Shari Damast, MD
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Appointments
Therapeutic Radiology
Primary
Titles
Chief, Gynecologic Radiotherapy Program, Therapeutic Radiology
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Appointments
Therapeutic Radiology
Primary
Titles
Chief, Gynecologic Radiotherapy Program, Therapeutic Radiology
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Appointments
Therapeutic Radiology
Primary
Titles
Chief, Gynecologic Radiotherapy Program, Therapeutic Radiology
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
About
Titles
Professor of Therapeutic Radiology
Chief, Gynecologic Radiotherapy Program, Therapeutic RadiologyBiography
Dr. Damast is board-certified radiation oncologist with a clinical and academic focus on treating gynecologic malignancies with radiation therapy. She has been on the faculty of the Department of Therapeutic Radiology at Yale since 2011, after completing her residency training in radiation oncology at Memorial Sloan-Kettering Cancer Center in New York City. Dr. Damast is a member of the American Society of Radiation Oncology (ASTRO), the American Brachytherapy Society (ABS), and the Scientific Network on Female Sexual Health and Cancer.
Appointments
Therapeutic Radiology
ProfessorPrimary
Other Departments & Organizations
Education & Training
- Residency
- Memorial Sloan Kettering Cancer Center (2011)
- Internship
- Beth Israel Medical Center - Petrie Division (2007)
- MD
- Weill Cornell Medical College (2006)
- BS
- Yale University (2002)
Research
Overview
Medical Subject Headings (MeSH)
Brachytherapy; Radiotherapy
Research at a Glance
Yale Co-Authors
Frequent collaborators of Shari Damast's published research.
Publications Timeline
A big-picture view of Shari Damast's research output by year.
Research Interests
Research topics Shari Damast is interested in exploring.
Henry S. Park, MD, MPH
Alessandro Santin, MD
Christopher J. Tien, PhD, DABR, FAAPM
Melissa Rasar Young, MD, PhD
Peter Schwartz, MD
Gloria Huang, MD, FACOG
68Publications
3,098Citations
Brachytherapy
Radiotherapy
Publications
2024
Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos S, Chino J, Chon H, Crispens M, Damast S, Fisher C, Frederick P, Gaffney D, Gaillard S, Giuntoli R, Glaser S, Holmes J, Howitt B, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington S, Wyse E, Zanotti K, McMillian N, Espinosa S. Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2024, 22: 117-135. PMID: 38503056, DOI: 10.6004/jnccn.2024.0013.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNCCN Clinical Practice GuidelinesVulvar cancerClinical practice guidelinesCell carcinomaHistologically squamous cell carcinomaSystemic therapy optionsSquamous cell carcinomaBasal cell carcinomaExtramammary Paget's diseasePractice guidelinesVerrucous carcinomaGynecologic malignanciesHuman papillomavirusVulvar neoplasiaTherapy optionsPaget's diseaseInflammatory conditionsRisk factorsCigarette smokingCarcinomaCancerIncreasing ageHistologyNCCNVulvarPrognostic Effect of Mismatch Repair Status in Early-Stage Endometrial Cancer Treated With Adjuvant Radiation: A Multi-institutional Analysis
Hathout L, Sherwani Z, Alegun J, Ohri N, Fields E, Shah S, Beriwal S, Horne Z, Kidd E, Leung E, Song J, Taunk N, Chino J, Huang C, Russo A, Dyer M, Li J, Albuquerque K, Damast S. Prognostic Effect of Mismatch Repair Status in Early-Stage Endometrial Cancer Treated With Adjuvant Radiation: A Multi-institutional Analysis. International Journal Of Radiation Oncology • Biology • Physics 2024, 119: 1158-1165. PMID: 38253292, DOI: 10.1016/j.ijrobp.2024.01.203.Peer-Reviewed Original ResearchAltmetricConceptsRecurrence-free survivalEndometrioid endometrial adenocarcinomaMismatch repair statusAdjuvant radiation therapyOverall survivalRadiation therapyVaginal brachytherapyMismatch repair deficiencyAssociated with worse recurrence-free survivalMulti-institutional retrospective cohort studyTreated with adjuvant radiation therapyAssociated with recurrence-free survivalMultivariate analysisExternal beam radiation therapyRecurrence-free survival ratesMismatch repair deficiency statusBeam radiation therapyGrades 1 to 2Kaplan-Meier methodOutcomes of patientsMulti-institutional analysisRetrospective cohort studyCox proportional hazards modelsProportional hazards modelAdjuvant radiation
