Prashanth Vallabhajosyula, MD, MS
ProfessorCards
About
Research
Publications
2026
Use of inverse probability weighting in cardiovascular surgical outcomes research–Principles, limitations, and recommendations
Liu Z, Ma W, Liu L, Vallabhajosyula P, Wang H. Use of inverse probability weighting in cardiovascular surgical outcomes research–Principles, limitations, and recommendations. European Journal Of Cardio-Thoracic Surgery 2026, ezag122. PMID: 41830434, DOI: 10.1093/ejcts/ezag122.Peer-Reviewed Original ResearchInverse probability of treatment weightingOutcomes researchInverse probabilityHeterogeneity of treatment effectsSurgical outcomes researchProbability of treatment weightingConfounding biasCardiovascular Outcomes ResearchResearch principlesConfoundingStatistical primerTreatment weightingAortic arch pathologiesSample sizeTreatment effectsArch pathologiesSurgical approachRetrospective studyBaselineImproper useRecommendationsHealthcare burden of mixed aortic valve stenosis and insufficiency disease
Sultan I, Ryan M, Gunnarsson C, Marfo G, Vallabhajosyula P. Healthcare burden of mixed aortic valve stenosis and insufficiency disease. Journal Of Medical Economics 2026, 29: 761-771. PMID: 41801137, DOI: 10.1080/13696998.2026.2635880.Peer-Reviewed Original ResearchConceptsMixed aortic valve diseaseHealthcare utilizationHealthcare burdenAortic valve replacementHealth care databasesHome health utilizationCare databaseAortic insufficiencyAsymptomatic patientsHealth utilityHigher annual costsCox proportional hazardsAortic stenosisMonths continuous enrollmentBaseline visitGeneralized linear modelHealthcareAortic valve stenosisContinuous enrollmentAortic valve diseaseProportional hazardsUS patientsAnnual costValve replacementEarly detectionManagement of Thoracic Aortic Infections
Hameed I, Vallabhajosyula P. Management of Thoracic Aortic Infections. Contemporary Cardiology 2026, 183-199. DOI: 10.1007/978-3-032-13134-8_13.Peer-Reviewed Original ResearchAortic infectionValve endocarditisAortic valve endocarditisProsthetic valve endocarditisAdequate follow-upInfectious aortitisGraft infectionClinical presentationTuberculous aortitisSurgical managementSurgical optionsClinical entityClinical findingsCase reportGood outcomeLaboratory valuesFollow-upOriginal graftSyphilitic aortitisTissue graftAortitisAbnormal inflammationAppropriate guidelinesAortic wallExtensive literature searchLeveraging in-silico deep learning and computational analyses to predict the pathogenicity of ROBO4 variants of uncertain significance in aortic aneurysm and dissection patients
Lee C, Hameed I, Cupo M, Erez E, Ahmad H, Lee J, Verma S, Saeed W, Fatimi A, Assi R, Vallabhajosyula P. Leveraging in-silico deep learning and computational analyses to predict the pathogenicity of ROBO4 variants of uncertain significance in aortic aneurysm and dissection patients. BMC Cardiovascular Disorders 2026, 26: 173. PMID: 41639767, PMCID: PMC12922274, DOI: 10.1186/s12872-025-05357-5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic Aneurysm, ThoracicAortic DissectionComputational BiologyDeep LearningFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMiddle AgedMutation, MissensePatient-Specific ModelingPedigreePhenotypePredictive Value of TestsReceptors, Cell SurfaceRoundabout ProteinsStructure-Activity RelationshipConceptsPathogenic potentialSignificance of genetic variantsThoracic aortic aneurysmBeta-sheet structureMissense VUSsGenotype-phenotype correlationPolyPhen-2Aortic aneurysmPathogenicity predictionPathogenic significanceGenetic dataResidue positionsGenetic variantsBiochemical propertiesROBO4 genesVUSClinical dataPathogensExtracellular domain variantsDomain variantsComputational predictionsAscending Aortic AneurysmGenesPrecision medicineVariantsPregnancy-associated Vascular Complications and Thoracic Aortic Growth Patterns
Nasir A, Waldron C, Vallabhajosyula P, Murugiah K, Assi R. Pregnancy-associated Vascular Complications and Thoracic Aortic Growth Patterns. JTCVS Structural And Endovascular 2026, 100104. DOI: 10.1016/j.xjse.2026.100104.Peer-Reviewed Original ResearchThoracic aortic diseaseThoracic aortic aneurysmElectronic health recordsAortic diseaseVascular complicationsAortic aneurysmDiagnosis of thoracic aortic aneurysmClinical managementPregnancy-related vascular complicationsRecords of pregnant patientsHeritable thoracic aortic diseaseClinical management of pregnancyManagement of pregnancyConnective tissue diseaseAcute aortic eventsAortic surveillanceObjective PregnancyObstetric populationPregnant patientsAortic eventsAortic sizeArterial complicationsAortic dissectionTissue diseaseThoracic aorta
