Lauren A. Baldassarre, MD, FACC
Associate Professor of Medicine (Cardiovascular Medicine)Cards
About
Research
Publications
2026
Fractional flow reserve in coronary computed tomography angiography: An expert consensus document of the society of cardiovascular computed tomography (SCCT) and the society for cardiovascular angiography and interventions (SCAI). Endorsed by the American college of cardiology (ACC)
Weir-McCall J, Koweek L, Suchá D, Nørgaard B, Curzen N, Fairbairn T, Baldassarre L, Cardoso R, Chinnaiyan K, Hadamitzky M, Karady J, Lee J, Maurovich-Horvat P, Nicol E, Nieman K, Pontone G, Rajiah P, Schoepf U, Seto A, Rajani R. Fractional flow reserve in coronary computed tomography angiography: An expert consensus document of the society of cardiovascular computed tomography (SCCT) and the society for cardiovascular angiography and interventions (SCAI). Endorsed by the American college of cardiology (ACC). Journal Of Cardiovascular Computed Tomography 2026 PMID: 42236373, DOI: 10.1016/j.jcct.2026.05.006.Peer-Reviewed Original ResearchRadiation Therapy-Induced Valvular Heart Disease A Comprehensive Review with a Multi-Modality Imaging and Multidisciplinary Approach
Alkhatib D, Akintoye E, Khattab M, Reinhardt S, Baldassarre L. Radiation Therapy-Induced Valvular Heart Disease A Comprehensive Review with a Multi-Modality Imaging and Multidisciplinary Approach. Cardiology Clinics 2026 DOI: 10.1016/j.ccl.2026.04.005.Peer-Reviewed Original ResearchDifferences in the receipt of recommended cardiovascular assessment among cancer survivors in the United States by atherosclerotic cardiovascular disease status.
Mszar R, Alpert A, Gallardo-Vara E, Kang E, Conlin K, Barac A, Hull S, Baldassarre L, Dinan M, Irwin M, Ferrucci L. Differences in the receipt of recommended cardiovascular assessment among cancer survivors in the United States by atherosclerotic cardiovascular disease status. Journal Of Clinical Oncology 2026, 44: 12027-12027. DOI: 10.1200/jco.2026.44.16_suppl.12027.Peer-Reviewed Original ResearchCancer survivorsAtherosclerotic cardiovascular diseaseProportion of cancer survivorsNational Health Interview SurveyPre-existing atherosclerotic cardiovascular diseaseHealth Interview SurveyConfidence intervalsInitial cancer diagnosisNoninstitutionalized U.S. populationPast-yearCardiovascular disease statusMultivariate logistic regressionCancer survivorshipScreening ratesCross-sectional dataLevel of educationInterview SurveySociodemographic characteristicsSocioeconomic statusSuboptimal uptakeMultistage samplingOdds ratioCancer diagnosisSelf-ReportU.S. populationProspective Serial Cardiovascular Magnetic Resonance Imaging of Immune Checkpoint Inhibitor Myocarditis Correlates with Cardiovascular Outcomes
Kwan J, Khattab M, Tysarowski M, Zarif T, Chehayeb R, Shah N, Guajardo A, Jeyashanmugaraja G, Henry M, Lin D, Christophides A, Alkhatib D, Martinez C, Y I, Ragheb E, Higgins A, Cuomo J, Redheuil A, Salem J, Hull S, Huber S, Bader A, Feher A, Lamy J, Mojibian H, Sinusas A, Peters D, Baldassarre L. Prospective Serial Cardiovascular Magnetic Resonance Imaging of Immune Checkpoint Inhibitor Myocarditis Correlates with Cardiovascular Outcomes. Journal Of Cardiovascular Magnetic Resonance 2026, 102743. PMID: 42134550, DOI: 10.1016/j.jocmr.2026.102743.Peer-Reviewed Original ResearchImmune checkpoint inhibitor myocarditisImmune checkpoint inhibitorsAssociated with adverse cardiovascular outcomesGlobal longitudinal strainLake Louise criteriaCMR parametersCMR-FT GLSCardiovascular outcomesLV global longitudinal strainCMR imagesLA strain parametersGlobal circumferential strainAdverse cardiovascular outcomesLimited prospective dataAssociated with deathCheckpoint inhibitorsMyocarditis patientsPre-ICIReservoir strainCMR evaluationHeart failureMyocarditisProspective dataLongitudinal strainLVEFProspective Serial Cardiovascular Magnetic Resonance Imaging of Immune Checkpoint Inhibitor Myocarditis Correlates with Cardiovascular Outcomes