2023
NCCN Guidelines® Insights: Cervical Cancer, Version 1.2024.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos S, Chino J, Chon H, Crispens M, Damast S, Fisher C, Frederick P, Gaffney D, Gaillard S, Giuntoli R, Glaser S, Holmes J, Howitt B, Lea J, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wyse E, McMillian N, Aggarwal S, Espinosa S. NCCN Guidelines® Insights: Cervical Cancer, Version 1.2024. Journal Of The National Comprehensive Cancer Network 2023, 21: 1224-1233. PMID: 38081139, DOI: 10.6004/jnccn.2023.0062.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCervical cancerNCCN guidelinesNCCN Guidelines InsightsSystemic therapy recommendationsAdvanced cervical cancerMetastatic diseaseTreatment landscapeClinical outcomesDiagnostic workupHistopathologic classificationTherapy recommendationsCancerMolecular profileAspects of managementRecent updatesDiagnostic featuresGuidelinesWorkupStagingDiseaseRecurrentPathologyInvestigating the Relationship between the Dose to the Recto-Vaginal Reference Point and Vaginal Stenosis among Cervical Cancer Patients Treated at a North American Academic Institution
Adefres B, Wallington D, Tien C, Damast S. Investigating the Relationship between the Dose to the Recto-Vaginal Reference Point and Vaginal Stenosis among Cervical Cancer Patients Treated at a North American Academic Institution. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e501. DOI: 10.1016/j.ijrobp.2023.06.1746.Peer-Reviewed Original ResearchConceptsVaginal stenosisDose constraintsMedian doseMultivariable Cox proportional hazards regressionCox proportional hazards regressionCohort median ageAdvanced cervical cancerInterstitial needlesKaplan-Meier methodCervical cancer patientsProportional hazards regressionLog-rank testHR-CTV D90MATERIAL/METHODSImage-guided brachytherapyNorth American academic institutionsLACC patientsPrimary endpointCumulative incidenceOnly patientsPatient demographicsMedian ageCervical cancerCancer patientsSingle institutionPrognostic Impact of Mismatch Repair Deficiency on Stage I-II Endometrioid Endometrial Cancer Treated with Adjuvant Radiation Therapy: A Multi-Institutional Analysis
Sherwani Z, Alegun J, Russo A, Damast S, Albuquerque K, Nwachukwu C, Dyer M, Fields E, Beriwal S, Horne Z, Vergalasova I, Ohri N, Taunk N, Chino J, Kidd E, Leung E, Song J, Hathout L. Prognostic Impact of Mismatch Repair Deficiency on Stage I-II Endometrioid Endometrial Cancer Treated with Adjuvant Radiation Therapy: A Multi-Institutional Analysis. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: s8. DOI: 10.1016/j.ijrobp.2023.06.217.Peer-Reviewed Original ResearchConceptsEndometrioid endometrial cancerEarly-stage endometrioid endometrial cancerExternal beam radiation therapyAdjuvant radiation therapyLymphovascular space invasionOverall survivalGrade 3Radiation therapyStage IMultivariate analysisWorse RFSWorse OSEndometrial cancerUnivariate analysisMulti-institutional retrospective cohort studyFIGO 2009 stage IRecurrence-free survival ratesCox proportional hazards modelPost-surgical stagingRetrospective cohort studyKaplan-Meier methodDeep myometrial invasionFIGO grade 1Proportional hazards modelBeam radiation therapyPO38 Clinical Outcomes Following Brachytherapy for Endometrial Cancer Patients with Narrow Vaginal Anatomy
Adefres B, Tien C, Damast S. PO38 Clinical Outcomes Following Brachytherapy for Endometrial Cancer Patients with Narrow Vaginal Anatomy. Brachytherapy 2023, 22: s84-s85. DOI: 10.1016/j.brachy.2023.06.139.Peer-Reviewed Original ResearchConceptsVaginal cuff brachytherapyVaginal recurrenceEndometrial cancerEC patientsVaginal surfaceClinical outcomesVaginal anatomyGrade 2Single-channel vaginal cylinderStage IVb endometrial cancerAdjuvant vaginal cuff brachytherapyConsecutive EC patientsEndometrial cancer patientsExcellent local controlKaplan-Meier methodExternal beam radiotherapyInsertional painBaseline painVaginal stenosisCTCAE v4.0Patient demographicsStage IIIAUrinary toxicityMedian ageMedian BMIRecent Key Studies in Cancers of the Uterine Corpus and Cervix: New Updates in Immunotherapy, the Microbiome, Bone Density, Quantifying Lymphovascular Invasion, and Hypofractionated Pelvic Radiation Therapy.
