Micha Sam Brickman Raredon, MD, PhD
Assistant Professor of AnesthesiologyCards
Appointments
Contact Info
Vascular Biology and Therapeutics Program
10 Amistad Street, Rm. 301A
New Haven, Connecticut 06519
United States
About
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Titles
Assistant Professor of Anesthesiology
Biography
Dr. Micha Sam Brickman Raredon is an Assistant Professor in the Department of Anesthesiology at the Yale School of Medicine. The Raredon Laboratory studies regenerative lung engineering, and develops primary-source algorithms focused on cell-to-cell communication networks, including NICHES and Connectome. Dr. Raredon's laboratory seeks to reverse-engineer tissues for regenerative medicine through the close study of single-cell systems biology.
Dr. Raredon completed his MD/PhD training at Yale in the laboratory of Dr. Laura Niklason (Biomedical Engineering), co-mentored by Dr. Naftali Kaminski (Pulmonary, Critical Care & Sleep Medicine), Dr. Andre Levchenko (Systems Biology) and Dr. Yuval Kluger (Applied Math). In 2022 he founded his lab as an independent group leader under the mentorship of Dr. Kaminski, Dr. Ruslan Medzhitov (Immunobiology), and Dr. Robert Schonberger (Anesthesiology). Dr. Raredon is now a faculty member of the Vascular Biology and Therapeutics Program at Yale and the Program in Translational Biomedicine.
Dr. Raredon received a master's degree in Materials Science and Engineering at the Massachusetts Institute of Technology, where he received the Draper Fellowship to develop vascular tissue micro-fabrication techniques in the laboratories of Dr. Linda Griffith (Bioengineering), Dr. Paula Hammond (Chemical Engineering), and Dr. Jeffrey Borenstein (Draper Labs). He completed his undergraduate work in Biomedical Engineering and the History of Art at Yale University and the University of Cambridge.
Dr. Raredon plays the cello and enjoys finding time to be outdoors and near water as much as possible.
Appointments
Anesthesiology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Independent Group Leader, T32 Fellowship
- Yale School of Medicine (2024)
- MD
- Yale School of Medicine (2022)
- PhD
- Yale School of Engineering and Applied Science, Biomedical Engineering (2021)
- MS
- Yale School of Engineering and Applied Science, Biomedical Engineering (2020)
- MPhil
- Yale School of Engineering and Applied Science, Biomedical Engineering (2020)
- MS
- Massachusetts Institute of Technology, Materials Science and Engineering (2014)
- BS
- Yale University, Biomedical Engineering & History of Art (2011)
Research
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Overview
Dr. Raredon's research group focuses on the mechanisms governing the behavior of complex multicellular systems and in leveraging these principles to engineer living tissues for regenerative medicine. Our work combines systems biology, stem-cell engineering, materials science, surgical fabrication, and biological engineering. The team is particularly invested in engineering, or controlling the self-organization of, cross-length scale perfusable vascular networks and tissue architecture, and in devising principles of microvascular construction and control that can be applied across organ types. We are a clinically-integrated laboratory with two broadly interconnected goals: the modeling of network-level mechanisms of tissue morphogenesis and phenotype regulation, and the application of those models to the design and fabrication of patient-specific tissues for therapeutic use.
Medical Research Interests
ORCID
0000-0003-1441-6122- View Lab Website
Raredon Laboratory
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Naftali Kaminski, MD
Jonas Christian Schupp, MD
Allison M. Greaney, PhD
Taylor Adams
Laura Niklason, PhD, MD
Pavlina Baevova
Tissue Engineering
Computational Biology
Publications
2025
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models
Hoffman E, Shah A, Barboza W, Rodriguez L, Dherwani R, Dooley P, Minakin K, Tomer Y, Ayers L, Jones D, Murthy A, Bennett A, Lange A, Bawa P, Wang F, Babu A, Chavez K, Nakamoto R, Cooper C, Basil M, Raredon M, Kotton D, Alysandratos K, Katzen J. Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models. Nature Communications 2025, 16: 8710. PMID: 41027873, PMCID: PMC12484947, DOI: 10.1038/s41467-025-63735-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntermediate epithelial cellsPulmonary fibrosisEpithelial cellsSpontaneous lung fibrosisTGF-bType 2 epithelial cellsAlveolar type 2 epithelial cellsActivation of lung fibroblastsAlveolar epithelial cellsSurfactant protein CTGF-b signalingEx vivo assaysProgressive diseaseProfibrotic stateBasaloid cellsMurine modelLung fibrosisFibrosis modelProtein CAT2Pathogenic activityFibroblast activationLung fibroblastsReciprocal signalingFibrosisSingle cell RNA seq reveals the pro-regenerative phenotype of thrombospondin-2 deficient dermal fibroblasts
Huang Y, Wang N, Xing H, Gao D, Hsia H, Raredon M, Kyriakides T. Single cell RNA seq reveals the pro-regenerative phenotype of thrombospondin-2 deficient dermal fibroblasts. Scientific Reports 2025, 15: 32304. PMID: 40897801, PMCID: PMC12405501, DOI: 10.1038/s41598-025-15839-3.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSingle cell RNA-seqSingle-cell RNA sequencingIn silico analysisThrombospondin-2Gene expression profilesDifferential signaling pathwaysDermal fibroblastsRNA-seqKO fibroblastsScRNA-seqSilico analysisRNA sequencingPro-survivalSignaling pathwayExpression profilesCell communicationTissue developmentCell heterogeneityPro-regenerative phenotypeSkin fibroblastsPro-regenerative featuresSOX10Schwann precursor cellsFibroblastsCellsUnderstanding and Reducing Cardiopulmonary Sequelae Associated With Chronic Hypoxia
