Dylan Gee, PhD
Research & Publications
Biography
News
Research Summary
Understanding how key neural circuits mature in typical development and how these processes go awry in atypical development is critical to the identification and treatment of mental health disorders. Thus, my laboratory bridges clinical, developmental, and neuroscience approaches to delineate the biological state of the developing brain to more effectively treat mental illness. My program of research aims to characterize typical and atypical frontolimbic trajectories across development, elucidate how early environments (e.g., early-life stress) and genetic factors influence sensitive periods in neurodevelopment and risk for psychopathology, and translate knowledge of brain development to optimize clinical interventions for affective psychopathology in childhood and adolescence. A central focus of this work is the nature and development of emotional behavior and related connections between limbic and prefrontal regions in children and adolescents with anxiety and stress-related disorders.
Coauthors
Selected Publications
- Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposureKribakaran S, Odriozola P, Cohodes E, McCauley S, Zacharek S, Hodges H, Haberman J, Pierre J, Gee D. Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposure. Neurobiology Of Stress 2022, 21: 100497. PMID: 36532365, PMCID: PMC9755062, DOI: 10.1016/j.ynstr.2022.100497.
- Leveraging the science of stress to promote resilience and optimize mental health interventions during adolescenceGee DG, Sisk LM, Cohodes EM, Bryce NV. Leveraging the science of stress to promote resilience and optimize mental health interventions during adolescence. Nature Communications 2022, 13: 5693. PMID: 36171218, PMCID: PMC9519553, DOI: 10.1038/s41467-022-33416-4.
- Neural effects of controllability as a key dimension of stress exposureCohodes EM, Odriozola P, Mandell JD, Caballero C, McCauley S, Zacharek SJ, Hodges HR, Haberman JT, Smith M, Thomas J, Meisner OC, Ellis CT, Hartley CA, Gee DG. Neural effects of controllability as a key dimension of stress exposure. Development And Psychopathology 2022, 35: 218-227. PMID: 35034670, DOI: 10.1017/s0954579421001498.
- Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and ResilienceGee DG. Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience. American Journal Of Psychiatry 2021, 178: 998-1013. PMID: 34734741, DOI: 10.1176/appi.ajp.2021.21090944.
- Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD StudyBrieant AE, Sisk LM, Gee DG. Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study. Developmental Cognitive Neuroscience 2021, 52: 101022. PMID: 34710799, PMCID: PMC8556598, DOI: 10.1016/j.dcn.2021.101022.
- Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in YouthIp KI, Sisk LM, Horien C, Conley MI, Rapuano KM, Rosenberg MD, Greene AS, Scheinost D, Constable RT, Casey BJ, Baskin-Sommers A, Gee DG. Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth. Journal Of Cognitive Neuroscience 2022, 34: 1810-1841. PMID: 35104356, DOI: 10.1162/jocn_a_01826.
- Associations Between Early-Life Stress Exposure and Internalizing Symptomatology During the COVID-19 Pandemic: Assessing the Role of Neurobehavioral MediatorsFoster JC, Cohodes EM, Brieant AE, McCauley S, Odriozola P, Zacharek SJ, Pierre JC, Hodges HR, Kribakaran S, Haberman JT, Holt-Gosselin B, Gee DG. Associations Between Early-Life Stress Exposure and Internalizing Symptomatology During the COVID-19 Pandemic: Assessing the Role of Neurobehavioral Mediators. Biological Psychiatry Global Open Science 2022, 3: 362-373. PMID: 35959474, PMCID: PMC9356644, DOI: 10.1016/j.bpsgos.2022.07.006.
- Family accommodation in pediatric anxiety: Relations with avoidance and self-efficacyKitt ER, Lewis KM, Galbraith J, Abend R, Smith AR, Lebowitz ER, Pine DS, Gee DG. Family accommodation in pediatric anxiety: Relations with avoidance and self-efficacy. Behaviour Research And Therapy 2022, 154: 104107. PMID: 35613517, PMCID: PMC9271364, DOI: 10.1016/j.brat.2022.104107.
- The role of perceived threats on mental health, social, and neurocognitive youth outcomes: A multicontextual, person-centered approach.Conley MI, Hernandez J, Salvati JM, Gee DG, Baskin-Sommers A. The role of perceived threats on mental health, social, and neurocognitive youth outcomes: A multicontextual, person-centered approach. Development And Psychopathology 2022, 35: 689-710. PMID: 35232507, PMCID: PMC9437149, DOI: 10.1017/s095457942100184x.
