Sang-Hun Choi
Postdoctoral Associate - NeuroscienceAbout
Research
Publications
2026
Competing programs shape cortical sensorimotor-association axis development.
Tsyporin J, Zhang M, Qi C, Segal A, Li X, Kim H, Choi SH, Pavlovic I, Bandiera S, Finn T, Kim SK, Shibata A, Nakamura T, Onishi K, Zhang Z, Hammarlund E, Su G, Salla N, Kachko J, Hawley C, Li S, Doyle DZ, Peng X, Nottoli T, Ruiz-Reig N, Tissir F, Nakagawa Y, Herzog E, Ma S, Gobeske K, Pattabiraman K, Shimogori T, Duque A, Fornito A, Huang H, Shibata M, Chen B, Sestan N. Competing programs shape cortical sensorimotor-association axis development. Nature 2026 PMID: 42386980, DOI: 10.1038/s41586-026-10699-x.Peer-Reviewed Original ResearchLoss of ABCA3 disrupts lipid balance and leads to AMPK-dependent suppression of SREBP1 in glioblastoma stem cells.
Kim JK, Park MG, Ham SW, Yoon S, Kim S, Jang J, Kim H, Hong N, Park JM, Park CG, Park MJ, Choi SH, Kim JY, Jeon HY, Seo S, Lee SY, Lee Y, Cho HJ, Gwak M, Kim EJ, Eun K, Shin YJ, Nam DH, Kim SH, Yoo SJ, Kim H. Loss of ABCA3 disrupts lipid balance and leads to AMPK-dependent suppression of SREBP1 in glioblastoma stem cells. Oncogene 2026 PMID: 41882102, DOI: 10.1038/s41388-026-03736-6.Peer-Reviewed Original ResearchAdaptive evolution of gene regulatory networks in mammalian neocortex
Li Z, Kaur N, Santpere G, Muchnik S, Sindhu S, Qi C, Shibata M, Clément O, Klarić T, de Martin X, Luria V, Cho H, Li M, Shibata A, Choi S, Kim H, Tebbenkamp A, Ma S, Han W, Kim S, Pochareddy S, Duy P, Xing X, Bao Y, Xu X, Gladwyn-Ng I, Cullen H, Paolino A, Fenlon L, Kozulin P, Suárez R, Risgaard R, Gulden F, Karger A, Suzuki I, Hirata T, Gobeske K, Richards L, Sousa A, Heng J, Sestan N. Adaptive evolution of gene regulatory networks in mammalian neocortex. Nature 2026, 653: 156-166. PMID: 41851468, PMCID: PMC13149332, DOI: 10.1038/s41586-026-10226-y.Peer-Reviewed Original ResearchCis-regulatory elementsAdaptive evolutionEvolution of gene regulatory networksPutative cis-regulatory elementsGene expressionGene regulatory networksLandscape of gene expressionAssociated with genesTarget gene expressionModern reptilesHighest conservationRegulatory networksBinding motifRegulatory nodesPrefrontal cortexEvolutionary adaptationIntellectual disabilityMolecular diversityBrain connectivityExcitatory projection neuronsZBTB18Complex brainsProjection neuronsMammalsBrainHuman-specific features of the cerebellum and ZP2-regulated synapse development
Kim S, Cherskov A, Sindhwani A, Choi S, Kim H, Li M, Zhang M, Mato-Blanco X, Liu Y, Micali N, Young D, Estacion M, Zhang Y, Ruiz-Jiménez J, Nadkarni A, Luria V, Sindhu S, Chatterjee I, Shibata A, Liang D, Cho H, Park S, Spajic A, Kovner R, Glavan M, Chen R, Risgaard R, Li X, Pochareddy S, Karger A, Huttner A, Morozov Y, Daadi E, Colantuoni C, Gobeske K, Ely J, Hof P, Daadi M, Sherwood C, Duque A, Ma S, Sousa A, Waxman S, Rakic P, Santpere G, Sanders S, Sestan N. Human-specific features of the cerebellum and ZP2-regulated synapse development. Cell 2026, 189: 1802-1819.e28. PMID: 41819103, DOI: 10.1016/j.cell.2026.02.014.Peer-Reviewed Original ResearchConceptsHuman granule cellsZona pellucida glycoprotein 2Granule cellsNeuronal electrophysiological activityAdult cerebellar cortexSynapse regulationCognitive functionGlomerular synapsesNon-human primatesCerebellar cortexMotor coordinationMossy fibersGamete interactionGlycoprotein 2Human brainSynapse developmentSynaptic proteinsElectrophysiological activityHuman cerebellumEvolutionary developmentHuman-specific featuresCo-optionCerebellumHuman adaptationChromatin accessibility profiles
2025
DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species.