Manning E, Ramachandra A, Sharma P, Nikola F, De Man R, Doddaballapur P, Raredon M, Szafron J, Baernthaler T, Justet A, Akingbesote N, Perry R, Adams T, Cavinato C, Yan X, Tellides G, Kaminski N, Humphrey J. Understanding and Reducing Cardiopulmonary Sequelae Associated With Chronic Hypoxia. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3336-a3336. DOI: 10.1164/ajrccm.2025.211.abstracts.a3336.Peer-Reviewed Original ResearchThe Human Proximal Pulmonary Artery Plays a Critical Role in Regulating Cardiopulmonary Function in Health and Disease
Manning E, Lee S, Ashadujjaman M, De Man R, Cai Z, Adams T, Raredon M, Ramachandra A, Cavinato C, Heerdt P, Singh I, Choudhary G, Yan X, Bellini C, Tellides G, Humphrey J, Kaminski N. The Human Proximal Pulmonary Artery Plays a Critical Role in Regulating Cardiopulmonary Function in Health and Disease. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a2891-a2891. DOI: 10.1164/ajrccm.2025.211.abstracts.a2891.Peer-Reviewed Original ResearchAdrenomedullin Is Enriched in Human Lung Vascular Niche and Enhances Endothelial Cell Maturation in Bioengineered Lung Models
Yoon Y, Kirk S, Raredon M, Kaminski N, Niklason L, Yuan Y. Adrenomedullin Is Enriched in Human Lung Vascular Niche and Enhances Endothelial Cell Maturation in Bioengineered Lung Models. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7243-a7243. DOI: 10.1164/ajrccm.2025.211.abstracts.a7243.Peer-Reviewed Original Research
2024
Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis.
Zhao A, Unterman A, Abu Hussein N, Sharma P, Nikola F, Flint J, Yan X, Adams T, Justet A, Sumida T, Zhao J, Schupp J, Raredon M, Ahangari F, Deluliis G, Zhang Y, Buendia-Roldan I, Adegunsoye A, Sperling A, Prasse A, Ryu C, Herzog E, Selman M, Pardo A, Kaminski N. Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 1252-1266. PMID: 38924775, PMCID: PMC11568434, DOI: 10.1164/rccm.202401-0078oc.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFibrotic hypersensitivity pneumonitisIdiopathic pulmonary fibrosisPeripheral blood mononuclear cellsBronchoalveolar lavage cellsBlood mononuclear cellsClassical monocytesHypersensitivity pneumonitisPulmonary fibrosisT cellsImmune perturbationsLavage cellsMononuclear cellsCD8+ T cellsCytotoxic T cellsInterstitial lung diseaseHypersensitivity pneumonitis patientsCytotoxic CD4Immune aberrationsPneumonic patientsPneumonitisLung diseaseHealthy controlsImmune mechanismsPatient cellsSingle-cell transcriptomicsSingle-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury. Physiology 2024, 39: 1314. DOI: 10.1152/physiol.2024.39.s1.1314.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAcute lung injuryChronic obstructive pulmonary diseaseAcute respiratory distress syndromeAnalysis of cell-cell communicationVEGF-DMicrovascular nicheSingle-cell RNA-seqLung injury modelSingle-cell RNA-seq analysisLung injuryCell-cell communicationLigand-receptor pairsLPS-induced lung injury modelRNA-seqAdjacent cell typesPulmonary diseaseInjury modelHuman lung endothelial cellsBarrier functionImmune cell infiltrationTumor necrosis factor-aRespiratory distress syndromeLung vascular integrityGene expressionVEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. VEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury. 2024, a4694-a4694. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4694.Peer-Reviewed Original ResearchAberrant Alveolar Epithelial Cells Alter the Alveolar Mesenchyme to Promote Fibrosis in a Clinical Sftpc Mutation Model of Lung Fibrosis
Hoffman E, Roque Barboza W, Rodriguez L, Murthy A, Dherwani R, Bennett A, Tomer Y, Raredon M, Beers M, Katzen J. Aberrant Alveolar Epithelial Cells Alter the Alveolar Mesenchyme to Promote Fibrosis in a Clinical Sftpc Mutation Model of Lung Fibrosis. 2024, a5197-a5197. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5197.Peer-Reviewed Original Research
2023
Rational engineering of lung alveolar epithelium
Leiby K, Yuan Y, Ng R, Raredon M, Adams T, Baevova P, Greaney A, Hirschi K, Campbell S, Kaminski N, Herzog E, Niklason L. Rational engineering of lung alveolar epithelium. Npj Regenerative Medicine 2023, 8: 22. PMID: 37117221, PMCID: PMC10147714, DOI: 10.1038/s41536-023-00295-2.Peer-Reviewed Original ResearchCitationsAltmetricConcepts
Academic Achievements & Community Involvement
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Honors
honor MD/PhD Thesis Prize
05/23/2022Yale School of Medicine AwardYale School of MedicineDetailsUnited Stateshonor Draper Fellowship
09/05/2012Other AwardDraper LaboratoriesDetailsUnited Stateshonor Distinction in Biomedical Engineering
05/05/2011Yale University AwardYale UniversityDetailsUnited Stateshonor Distinction in History of Art
05/05/2011Yale University AwardYale UniversityDetailsUnited Stateshonor Engineering Honors
05/01/2011National AwardTau Beta PiDetailsUnited States
Links
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Media
- Photo by Micha Sam Brickman Raredon
Immunostaining of cellular communities at the bronchioalveolar junction in lung tissue
Get In Touch
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Contacts
Vascular Biology and Therapeutics Program
10 Amistad Street, Rm. 301A
New Haven, Connecticut 06519
United States