Victor Luria, PhD
Research Scientist in NeuroscienceCards
About
Research
Publications
2026
Adaptive evolution of gene regulatory networks in mammalian neocortex
Li Z, Kaur N, Santpere G, Muchnik S, Sindhu S, Qi C, Shibata M, Clément O, Klarić T, de Martin X, Luria V, Cho H, Li M, Shibata A, Choi S, Kim H, Tebbenkamp A, Ma S, Han W, Kim S, Pochareddy S, Duy P, Xing X, Bao Y, Xu X, Gladwyn-Ng I, Cullen H, Paolino A, Fenlon L, Kozulin P, Suárez R, Risgaard R, Gulden F, Karger A, Suzuki I, Hirata T, Gobeske K, Richards L, Sousa A, Heng J, Sestan N. Adaptive evolution of gene regulatory networks in mammalian neocortex. Nature 2026, 1-11. PMID: 41851468, DOI: 10.1038/s41586-026-10226-y.Peer-Reviewed Original ResearchCis-regulatory elementsAdaptive evolutionEvolution of gene regulatory networksPutative cis-regulatory elementsGene expressionGene regulatory networksLandscape of gene expressionAssociated with genesTarget gene expressionModern reptilesHighest conservationRegulatory networksBinding motifRegulatory nodesPrefrontal cortexEvolutionary adaptationIntellectual disabilityMolecular diversityBrain connectivityExcitatory projection neuronsZBTB18Complex brainsProjection neuronsMammalsBrainHuman-specific features of the cerebellum and ZP2-regulated synapse development
Kim S, Cherskov A, Sindhwani A, Choi S, Kim H, Li M, Zhang M, Mato-Blanco X, Liu Y, Micali N, Young D, Estacion M, Zhang Y, Ruiz-Jiménez J, Nadkarni A, Luria V, Sindhu S, Chatterjee I, Shibata A, Liang D, Cho H, Park S, Spajic A, Kovner R, Glavan M, Chen R, Risgaard R, Li X, Pochareddy S, Karger A, Huttner A, Morozov Y, Daadi E, Colantuoni C, Gobeske K, Ely J, Hof P, Daadi M, Sherwood C, Duque A, Ma S, Sousa A, Waxman S, Rakic P, Santpere G, Sanders S, Sestan N. Human-specific features of the cerebellum and ZP2-regulated synapse development. Cell 2026, 189: 1802-1819.e28. PMID: 41819103, DOI: 10.1016/j.cell.2026.02.014.Peer-Reviewed Original ResearchConceptsHuman granule cellsZona pellucida glycoprotein 2Granule cellsNeuronal electrophysiological activityAdult cerebellar cortexSynapse regulationCognitive functionGlomerular synapsesNon-human primatesCerebellar cortexMotor coordinationMossy fibersGamete interactionGlycoprotein 2Human brainSynapse developmentSynaptic proteinsElectrophysiological activityHuman cerebellumEvolutionary developmentHuman-specific featuresCo-optionCerebellumHuman adaptationChromatin accessibility profiles
2025
De Novo Genes: Current Status and Future Goals
Casola C, Luria V, Vakirlis N, Zhao L. De Novo Genes: Current Status and Future Goals. Genome Biology And Evolution 2025, 17: evaf230. PMID: 41313722, PMCID: PMC12708343, DOI: 10.1093/gbe/evaf230.Peer-Reviewed Original ResearchDe Novo Gene Emergence: Summary, Classification, and Challenges of Current Methods
Grandchamp A, Aubel M, Eicholt L, Roginski P, Luria V, Karger A, Dohmen E. De Novo Gene Emergence: Summary, Classification, and Challenges of Current Methods. Genome Biology And Evolution 2025, 17: evaf197. PMID: 41126639, PMCID: PMC12605812, DOI: 10.1093/gbe/evaf197.Peer-Reviewed Original ResearchDeNoFo: a file format and toolkit for standardized, comparable de novo gene annotation
Dohmen E, Aubel M, Eicholt L, Roginski P, Luria V, Karger A, Grandchamp A. DeNoFo: a file format and toolkit for standardized, comparable de novo gene annotation. Bioinformatics 2025, 41: btaf539. PMID: 41051215, PMCID: PMC12516307, DOI: 10.1093/bioinformatics/btaf539.Peer-Reviewed Original Research
2024
Expression of Random Sequences and de novo Evolved Genes From the Mouse in Human Cells Reveals Functional Diversity and Specificity