2025
Prosthesis–Patient Mismatch Following Aortic Valve Replacement—A Comprehensive Review
Talapaneni S, Ahmad D, Khandelwal M, Mesiha M, Jalali P, Celik N, Tabraiz S, Dankwa S, Hameed I, Milewski R, Vallabhajosyula P. Prosthesis–Patient Mismatch Following Aortic Valve Replacement—A Comprehensive Review. Journal Of Clinical Medicine 2025, 14: 8868. PMID: 41464770, PMCID: PMC12733721, DOI: 10.3390/jcm14248868.Peer-Reviewed Original ResearchProsthesis-patient mismatchAortic valve replacementPatient's body surface areaBioprosthetic valve fractureValve replacementTransvalvular gradientSurgical valvesLeft ventricular mass regressionAccurate preoperative imagingRates of heart failureCoronary flow abnormalitiesLong-term outcomesBody surface areaValve-in-valveEffective orifice areaIndividual patient anatomyNarrative reviewAnnular enlargementPreoperative imagingLate mortalityPatient survivalClinical outcomesCardiac remodelingMass regressionCoronary accessSuccessful Application of TEVAR With a Vascular Plug for Treatment of Pseudoaneurysm in Ascending Aorta
Dankwa S, Hameed I, Khandelwal M, Saeed W, Patel R, Kuwayama D, Vallabhajosyula P. Successful Application of TEVAR With a Vascular Plug for Treatment of Pseudoaneurysm in Ascending Aorta. JACC Case Reports 2025, 30: 105730. PMID: 41271380, PMCID: PMC12790233, DOI: 10.1016/j.jaccas.2025.105730.Peer-Reviewed Original ResearchThoracic endovascular aortic repairAortic pseudoaneurysmAortic surgeryEndovascular repairAVP IIApplication of thoracic endovascular aortic repairFollow-up computed tomography angiographyAortic wall fragilityAscending aortic pseudoaneurysmComplex surgical historyEndovascular aortic repairAortic aneurysm repairTreatment of pseudoaneurysmsComputed tomography angiographyShortness of breathRisk of mortalityMitraClip implantationArch replacementAortic repairChest painGenetic aortopathiesOpen surgeryAneurysm repairSurgical riskSurgical historyManagement of Complex Endoleak From Endovascular Graft Component Separation in the Thoracoabdominal Aorta
Ahmed A, Hameed I, Colon S, Colon G, Talapaneni S, Fatimi A, Cardella J, Aboian E, Nassiri N, Vallabhajosyula P, Kuwayama D. Management of Complex Endoleak From Endovascular Graft Component Separation in the Thoracoabdominal Aorta. JACC Case Reports 2025, 31: 105938. PMID: 41182218, PMCID: PMC12833642, DOI: 10.1016/j.jaccas.2025.105938.Peer-Reviewed Original ResearchThoracoabdominal aortic repairLong-term complicationsType IIIa endoleakAortic repairComplex aortic interventionsAneurysm sac enlargementII thoracoabdominal aneurysmThoracoabdominal aortic pathologiesRigorous follow-upAortic interventionThoracoabdominal aortaSac enlargementThoracoabdominal aneurysmsAortic pathologyGraft migrationComponent separationSurgical techniqueAortic implantationFollow-upEndoleakEndovascular interventionEndograft devicesEndograftBranch perfusionGraftLeft Ventricular Remodeling After Hybrid Arch Repair With Zone 0 to 5 Thoracic Endovascular Aortic Repair
Hameed I, Mubasher A, Lee C, Berry G, Talapaneni S, Ahmed A, Ahmad H, Cangut B, Erez E, Colon S, Colon G, Williams M, Kuwayama D, Assi R, Lombo B, Reinhardt S, Akintoye E, Vallabhajosyula P. Left Ventricular Remodeling After Hybrid Arch Repair With Zone 0 to 5 Thoracic Endovascular Aortic Repair. European Journal Of Cardio-Thoracic Surgery 2025, 67: ezaf324. PMID: 41002188, DOI: 10.1093/ejcts/ezaf324.Peer-Reviewed Original ResearchConceptsThoracic endovascular aortic repairEndovascular aortic repairLeft ventricular remodelingHybrid aortic repairAortic repairType 1a endoleakVentricular remodelingLong-term outcomesFollow-upUtilization of thoracic endovascular aortic repairCT angiography follow-upEchocardiographic follow-up dataGraft patencyProximal extensionFollow-up CT angiographySingle-institution experienceAngiography follow-upAortic arch pathologiesHybrid arch repairSingle-institution studyMidterm follow-upZone 0Left ventricular sizeDescending Thoracic AortaFollow-up dataInstruction-Tuned Large Language Models for Clinical Data Extraction: Creating an Aortic Measurement Database from CT Radiology Reports
