About
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Research Scientist
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Cardiac Surgery
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Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Laxminarayana Korutla's published research.
Publications Timeline
A big-picture view of Laxminarayana Korutla's research output by year.
Prashanth Vallabhajosyula, MD, MS
Clancy Mullan, MD
Sounok Sen, MD
38Publications
1,054Citations
Publications
2024
Peripheral Blood Extracellular Vesicle RNA Profiling: The Next Step in Cancer Liquid Biopsies
Hu R, Korutla L, Vallabhajosyula P. Peripheral Blood Extracellular Vesicle RNA Profiling: The Next Step in Cancer Liquid Biopsies. Annals Of Surgical Oncology 2024, 31: 4179-4181. PMID: 38755337, DOI: 10.1245/s10434-024-15400-y.Peer-Reviewed Original Research
2023
Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection
Korutla L, Hoffman J, Rostami S, Hu R, Korutla V, Markmann C, Mullan C, Sotolongo A, Habertheuer A, Romano C, Acker M, Sen S, Agarwal D, Jayaraman A, Li B, Davis M, Naji A, Vallabhajosyula P. Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection. American Journal Of Transplantation 2023, 24: 419-435. PMID: 38295008, DOI: 10.1016/j.ajt.2023.10.021.Peer-Reviewed Original ResearchAltmetricConceptsAcute cellular rejectionAllogeneic transplant recipientsTransplant recipientsCellular rejectionHeart transplantationAlloreactive T cell activationEarly acute cellular rejectionT-cell receptor sequencingSyngeneic transplant recipientsCell receptor sequencingClinical heart transplantationT cell clonesNovel candidate biomarkersT cell activationQuantitative RT-PCRRecipient circulationOrgan transplantationT cellsVesicle profilesNoninvasive biomarkersCandidate biomarkersCell activationRegulatory markersDonor cardiomyocytesTransplantationIntramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial
Kaushal S, Hare J, Hoffman J, Boyd R, Ramdas K, Pietris N, Kutty S, Tweddell J, Husain S, Menon S, Lambert L, Danford D, Kligerman S, Hibino N, Korutla L, Vallabhajosyula P, Campbell M, Khan A, Naioti E, Yousefi K, Mehranfard D, McClain-Moss L, Oliva A, Davis M. Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial. European Heart Journal Open 2023, 3: oead002. PMID: 36950450, PMCID: PMC10026620, DOI: 10.1093/ehjopen/oead002.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCardiac magnetic resonance imagingGlobal longitudinal strainMedicinal signaling cellsEjection fractionRight ventricleOpen-label multicentre trialMajor adverse cardiac eventsHypoplastic left heart syndromeAdverse cardiac eventsInvestigational cell therapyBidirectional cavopulmonary anastomosisPhase I trialRV ejection fractionRisk of deathMagnetic resonance imagingPrimary endpointCardiac eventsRV functionSurgical palliationI trialMulticentre trialCavopulmonary anastomosisCell-based therapiesHeart syndromeRibonucleic acid
2022
Donor extracellular vesicle trafficking via the pleural space represents a novel pathway for allorecognition after lung transplantation
Habertheuer A, Chatterjee S, Sada Japp A, Ram C, Korutla L, Ochiya T, Li W, Terada Y, Takahashi T, Nava RG, Puri V, Kreisel D, Vallabhajosyula P. Donor extracellular vesicle trafficking via the pleural space represents a novel pathway for allorecognition after lung transplantation. American Journal Of Transplantation 2022, 22: 1909-1918. PMID: 35285127, DOI: 10.1111/ajt.17023.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMediastinal lymph nodesLymph nodesLung transplantationDonor antigensPleural spaceBronchial anastomosisGraft-draining lymph nodesLocoregional lymph nodesLung transplant recipientsPeripheral lymph nodesTransplant recipientsAllorecognition pathwaysPulmonary transplantationMHC-IIPleural fluidRat modelT cellsLymphatic drainageTransplantationDonor extracellular vesiclesPleural lymphaticsCell traffickingRapid rejectionAlternative pathwayAntigen
2021
Unlocking the Potential of Induced Pluripotent Stem Cells for Wound Healing: The Next Frontier of Regenerative Medicine