- Training the Next Generation of Clinical Psychological Scientists: A Data-Driven Call to ActionGee DG, DeYoung KA, McLaughlin KA, Tillman RM, Barch DM, Forbes EE, Krueger RF, Strauman TJ, Weierich MR, Shackman AJ. Training the Next Generation of Clinical Psychological Scientists: A Data-Driven Call to Action. Annual Review Of Clinical Psychology 2022, 18: 43-70. PMID: 35216523, PMCID: PMC9086080, DOI: 10.1146/annurev-clinpsy-081219-092500.
- Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot studyGee DG, Hanson C, Caglar LR, Fareri DS, Gabard‐Durnam L, Mills‐Finnerty C, Goff B, Caldera CJ, Lumian DS, Flannery J, Hanson SJ, Tottenham N. Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study. Developmental Science 2022, 25: e13238. PMID: 35080089, PMCID: PMC9232876, DOI: 10.1111/desc.13238.
- When do sensitive periods emerge later in development?Gee DG. When do sensitive periods emerge later in development? Trends In Cognitive Sciences 2021, 26: 97-98. PMID: 34933793, DOI: 10.1016/j.tics.2021.12.001.
- Stress and adolescence: vulnerability and opportunity during a sensitive window of developmentSisk LM, Gee DG. Stress and adolescence: vulnerability and opportunity during a sensitive window of development. Current Opinion In Psychology 2021, 44: 286-292. PMID: 34818623, PMCID: PMC9007828, DOI: 10.1016/j.copsyc.2021.10.005.
- When Uncertainty Is a Certainty: Optimizing Exposure-Based TherapiesGee D, Odriozola P. When Uncertainty Is a Certainty: Optimizing Exposure-Based Therapies. Biological Psychiatry Global Open Science 2021, 1: 166-167. PMID: 36325300, PMCID: PMC9616301, DOI: 10.1016/j.bpsgos.2021.08.001.
- Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youthSisk LM, Rapuano KM, Conley MI, Greene AS, Horien C, Rosenberg MD, Scheinost D, Constable RT, Glatt CE, Casey BJ, Gee DG. Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth. Journal Of Neuroscience Research 2021, 100: 731-743. PMID: 34496065, PMCID: PMC8866205, DOI: 10.1002/jnr.24946.
- Influences of Caregiving on Development: A Sensitive Period for Biological Embedding of Predictability and Safety CuesGee DG, Cohodes EM. Influences of Caregiving on Development: A Sensitive Period for Biological Embedding of Predictability and Safety Cues. Current Directions In Psychological Science 2021, 30: 376-383. PMID: 34675455, PMCID: PMC8528226, DOI: 10.1177/09637214211015673.
- Migration‐related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policyCohodes EM, Kribakaran S, Odriozola P, Bakirci S, McCauley S, Hodges HR, Sisk LM, Zacharek SJ, Gee DG. Migration‐related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy. Developmental Psychobiology 2021, 63: e22158. PMID: 34292596, PMCID: PMC8410670, DOI: 10.1002/dev.22158.
- Leveraging big data to map neurodevelopmental trajectories in pediatric anxietyZacharek SJ, Kribakaran S, Kitt ER, Gee DG. Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety. Developmental Cognitive Neuroscience 2021, 50: 100974. PMID: 34147988, PMCID: PMC8225701, DOI: 10.1016/j.dcn.2021.100974.
- Emotion and Emotion Preferences in Daily Life: The Role of AnxietyVanderlind WM, Everaert J, Caballero C, Cohodes EM, Gee DG. Emotion and Emotion Preferences in Daily Life: The Role of Anxiety. Clinical Psychological Science 2021, 10: 109-126. PMID: 35174008, PMCID: PMC8845725, DOI: 10.1177/21677026211009500.