Seo S, Park MJ, Park MG, Gwak M, Kim Y, Jang J, Hong N, Lee BS, Kim C, Jo S, Shim HB, Kim HJ, Kim MH, Yoo SH, Yoon S, Kim S, Lee JH, Choi SH, Lee SY, Yeon GB, Park SH, Kim SH, Lee H, Lee JY, Kim DS, Lee BC, Park JW, Kim H. DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species. Nat Commun 2025, 16: 6996. PMID: 40739132, DOI: 10.1038/s41467-025-62148-4.Peer-Reviewed Original ResearchEarly developmental origins of cortical disorders modeled in human neural stem cells
Mato-Blanco X, Kim S, Jourdon A, Ma S, Choi S, Giani A, Paredes M, Tebbenkamp A, Liu F, Duque A, Vaccarino F, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. Early developmental origins of cortical disorders modeled in human neural stem cells. Nature Communications 2025, 16: 6347. PMID: 40634286, PMCID: PMC12241556, DOI: 10.1038/s41467-025-61316-w.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomicsNeural stem cellsNeural stem cell lineage commitmentGene regulatory networksEarly developmental originHuman neural stem cellsRegulatory networksExpression dynamicsRisk genesStem cellsCortical disordersTransition in vitroTelencephalic developmentEarly phaseGene dysfunctionLineage commitmentCell trajectoriesHuman corticogenesisHuman brain dysfunctionGenesNSCs in vitroMultiple diseasesIn vivoBrain dysfunctionCorticogenesisMFGE-8, a Corona Protein on Extracellular Vesicles, Mediates Self-Renewal and Survival of Human Pluripotent Stem Cells.
Lee Y, Kim H, Yoon H, Cho S, Kim J, Lee J, Choi SH, Cho H, Woo DH, Park JH, Han C, Kim JH. MFGE-8, a Corona Protein on Extracellular Vesicles, Mediates Self-Renewal and Survival of Human Pluripotent Stem Cells. J Extracell Vesicles 2025, 14: e70056. PMID: 40130745, DOI: 10.1002/jev2.70056.Peer-Reviewed Original Research
2024
ID1high/activin Ahigh glioblastoma cells contribute to resistance to anti-angiogenesis therapy through malformed vasculature
Choi S, Jang J, Kim Y, Park C, Lee S, Kim H, Kim H. ID1high/activin Ahigh glioblastoma cells contribute to resistance to anti-angiogenesis therapy through malformed vasculature. Cell Death & Disease 2024, 15: 292. PMID: 38658527, PMCID: PMC11043395, DOI: 10.1038/s41419-024-06678-7.Peer-Reviewed Original ResearchMigrasomal autophagosomes relieve endoplasmic reticulum stress in glioblastoma cells
Lee S, Choi S, Kim Y, Ahn H, Ko Y, Kim K, Chi S, Kim H. Migrasomal autophagosomes relieve endoplasmic reticulum stress in glioblastoma cells. BMC Biology 2024, 22: 23. PMID: 38287397, PMCID: PMC10826056, DOI: 10.1186/s12915-024-01829-w.Peer-Reviewed Original Research
2022
The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2
. The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2. Cell Reports 2022, 41: 111626. PMID: 36417870, DOI: 10.1016/j.celrep.2022.111626.Peer-Reviewed Original Research