Dash BC, Korutla L, Vallabhajosyula P, Hsia HC. Unlocking the Potential of Induced Pluripotent Stem Cells for Wound Healing: The Next Frontier of Regenerative Medicine. Advances In Wound Care 2021, 11: 622-638. PMID: 34155919, DOI: 10.1089/wound.2021.0049.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInduced pluripotent stem cell (iPSC) technologyTissue-engineered skin constructsSkin constructsSkin tissue engineeringStem cell technologyPluripotent stem cell (iPSC) technologyInduced pluripotent stem cellsPluripotent stem cellsCell-based therapiesRegenerative medicineTissue engineeringCell technologyCurrent advancementsTissue regenerationDisease modelingHiPSC linesEfficient manufacturing processesIPSC linesCurrent progressFunctional cellsLarge animal studiesNext generationCirculating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model
Habertheuer A, Ram C, Schmierer M, Chatterjee S, Hu R, Freas A, Zielinski P, Rogers W, Silvestro EM, McGrane M, Moore JS, Korutla L, Siddiqui S, Xin Y, Rizi R, Tao J, Kreisel D, Naji A, Ochiya T, Vallabhajosyula P. Circulating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model. Transplantation 2021, 106: 754-766. PMID: 33993180, DOI: 10.1097/tp.0000000000003820.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute rejectionDonor exosomesExosome profileSyngeneic controlsRat orthotopic lung transplant modelChronic lung allograft dysfunctionOrthotopic lung transplantation modelLung transplant modelPosttransplant time pointsAcute rejection episodesLung allograft dysfunctionLung transplant patientsLung transplant rejectionLung transplantation modelEarly therapeutic interventionMajor risk factorTime-sensitive diagnosisDevelopment of biomarkersAllograft dysfunctionRejection episodesLewis recipientsTransplant patientsPulmonary allograftsRecipient bloodAllogeneic grafts
2020
Circulating Donor Heart Exosome Profiling Enables Noninvasive Detection of Antibody-mediated Rejection
Hu RW, Korutla L, Reddy S, Harmon J, Zielinski PD, Bueker A, Molina M, Romano C, Margulies K, McLean R, Lal P, Vallabhajosyula P. Circulating Donor Heart Exosome Profiling Enables Noninvasive Detection of Antibody-mediated Rejection. Transplantation Direct 2020, 6: e615. PMID: 33134491, PMCID: PMC7575166, DOI: 10.1097/txd.0000000000001057.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAntibody-mediated rejectionDonor exosomesEndomyocardial biopsyDonor heartsHuman leukocyte antigen (HLA) IHLA-I antibodiesRejection episodesTransplanted heartsComplement depositionI antibodiesPatientsClinical settingMRNA expressionAntigen IRejection typeTissue levelsI specificityProtein expressionTime pointsGold standardNoninvasive detectionAntibodiesTroponin proteinsBiopsyExosomesIslet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes
Yu M, Agarwal D, Korutla L, May CL, Wang W, Griffith NN, Hering BJ, Kaestner KH, Velazquez OC, Markmann JF, Vallabhajosyula P, Liu C, Naji A. Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes. Nature Metabolism 2020, 2: 1013-1020. PMID: 32895576, PMCID: PMC7572844, DOI: 10.1038/s42255-020-0269-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIslet transplantationSubcutaneous spacePancreatic isletsNon-human primate modelSyngeneic islet transplantationType 1 diabetesTreatment of typeLack of neovascularizationPancreatic islet transplantationNew therapeutic paradigmHuman pancreatic isletsSustained normoglycaemiaGraft survivalHypoxic cell deathPrimate modelPreclinical modelsAnimal modelsTransplantationSubcutaneous transplantationTherapeutic paradigmDiabetesEuglycaemiaCell deathIsletsTransplantation methodologiesSyncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia
Levine L, Habertheuer A, Ram C, Korutla L, Schwartz N, Hu RW, Reddy S, Freas A, Zielinski PD, Harmon J, Molugu SK, Parry S, Vallabhajosyula P. Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia. Scientific Reports 2020, 10: 6398. PMID: 32286341, PMCID: PMC7156695, DOI: 10.1038/s41598-020-62193-7.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSyncytin-1Preeclampsia groupMaternal circulationExtracellular vesiclesCommon placental pathologyHigh expressionDiagnosis of preeclampsiaConditions of preeclampsiaBone alkaline phosphatasePotential physiologic roleTissue-specific biomarkersExtracellular microvesiclesPlasma extracellular vesiclesAlkaline phosphatasePreeclampsia subjectsNormal pregnancyPlacental pathologyCell extracellular vesiclesImproved biomarkersMaternal bloodPreeclampsiaPlacental syncytiotrophoblastMaternal plasmaPlacental alkaline phosphatasePhysiologic role905: Release of placental exosomes is reduced in spontaneous preterm births
Parry S, Leite R, Korutla L, Vallabhajosyula P. 905: Release of placental exosomes is reduced in spontaneous preterm births. American Journal Of Obstetrics And Gynecology 2020, 222: s561-s562. DOI: 10.1016/j.ajog.2019.11.916.Peer-Reviewed Original Research