Kwan JM, Khattab M, Tysarowski M, Zarif TE, Chehayeb RJ, Shah N, Guajardo AF, Jeyashanmugaraja G, Henry ML, Lin D, Christophides A, Alkhatib D, Martinez C, Y I, Ragheb E, Higgins A, Cuomo J, Redheuil A, Salem J, Hull S, Huber S, Bader AS, Feher A, Lamy J, Mojibian H, Sinusas A, Peters DC, Baldassarre LA. Prospective Serial Cardiovascular Magnetic Resonance Imaging of Immune Checkpoint Inhibitor Myocarditis Correlates with Cardiovascular Outcomes. Journal Of Cardiovascular Magnetic Resonance 2026, 102743. DOI: 10.1016/j.jocmr.2026.102743.Peer-Reviewed Original ResearchThis study investigates how serial cardiovascular magnetic resonance imaging helps predict adverse cardiovascular events in immune checkpoint inhibitor myocarditis, highlighting its potential for improved patient risk stratification and outcomes.26-A-16612-ACC PREDICTIVE ROLE OF FEATURE-TRACKING CARDIOVASCULAR MAGNETIC RESONANCE (FT-CMR) IMAGING STRAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS
Csecs I, Wright C, Ahmed A, Frohlich B, Hinchcliff M, Baldassarre L, Feher A. 26-A-16612-ACC PREDICTIVE ROLE OF FEATURE-TRACKING CARDIOVASCULAR MAGNETIC RESONANCE (FT-CMR) IMAGING STRAIN IN PATIENTS WITH RHEUMATOID ARTHRITIS. Journal Of The American College Of Cardiology 2026, 87: a924. DOI: 10.1016/j.jacc.2026.02.2278.Peer-Reviewed Original ResearchCoronary Atherosclerosis in Patients With Cancer and Survivors: A Scientific Statement From the American Heart Association
Zhang L, Iliescu C, Ferencik M, Finamore V, Beavers C, Patel A, Ghoshhajra B, Milgrom S, Dent S, Baldassarre L, Jaffe I, Lopez-Mattei J, Health O. Coronary Atherosclerosis in Patients With Cancer and Survivors: A Scientific Statement From the American Heart Association. Circulation 2026, 153: e916-e933. PMID: 41657216, DOI: 10.1161/cir.0000000000001391.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAtherosclerotic cardiovascular diseaseCoronary atherosclerosisClonal hematopoiesisRisk stratificationClonal hematopoiesis of indeterminate potentialImmune checkpoint inhibitorsCardiovascular diseaseRisk of cardiotoxicityCoronary artery diseaseNoninvasive imaging modalityInvasive imaging techniquesCheckpoint inhibitorsElevated bleedingScientific statementAmerican Heart AssociationRadiation therapyHormone therapyIndividualized managementThrombotic riskIndeterminate potentialEndothelial dysfunctionIntervention medicationPathophysiological mechanismsArtery diseaseHeart AssociationResearch Priorities and Future Directions in Cardio-Oncology
Mszar R, Ali A, Hull S, Ferrucci L, Baldassarre L, Khera R, Irwin M, Clasen S. Research Priorities and Future Directions in Cardio-Oncology. Current Treatment Options In Oncology 2026, 27: 4. PMID: 41484494, DOI: 10.1007/s11864-025-01366-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIndividual health outcomesCancer survivorsSocial determinantsSocial determinants of healthQuality-of-care metricsCardiovascular diseaseCardio-oncology rehabilitationHealthy lifestyle behaviorsDeterminants of healthCancer risk factorsCardio-OncologyRisk factorsEvidence-based strategiesContemporary clinical guidelinesHealth equityLifestyle behaviorsLong-term cardiac surveillanceHealth outcomesHealth disciplinesCardiac radiation exposureTreatment continuumEvidence gapsImmune checkpoint inhibitorsInnovative clinical trialsClinical guidelines
2025
Myocarditis‐Associated Cardiogenic Shock: A Nationwide Multicenter Study
Zarif T, Ambrosini A, Shahu A, Shen M, Gastanadui M, Safiriyu I, Guha A, Jacobs M, Ali T, Kwan J, Hull S, Baldassarre L, Miller P. Myocarditis‐Associated Cardiogenic Shock: A Nationwide Multicenter Study. Journal Of The American Heart Association 2025, 14: e042850. PMID: 41220123, PMCID: PMC12887199, DOI: 10.1161/jaha.125.042850.Peer-Reviewed Original ResearchConceptsCardiogenic shockClinical outcomesClinical outcomes of patientsInverse probability weightingCoronary Artery Bypass GraftingIn-hospital mortality ratePulmonary artery catheterizationMortality rateOutcomes of patientsLeft heart catheterizationLeft ventricular assist device implantationVentricular assist device implantationCritically Ill PopulationAugmented inverse probability weightingArtery Bypass GraftingCharlson Comorbidity IndexIn-Hospital DeathAssist device implantationCritical care therapiesPercutaneous coronary interventionMechanical circulatory supportRates of cancerHeart catheterizationVizient Clinical Data BaseInotropic medicationsCardiac Magnetic Resonance Imaging in Immune Checkpoint Inhibitor–Myocarditis: Diagnostic and Prognostic Evidence and Limitations