Erez E, Dankwa S, Tuttle M, Nasir A, Vallabhajosyula P, Schneider E, Assi R, Ong C. Instruction-Tuned Large Language Models for Clinical Data Extraction: Creating an Aortic Measurement Database from CT Radiology Reports. Journal Of Healthcare Informatics Research 2025, 9: 587-605. PMID: 41230242, PMCID: PMC12602774, DOI: 10.1007/s41666-025-00210-y.Peer-Reviewed Original ResearchLanguage modelFew-shotZero-ShotInformation extraction tasksMacro F1-scoreBERT-based modelsExtraction taskBERT modelChest Computed TomographyF1 scoreElectronic health recordsMinimal annotationStructure extractionTest setAortic measurementsAortic diameterHealth recordsThoracic aortic dilatationCT radiology reportsRelevant informationChest CT reportsHigh performanceAortic dilatationCT reportsAortic disease
Clinical Trials
Current Trials
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation after Coronary Artery Bypass Surgery
IRB ID2000027269RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge18+ yearsCorMatrix Cor TRICUSPID ECM Valve Replacement Study
IRB ID2000028726RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge1 year - 70 years
Academic Achievements & Community Involvement
Clinical Care
Overview
Prashanth Vallabhajosyula, MD, MS, is surgical director of the Aortic Institute, which is part of the Yale New Haven Health Heart & Vascular Center. He is a cardiothoracic surgeon who performs the entire spectrum of heart surgeries, including coronary artery bypass grafting, valve surgery, and heart transplantation. His primary focus is endovascular and open surgeries of the aorta, and hybrid surgeries that combine the two.
Dr. Vallabhajosyula is skilled in complex procedures, such as thoracic endovascular aortic repair (TEVAR), a minimally invasive procedure that uses a stent graft to reinforce an aneurysm and prevent it from bursting. He also introduced pulmonary thromboendarterectomy to Yale. The latter is a highly specialized surgical procedure that removes chronic blood clots from the arteries in the lung.
As director of the Aortic Institute, Dr. Vallabhajosyula says a large part of his work is coordinating and integrating a variety of services. “A multidisciplinary approach is important, because what we can offer patients for a particular aortic disease is rapidly evolving,” Dr. Vallabhajosyula says, explaining this that can change how different specialists can contribute to a case. “People draw arbitrary lines around what vascular surgery will do, what cardiology will do, and what a heart surgeon will do, but patients don't always understand that or come in that way. Our goal is to integrate all the services and provide a single place for patients to come if they have an aortic problem.”
Dr. Vallabhajosyula says one thing that led him to medicine was a lifelong love of science. “When I was in sixth grade, growing up in India, my mother took me to a medical university for a show they had where kids from elementary school could see human bones,” he says. “There was an anatomy lab going on, and I snuck into it and saw some cadavers. I wasn’t scared at all. I was fascinated by the human body and with seeing all these parts, and truly understanding that there is such an organic basis to everything that we do. I was hooked from the very beginning.”
He also enjoyed any experience that involved helping people, which led to his decision to be a surgeon. “Patient care is a phenomenal thing,” he says. While patients and their families are grateful for what he can do for them, he also gets a lot back, he adds. “I really try to understand patients for who they are and where they are coming from. If you approach patient care that way, you come to realize that we're all pretty similar. I think that’s made me a better person,” he says.
Clinical Specialties
Fact Sheets
Aortic Aneurysm
Learn More on Yale MedicineEndovascular Debranching Aortic Repair for Thoracoabdominal Aortic Aneurysms
Learn More on Yale MedicinePulmonary Thromboendarterectomy
Learn More on Yale MedicineReoperative Heart Surgery
Learn More on Yale Medicine
Board Certifications
Thoracic & Cardiac Surgery
- Certification Organization
- AB of Thoracic Surgery
- Original Certification Date
- 2012
Yale Medicine News
News
News
- June 26, 2025
For Heart Transplant Patients, Blood Test May Detect Rejection Earlier and More Easily
- March 11, 2025Source: New Haven Register
How Yale doctors used a balloon in surgery to treat heart issue
- January 14, 2025
Yale Team Performs State’s First BATMAN Procedure
- June 04, 2024
Surgery Research Presented at Blavatnik Fund for Innovation at Yale
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Cardiac Surgery
PO Box 208062
New Haven, CT 06520-8062
United States
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