- Responsible Use of Open-Access Developmental Data: The Adolescent Brain Cognitive Development (ABCD) StudySimmons C, Conley MI, Gee DG, Baskin-Sommers A, Barch DM, Hoffman EA, Huber RS, Iacono WG, Nagel BJ, Palmer CE, Sheth CS, Sowell ER, Thompson WK, Casey BJ. Responsible Use of Open-Access Developmental Data: The Adolescent Brain Cognitive Development (ABCD) Study. Psychological Science 2021, 32: 866-870. PMID: 34043478, PMCID: PMC8726588, DOI: 10.1177/09567976211003564.
- Parental Buffering of Stress in the Time of COVID-19: Family-Level Factors May Moderate the Association Between Pandemic-Related Stress and Youth SymptomatologyCohodes EM, McCauley S, Gee DG. Parental Buffering of Stress in the Time of COVID-19: Family-Level Factors May Moderate the Association Between Pandemic-Related Stress and Youth Symptomatology. Research On Child And Adolescent Psychopathology 2021, 49: 935-948. PMID: 33591457, PMCID: PMC7885749, DOI: 10.1007/s10802-020-00732-6.
- Decomposing complex links between the childhood environment and brain structure in school-aged youthHong SJ, Sisk LM, Caballero C, Mekhanik A, Roy AK, Milham MP, Gee DG. Decomposing complex links between the childhood environment and brain structure in school-aged youth. Developmental Cognitive Neuroscience 2021, 48: 100919. PMID: 33556882, PMCID: PMC7868609, DOI: 10.1016/j.dcn.2021.100919.
- Development and Validation of the Parental Assistance with Child Emotion Regulation (PACER) QuestionnaireCohodes EM, Preece DA, McCauley S, Rogers MK, Gross JJ, Gee DG. Development and Validation of the Parental Assistance with Child Emotion Regulation (PACER) Questionnaire. Research On Child And Adolescent Psychopathology 2021, 50: 133-148. PMID: 33411232, DOI: 10.1007/s10802-020-00759-9.
- Caregiving influences on emotional learning and regulation: applying a sensitive period modelGee DG. Caregiving influences on emotional learning and regulation: applying a sensitive period model. Current Opinion In Behavioral Sciences 2020, 36: 177-184. PMID: 33718534, PMCID: PMC7945765, DOI: 10.1016/j.cobeha.2020.11.003.
- Commentary: COVID-19 and mental health equity in the United StatesCondon EM, Dettmer AM, Gee DG, Hagan C, Lee KS, Mayes LC, Stover CS, Tseng WL. Commentary: COVID-19 and mental health equity in the United States. Frontiers In Sociology 2020, 5: 584390. PMID: 33869513, PMCID: PMC8022536, DOI: 10.3389/fsoc.2020.584390.
- Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing BrainOdriozola P, Gee DG. Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain. American Journal Of Psychiatry 2020, 178: 136-155. PMID: 33167673, PMCID: PMC7951569, DOI: 10.1176/appi.ajp.2020.20020232.
- Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary studyHarrewijn A, Kitt ER, Abend R, Matsumoto C, Odriozola P, Winkler AM, Leibenluft E, Pine DS, Gee DG. Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders – A preliminary study. Behavioural Brain Research 2020, 399: 112994. PMID: 33160010, PMCID: PMC7855938, DOI: 10.1016/j.bbr.2020.112994.
- Early-Life Trauma and Resilience: Insights From Developmental Neuroscience for PolicyGee DG. Early-Life Trauma and Resilience: Insights From Developmental Neuroscience for Policy. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2020, 6: 141-143. PMID: 32807721, DOI: 10.1016/j.bpsc.2020.07.005.
- Developmental Differences in Neural Responding to Threat and Safety: Implications for Treating Youths With AnxietyGee DG, Kribakaran S. Developmental Differences in Neural Responding to Threat and Safety: Implications for Treating Youths With Anxiety. American Journal Of Psychiatry 2020, 177: 378-380. PMID: 32354263, DOI: 10.1176/appi.ajp.2020.20020225.
- Influences of early‐life stress on frontolimbic circuitry: Harnessing a dimensional approach to elucidate the effects of heterogeneity in stress exposureCohodes EM, Kitt ER, Baskin‐Sommers A, Gee DG. Influences of early‐life stress on frontolimbic circuitry: Harnessing a dimensional approach to elucidate the effects of heterogeneity in stress exposure. Developmental Psychobiology 2020, 63: 153-172. PMID: 32227350, DOI: 10.1002/dev.21969.
- Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humansMeyer HC, Odriozola P, Cohodes EM, Mandell JD, Li A, Yang R, Hall BS, Haberman JT, Zacharek SJ, Liston C, Lee FS, Gee DG. Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 26970-26979. PMID: 31822612, PMCID: PMC6936350, DOI: 10.1073/pnas.1910481116.
- Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related ConditionsKribakaran S, Danese A, Bromis K, Kempton MJ, Gee DG. Meta-analysis of Structural Magnetic Resonance Imaging Studies in Pediatric Posttraumatic Stress Disorder and Comparison With Related Conditions. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 5: 23-34. PMID: 31690501, PMCID: PMC6954289, DOI: 10.1016/j.bpsc.2019.08.006.
- Predicting Mental Health in Adolescence: Frontoinsular Circuitry, Emotion in Daily Life, and Risk for DepressionGee DG, Caballero C. Predicting Mental Health in Adolescence: Frontoinsular Circuitry, Emotion in Daily Life, and Risk for Depression. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 684-685. PMID: 31395211, DOI: 10.1016/j.bpsc.2019.06.004.
- A call for action on migrant children's mental healthGee DG, Cohodes EM. A call for action on migrant children's mental health. The Lancet Psychiatry 2019, 6: 286. PMID: 30904123, DOI: 10.1016/s2215-0366(19)30094-x.
- Novel insights from actigraphy: Anxiety is associated with sleep quantity but not quality during childhoodCohodes EM, Abusch A, Odriozola P, Gee DG. Novel insights from actigraphy: Anxiety is associated with sleep quantity but not quality during childhood. Clinical Child Psychology And Psychiatry 2019, 25: 189-199. PMID: 30696260, PMCID: PMC6667310, DOI: 10.1177/1359104518822685.
- Atypical frontoamygdala functional connectivity in youth with autismOdriozola P, Dajani DR, Burrows CA, Gabard-Durnam LJ, Goodman E, Baez AC, Tottenham N, Uddin LQ, Gee DG. Atypical frontoamygdala functional connectivity in youth with autism. Developmental Cognitive Neuroscience 2018, 37: 100603. PMID: 30581125, PMCID: PMC6570504, DOI: 10.1016/j.dcn.2018.12.001.
- Neurocognitive Development of Motivated Behavior: Dynamic Changes across Childhood and AdolescenceGee DG, Bath KG, Johnson CM, Meyer HC, Murty VP, van den Bos W, Hartley CA. Neurocognitive Development of Motivated Behavior: Dynamic Changes across Childhood and Adolescence. Journal Of Neuroscience 2018, 38: 9433-9445. PMID: 30381435, PMCID: PMC6209847, DOI: 10.1523/jneurosci.1674-18.2018.
- Implications of the Research Domain Criteria project for childhood anxiety and its disordersLebowitz ER, Gee DG, Pine DS, Silverman WK. Implications of the Research Domain Criteria project for childhood anxiety and its disorders. Clinical Psychology Review 2018, 64: 99-109. PMID: 29526524, PMCID: PMC6668617, DOI: 10.1016/j.cpr.2018.01.005.
- Development of the emotional brainCasey BJ, Heller AS, Gee DG, Cohen AO. Development of the emotional brain. Neuroscience Letters 2017, 693: 29-34. PMID: 29197573, PMCID: PMC5984129, DOI: 10.1016/j.neulet.2017.11.055.
- The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain DevelopmentMeyer HC, Lee FS, Gee DG. The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development. Neuropsychopharmacology 2017, 43: 21-33. PMID: 28685756, PMCID: PMC5719094, DOI: 10.1038/npp.2017.143.
- Sensitive Periods of Emotion Regulation: Influences of Parental Care on Frontoamygdala Circuitry and PlasticityGee DG. Sensitive Periods of Emotion Regulation: Influences of Parental Care on Frontoamygdala Circuitry and Plasticity. New Directions For Child And Adolescent Development 2016, 2016: 87-110. PMID: 27589500, DOI: 10.1002/cad.20166.
- Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective StudyGabard-Durnam LJ, Gee DG, Goff B, Flannery J, Telzer E, Humphreys KL, Lumian DS, Fareri DS, Caldera C, Tottenham N. Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study. Journal Of Neuroscience 2016, 36: 4771-4784. PMID: 27122035, PMCID: PMC4846673, DOI: 10.1523/jneurosci.0598-16.2016.
- Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across speciesGee DG, Fetcho RN, Jing D, Li A, Glatt CE, Drysdale AT, Cohen AO, Dellarco DV, Yang RR, Dale AM, Jernigan TL, Lee FS, Casey BJ, Jernigan T, San Diego U, McCabe C, San Diego U, Chang L, Hawaii U, Akshoomoff N, San Diego U, Newman E, San Diego U, Dale A, San Diego U, Core M, Ernst T, Hawaii U, Dale A, San Diego U, Van Zijl P, Kuperman J, San Diego U, Murray S, Bloss C, Schork N, Appelbaum M, San Diego U, Gamst A, San Diego U, Thompson W, San Diego U, Bartsch H, San Diego U, Jernigan T, Dale A, Akshoomoff N, Chang L, Ernst T, Keating B, Amaral D, Sowell E, Kaufmann W, Van Zijl P, Mostofsky S, Casey B, Ruberry E, Powers A, Rosen B, Kenet T, Frazier J, Kennedy D, University Y, Gruen J. Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 4500-4505. PMID: 27001846, PMCID: PMC4843434, DOI: 10.1073/pnas.1600013113.
- Reliability of an fMRI paradigm for emotional processing in a multisite longitudinal studyGee DG, McEwen SC, Forsyth JK, Haut KM, Bearden CE, Addington J, Goodyear B, Cadenhead KS, Mirzakhanian H, Cornblatt BA, Olvet D, Mathalon DH, McGlashan TH, Perkins DO, Belger A, Seidman LJ, Thermenos H, Tsuang MT, van Erp TG, Walker EF, Hamann S, Woods SW, Constable T, Cannon TD. Reliability of an fMRI paradigm for emotional processing in a multisite longitudinal study. Human Brain Mapping 2015, 36: 2558-2579. PMID: 25821147, PMCID: PMC4478164, DOI: 10.1002/hbm.22791.
- The impact of developmental timing for stress and recoveryGee DG, Casey BJ. The impact of developmental timing for stress and recovery. Neurobiology Of Stress 2015, 1: 184-194. PMID: 25798454, PMCID: PMC4363736, DOI: 10.1016/j.ynstr.2015.02.001.
- Maternal Buffering of Human Amygdala-Prefrontal Circuitry During Childhood but Not During AdolescenceGee DG, Gabard-Durnam L, Telzer EH, Humphreys KL, Goff B, Shapiro M, Flannery J, Lumian DS, Fareri DS, Caldera C, Tottenham N. Maternal Buffering of Human Amygdala-Prefrontal Circuitry During Childhood but Not During Adolescence. Psychological Science 2014, 25: 2067-2078. PMID: 25280904, PMCID: PMC4377225, DOI: 10.1177/0956797614550878.
- Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivationGee DG, Gabard-Durnam LJ, Flannery J, Goff B, Humphreys KL, Telzer EH, Hare TA, Bookheimer SY, Tottenham N. Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 15638-15643. PMID: 24019460, PMCID: PMC3785723, DOI: 10.1073/pnas.1307893110.
- A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal CircuitryGee DG, Humphreys KL, Flannery J, Goff B, Telzer EH, Shapiro M, Hare TA, Bookheimer SY, Tottenham N. A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry. Journal Of Neuroscience 2013, 33: 4584-4593. PMID: 23467374, PMCID: PMC3670947, DOI: 10.1523/jneurosci.3446-12.2013.
- Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary studyGee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T, Woods SW, Addington J, Cadenhead KS, McGlashan TH, Seidman LJ, Tsuang MT, Walker EF, Cannon TD, Consortium O. Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study. Schizophrenia Research 2011, 134: 1-9. PMID: 22056201, PMCID: PMC3245800, DOI: 10.1016/j.schres.2011.10.005.
- Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheresGee DG, Biswal BB, Kelly C, Stark DE, Margulies DS, Shehzad Z, Uddin LQ, Klein DF, Banich MT, Castellanos FX, Milham MP. Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres. NeuroImage 2010, 54: 517-527. PMID: 20570737, PMCID: PMC3134281, DOI: 10.1016/j.neuroimage.2010.05.073.