XJ Xu
About
Research
Publications
2026
Distinct impact of PI(4)P flux on PI(4,5)P2 steady states and oscillations
Xǔ X, Tong C, Wu M. Distinct impact of PI(4)P flux on PI(4,5)P2 steady states and oscillations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2518354123. PMID: 41701834, PMCID: PMC12933082, DOI: 10.1073/pnas.2518354123.Peer-Reviewed Original ResearchThis study demonstrates that PI(4)P flux regulates plasma membrane signaling lipid PI(4,5)P2 flux without changing the steady level of PI(4,5)P2.
2024
Competition and synergy of Arp2/3 and formins in nucleating actin waves
Le Chua X, San Tong C, Su M, Xǔ X, Xiao S, Wu X, Wu M. Competition and synergy of Arp2/3 and formins in nucleating actin waves. Cell Reports 2024, 43: 114423. PMID: 38968072, PMCID: PMC11378572, DOI: 10.1016/j.celrep.2024.114423.Peer-Reviewed Original ResearchActin wavesActin regulatory proteinsActin cytoskeletal networkConstitutively active mutantArp2/3 complexActin assemblyMonomeric actinActive Cdc42Cdc42-interactingCytoskeletal networkArp2/3Active mutantCellular processesRegulatory proteinsUpstream regulatorCdc42ActinPlasma membraneFMNL1Complex feedback loopsForminPhysiological stateDelayed recruitmentFeedback loopGTPaseNonlinear dynamics in phosphoinositide metabolism
Fung S, Xǔ X, Wu M. Nonlinear dynamics in phosphoinositide metabolism. Current Opinion In Cell Biology 2024, 88: 102373. PMID: 38797149, PMCID: PMC11186694, DOI: 10.1016/j.ceb.2024.102373.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMetabolic networksPhosphoinositide metabolismNegative feedback loopCellular physiologyEnzymatic functionSignaling ComplexSignal transductionMembrane dynamicsNetwork motifsMetabolic pathwaysLipid fluxCellular behaviorMolecular circuitsPhosphoinositideFeedforward loopProducts of metabolismMetabolismFeedback loopExperimental challengeNonlinear dynamicsMotifFramework of nonlinear dynamicsTransductionExcited statesComprehensive understanding
2023
Periodicity, mixed-mode oscillations, and multiple timescales in a phosphoinositide-Rho GTPase network
San Tong C, Xǔ X, Wu M. Periodicity, mixed-mode oscillations, and multiple timescales in a phosphoinositide-Rho GTPase network. Cell Reports 2023, 42: 112857. PMID: 37494180, DOI: 10.1016/j.celrep.2023.112857.Peer-Reviewed Original Research
2022
Mechanical Resilience of Biofilms toward Environmental Perturbations Mediated by Extracellular Matrix
Zhang Q, Nguyen D, Tai J, Xu X, Nijjer J, Huang X, Li Y, Yan J. Mechanical Resilience of Biofilms toward Environmental Perturbations Mediated by Extracellular Matrix. Advanced Functional Materials 2022, 32 DOI: 10.1002/adfm.202110699.Peer-Reviewed Original ResearchMechanical resilienceNonlinear viscoelastic behaviorMaterials science pointLarge shear forcesBiofilm removal strategiesMechanical behaviorViscoelastic materialsViscoelastic behaviorBiofilm mechanicsSoft materialsStructure-property relationshipsRheological regimesRheological measurementsShear forceFunctional soft materialsLarge mechanical perturbationsPhysical insightPolymeric networkRemoval strategiesDynamics simulationsMolecular dynamics simulationsMaterialsDynamic environmentMatrixMechanical perturbations
2018
Simulation of laser-induced rectification in a nano-scale diode
Kidd D, Xu X, Covington C, Watanabe K, Varga K. Simulation of laser-induced rectification in a nano-scale diode. Journal Of Applied Physics 2018, 123: 054501. DOI: 10.1063/1.5019259.Peer-Reviewed Original ResearchJellium modelTime-dependent density functional theoryRate of electron transferNear-field enhancementDensity functional theoryLaser fieldLocal near-field enhancementLaser intensityElectron transferEffective anodeFunctional theoryPhase parametersField emissionCathode tipLaserSeparation distanceDiodesJellium