My background and research are in translational immunology. I am interested in understanding the basis for autoimmune diseases and developing new therapies based on our understanding of disease mechanisms. My focus has largely been in the field of autoimmune Type 1 diabetes. The work encompasses basic laboratory work as well as clinical studies to understanding the regulation of autoreactive T cells to clinical trials that involve novel therapeutics. As part of these studies my lab has been very interested in analysis of beta cell function in Type 1 diabetes and identifying the cellular mechanisms that can protect them from immune killing. We have also been studying the development of autoimmune diabetes in patients with cancers who are treated with checkpoint inhibitors. Our clinical and basic studies are focused on understanding how beta cells are destroyed and react to inflammation. Finally, with the COVID-19 pandemic, we have been studying the immunologic basis for responses in children and adults who are hospitalized with COVID-19 to understand the mechanisms that can lead to disease protection.