Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsAurélien Justet
Assistant Professor AdjunctAbout
Research
Publications
2026
The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis
Ruwisch J, Cazes A, Leiber L, Borie R, Neubert L, Christian L, de Montpréville V, Szmul A, Moussa F, Verleden S, Gaedcke S, Hegermann J, Fuge J, Ballmaier M, Kamp J, Greer M, Braubach P, Werlein C, Ius F, Graalmann T, Aburahma K, De Sadeleer L, Egashira R, Ackermann M, Yamada D, Hoeper M, Falk C, Gottlieb J, Schiller H, Vanaudenaerde B, Seeliger B, Debray M, Bernaudin J, Knudsen L, Bergot E, Jacob J, Mal H, Jonigk D, Dettmer S, Mordant P, Prasse A, Fadel E, Wuyts W, Crestani B, Kaminski N, Justet A, Schupp J. The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis. Science Advances 2026, 12: eaeb5967. PMID: 42102198, PMCID: PMC13162212, DOI: 10.1126/sciadv.aeb5967.Peer-Reviewed Original ResearchConceptsInterstitial lung diseasePleuroparenchymal fibroelastosisProgressive interstitial lung diseaseCellular landscapeTertiary lymphoid structuresAberrant cell statesIdiopathic pulmonary fibrosisRNA in situ hybridizationIntra-alveolar fibrosisCellular disease processesCellular machineryLymphoid structuresSeptal elastosisImmune cellsPulmonary fibrosisBasaloid cellsFibrotic remodelingLung fibrosisInflammatory microenvironmentLung diseaseCell statesTherapeutic strategiesCollagen depositionMolecular rationaleFibrosisProximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arterySmooth muscle cellsPerivascular macrophagesMouse modelMuscle cellsRight ventricle functionMedial smooth muscle cellsPulmonary arterial stiffeningRight ventricleVentricle functionAssociated with senescenceECM turnoverLung functionArterial stiffeningArteryAdventitial fibroblastsMolecular targetsAge-relatedGeroscience hypothesisLungAgeIntercellular signalingMiceMacrophages
2025
From spatial transcriptomics to mouse model: the (re-)emergence of ductal myofibroblasts as a new cellular target in idiopathic pulmonary fibrosis
Justet A, Schupp J. From spatial transcriptomics to mouse model: the (re-)emergence of ductal myofibroblasts as a new cellular target in idiopathic pulmonary fibrosis. European Respiratory Journal 2025, 66: 2501466. PMID: 41057218, DOI: 10.1183/13993003.01466-2025.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisExtracellular matrix componentsPulmonary fibrosisExcessive deposition of extracellular matrix componentsIdiopathic interstitial lung diseaseDeposition of extracellular matrix componentsPathological wound-healing responsePotential therapeutic targetExcessive depositionInterstitial lung diseaseCellular targetsImpaired gas exchangeWound healing responseGas exchangeMatrix componentsTherapeutic targetRespiratory failureCell populationsLung diseaseFatal disorderMouse modelSevere formLung parenchymaIrreversible remodelingFibrosisInhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models
Wagner D, Alsafadi H, Mitash N, Justet A, Hu Q, Pineda R, Staab-Weijnitz C, Korfei M, Gvazava N, Wannemo K, Onwuka U, Mozurak M, Estrada-Bernal A, Cala-Garcia J, Mutze K, Costa R, Bölükbas D, Stegmayr J, Skronska-Wasek W, Klee S, Ota C, Baarsma H, Wang J, Sembrat J, Hilgendorff A, Ding J, Günther A, Chambers R, Rosas I, de Langhe S, Kaminski N, Lehmann M, Eickelberg O, Königshoff M. Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models. Nature Communications 2025, 16: 7099. PMID: 40753090, PMCID: PMC12318044, DOI: 10.1038/s41467-025-61795-x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAlveolar Epithelial CellsAnimalsCell Cycle ProteinsDisease Models, AnimalDNA-Binding ProteinsExtracellular MatrixFemaleHumansIdiopathic Pulmonary FibrosisLungMaleMiceMice, Inbred C57BLProtein-Lysine 6-OxidaseSignal TransductionTranscription FactorsVerteporfinYAP-Signaling ProteinsConceptsIdiopathic pulmonary fibrosisAlveolar typePulmonary fibrosisIdiopathic pulmonary fibrosis patientsAlveolar type II cellsFibrosis in vivoLung fibrosis in vivoExcessive extracellular matrix depositionType II cellsExcessive extracellular matrix productionPreclinical modelsExtracellular matrix depositionDisease progressionPotential therapiesTissue ex vivoYAP inhibitionCrosslinking of extracellular matrixII cellsLethal diseaseExtracellular matrix productionActive YAPFibrosisMatrix depositionInhibitionDiseaseA deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases
Zheng Y, Schupp J, Adams T, Clair G, Justet A, Ahangari F, Yan X, Hansen P, Carlon M, Cortesi E, Vermant M, Vos R, De Sadeleer L, Rosas I, Pineda R, Sembrat J, Königshoff M, McDonough J, Vanaudenaerde B, Wuyts W, Kaminski N, Ding J. A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases. Nature Biomedical Engineering 2025, 9: 2155-2180. PMID: 40542107, PMCID: PMC12705450, DOI: 10.1038/s41551-025-01423-7.Peer-Reviewed Original ResearchComplex cellular dynamicsCellular dynamicsSingle-cell transcriptomic dataIn silico drug discoverySingle-cell transcriptomicsTranscriptome dataPotential therapeutic drug candidateComplex diseasesHuman diseasesIdiopathic pulmonary fibrosisTherapeutic drug candidateCell embeddingDrug discoveryPulmonary fibrosisDrug candidatesDisease progressionHuman tissuesHuman precision-cut lung slicesDynamic analysisPrecision-cut lung slicesPathological landscapeComputational toolsAnti-fibrotic effectsUnagiTranscriptomeRadiation toxicity and survival in patients with interstitial lung disease and non-small cell lung cancer: A case control study
Justet A, Jackson L, Bardon M, Lerouge D, Césaire M, Loiseau C, Bergot E, Christy F, Thariat J. Radiation toxicity and survival in patients with interstitial lung disease and non-small cell lung cancer: A case control study. Cancer/Radiothérapie 2025, 29: 104622. PMID: 40311519, DOI: 10.1016/j.canrad.2025.104622.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseNon-small cell lung cancerProgression-free survivalCell lung cancerOverall survivalLung diseaseCase-control studyLung cancerCentral reviewOligometastatic non-small cell lung cancerMedian progression-free survivalCase-control study of patientsPrevalence of interstitial lung diseaseConsecutive lung cancer patientsIntensity-modulated radiotherapyStereotactic body radiotherapyMedian overall survivalThree-dimensional radiotherapyScore of fibrosisPrognosis of patientsGround-glass patternInterstitial pulmonary fibrosisStudy of patientsLung cancer patientsCancer treatment characteristicsFGF21 Signaling Exerts Antifibrotic Properties during Pulmonary Fibrosis
Ghanem M, Archer G, Justet A, Jaillet M, Vasarmidi E, Mordant P, Castier Y, Mal H, Cazes A, Poté N, Crestani B, Mailleux A. FGF21 Signaling Exerts Antifibrotic Properties during Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 486-498. PMID: 39637324, DOI: 10.1164/rccm.202311-2021oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisWild-type littermatesPlasma of patientsPulmonary fibrosisAntifibrotic propertiesIntratracheal injection of bleomycinDevelopment of pulmonary fibrosisDecreased fibrosis markersEffects of FGF21Increased sensitivity to bleomycinInjection of bleomycinPulmonary fibrosis developmentSensitivity to bleomycinDecrease of BaxConcentrations of FGF21Human lung fibroblastsTherapeutic optionsFibrosis markersAntifibrotic effectsControl subjectsInjury scoreIntratracheal injectionLiver fibrosisLung fibrogenesisFibroblast growth factorTracing the origins of fibrotic fibroblasts: does the name matter? Look at the genes!
Mailleux A, Justet A. Tracing the origins of fibrotic fibroblasts: does the name matter? Look at the genes! European Respiratory Journal 2025, 65: 2402170. PMID: 39915043, DOI: 10.1183/13993003.02170-2024.Peer-Reviewed Original Research
2024
Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis.
Zhao A, Unterman A, Abu Hussein N, Sharma P, Nikola F, Flint J, Yan X, Adams T, Justet A, Sumida T, Zhao J, Schupp J, Raredon M, Ahangari F, Deluliis G, Zhang Y, Buendia-Roldan I, Adegunsoye A, Sperling A, Prasse A, Ryu C, Herzog E, Selman M, Pardo A, Kaminski N. Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 1252-1266. PMID: 38924775, PMCID: PMC11568434, DOI: 10.1164/rccm.202401-0078oc.Peer-Reviewed Original ResearchFibrotic hypersensitivity pneumonitisIdiopathic pulmonary fibrosisPeripheral blood mononuclear cellsBronchoalveolar lavage cellsBlood mononuclear cellsClassical monocytesHypersensitivity pneumonitisPulmonary fibrosisT cellsImmune perturbationsLavage cellsMononuclear cellsCD8+ T cellsCytotoxic T cellsInterstitial lung diseaseHypersensitivity pneumonitis patientsCytotoxic CD4Immune aberrationsPneumonic patientsPneumonitisLung diseaseHealthy controlsImmune mechanismsPatient cellsSingle-cell transcriptomicsSDePER: a hybrid machine learning and regression method for cell-type deconvolution of spatial barcoding-based transcriptomic data
Liu Y, Li N, Qi J, Xu G, Zhao J, Wang N, Huang X, Jiang W, Wei H, Justet A, Adams T, Homer R, Amei A, Rosas I, Kaminski N, Wang Z, Yan X. SDePER: a hybrid machine learning and regression method for cell-type deconvolution of spatial barcoding-based transcriptomic data. Genome Biology 2024, 25: 271. PMID: 39402626, PMCID: PMC11475911, DOI: 10.1186/s13059-024-03416-2.Peer-Reviewed Original Research