Aldrovandi S, Castro J, Ullrich K, Karger A, Luria V, Tautz D. Expression of Random Sequences and de novo Evolved Genes From the Mouse in Human Cells Reveals Functional Diversity and Specificity. Genome Biology And Evolution 2024, 16: evae175. PMID: 39663928, PMCID: PMC11635099, DOI: 10.1093/gbe/evae175.Peer-Reviewed Original ResearchConceptsOpen reading frameGene open reading frameCellular regulatory pathwaysNoncoding DNAReading frameHuman cell linesHuman genomeAlpha-helicesGrowth experimentsCellular physiologyFunctional diversityPositive selectionBeta-sheetTranscriptomic responseRegulatory pathwaysAdaptive advantageHuman cellsGenesCell clonesCell linesSequenceClonesRandom sequencePathwayCellsIndividual variation in the emergence of anterior-to-posterior neural fates from human pluripotent stem cells
Kim S, Seo S, Stein-O’Brien G, Jaishankar A, Ogawa K, Micali N, Luria V, Karger A, Wang Y, Kim H, Hyde T, Kleinman J, Voss T, Fertig E, Shin J, Bürli R, Cross A, Brandon N, Weinberger D, Chenoweth J, Hoeppner D, Sestan N, Colantuoni C, McKay R. Individual variation in the emergence of anterior-to-posterior neural fates from human pluripotent stem cells. Stem Cell Reports 2024, 19: 1336-1350. PMID: 39151428, PMCID: PMC11411333, DOI: 10.1016/j.stemcr.2024.07.004.Peer-Reviewed Original ResearchHuman pluripotent stem cellsEarly mammalian developmentConsequences of variationPluripotent stem cellsTranscriptomic variationMammalian developmentTranscriptomic patternsTranscriptomic traitsReplicate linesMesendodermal lineagesNeural fateAdult tissuesLineagesHindbrain fateTranscriptional signatureTranscriptomic signaturesEarly eventLineage biasHuman pluripotent stem cell linesStem cellsFateIndividual variationAnterior to posterior structuresEpigenetic originCells
2023
Human-specific features and developmental dynamics of the brain N-glycome
Klarić T, Gudelj I, Santpere G, Novokmet M, Vučković F, Ma S, Doll H, Risgaard R, Bathla S, Karger A, Nairn A, Luria V, Bečeheli I, Sherwood C, Ely J, Hof P, Sousa A, Josić D, Lauc G, Sestan N. Human-specific features and developmental dynamics of the brain N-glycome. Science Advances 2023, 9: eadg2615. PMID: 38055821, PMCID: PMC10699788, DOI: 10.1126/sciadv.adg2615.Peer-Reviewed Original ResearchMolecular and cellular mechanisms of human cortical connectivity
Luria V, Ma S, Shibata M, Pattabiraman K, Sestan N. Molecular and cellular mechanisms of human cortical connectivity. Current Opinion In Neurobiology 2023, 80: 102699. PMID: 36921362, DOI: 10.1016/j.conb.2023.102699.Peer-Reviewed Original Research
2021
Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation
Li F, Rane R, Luria V, Xiong Z, Chen J, Li Z, Catullo R, Griffin P, Schiffer M, Pearce S, Lee S, McElroy K, Stocker A, Shirriffs J, Cockerell F, Coppin C, Sgrò C, Karger A, Cain J, Weber J, Santpere G, Kirschner M, Hoffmann A, Oakeshott J, Zhang G. Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation. Molecular Ecology Resources 2021, 22: 1559-1581. PMID: 34839580, PMCID: PMC9299920, DOI: 10.1111/1755-0998.13561.Peer-Reviewed Original ResearchConceptsClimate generalistsDrosophila speciesGenus DrosophilaPhylogenomic analysisSignificant phylogenetic incongruenceEvolutionary genomic studiesMelanogaster species groupGenome-wide signalsDifferent climatic nichesHigh-quality assemblySmall population sizeIncomplete lineageSubgenus DrosophilaAsymmetric introgressionSubgenus SophophoraPhylogenetic incongruenceNew transcriptomesGene gainClimatic nicheGenome diversityNatural populationsWidespread speciesGenomic signalsSpecies groupsClimate niche