Harkenrider M, Fields E, Chopra S, Damast S, Kidd E, Chino J. Recent Key Studies in Cancers of the Uterine Corpus and Cervix: New Updates in Immunotherapy, the Microbiome, Bone Density, Quantifying Lymphovascular Invasion, and Hypofractionated Pelvic Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2023, 115: 269-275. PMID: 36621226, DOI: 10.1016/j.ijrobp.2022.07.1833.Peer-Reviewed Original ResearchAltmetricUterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos S, Chino J, Chon H, Chu C, Crispens M, Damast S, Fisher C, Frederick P, Gaffney D, Giuntoli R, Han E, Holmes J, Howitt B, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington S, Wyse E, Zanotti K, McMillian N, Aggarwal S. Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2023, 21: 181-209. PMID: 36791750, DOI: 10.6004/jnccn.2023.0006.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsUterine neoplasmsNCCN guidelinesNCCN Clinical Practice GuidelinesPure endometrioid carcinomasUterine cancer casesClinical practice guidelinesFemale genital tractMesenchymal sarcomaEndometrial histologyEndometrioid cancerCommon malignancyEndometrial carcinomaUncommon subtypeEndometrioid carcinomaUterine cancerGenital tractCancer casesPractice guidelinesCarcinomaNeoplasmsCancerGuidelinesAdenocarcinomaEndometriumSarcomaThe Impact of Racial Disparities on Outcome in Patients With Stage IIIC Endometrial Carcinoma
Patrich T, Wang Y, Elshaikh M, Zhu S, Damast S, Li J, Fields E, Beriwal S, Keller A, Kidd E, Usoz M, Jolly S, Jaworski E, Leung E, Taunk N, Chino J, Russo A, Lea J, Lee L, Albuquerque K, Hathout L. The Impact of Racial Disparities on Outcome in Patients With Stage IIIC Endometrial Carcinoma. American Journal Of Clinical Oncology 2023, 46: 114-120. PMID: 36625449, DOI: 10.1097/coc.0000000000000975.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsStage IIIC endometrial carcinomaRecurrence-free survivalNon-black patientsParaaortic lymph nodesGrade 3 tumorsBlack patientsOverall survivalEndometrial carcinomaWorse OSLymph nodesNonendometrioid histologyPositive paraaortic lymph nodesRetrospective multi-institutional studyKaplan-Meier methodMulti-institutional studySPSS version 27Adjuvant chemotherapyConcurrent chemoradiotherapyHazard ratioRFS ratesClinical outcomesRandomized trialsNonsignificant trendPatientsPrognostic covariates
2022
Brachytherapy impacts on sexual function: An integrative review of the literature focusing on cervical cancer
Chin C, Damast S. Brachytherapy impacts on sexual function: An integrative review of the literature focusing on cervical cancer. Brachytherapy 2022, 22: 30-46. PMID: 36567175, DOI: 10.1016/j.brachy.2022.10.012.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSexual morbidityCervical cancerSexual sequelaeImage-guided adaptive brachytherapyQuality of lifeSecondary preventionCurative treatmentDosimetric factorsCommon symptomsVaginal doseCancer patientsClose surveillanceSexual functionIndirect sequelaeSexual symptomsVaginal morbidityVaginal toxicitySexual dysfunctionAdaptive brachytherapySexual healthClinical interventionsMorbidityCritical organsSequelaeEffect relationship
Clinical Trials
Current Trials
Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk With Radiation (PREDICT-RT*)
HIC ID2000032279RoleSub InvestigatorPrimary Completion Date12/31/2033Recruiting ParticipantsA Randomized Phase III Trial of Induction/Consolidation Atezolizumab (NSC #783608) + SBRT Versus SBRT Alone in High Risk, Early Stage NSCLC
HIC ID2000030031RoleSub InvestigatorPrimary Completion Date05/01/2028Recruiting Participants
Academic Achievements and Community Involvement
honor 2020 Yale Cancer Center Award for Clinical Excellence
Yale School of Medicine AwardDetails01/26/2021United Stateshonor 2019-2020 ARRO Educator of the Year Award
Other AwardDetails04/15/2020United Stateshonor YNHH/Smilow Cancer Hospital Luminary Award of Excellence
Other AwardDetails09/10/2019United Stateshonor ABR Volunteer Service Award
Other AwardDetails05/15/2019United States
Clinical Care
Overview
Clinical Specialties
Therapeutic Radiology; Gynecologic Oncology
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Brachytherapy
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Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
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Yale Therapeutic Radiology
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Hunter Building
15 York Street, Ste HRT 136
New Haven, CT 06510
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