Liqin Lin
Postgraduate AssociateAbout
Research
Publications
2026
D29-18 Targeting Mir-33 Ameliorates Pulmonary Fibrosis Through Metabolic Reprogramming of Macrophages and Improves Lung Function Beyond Nintedanib
Salimi M, Lin L, Johad K, Velasco Alzate K, Anderson S, Rangel R, Deiuliis G, Kaminski N, Ahangari F. D29-18 Targeting Mir-33 Ameliorates Pulmonary Fibrosis Through Metabolic Reprogramming of Macrophages and Improves Lung Function Beyond Nintedanib. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.2878. DOI: 10.1093/ajrccm/aamag162.2878.Peer-Reviewed Original Researchhuman precision-cut lung slicespulmonary fibrosispulmonary function testsin situ hybridizationIPF patientshealthy controlsmetabolic reprogrammingfunction testslung functionlung tissuemacrophage metabolismhistological analysisameliorated pulmonary fibrosisinstillation of bleomycinbleomycin-induced PF modelprecision-cut lung slicesvehicle-treated groupmetabolic reprogramming of macrophagesimprove lung functionprogression of fibrosistotal respiratory compliancefatal lung diseasereprogramming of macrophagesantifibrotic genesmacrophage signatureA74-12 An Ex Vivo Model of Induced Lung Aging Reveals Age-dependent Predisposition to Oxidative Stress and Cellular Senescence
De Man R, Rangel R, Marti Munoz J, Khoury J, Anderson S, Lin L, Adams T, Ahangari F, Manning E, Kaminski N. A74-12 An Ex Vivo Model of Induced Lung Aging Reveals Age-dependent Predisposition to Oxidative Stress and Cellular Senescence. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.5347. DOI: 10.1093/ajrccm/aamag162.5347.Peer-Reviewed Original Researchprecision-cut lung slicesproportion of Ki67-positive cellsex vivo modelKi67-positive cellsAging Lunglung diseasepositive cellscellular senescencelung slicesage-related lung diseasepredisposition to oxidative stressproportion of positive cellssenescence inductionhydrogen peroxide treatmentsenescence marker p21p21-positive cellsCdkn1a (p21differential gene expressiondose-dependent effectdose-dependent manneroxidative stress-induced cellular senescencefetal bovine serumalveolar simplificationstress-induced cellular senescenceproliferation markersA109-23 The Profibrotic Effect of Mechanical Force on Airway Basal Cells in Pulmonary Fibrosis
Lin L, Salimi M, Du H, Khoury J, Giuseppe D, Alzate K, Szafron J, Manning E, Kaminski N, Ahangari F. A109-23 The Profibrotic Effect of Mechanical Force on Airway Basal Cells in Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.2423. DOI: 10.1093/ajrccm/aamag162.2423.Peer-Reviewed Original Researchairway basal cellsidiopathic pulmonary fibrosispulmonary fibrosisprofibrotic effectsbasal cellsbleomycin-treated miceTGF-b1 expressionidiopathic pulmonary fibrosis progressionairway epithelial cellsscarring lung diseaseair-liquid interfacedifferentiation stateAnnexin V-FITC/PI staininggene expressionfibrotic remodelingfibrosis progressionNo significant changeshealthy miceabnormal responselung diseaseventilated lungfibrotic genesalveolar destructionelevated mechanical stressepithelial cellsThe interplay of airway epithelium and biomechanical stress in pulmonary fibrosis
Lin L, Khoury J, Zhang G, Szafron J, Manning E, Ahangari F. The interplay of airway epithelium and biomechanical stress in pulmonary fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2026, 74: 1016-1031. PMID: 42089315, DOI: 10.1093/ajrcmb/aanag066.Peer-Reviewed Original Researchidiopathic pulmonary fibrosisairway epitheliumpulmonary fibrosisepithelial responsesepithelial cellsresponse of airway epithelial cellspathogenesis of idiopathic pulmonary fibrosisregulation of lung functionprogression of idiopathic pulmonary fibrosisairway epithelial cellsprogression of fibrosisairway epithelial responsespro-fibrotic responseindicators of disease onsetfatal lung diseaseearly indicatorlung fibrosisabnormal responselung diseasedisease onsetlung functionlung tissuefibrosisairwaytherapeutic interventionsProximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.Peer-Reviewed Original ResearchConceptsproximal pulmonary arteriespulmonary arterysmooth muscle cellsperivascular macrophagesmouse modelmuscle cellsright ventricle functionmedial smooth muscle cellspulmonary arterial stiffeningright ventricleventricle functionassociated with senescenceECM turnoverlung functionarterial stiffeningarteryadventitial fibroblastsmolecular targetsage-relatedgeroscience hypothesislungageintercellular signalingmicemacrophages
2024
GLUT1 mediates bronchial epithelial E-cadherin disruption in TDI-induced steroid-insensitive asthma
Lv Y, Gan S, Chen Z, Luo T, Yang C, Fu L, Lin L, Yao L, Tang H. GLUT1 mediates bronchial epithelial E-cadherin disruption in TDI-induced steroid-insensitive asthma. Journal Of Asthma 2024, 61: 1571-1580. PMID: 38865204, DOI: 10.1080/02770903.2024.2368199.Peer-Reviewed Original ResearchFerroptosis contributes to airway epithelial E-cadherin disruption in a mixed granulocytic asthma mouse model
Gan S, Lin L, Chen Z, Zhang H, Tang H, Yang C, Li J, Li S, Yao L. Ferroptosis contributes to airway epithelial E-cadherin disruption in a mixed granulocytic asthma mouse model. Experimental Cell Research 2024, 438: 114029. PMID: 38608805, DOI: 10.1016/j.yexcr.2024.114029.Peer-Reviewed Original ResearchGLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma
Tang H, Guo Y, Gan S, Chen Z, Dong M, Lin L, Chen H, Ji X, Xian M, Shi X, Tao A, Lv Y, Yao L, Chen R, Li S, Li J. GLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2024, 1870: 167040. PMID: 38281711, DOI: 10.1016/j.bbadis.2024.167040.Peer-Reviewed Original Research
2023
GLUT1 contributes to impaired epithelial tight junction in the late phase of acute lung injury
Tang H, Chen Z, Gan S, Liang Y, Zhang H, Yang C, Lin L, Guo Y, Li S, Li J, Yao L. GLUT1 contributes to impaired epithelial tight junction in the late phase of acute lung injury. European Journal Of Pharmacology 2023, 961: 176185. PMID: 37944848, DOI: 10.1016/j.ejphar.2023.176185.Peer-Reviewed Original ResearchLong-term efficacy and safety of the Dumon stent for treatment of benign airway stenosis
Lin L, Chen D, Wu H, Chen Y, Zhong C, Chen X, Tang C, Zhou Z, Li S. Long-term efficacy and safety of the Dumon stent for treatment of benign airway stenosis. Therapeutic Advances In Respiratory Disease 2023, 17: 17534666231181269. PMID: 37439480, PMCID: PMC10350742, DOI: 10.1177/17534666231181269.Peer-Reviewed Original Research
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