Dustin Scheinost, PhD, BS
Associate Professor of Radiology and Biomedical ImagingCards
About
Research
Publications
Featured Publications
Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences
Rodriguez R, Noble S, Camp C, Scheinost D. Connectome caricatures remove large-amplitude coactivation patterns in resting-state fMRI to emphasize individual differences. Nature Neuroscience 2025, 28: 2601-2611. PMID: 41184631, PMCID: PMC12641774, DOI: 10.1038/s41593-025-02099-7.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingResting-state functional magnetic resonance imagingResting-state dataCoactivation patternsFunctional connectivityResting-state signalsBrain's intrinsic functional architectureResting-state functional connectivityIntrinsic functional architectureTask activation patternsTask fMRI dataHigh identifiersFMRI dataLarge-scale neuroimaging datasetsConnectomeFunctional architectureNeuroimaging datasetsActivity patternsTask dataMagnetic resonance imagingTaskResonance imagingPhenotypic measurementsConnectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors
Ben-Zion Z, Simon A, Rosenblatt M, Korem N, Duek O, Liberzon I, Shalev A, Hendler T, Levy I, Harpaz-Rotem I, Scheinost D. Connectome-Based Predictive Modeling of PTSD Development Among Recent Trauma Survivors. JAMA Network Open 2025, 8: e250331. PMID: 40063028, PMCID: PMC11894499, DOI: 10.1001/jamanetworkopen.2025.0331.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingPosttraumatic stress disorderClinician-Administered PTSD Scale for DSM-5Months post-traumaFunctional magnetic resonance imagingTrauma survivorsDSM-5Post-traumaPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptom severityPosttraumatic stress disorder symptom trajectoriesPosttraumatic stress disorder severityTask-based fMRI dataAnterior default modePredictive of symptomsFollow-up assessmentDevelopment of effective personalized treatmentsComprehensive clinical assessmentClinician-AdministeredNeurobiological indicesPosttraumatic psychopathologyHyperarousal symptomsCentral executiveTrauma exposureSalience networkBrain age prediction and deviations from normative trajectories in the neonatal connectome
Sun H, Mehta S, Khaitova M, Cheng B, Hao X, Spann M, Scheinost D. Brain age prediction and deviations from normative trajectories in the neonatal connectome. Nature Communications 2024, 15: 10251. PMID: 39592647, PMCID: PMC11599754, DOI: 10.1038/s41467-024-54657-5.Peer-Reviewed Original ResearchConceptsPostmenstrual agePerinatal periodBrain age predictionFunctional connectomeMonths of postnatal lifeMonths of lifePreterm infantsNormative trajectoryConnectome-based predictive modelingThird trimesterPerinatal exposureBrain age gapPostnatal lifeResting-state fMRIInfantsHuman Connectome ProjectNeonatal connectomeDevelopmental trajectoriesBrainBehavioral outcomesNormative dataMonthsConnectome ProjectDTI dataConnectomeThe tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research
Noble S, Curtiss J, Pessoa L, Scheinost D. The tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research. Imaging Neuroscience 2024, 2: imag-2-00138. PMID: 40740614, PMCID: PMC12247580, DOI: 10.1162/imag_a_00138.Peer-Reviewed Original Research
2025
Associations of Prenatal Social Support in Adolescent Mothers With Measures of Social‐Emotional Development in Their Young Children
Holland C, Sun H, Rodriguez R, Bennett M, Cheng B, Peterson B, Scheinost D, Spann M. Associations of Prenatal Social Support in Adolescent Mothers With Measures of Social‐Emotional Development in Their Young Children. Brain And Behavior 2025, 15: e71059. PMID: 41250941, PMCID: PMC12623451, DOI: 10.1002/brb3.71059.Peer-Reviewed Original ResearchConceptsLanguage developmentMaternal sensitivityMaternal social supportSocial-emotional developmentSocial supportChild attachmentSocial behaviorLanguage development of infantsSocial brain networkInfant language developmentPath analysisSocial support satisfactionBrain network connectivityInfant social developmentPrenatal social supportExploratory path analysisAssociated with attachmentMaternal-infant interactionInfant languageMonths of ageBrain networksFunctional connectivityInfant factorsSupport satisfactionBrain connectivityBrainEffeX: A web app for exploring fMRI effect sizes
Shearer H, Rosenblatt M, Ye J, Jiang R, Tejavibulya L, Foster M, Liang Q, Dadashkarimi J, Westwater M, Cahill C, Cheng I, Fischbach A, Humphries A, Rolison M, Peterson H, Adkinson B, Mehta S, Camp C, Nichols T, Curtiss J, Scheinost D, Noble S. BrainEffeX: A web app for exploring fMRI effect sizes. Aperture Neuro 2025, 5 DOI: 10.52294/001c.146251.Peer-Reviewed Original ResearchShared and Unique Connectivity Signatures of Reading and Language Deficits.
