Chee San Tong
Associate Research Scientist in Cell BiologyCards
About
Research
Publications
2026
STIM1 and endoplasmic reticulum–plasma membrane contact sites oscillate independently of calcium-induced calcium release
Xiong D, Tong C, Fung S, McClellan S, Yang Y, Yong J, Wu M. STIM1 and endoplasmic reticulum–plasma membrane contact sites oscillate independently of calcium-induced calcium release. Open Biology 2026, 16: 250220. PMID: 41844235, DOI: 10.1098/rsob.250220.Peer-Reviewed Original ResearchThis study investigates how STIM1 and ER-plasma membrane contact sites oscillate independently of calcium signaling, revealing a new mechanism regulating calcium dynamics in cells.Distinct impact of PI(4)P flux on PI(4,5)P2 steady states and oscillations
Xǔ X, Tong C, Wu M. Distinct impact of PI(4)P flux on PI(4,5)P2 steady states and oscillations. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2518354123. PMID: 41701834, PMCID: PMC12933082, DOI: 10.1073/pnas.2518354123.Peer-Reviewed Original ResearchThis study demonstrates that PI(4)P flux regulates plasma membrane signaling lipid PI(4,5)P2 flux without changing the steady level of PI(4,5)P2.
2025
A molecular systems perspective on calcium oscillations beyond ion fluxes
Xiong D, Tong C, Wu M. A molecular systems perspective on calcium oscillations beyond ion fluxes. Current Opinion In Cell Biology 2025, 94: 102523. PMID: 40311263, PMCID: PMC12113571, DOI: 10.1016/j.ceb.2025.102523.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
Competition and synergy of Arp2/3 and formins in nucleating actin waves
Le Chua X, San Tong C, Su M, Xǔ X, Xiao S, Wu X, Wu M. Competition and synergy of Arp2/3 and formins in nucleating actin waves. Cell Reports 2024, 43: 114423. PMID: 38968072, PMCID: PMC11378572, DOI: 10.1016/j.celrep.2024.114423.Peer-Reviewed Original ResearchActin wavesActin regulatory proteinsActin cytoskeletal networkConstitutively active mutantArp2/3 complexActin assemblyMonomeric actinActive Cdc42Cdc42-interactingCytoskeletal networkArp2/3Active mutantCellular processesRegulatory proteinsUpstream regulatorCdc42ActinPlasma membraneFMNL1Complex feedback loopsForminPhysiological stateDelayed recruitmentFeedback loopGTPase
2023
Periodicity, mixed-mode oscillations, and multiple timescales in a phosphoinositide-Rho GTPase network
San Tong C, Xǔ X, Wu M. Periodicity, mixed-mode oscillations, and multiple timescales in a phosphoinositide-Rho GTPase network. Cell Reports 2023, 42: 112857. PMID: 37494180, DOI: 10.1016/j.celrep.2023.112857.Peer-Reviewed Original Research
2018
Membrane shape-mediated wave propagation of cortical protein dynamics
Wu Z, Su M, Tong C, Wu M, Liu J. Membrane shape-mediated wave propagation of cortical protein dynamics. Nature Communications 2018, 9: 136. PMID: 29321558, PMCID: PMC5762918, DOI: 10.1038/s41467-017-02469-1.Peer-Reviewed Original ResearchConceptsMembrane shape changesF-BAR proteinsDomain-containing proteinsPeripheral membrane proteinsProtein lateral diffusionActin machineryProtein recruitmentMembrane proteinsProtein dynamicsCortical proteinsShape changesProtein waveActin wavesUnderappreciated roleProteinMembrane undulationsLateral diffusionSpatial gradientsMachineryCytoplasmImmune cellsRecruitmentAssemblyCells
2017
Mitotic Cortical Waves Predict Future Division Sites by Encoding Positional and Size Information
Xiao S, Tong C, Yang Y, Wu M. Mitotic Cortical Waves Predict Future Division Sites by Encoding Positional and Size Information. Developmental Cell 2017, 43: 493-506.e3. PMID: 29161593, DOI: 10.1016/j.devcel.2017.10.023.Peer-Reviewed Original Research