Salem J, Baldassarre L, Redheuil A, Boussouar S, Thavendiranathan P, Procureur A. Cardiac Magnetic Resonance Imaging in Immune Checkpoint Inhibitor–Myocarditis: Diagnostic and Prognostic Evidence and Limitations. Current Heart Failure Reports 2025, 22: 28. PMID: 41123742, DOI: 10.1007/s11897-025-00717-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac magnetic resonance imagingLate gadolinium enhancementMagnetic resonance imagingCardiac magnetic resonance imaging findingsImmune checkpoint inhibitor myocarditisSeptal late gadolinium enhancementResonance imagingNative myocardial T1Multicenter prospective studyDiagnostic work-upMyocardial involvementGadolinium enhancementMyocardial abnormalitiesPrognostic markerPrognostic associationPrognostic evidenceProspective studyMyocardial edemaPathological dataMyocardial T1Work-upOncology patientsImpaired strainScan timeMethodological limitations
Academic Achievements & Community Involvement
Clinical Care
Overview
Lauren Baldassarre, MD, is a cardiologist at Yale Medicine and director of the Cardio-Oncology Program at the Yale Cancer Center.
Cardio-oncology is a relatively new field that helps patients manage the cardiac side effects of therapies they’re receiving for cancer treatment (such as chemotherapy, radiation and immunotherapy). The goal of the cardio-oncology program is to diagnose and treat those side effects as early as possible.
Dr. Baldassarre first became interested in cardio-oncology during her cardiology fellowship, and she decided to pursue and complete an additional year of fellowship training at the Memorial Sloan Kettering Cancer Center in New York City. That fellowship focused on advanced cardiac imaging with cardiac MRI and caring for cancer patients with cardiac questions or complications. It was a way for Dr. Baldassarre to combine her interests in women’s heart disease and cardiac imaging, and introduced her to the field of cardio-oncology. In 2013, she arrived at Yale Medicine and became the director of the cardio-oncology program in 2015.
As the director, Dr. Baldassarre’s goals have been to offer care to any patient who might benefit from cardiovascular risk assessment and monitoring not only at the main hospital, but also at Yale Medicine satellite sites, and to expand research and clinical trials that investigate ways to diagnose cardiac complications from cancer earlier.
When meeting with new patients, Dr. Baldassarre takes a thorough history and physical and completes a cardiovascular risk assessment based on the type of cancer therapy they will be receiving. Patients can also expect to undergo some cardiac imaging as part of that risk assessment.
“I really hope to be able to put patients at ease,” says Dr. Baldassarre. “I know that patients are concerned especially when they’re going through so much already.” She walks them through established monitoring and treatments protocols, which may be used to prevent complications or treat them, if they do arise.
In addition to seeing patients, Dr. Baldassarre researches the cardiac side effects of immunotherapy, one of the most promising therapies for cancer. She is also an associate professor (cardiology) at Yale Medicine.
Clinical Specialties
Fact Sheets
CT Scan for Coronary Artery Disease
Learn More on Yale MedicineChronic Total Occlusion (CTO)
Learn More on Yale MedicineCoronary Artery Disease (CAD)
Learn More on Yale MedicineHeart Disease in Women
Learn More on Yale Medicine
Board Certifications
Cardiovascular Computed Tomography
- Certification Organization
- Certification Board of Cardiovascular Computed Tomography
- Original Certification Date
- 2012
Yale Medicine News
News & Links
News
- April 09, 2026
Fellow Focus in Four: Ibolya Csecs, MD, Cardiovascular Medicine
- July 28, 2025
Smilow Cancer Hospital Cardio-Oncology Program
- September 18, 2024
Drs. Gallegos and Akintoye Named New Leaders of Yale’s Advanced Cardiac Imaging Fellowship Program
- July 24, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (July 2024)
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Cardiovascular Medicine
15 York Street, PO Box 208017
New Haven, CT 06520-8017
United States
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