Daucourt M, Rosenblatt M, Frijters J, Bosson-Heenan J, Gruen J, Scheinost D. Shared and Unique Connectivity Signatures of Reading and Language Deficits. Journal Of Cognitive Neuroscience 2025, 1-24. PMID: 40991681, DOI: 10.1162/jocn.a.98.Peer-Reviewed Original ResearchConnectome-based predictive modelingLanguage comprehensionTests of word readingPsychometric testsCPM modelsLarge-scale functional connectivity patternsLanguage comprehension difficultiesBrain-behavior relationshipsMultiple cognitive skillsCognitive Development StudyAssociated with readingFunctional connectivity dataFunctional connectivity patternsFunctional connectivity measuresBrain basisWord readingAdolescent brainLanguage deficitsFrontal networkComprehension difficultiesLanguage abilityLanguage difficultiesConnectivity signaturesReading abilityNeuroimaging dataFunctional Connectivity in the Social Perception Pathway at Birth Is Linked to Attention to Faces at Four Months
Chawarska K, Vernetti A, Sun H, Hampson M, Li C, Macari S, Powell K, Constable R, Chang J, Ment L, Scheinost D. Functional Connectivity in the Social Perception Pathway at Birth Is Linked to Attention to Faces at Four Months. Biological Psychiatry Global Open Science 2025, 5: 100597. PMID: 41127567, PMCID: PMC12538059, DOI: 10.1016/j.bpsgos.2025.100597.Peer-Reviewed Original ResearchIntrinsic functional connectivityFunctional connectivityNeural markersFamily history of autismSuperior temporal sulcusAssociated with attentionStatic facial featuresHistory of autismNo sex differencesSocial pathwaysHuman Connectome ProjectFusiform gyrusFacial cuesTemporal sulcusVentral pathwayFamilial riskSex differencesPerception pathwaysAutismConnectome ProjectSocial outcomesFamily historyFacial featuresAutism biomarkersWeeks postmenstrual ageSocial and behavioral correlates of sleep health among adults receiving medication treatment for opioid use disorder
Sadler L, Jeon S, Ibrahim A, Barry D, Nwananji-Enwerem U, Scheinost D, Yaggi H, Redeker N. Social and behavioral correlates of sleep health among adults receiving medication treatment for opioid use disorder. Addiction Research & Theory 2025, ahead-of-print: 1-14. PMID: 40822529, PMCID: PMC12356222, DOI: 10.1080/16066359.2025.2530997.Peer-Reviewed Original ResearchSelf-report measuresOpioid use disorderUse disorderBehavioral correlatesSleep profilesSleep healthAdverse life experiencesPerceptions of community supportPoor sleep healthAddictive behaviorsAddictive useFamily functioningPsychological healthDysfunctional familiesPoor quality of lifeSocial interactionHealth profileSleep timeLife experiencesHealthy sleepAddictionDisordersSleepOpioidDaytime sleepinessNeural Mechanisms of Feedback Processing and Regulation Recalibration During Neurofeedback Training
Pamplona G, Zweerings J, Lor C, deErney L, Roecher E, Taebi A, Hellrung L, Amano K, Scheinost D, Krause F, Rosenberg M, Ionta S, Brem S, Hermans E, Mathiak K, Scharnowski F. Neural Mechanisms of Feedback Processing and Regulation Recalibration During Neurofeedback Training. Human Brain Mapping 2025, 46: e70279. PMID: 40626604, PMCID: PMC12235576, DOI: 10.1002/hbm.70279.Peer-Reviewed Original ResearchConceptsNeural mechanismsBrain activityReward systemNeural mechanisms of feedback processingNeurofeedback trainingSelf-regulation of brain activityMechanisms of feedback processingFeedback-driven learningPerformance-related feedbackDefault mode networkDorsal attention networkFeedback processesHigher-level processesLinear model analysisSalience networkMode networkNeurofeedback learningBrain regionsNeurofeedback studiesGeneral linear model analysisMega-AnalysisBrain trainingSelf-RegulationRe-analyze dataNeurofeedback
Clinical Trials
Current Trials
Connectivity While Coming of Age
HIC ID2000028368RoleSub InvestigatorPrimary Completion Date12/31/2026Recruiting ParticipantsGenderBothAge18 years - 25 yearsBrain Imaging Study of Emotion Regulation in Children
HIC ID2000031303RoleSub InvestigatorPrimary Completion Date11/30/2023Recruiting ParticipantsGenderBothAge5 years - 15 yearsStudying the Adult Brain
HIC ID2000025671RoleSub InvestigatorPrimary Completion Date07/31/2025Recruiting ParticipantsGenomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)
HIC ID2000020449RoleSub InvestigatorPrimary Completion Date12/31/2027Recruiting ParticipantsGenderBothAge8+ yearsStudy of Brain Function Across the Lifespan
HIC ID2000020891RoleSub InvestigatorPrimary Completion Date07/31/2022Recruiting ParticipantsGenderBothAge18 years - 65 years
News
News
- November 12, 2025
Twenty-Seven YSM Faculty Members Recognized for Highly Cited Research
- November 03, 2025
Caricaturing Brain Activity Yields Better Prediction of Behaviors
- October 01, 2025
Brain Network Active at Birth is Linked to Social Behavior Later in Life
- September 22, 2025
Brain Activity is Increasingly Variable During Development
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